Reviewed, UniProtKB/Swiss-Prot P51779 (CFAD_PIG)

Names and origin

Protein names

Recommended name:
    Complement factor D
    EC=3.4.21.46
Alternative name(s):
    C3 convertase activator
    Properdin factor D
    Adipsin

Gene names

Name:	CFD
Synonyms:	DF

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway By similarity.
Catalytic activity	Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.
Subcellular location	Secreted.
Sequence similarities	Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain.

Ontologies

Keywords
Biological process	Complement alternate pathway Immune response Innate immunity
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase Protease Serine protease
PTM	Disulfide bond Zymogen
Gene Ontology (GO)
Biological process	complement activation, alternative pathway Inferred from electronic annotation. Source: UniProtKB-KW proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Propeptide	22 – 26	5	Activation peptide Potential		PRO_0000027564
	Chain	27 – 259	233	Complement factor D		PRO_0000027565
Regions
	Domain	27 – 254	228	Peptidase S1
Sites
	Active site	67	1	Charge relay system
	Active site	115	1	Charge relay system
	Active site	209	1	Charge relay system
Amino acid modifications
	Disulfide bond	52 ↔ 68		By similarity
	Disulfide bond	149 ↔ 215		By similarity
	Disulfide bond	180 ↔ 196		By similarity
	Disulfide bond	205 ↔ 230		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P51779-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 0121AAE0E34CA1ED	FASTA	259	27,764
	10 20 30 40 50 60 MADRSGHLAA LILLGAAVCV AQPRGRILGG QEAKSHERPY MASVQVNGKH VCGGFLVSEQ 70 80 90 100 110 120 WVLSAAHCLE DVAEGKLQVL LGAHSLSQPE PSKRLYDVLR AVPHPDSQPD TIDHDLLLLK 130 140 150 160 170 180 LSEKAELGPA VQPLAWQRED HEVPAGTLCD VAGWGVVSHT GRRPDRLQHL LLPVLDRTTC 190 200 210 220 230 240 NLRTYHDGTI TERMMCAESN RRDSCKGDSG GPLVCGGVAE GVVTSGSRVC GNRKKPGIYT 250 RLASYVAWID GVMADSAAA

References

[1]	Miner J.L., Hahn K.J., Staten N.R., Baile C.A. Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Adipose tissue.
[2]	Nicolas N. Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 69-259. Tissue: Adipose tissue.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U29948 mRNA. Translation: AAA73627.1. Z49058 mRNA. Translation: CAA88844.1.
PIR	S54115.
UniGene	Ssc.11074
3D structure databases
HSSP	HSSP built from PDB template 1FDP based on UniProtKB P00746.
SMR	P51779. Positions 27-254.
ModBase	Search...
Protein family/group databases
MEROPS	S01.191.
Phylogenomic databases
HOVERGEN	P51779.
Enzyme and pathway databases
BRENDA	3.4.21.46. 249.
Family and domain databases
InterPro	IPR018114. Peptidase_S1/S6_AS. IPR001254. Peptidase_S1_S6. IPR001314. Peptidase_S1A. [Graphical view]
Pfam	PF00089. Trypsin. 1 hit. [Graphical view]
PRINTS	PR00722. CHYMOTRYPSIN.
SMART	SM00020. Tryp_SPc. 1 hit. [Graphical view]
PROSITE	PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CFAD_PIG

Accession

Primary (citable) accession number: P51779

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)