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Protein

Signal transducer and activator of transcription 5B

Gene

STAT5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1170546. Prolactin receptor signaling.
R-HSA-1266695. Interleukin-7 signaling.
R-HSA-1433557. Signaling by SCF-KIT.
R-HSA-1839117. Signaling by cytosolic FGFR1 fusion mutants.
R-HSA-186763. Downstream signal transduction.
R-HSA-2586552. Signaling by Leptin.
R-HSA-451927. Interleukin-2 family signaling.
R-HSA-512988. Interleukin-3, 5 and GM-CSF signaling.
R-HSA-8983432. Interleukin-15 signaling.
R-HSA-982772. Growth hormone receptor signaling.
SignaLinkiP51692.
SIGNORiP51692.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcription 5B
Gene namesi
Name:STAT5B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000173757.9.
HGNCiHGNC:11367. STAT5B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Growth hormone insensitivity with immunodeficiency (GHII)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by short stature, growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, resistance to hexogeneous growth hormone therapy, and recurrent infections.
See also OMIM:245590
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018728630A → P in GHII; affects activation by growth hormone or interferon-gamma. 1 PublicationCorresponds to variant dbSNP:rs121908501Ensembl.1
Natural variantiVAR_067368646F → S in GHII; transcriptionally inactive. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi684T → A: Abolishes interaction with INSR. 1 Publication1
Mutagenesisi699Y → F: Abolishes phosphorylation by HCK. 1 Publication1

Keywords - Diseasei

Disease mutation, Dwarfism

Organism-specific databases

DisGeNETi6777.
MalaCardsiSTAT5B.
MIMi245590. phenotype.
OpenTargetsiENSG00000173757.
Orphaneti520. Acute promyelocytic leukemia.
220465. Laron syndrome with immunodeficiency.
PharmGKBiPA36186.

Chemistry databases

ChEMBLiCHEMBL5817.
DrugBankiDB01254. Dasatinib.

Polymorphism and mutation databases

BioMutaiSTAT5B.
DMDMi41019536.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001824291 – 787Signal transducer and activator of transcription 5BAdd BLAST787

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei90PhosphotyrosineCombined sources1
Modified residuei128PhosphoserineCombined sources1
Modified residuei193PhosphoserineCombined sources1
Modified residuei699Phosphotyrosine; by HCK, JAK and PTK62 Publications1

Post-translational modificationi

Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2. Phosphorylation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity.6 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP51692.
MaxQBiP51692.
PaxDbiP51692.
PeptideAtlasiP51692.
PRIDEiP51692.

PTM databases

iPTMnetiP51692.
PhosphoSitePlusiP51692.

Miscellaneous databases

PMAP-CutDBiP51692.

Expressioni

Gene expression databases

BgeeiENSG00000173757.
CleanExiHS_STAT5B.
ExpressionAtlasiP51692. baseline and differential.
GenevisibleiP51692. HS.

Organism-specific databases

HPAiCAB004298.
HPA042128.
HPA049883.
HPA051156.

Interactioni

Subunit structurei

Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1 (PubMed:12954634). Interacts with NMI (PubMed:9989503). Interacts with SOCS7 (PubMed:15677474). Interacts (via SH2 domain) with INSR (PubMed:9428692). Interacts with CPEB3; this inhibits STAT5B-mediated transcriptional activation (PubMed:20639532).By similarity5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • glucocorticoid receptor binding Source: BHF-UCL
  • protein dimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi112654. 57 interactors.
CORUMiP51692.
IntActiP51692. 26 interactors.
MINTiMINT-132900.
STRINGi9606.ENSP00000293328.

Chemistry databases

BindingDBiP51692.

Structurei

3D structure databases

ProteinModelPortaliP51692.
SMRiP51692.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini589 – 686SH2PROSITE-ProRule annotationAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni232 – 321Required for interaction with NMI1 PublicationAdd BLAST90

Sequence similaritiesi

Belongs to the transcription factor STAT family.Curated

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG3667. Eukaryota.
ENOG410XPN8. LUCA.
GeneTreeiENSGT00760000119236.
HOVERGENiHBG107486.
InParanoidiP51692.
KOiK11224.
OMAiVWNLMPY.
OrthoDBiEOG091G03O3.
PhylomeDBiP51692.
TreeFamiTF318648.

Family and domain databases

CDDicd10420. SH2_STAT5b. 1 hit.
Gene3Di1.10.532.10. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR036860. SH2_dom_sf.
IPR001217. STAT.
IPR035858. STAT5a/5b.
IPR035886. STAT5b_SH2.
IPR036535. STAT_N_sf.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_N.
IPR013799. STAT_TF_prot_interaction.
PANTHERiPTHR11801. PTHR11801. 1 hit.
PTHR11801:SF39. PTHR11801:SF39. 1 hit.
PfamiView protein in Pfam
PF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiView protein in PROSITE
PS50001. SH2. 1 hit.

Sequencei

Sequence statusi: Complete.

P51692-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVWIQAQQL QGEALHQMQA LYGQHFPIEV RHYLSQWIES QAWDSVDLDN
60 70 80 90 100
PQENIKATQL LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQNTYDR
110 120 130 140 150
CPMELVRCIR HILYNEQRLV REANNGSSPA GSLADAMSQK HLQINQTFEE
160 170 180 190 200
LRLVTQDTEN ELKKLQQTQE YFIIQYQESL RIQAQFGPLA QLSPQERLSR
210 220 230 240 250
ETALQQKQVS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL RKQQTIILDD
260 270 280 290 300
ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC
310 320 330 340 350
QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA
360 370 380 390 400
TVRLLVGGKL NVHMNPPQVK ATIISEQQAK SLLKNENTRN DYSGEILNNC
410 420 430 440 450
CVMEYHQATG TLSAHFRNMS LKRIKRSDRR GAESVTEEKF TILFESQFSV
460 470 480 490 500
GGNELVFQVK TLSLPVVVIV HGSQDNNATA TVLWDNAFAE PGRVPFAVPD
510 520 530 540 550
KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNN SSSHLEDYSG
560 570 580 590 600
LSVSWSQFNR ENLPGRNYTF WQWFDGVMEV LKKHLKPHWN DGAILGFVNK
610 620 630 640 650
QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSQERMF WNLMPFTTRD
660 670 680 690 700
FSIRSLADRL GDLNYLIYVF PDRPKDEVYS KYYTPVPCES ATAKAVDGYV
710 720 730 740 750
KPQIKQVVPE FVNASADAGG GSATYMDQAP SPAVCPQAHY NMYPQNPDSV
760 770 780
LDTDGDFDLE DTMDVARRVE ELLGRPMDSQ WIPHAQS
Length:787
Mass (Da):89,866
Last modified:January 16, 2004 - v2
Checksum:iAA2F1CAB20955ACA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti230A → P in AAC50491 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052074130A → V. Corresponds to variant dbSNP:rs2277619Ensembl.1
Natural variantiVAR_018728630A → P in GHII; affects activation by growth hormone or interferon-gamma. 1 PublicationCorresponds to variant dbSNP:rs121908501Ensembl.1
Natural variantiVAR_067368646F → S in GHII; transcriptionally inactive. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48730 mRNA. Translation: AAC50485.2.
U47686 mRNA. Translation: AAC50491.1.
AJ412888
, AJ412889, AJ412890, AJ412891, AJ412892, AJ412893, AJ412894, AJ412895, AJ412896, AJ412897, AJ412898, AJ412899 Genomic DNA. Translation: CAD19638.1.
BC065227 mRNA. Translation: AAH65227.1.
CCDSiCCDS11423.1.
RefSeqiNP_036580.2. NM_012448.3.
UniGeneiHs.595276.

Genome annotation databases

EnsembliENST00000293328; ENSP00000293328; ENSG00000173757.
GeneIDi6777.
KEGGihsa:6777.
UCSCiuc002hzh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSTA5B_HUMAN
AccessioniPrimary (citable) accession number: P51692
Secondary accession number(s): Q8WWS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 16, 2004
Last modified: November 22, 2017
This is version 181 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It was reported that dephosphorylation on tyrosine residues by PTPN2 would negatively regulate prolactin signaling pathway (PubMed:11773439). However, the corresponding article has been retracted (PubMed:24319783).1 Publication1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families