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Protein

Complement factor D

Gene

CFD

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway (By similarity).By similarity

Catalytic activityi

Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei67Charge relay system1
Active sitei115Charge relay system1
Active sitei209Charge relay system1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processComplement alternate pathway, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-SSC-114608 Platelet degranulation
R-SSC-173736 Alternative complement activation
R-SSC-6798695 Neutrophil degranulation

Protein family/group databases

MEROPSiS01.191

Names & Taxonomyi

Protein namesi
Recommended name:
Complement factor D (EC:3.4.21.46)
Alternative name(s):
Adipsin
C3 convertase activator
Properdin factor D
Gene namesi
Name:CFD
Synonyms:DF
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000002756422 – 26Activation peptideSequence analysis5
ChainiPRO_000002756527 – 259Complement factor DAdd BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 68PROSITE-ProRule annotation
Disulfide bondi149 ↔ 215PROSITE-ProRule annotation
Disulfide bondi180 ↔ 196PROSITE-ProRule annotation
Disulfide bondi205 ↔ 230PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP51779
PeptideAtlasiP51779
PRIDEiP51779

Expressioni

Gene expression databases

BgeeiENSSSCG00000013418
GenevisibleiP51779 SS

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000014267

Structurei

3D structure databases

ProteinModelPortaliP51779
SMRiP51779
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 254Peptidase S1PROSITE-ProRule annotationAdd BLAST228

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118895
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiP51779
KOiK01334
OMAiAHARPYM
OrthoDBiEOG091G0DF7
TreeFamiTF333630

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR037561 Complement_factor_D
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PANTHERiPTHR43890:SF17 PTHR43890:SF17, 1 hit
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51779-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADRSGHLAA LILLGAAVCV AQPRGRILGG QEAKSHERPY MASVQVNGKH
60 70 80 90 100
VCGGFLVSEQ WVLSAAHCLE DVAEGKLQVL LGAHSLSQPE PSKRLYDVLR
110 120 130 140 150
AVPHPDSQPD TIDHDLLLLK LSEKAELGPA VQPLAWQRED HEVPAGTLCD
160 170 180 190 200
VAGWGVVSHT GRRPDRLQHL LLPVLDRTTC NLRTYHDGTI TERMMCAESN
210 220 230 240 250
RRDSCKGDSG GPLVCGGVAE GVVTSGSRVC GNRKKPGIYT RLASYVAWID

GVMADSAAA
Length:259
Mass (Da):27,764
Last modified:October 1, 1996 - v1
Checksum:i0121AAE0E34CA1ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29948 mRNA Translation: AAA73627.1
Z49058 mRNA Translation: CAA88844.1
PIRiS54115
RefSeqiXP_013850255.1, XM_013994801.1
UniGeneiSsc.11074

Genome annotation databases

EnsembliENSSSCT00000014662; ENSSSCP00000014267; ENSSSCG00000013418
GeneIDi396877
KEGGissc:396877

Similar proteinsi

Entry informationi

Entry nameiCFAD_PIG
AccessioniPrimary (citable) accession number: P51779
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 31, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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