Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P51728 (LYS_BPHC1) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysozyme

EC=3.2.1.17
Alternative name(s):
Endolysin
Lysis protein
Muramidase
Gene names
Name:lys
OrganismHaemophilus phage HP1 (strain HP1c1) (Bacteriophage HP1) [Reference proteome]
Taxonomic identifier1289570 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaePeduovirinaeHpunalikevirus
Virus hostHaemophilus [TaxID: 724]

Protein attributes

Sequence length186 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity.

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sequence similarities

Belongs to the glycosyl hydrolase 24 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 186169Lysozyme
PRO_0000018519

Sites

Active site471Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
P51728 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 0203E9A32EF45907

FASTA18620,553
        10         20         30         40         50         60 
MSKKFGAMIL CSAAAVAAAF FAQQKGLPTQ QQNQVSPKAV SMIVNLEGCV RNPYKCPADV 

        70         80         90        100        110        120 
WTNGVGNTHN VDKTKILTID EVATDLRRNI KEAENCINTY FNGEKMNQGQ YDAMVSLAFN 

       130        140        150        160        170        180 
VGCGNIKTYY SKTQGKRVAT TIYRAAQAEN WILMCNRIED FNKSGGRVLK GLQNRRAKEK 


ALCLGE 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of cloned DNA segments of the Haemophilus influenzae bacteriophage HP1c1."
Benjamin R.C., Fitzmaurice W.P., Huang P.C., Scocca J.J.
Gene 31:173-185(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The complete nucleotide sequence of bacteriophage HP1 DNA."
Esposito D., Fitzmaurice W.P., Benjamin R.C., Goodman S.D., Waldman A.S., Scocca J.J.
Nucleic Acids Res. 24:2360-2368(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U24159 Genomic DNA. Translation: AAB09211.1.
PIRS69532.
RefSeqNP_043495.1. NC_001697.1.

3D structure databases

ProteinModelPortalP51728.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1261120.

Phylogenomic databases

ProtClustDBCLSP2343231.

Family and domain databases

Gene3D1.10.530.40. 1 hit.
InterProIPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view]
PfamPF00959. Phage_lysozyme. 1 hit.
[Graphical view]
SUPFAMSSF53955. SSF53955. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLYS_BPHC1
AccessionPrimary (citable) accession number: P51728
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 16, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries