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P51771

- ENLYS_BPP2

UniProt

P51771 - ENLYS_BPP2

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Protein

Endolysin

Gene
K
Organism
Enterobacteria phage P2 (Bacteriophage P2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer By similarity.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei21 – 211 By similarity

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: InterPro
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
  4. peptidoglycan catabolic process Source: InterPro
  5. viral release from host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Keywords - Biological processi

Cytolysis, Host cell lysis by virus, Virus exit from host cell

Protein family/group databases

CAZyiGH104. Glycoside Hydrolase Family 104.

Names & Taxonomyi

Protein namesi
Recommended name:
Endolysin (EC:3.2.1.17)
Alternative name(s):
Lysis protein
Lysozyme
Muramidase
Protein gpK
Gene namesi
Name:K
OrganismiEnterobacteria phage P2 (Bacteriophage P2)
Taxonomic identifieri10679 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaePeduovirinaeP2likevirus
Virus hostiEnterobacteriaceae [TaxID: 543]
ProteomesiUP000009092: Genome

Subcellular locationi

Host cytoplasm Reviewed prediction
Note: The endolysin is cytoplasmic, but can reach the periplasmic space with the help of the holins which disrupt the host cell membrane By similarity.

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 165165EndolysinPRO_0000218100Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP51771.
SMRiP51771. Positions 7-164.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamiPF00959. Phage_lysozyme. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

P51771-1 [UniParc]FASTAAdd to Basket

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MPVINTHQNI AAFLDMLAVS EGTANHPLTK NRGYDVIVTG LDGKPEIFTD    50
YSDHPFAHGR PAKVFNRRGE KSTASGRYQQ LYLFWPHYRK QLALPDFSPL 100
SQDRLAIQLI RERGALDDIR AGRIERAISR CRNIWASLPG AGYGQREHSL 150
EKLVTVWRTA GGVPA 165
Length:165
Mass (Da):18,538
Last modified:October 1, 1996 - v1
Checksum:i82388A6A86C2B35E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 401G → R in temperature-sensitive KTS60.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF063097 Genomic DNA. Translation: AAD03276.1.
PIRiD55855.
RefSeqiNP_046765.1. NC_001895.1.

Genome annotation databases

GeneIDi1261544.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF063097 Genomic DNA. Translation: AAD03276.1 .
PIRi D55855.
RefSeqi NP_046765.1. NC_001895.1.

3D structure databases

ProteinModelPortali P51771.
SMRi P51771. Positions 7-164.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH104. Glycoside Hydrolase Family 104.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1261544.

Family and domain databases

InterProi IPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
[Graphical view ]
Pfami PF00959. Phage_lysozyme. 1 hit.
[Graphical view ]
SUPFAMi SSF53955. SSF53955. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Functions involved in bacteriophage P2-induced host cell lysis and identification of a new tail gene."
    Ziermann R., Bartlett B., Calendar R., Christie G.E.
    J. Bacteriol. 176:4974-4984(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiENLYS_BPP2
AccessioniPrimary (citable) accession number: P51771
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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