Reviewed, UniProtKB/Swiss-Prot P51781 (GSTA1_PIG)

Names and origin

Protein names	Recommended name:     Glutathione S-transferase alpha M14     EC=2.5.1.18 Alternative name(s):     GST class-alpha
Organism	Sus scrofa (Pig)
Taxonomic identifier	9823 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GST superfamily. Alpha family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Transferase
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 222	221	Glutathione S-transferase alpha M14		PRO_0000185797
Regions
	Domain	3 – 83	81	GST N-terminal
	Domain	85 – 208	124	GST C-terminal

Sequences

	Sequence		Length	Mass (Da)
	P51781-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 8AAF741EEC8DDD4B	FASTA	222	25,281
	10 20 30 40 50 60 MAGKPILHYF NGRGRMECIR WLLAAAGVEF EEKFIKTPED LDKLTNDGSL LFQQVPMVEI 70 80 90 100 110 120 DGMKLVQTRA ILNYIATKYN LYGKDAKERA LIDMYTEGVA DLGEMILLLP LCPPNEKDAK 130 140 150 160 170 180 VASIKEKSTN RYLPAFEKVL KSHGQDYLVG NKLSRADIQL VELLYYVEEL DPSLLANFPL 190 200 210 220 LKALKTRVSN LPTVKKFLQP GSQRKPPMDA KKIRRSQEYF PD

References

[1]	Hatey F., Tosser G. Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z69585 mRNA. Translation: CAA93433.1.
RefSeq	NP_999554.1.
UniGene	Ssc.69976
3D structure databases
SMR	P51781. Positions 2-220.
ModBase	Search...
Genome annotation databases
GeneID	397682.
KEGG	ssc:397682.
Organism-specific databases
CTD	397682.
Phylogenomic databases
HOVERGEN	P51781.
Enzyme and pathway databases
BRENDA	2.5.1.18. 249.
Family and domain databases
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR003080. GST_alpha. IPR004046. GST_C. IPR012336. Thioredoxin-like_fold. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:1.20.1050.10. GST_C_like. 1 hit. G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11571:SF4. GST_alpha. 1 hit.
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
PRINTS	PR01266. GSTRNSFRASEA.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSTA1_PIG

Accession

Primary (citable) accession number: P51781

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	January 23, 2007
Last modified:	November 24, 2009
This is version 56 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)