P51728 (LYS_BPHC1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lysozyme
EC=3.2.1.17

Alternative name(s):
Endolysin
Lysis protein
Muramidase

Gene names

Name:

lys

Organism

Haemophilus phage HP1 (strain HP1c1) (Bacteriophage HP1) [Complete proteome]

Taxonomic identifier

1289570 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Caudovirales › Myoviridae › Peduovirinae › Hpunalikevirus › Haemophilus phage HP1

Virus host

Haemophilus [TaxID: 724]

Protein attributes

Sequence length	186 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity.
Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Sequence similarities	Belongs to the glycosyl hydrolase 24 family.

Ontologies

Keywords
Domain	Signal
Molecular function	Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan catabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 186	169	Lysozyme		PRO_0000018519
Sites
	Active site	47	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	P51728 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 0203E9A32EF45907	FASTA	186	20,553
	10 20 30 40 50 60 MSKKFGAMIL CSAAAVAAAF FAQQKGLPTQ QQNQVSPKAV SMIVNLEGCV RNPYKCPADV 70 80 90 100 110 120 WTNGVGNTHN VDKTKILTID EVATDLRRNI KEAENCINTY FNGEKMNQGQ YDAMVSLAFN 130 140 150 160 170 180 VGCGNIKTYY SKTQGKRVAT TIYRAAQAEN WILMCNRIED FNKSGGRVLK GLQNRRAKEK ALCLGE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of cloned DNA segments of the Haemophilus influenzae bacteriophage HP1c1." Benjamin R.C., Fitzmaurice W.P., Huang P.C., Scocca J.J. Gene 31:173-185(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The complete nucleotide sequence of bacteriophage HP1 DNA." Esposito D., Fitzmaurice W.P., Benjamin R.C., Goodman S.D., Waldman A.S., Scocca J.J. Nucleic Acids Res. 24:2360-2368(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U24159 Genomic DNA. Translation: AAB09211.1.
PIR	S69532.
RefSeq	NP_043495.1. NC_001697.1.
3D structure databases
ProteinModelPortal	P51728.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1261120.
Phylogenomic databases
ProtClustDB	CLSP2343231.
Family and domain databases
Gene3D	1.10.530.40. 1 hit.
InterPro	IPR002196. Glyco_hydro_24. IPR023346. Lysozyme-like_dom. IPR023347. Lysozyme_dom. [Graphical view]
Pfam	PF00959. Phage_lysozyme. 1 hit. [Graphical view]
SUPFAM	SSF53955. SSF53955. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LYS_BPHC1

Accession

Primary (citable) accession number: P51728

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program