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Protein

E3 SUMO-protein ligase EGR2

Gene

Egr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Binds to the promoter region of ERBB2 (By similarity).By similarity
E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity.By similarity

Pathwayi: protein sumoylation

This protein is involved in the pathway protein sumoylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein sumoylation and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri337 – 361C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri367 – 389C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Ligase

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00886.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 SUMO-protein ligase EGR2 (EC:6.3.2.-)
Alternative name(s):
Early growth response protein 2
Short name:
EGR-2
Zinc finger protein Krox-20
Gene namesi
Name:Egr2
Synonyms:Egr-2, Krox-20, Krox20
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi621608. Egr2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471211 – 470E3 SUMO-protein ligase EGR2Add BLAST470

Post-translational modificationi

Ubiquitinated by WWP2 leading to proteasomal degradation.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiP51774.

Expressioni

Gene expression databases

BgeeiENSRNOG00000000640.
GenevisibleiP51774. RN.

Interactioni

Subunit structurei

Interacts with HCFC1. Interacts with WWP2. Interacts with CITED1. Interacts (via phosphorylated form) with SFN. Interacts with UBC9 (By similarity).By similarity

GO - Molecular functioni

  • HMG box domain binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000792.

Structurei

3D structure databases

ProteinModelPortaliP51774.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi167 – 173Poly-Pro7

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri337 – 361C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri367 – 389C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00550000074455.
HOGENOMiHOG000036856.
HOVERGENiHBG003909.
InParanoidiP51774.
KOiK12496.
OMAiASCTSRT.
OrthoDBiEOG091G06VX.
PhylomeDBiP51774.
TreeFamiTF318980.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR021849. DUF3446.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF11928. DUF3446. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P51774-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMTAKAVDKI PVTLSGFMHQ LPDSLYPVED LAAPSVTIFP NGELGGPFDQ
60 70 80 90 100
MNGVAGDGMI NIDMTGEKRP LDLPYPSSFA PISAPRNQTF TYMGKFSIDP
110 120 130 140 150
QYPGASCYPE GIINIVSAGI LQGVTPPAST TASSSVTSAS PNPLATGPLG
160 170 180 190 200
VCTMSQTQPE LDHLYSPPPP PPPYSGCTGD LYQDPSAFLS PPPTTSTSSL
210 220 230 240 250
AYQPPPSYPS PKPAMDPGLI PMIPDYPGFF PSPCQRDPHG AAGPDRKPFP
260 270 280 290 300
CPLDSLRVPP PLTPLSTIRN FTLGGPSAGV TGPGASGGGE GPRLPGSGSA
310 320 330 340 350
AVTATPYNPH HLPLRPILRP RKYPNRPSKT PVHERPYPCP AEGCDRRFSR
360 370 380 390 400
SDELTRHIRI HTGHKPFQCR ICMRNFSRSD HLTTHIRTHT GEKPFACDYC
410 420 430 440 450
GRKFARSDER KRHTKIHLRQ KERKSSAPSS SASAQSSASG PGGSQAGGSL
460 470
CGNSAIGGPL ASCTSRTRTP
Length:470
Mass (Da):49,849
Last modified:November 1, 1997 - v2
Checksum:i2B28185752A91F76
GO
Isoform Short (identifier: P51774-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.

Show »
Length:420
Mass (Da):44,520
Checksum:i5A29B11D9A273284
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0068651 – 50Missing in isoform Short. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78102 mRNA. Translation: AAB36783.1.
D83508 mRNA. Translation: BAA11932.1.
AB032420 mRNA. Translation: BAA89319.1.
PIRiJC4716.
RefSeqiNP_446085.1. NM_053633.1. [P51774-1]
XP_017457019.1. XM_017601530.1. [P51774-2]
UniGeneiRn.89235.

Genome annotation databases

EnsembliENSRNOT00000000792; ENSRNOP00000000792; ENSRNOG00000000640. [P51774-1]
GeneIDi114090.
KEGGirno:114090.
UCSCiRGD:621608. rat. [P51774-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78102 mRNA. Translation: AAB36783.1.
D83508 mRNA. Translation: BAA11932.1.
AB032420 mRNA. Translation: BAA89319.1.
PIRiJC4716.
RefSeqiNP_446085.1. NM_053633.1. [P51774-1]
XP_017457019.1. XM_017601530.1. [P51774-2]
UniGeneiRn.89235.

3D structure databases

ProteinModelPortaliP51774.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000792.

Proteomic databases

PaxDbiP51774.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000792; ENSRNOP00000000792; ENSRNOG00000000640. [P51774-1]
GeneIDi114090.
KEGGirno:114090.
UCSCiRGD:621608. rat. [P51774-1]

Organism-specific databases

CTDi1959.
RGDi621608. Egr2.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00550000074455.
HOGENOMiHOG000036856.
HOVERGENiHBG003909.
InParanoidiP51774.
KOiK12496.
OMAiASCTSRT.
OrthoDBiEOG091G06VX.
PhylomeDBiP51774.
TreeFamiTF318980.

Enzyme and pathway databases

UniPathwayiUPA00886.

Miscellaneous databases

PROiP51774.

Gene expression databases

BgeeiENSRNOG00000000640.
GenevisibleiP51774. RN.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR021849. DUF3446.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF11928. DUF3446. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEGR2_RAT
AccessioniPrimary (citable) accession number: P51774
Secondary accession number(s): Q54AG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.