P51771 (LYS_BPP2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lysozyme
EC=3.2.1.17

Alternative name(s):
Endolysin
Lysis protein
Muramidase
Protein gpK

Gene names

Name:

K

Organism

Enterobacteria phage P2 (Bacteriophage P2)

Taxonomic identifier

10679 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Caudovirales › Myoviridae › Peduovirinae › P2-like viruses

Virus host

Enterobacteriaceae [TaxID: 543]

Protein attributes

Sequence length	165 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity. Acts as a transglycosylase By similarity.
Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Sequence similarities	Belongs to the glycosyl hydrolase 24 family.

Ontologies

Keywords
Molecular function	Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 165	165	Lysozyme		PRO_0000218100
Natural variations
	Natural variant	40	1	G → R in temperature-sensitive KTS60.

Sequences

	Sequence		Length	Mass (Da)
	P51771 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 82388A6A86C2B35E	FASTA	165	18,538
	10 20 30 40 50 60 MPVINTHQNI AAFLDMLAVS EGTANHPLTK NRGYDVIVTG LDGKPEIFTD YSDHPFAHGR 70 80 90 100 110 120 PAKVFNRRGE KSTASGRYQQ LYLFWPHYRK QLALPDFSPL SQDRLAIQLI RERGALDDIR 130 140 150 160 AGRIERAISR CRNIWASLPG AGYGQREHSL EKLVTVWRTA GGVPA

References

[1]	"Functions involved in bacteriophage P2-induced host cell lysis and identification of a new tail gene." Ziermann R., Bartlett B., Calendar R., Christie G.E. J. Bacteriol. 176:4974-4984(1994) [PubMed: 8051010] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF063097 Genomic DNA. Translation: AAD03276.1.
PIR	D55855.
RefSeq	NP_046765.1. NC_001895.1.
3D structure databases
ProteinModelPortal	P51771.
SMR	P51771. Positions 7-164.
ModBase	Search...
Protein family/group databases
CAZy	GH104. Glycoside Hydrolase Family 104.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1261544.
GenomeReviews	Gene locus P2p10 in contig AF063097_GR.
Phylogenomic databases
ProtClustDB	CLSP2343790.
Family and domain databases
InterPro	IPR002196. Glyco_hydro_24. IPR023346. Lysozyme-like_dom. [Graphical view]
Pfam	PF00959. Phage_lysozyme. 1 hit. [Graphical view]
SUPFAM	SSF53955. SSF53955. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LYS_BPP2

Accession

Primary (citable) accession number: P51771

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	September 21, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program