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P51728

- LYS_BPHC1

UniProt

P51728 - LYS_BPHC1

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Protein

Lysozyme

Gene

lys

Organism
Haemophilus phage HP1 (strain HP1c1) (Bacteriophage HP1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei47 – 471Proton donorBy similarity

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: InterPro
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
  4. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme (EC:3.2.1.17)
Alternative name(s):
Endolysin
Lysis protein
Muramidase
Gene namesi
Name:lys
OrganismiHaemophilus phage HP1 (strain HP1c1) (Bacteriophage HP1)
Taxonomic identifieri1289570 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaePeduovirinaeHpunalikevirus
Virus hostiHaemophilus [TaxID: 724]
ProteomesiUP000001713: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 186169LysozymePRO_0000018519Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP51728.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 24 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.10.530.40. 1 hit.
InterProiIPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view]
PfamiPF00959. Phage_lysozyme. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51728-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKKFGAMIL CSAAAVAAAF FAQQKGLPTQ QQNQVSPKAV SMIVNLEGCV
60 70 80 90 100
RNPYKCPADV WTNGVGNTHN VDKTKILTID EVATDLRRNI KEAENCINTY
110 120 130 140 150
FNGEKMNQGQ YDAMVSLAFN VGCGNIKTYY SKTQGKRVAT TIYRAAQAEN
160 170 180
WILMCNRIED FNKSGGRVLK GLQNRRAKEK ALCLGE
Length:186
Mass (Da):20,553
Last modified:October 1, 1996 - v1
Checksum:i0203E9A32EF45907
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U24159 Genomic DNA. Translation: AAB09211.1.
PIRiS69532.
RefSeqiNP_043495.1. NC_001697.1.

Genome annotation databases

GeneIDi1261120.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U24159 Genomic DNA. Translation: AAB09211.1 .
PIRi S69532.
RefSeqi NP_043495.1. NC_001697.1.

3D structure databases

ProteinModelPortali P51728.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1261120.

Family and domain databases

Gene3Di 1.10.530.40. 1 hit.
InterProi IPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view ]
Pfami PF00959. Phage_lysozyme. 1 hit.
[Graphical view ]
SUPFAMi SSF53955. SSF53955. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of cloned DNA segments of the Haemophilus influenzae bacteriophage HP1c1."
    Benjamin R.C., Fitzmaurice W.P., Huang P.C., Scocca J.J.
    Gene 31:173-185(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiLYS_BPHC1
AccessioniPrimary (citable) accession number: P51728
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 1, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3