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P51728

- LYS_BPHC1

UniProt

P51728 - LYS_BPHC1

Protein

Lysozyme

Gene

lys

Organism
Haemophilus phage HP1 (strain HP1c1) (Bacteriophage HP1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity.

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei47 – 471Proton donorBy similarity

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell wall macromolecule catabolic process Source: InterPro
    2. cytolysis Source: UniProtKB-KW
    3. defense response to bacterium Source: UniProtKB-KW
    4. peptidoglycan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysozyme (EC:3.2.1.17)
    Alternative name(s):
    Endolysin
    Lysis protein
    Muramidase
    Gene namesi
    Name:lys
    OrganismiHaemophilus phage HP1 (strain HP1c1) (Bacteriophage HP1)
    Taxonomic identifieri1289570 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaePeduovirinaeHpunalikevirus
    Virus hostiHaemophilus [TaxID: 724]
    ProteomesiUP000001713: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 186169LysozymePRO_0000018519Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP51728.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 24 family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di1.10.530.40. 1 hit.
    InterProiIPR002196. Glyco_hydro_24.
    IPR023346. Lysozyme-like_dom.
    IPR023347. Lysozyme_dom.
    [Graphical view]
    PfamiPF00959. Phage_lysozyme. 1 hit.
    [Graphical view]
    SUPFAMiSSF53955. SSF53955. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P51728-1 [UniParc]FASTAAdd to Basket

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    MSKKFGAMIL CSAAAVAAAF FAQQKGLPTQ QQNQVSPKAV SMIVNLEGCV    50
    RNPYKCPADV WTNGVGNTHN VDKTKILTID EVATDLRRNI KEAENCINTY 100
    FNGEKMNQGQ YDAMVSLAFN VGCGNIKTYY SKTQGKRVAT TIYRAAQAEN 150
    WILMCNRIED FNKSGGRVLK GLQNRRAKEK ALCLGE 186
    Length:186
    Mass (Da):20,553
    Last modified:October 1, 1996 - v1
    Checksum:i0203E9A32EF45907
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U24159 Genomic DNA. Translation: AAB09211.1.
    PIRiS69532.
    RefSeqiNP_043495.1. NC_001697.1.

    Genome annotation databases

    GeneIDi1261120.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U24159 Genomic DNA. Translation: AAB09211.1 .
    PIRi S69532.
    RefSeqi NP_043495.1. NC_001697.1.

    3D structure databases

    ProteinModelPortali P51728.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1261120.

    Family and domain databases

    Gene3Di 1.10.530.40. 1 hit.
    InterProi IPR002196. Glyco_hydro_24.
    IPR023346. Lysozyme-like_dom.
    IPR023347. Lysozyme_dom.
    [Graphical view ]
    Pfami PF00959. Phage_lysozyme. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53955. SSF53955. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of cloned DNA segments of the Haemophilus influenzae bacteriophage HP1c1."
      Benjamin R.C., Fitzmaurice W.P., Huang P.C., Scocca J.J.
      Gene 31:173-185(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiLYS_BPHC1
    AccessioniPrimary (citable) accession number: P51728
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3