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P51771 (ENLYS_BPP2) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endolysin

EC=3.2.1.17
Alternative name(s):
Lysis protein
Lysozyme
Muramidase
Protein gpK
Gene names
Name:K
OrganismEnterobacteria phage P2 (Bacteriophage P2) [Reference proteome]
Taxonomic identifier10679 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaePeduovirinaeP2likevirus
Virus hostEnterobacteriaceae [TaxID: 543]

Protein attributes

Sequence length165 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer By similarity.

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Subcellular location

Host cytoplasm Potential. Note: The endolysin is cytoplasmic, but can reach the periplasmic space with the help of the holins which disrupt the host cell membrane By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 24 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 165165Endolysin
PRO_0000218100

Sites

Active site211 By similarity

Natural variations

Natural variant401G → R in temperature-sensitive KTS60.

Sequences

Sequence LengthMass (Da)Tools
P51771 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 82388A6A86C2B35E

FASTA16518,538
        10         20         30         40         50         60 
MPVINTHQNI AAFLDMLAVS EGTANHPLTK NRGYDVIVTG LDGKPEIFTD YSDHPFAHGR 

        70         80         90        100        110        120 
PAKVFNRRGE KSTASGRYQQ LYLFWPHYRK QLALPDFSPL SQDRLAIQLI RERGALDDIR 

       130        140        150        160 
AGRIERAISR CRNIWASLPG AGYGQREHSL EKLVTVWRTA GGVPA 

« Hide

References

[1]"Functions involved in bacteriophage P2-induced host cell lysis and identification of a new tail gene."
Ziermann R., Bartlett B., Calendar R., Christie G.E.
J. Bacteriol. 176:4974-4984(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF063097 Genomic DNA. Translation: AAD03276.1.
PIRD55855.
RefSeqNP_046765.1. NC_001895.1.

3D structure databases

ProteinModelPortalP51771.
SMRP51771. Positions 7-164.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH104. Glycoside Hydrolase Family 104.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1261544.

Family and domain databases

InterProIPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamPF00959. Phage_lysozyme. 1 hit.
[Graphical view]
SUPFAMSSF53955. SSF53955. 1 hit.
ProtoNetSearch...

Entry information

Entry nameENLYS_BPP2
AccessionPrimary (citable) accession number: P51771
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries