Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P51692

- STA5B_HUMAN

UniProt

P51692 - STA5B_HUMAN

Protein

Signal transducer and activator of transcription 5B

Gene

STAT5B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 151 (01 Oct 2014)
      Sequence version 2 (16 Jan 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription.1 Publication

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. chromatin binding Source: UniProtKB
    3. double-stranded DNA binding Source: Ensembl
    4. glucocorticoid receptor binding Source: BHF-UCL
    5. protein binding Source: UniProtKB
    6. protein dimerization activity Source: UniProtKB
    7. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
    8. sequence-specific DNA binding transcription factor activity Source: ProtInc
    9. signal transducer activity Source: Ensembl

    GO - Biological processi

    1. 2-oxoglutarate metabolic process Source: BHF-UCL
    2. acute-phase response Source: Ensembl
    3. allantoin metabolic process Source: BHF-UCL
    4. cellular response to epidermal growth factor stimulus Source: UniProtKB
    5. cellular response to growth factor stimulus Source: UniProtKB
    6. cellular response to hormone stimulus Source: BHF-UCL
    7. citrate metabolic process Source: BHF-UCL
    8. creatine metabolic process Source: BHF-UCL
    9. creatinine metabolic process Source: BHF-UCL
    10. development of secondary female sexual characteristics Source: Ensembl
    11. development of secondary male sexual characteristics Source: Ensembl
    12. fatty acid metabolic process Source: BHF-UCL
    13. female pregnancy Source: Ensembl
    14. isoleucine metabolic process Source: BHF-UCL
    15. JAK-STAT cascade Source: ProtInc
    16. JAK-STAT cascade involved in growth hormone signaling pathway Source: BHF-UCL
    17. lactation Source: Ensembl
    18. lipid storage Source: Ensembl
    19. liver development Source: Ensembl
    20. luteinization Source: Ensembl
    21. natural killer cell differentiation Source: Ensembl
    22. negative regulation of apoptotic process Source: Ensembl
    23. negative regulation of erythrocyte differentiation Source: Ensembl
    24. oxaloacetate metabolic process Source: BHF-UCL
    25. Peyer's patch development Source: Ensembl
    26. positive regulation of activated T cell proliferation Source: Ensembl
    27. positive regulation of B cell differentiation Source: Ensembl
    28. positive regulation of cellular component movement Source: Ensembl
    29. positive regulation of gamma-delta T cell differentiation Source: Ensembl
    30. positive regulation of inflammatory response Source: Ensembl
    31. positive regulation of interleukin-2 biosynthetic process Source: Ensembl
    32. positive regulation of mitotic cell cycle Source: Ensembl
    33. positive regulation of multicellular organism growth Source: Ensembl
    34. positive regulation of natural killer cell differentiation Source: Ensembl
    35. positive regulation of natural killer cell mediated cytotoxicity Source: Ensembl
    36. positive regulation of natural killer cell proliferation Source: Ensembl
    37. positive regulation of smooth muscle cell proliferation Source: Ensembl
    38. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    39. progesterone metabolic process Source: Ensembl
    40. prolactin signaling pathway Source: UniProtKB
    41. regulation of cell adhesion Source: Ensembl
    42. regulation of epithelial cell differentiation Source: Ensembl
    43. regulation of multicellular organism growth Source: BHF-UCL
    44. regulation of steroid metabolic process Source: Ensembl
    45. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    46. response to estradiol Source: BHF-UCL
    47. response to ethanol Source: Ensembl
    48. response to hypoxia Source: Ensembl
    49. response to interleukin-15 Source: Ensembl
    50. response to interleukin-2 Source: Ensembl
    51. response to interleukin-4 Source: Ensembl
    52. response to lipopolysaccharide Source: Ensembl
    53. succinate metabolic process Source: BHF-UCL
    54. taurine metabolic process Source: BHF-UCL
    55. T cell differentiation in thymus Source: Ensembl
    56. T cell homeostasis Source: Ensembl
    57. transcription from RNA polymerase II promoter Source: Ensembl
    58. valine metabolic process Source: BHF-UCL

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_111040. Signaling by SCF-KIT.
    REACT_111133. Growth hormone receptor signaling.
    REACT_115529. Interleukin-7 signaling.
    REACT_115697. Prolactin receptor signaling.
    REACT_121141. Signaling by FGFR1 fusion mutants.
    REACT_169118. Signaling by Leptin.
    REACT_17025. Downstream signal transduction.
    REACT_23837. Interleukin-3, 5 and GM-CSF signaling.
    REACT_27283. Interleukin-2 signaling.
    SignaLinkiP51692.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Signal transducer and activator of transcription 5B
    Gene namesi
    Name:STAT5B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:11367. STAT5B.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: Translocated into the nucleus in response to phosphorylation.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: Reactome
    3. nucleoplasm Source: Reactome
    4. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Growth hormone insensitivity with immunodeficiency (GHII) [MIM:245590]: A disease characterized by short stature, growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, resistance to hexogeneous growth hormone therapy, and recurrent infections.3 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti630 – 6301A → P in GHII; affects activation by growth hormone or interferon-gamma. 1 Publication
    VAR_018728
    Natural varianti646 – 6461F → S in GHII; transcriptionally inactive. 1 Publication
    VAR_067368

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi684 – 6841T → A: Abolishes interaction with INSR. 1 Publication
    Mutagenesisi699 – 6991Y → F: Abolishes phosphorylation by HCK. 1 Publication

    Keywords - Diseasei

    Disease mutation, Dwarfism

    Organism-specific databases

    MIMi245590. phenotype.
    Orphaneti520. Acute promyelocytic leukemia.
    220465. Laron syndrome with immunodeficiency.
    PharmGKBiPA36186.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 787787Signal transducer and activator of transcription 5BPRO_0000182429Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei128 – 1281Phosphoserine1 Publication
    Modified residuei193 – 1931Phosphoserine3 Publications
    Modified residuei699 – 6991Phosphotyrosine; by HCK, JAK and PTK62 Publications

    Post-translational modificationi

    Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2. Phosphoryation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates prolactin signaling pathway.11 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP51692.
    PaxDbiP51692.
    PeptideAtlasiP51692.
    PRIDEiP51692.

    PTM databases

    PhosphoSiteiP51692.

    Miscellaneous databases

    PMAP-CutDBP51692.

    Expressioni

    Gene expression databases

    ArrayExpressiP51692.
    BgeeiP51692.
    CleanExiHS_STAT5B.
    GenevestigatoriP51692.

    Organism-specific databases

    HPAiCAB004298.

    Interactioni

    Subunit structurei

    Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 By similarity. Interacts with NCOA1, NMI and SOCS7. Interacts (via SH2 domain) with INSR.By similarity4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DNAJA3Q96EY12EBI-1186119,EBI-356767
    NMIQ132877EBI-1186119,EBI-372942

    Protein-protein interaction databases

    BioGridi112654. 40 interactions.
    IntActiP51692. 16 interactions.
    MINTiMINT-132900.
    STRINGi9606.ENSP00000293328.

    Structurei

    3D structure databases

    ProteinModelPortaliP51692.
    SMRiP51692. Positions 4-686.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini589 – 68698SH2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni232 – 32190Required for interaction with NMIAdd
    BLAST

    Sequence similaritiesi

    Belongs to the transcription factor STAT family.Curated
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiNOG245085.
    HOVERGENiHBG107486.
    InParanoidiP51692.
    KOiK11224.
    OMAiVREATNS.
    OrthoDBiEOG73JKTT.
    PhylomeDBiP51692.
    TreeFamiTF318648.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.10.532.10. 1 hit.
    1.20.1050.20. 1 hit.
    2.60.40.630. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR008967. p53-like_TF_DNA-bd.
    IPR000980. SH2.
    IPR001217. STAT.
    IPR013800. STAT_TF_alpha.
    IPR015988. STAT_TF_coiled-coil.
    IPR013801. STAT_TF_DNA-bd.
    IPR012345. STAT_TF_DNA-bd_sub.
    IPR013799. STAT_TF_prot_interaction.
    [Graphical view]
    PANTHERiPTHR11801. PTHR11801. 1 hit.
    PfamiPF00017. SH2. 1 hit.
    PF01017. STAT_alpha. 1 hit.
    PF02864. STAT_bind. 1 hit.
    PF02865. STAT_int. 1 hit.
    [Graphical view]
    SMARTiSM00252. SH2. 1 hit.
    SM00964. STAT_int. 1 hit.
    [Graphical view]
    SUPFAMiSSF47655. SSF47655. 1 hit.
    SSF48092. SSF48092. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51692-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVWIQAQQL QGEALHQMQA LYGQHFPIEV RHYLSQWIES QAWDSVDLDN    50
    PQENIKATQL LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQNTYDR 100
    CPMELVRCIR HILYNEQRLV REANNGSSPA GSLADAMSQK HLQINQTFEE 150
    LRLVTQDTEN ELKKLQQTQE YFIIQYQESL RIQAQFGPLA QLSPQERLSR 200
    ETALQQKQVS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL RKQQTIILDD 250
    ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC 300
    QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA 350
    TVRLLVGGKL NVHMNPPQVK ATIISEQQAK SLLKNENTRN DYSGEILNNC 400
    CVMEYHQATG TLSAHFRNMS LKRIKRSDRR GAESVTEEKF TILFESQFSV 450
    GGNELVFQVK TLSLPVVVIV HGSQDNNATA TVLWDNAFAE PGRVPFAVPD 500
    KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNN SSSHLEDYSG 550
    LSVSWSQFNR ENLPGRNYTF WQWFDGVMEV LKKHLKPHWN DGAILGFVNK 600
    QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSQERMF WNLMPFTTRD 650
    FSIRSLADRL GDLNYLIYVF PDRPKDEVYS KYYTPVPCES ATAKAVDGYV 700
    KPQIKQVVPE FVNASADAGG GSATYMDQAP SPAVCPQAHY NMYPQNPDSV 750
    LDTDGDFDLE DTMDVARRVE ELLGRPMDSQ WIPHAQS 787
    Length:787
    Mass (Da):89,866
    Last modified:January 16, 2004 - v2
    Checksum:iAA2F1CAB20955ACA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti230 – 2301A → P in AAC50491. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti130 – 1301A → V.
    Corresponds to variant rs2277619 [ dbSNP | Ensembl ].
    VAR_052074
    Natural varianti630 – 6301A → P in GHII; affects activation by growth hormone or interferon-gamma. 1 Publication
    VAR_018728
    Natural varianti646 – 6461F → S in GHII; transcriptionally inactive. 1 Publication
    VAR_067368

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U48730 mRNA. Translation: AAC50485.2.
    U47686 mRNA. Translation: AAC50491.1.
    AJ412888
    , AJ412889, AJ412890, AJ412891, AJ412892, AJ412893, AJ412894, AJ412895, AJ412896, AJ412897, AJ412898, AJ412899 Genomic DNA. Translation: CAD19638.1.
    BC065227 mRNA. Translation: AAH65227.1.
    CCDSiCCDS11423.1.
    RefSeqiNP_036580.2. NM_012448.3.
    UniGeneiHs.595276.

    Genome annotation databases

    EnsembliENST00000293328; ENSP00000293328; ENSG00000173757.
    GeneIDi6777.
    KEGGihsa:6777.
    UCSCiuc002hzh.3. human.

    Polymorphism databases

    DMDMi41019536.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    STAT5Bbase

    STAT5B mutation db

    Wikipedia

    STAT5 entry

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U48730 mRNA. Translation: AAC50485.2 .
    U47686 mRNA. Translation: AAC50491.1 .
    AJ412888
    , AJ412889 , AJ412890 , AJ412891 , AJ412892 , AJ412893 , AJ412894 , AJ412895 , AJ412896 , AJ412897 , AJ412898 , AJ412899 Genomic DNA. Translation: CAD19638.1 .
    BC065227 mRNA. Translation: AAH65227.1 .
    CCDSi CCDS11423.1.
    RefSeqi NP_036580.2. NM_012448.3.
    UniGenei Hs.595276.

    3D structure databases

    ProteinModelPortali P51692.
    SMRi P51692. Positions 4-686.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112654. 40 interactions.
    IntActi P51692. 16 interactions.
    MINTi MINT-132900.
    STRINGi 9606.ENSP00000293328.

    Chemistry

    BindingDBi P51692.
    ChEMBLi CHEMBL5817.
    DrugBanki DB01254. Dasatinib.

    PTM databases

    PhosphoSitei P51692.

    Polymorphism databases

    DMDMi 41019536.

    Proteomic databases

    MaxQBi P51692.
    PaxDbi P51692.
    PeptideAtlasi P51692.
    PRIDEi P51692.

    Protocols and materials databases

    DNASUi 6777.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000293328 ; ENSP00000293328 ; ENSG00000173757 .
    GeneIDi 6777.
    KEGGi hsa:6777.
    UCSCi uc002hzh.3. human.

    Organism-specific databases

    CTDi 6777.
    GeneCardsi GC17M040351.
    HGNCi HGNC:11367. STAT5B.
    HPAi CAB004298.
    MIMi 245590. phenotype.
    604260. gene.
    neXtProti NX_P51692.
    Orphaneti 520. Acute promyelocytic leukemia.
    220465. Laron syndrome with immunodeficiency.
    PharmGKBi PA36186.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG245085.
    HOVERGENi HBG107486.
    InParanoidi P51692.
    KOi K11224.
    OMAi VREATNS.
    OrthoDBi EOG73JKTT.
    PhylomeDBi P51692.
    TreeFami TF318648.

    Enzyme and pathway databases

    Reactomei REACT_111040. Signaling by SCF-KIT.
    REACT_111133. Growth hormone receptor signaling.
    REACT_115529. Interleukin-7 signaling.
    REACT_115697. Prolactin receptor signaling.
    REACT_121141. Signaling by FGFR1 fusion mutants.
    REACT_169118. Signaling by Leptin.
    REACT_17025. Downstream signal transduction.
    REACT_23837. Interleukin-3, 5 and GM-CSF signaling.
    REACT_27283. Interleukin-2 signaling.
    SignaLinki P51692.

    Miscellaneous databases

    ChiTaRSi STAT5B. human.
    GeneWikii STAT5B.
    GenomeRNAii 6777.
    NextBioi 26454.
    PMAP-CutDB P51692.
    PROi P51692.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51692.
    Bgeei P51692.
    CleanExi HS_STAT5B.
    Genevestigatori P51692.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.10.532.10. 1 hit.
    1.20.1050.20. 1 hit.
    2.60.40.630. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR008967. p53-like_TF_DNA-bd.
    IPR000980. SH2.
    IPR001217. STAT.
    IPR013800. STAT_TF_alpha.
    IPR015988. STAT_TF_coiled-coil.
    IPR013801. STAT_TF_DNA-bd.
    IPR012345. STAT_TF_DNA-bd_sub.
    IPR013799. STAT_TF_prot_interaction.
    [Graphical view ]
    PANTHERi PTHR11801. PTHR11801. 1 hit.
    Pfami PF00017. SH2. 1 hit.
    PF01017. STAT_alpha. 1 hit.
    PF02864. STAT_bind. 1 hit.
    PF02865. STAT_int. 1 hit.
    [Graphical view ]
    SMARTi SM00252. SH2. 1 hit.
    SM00964. STAT_int. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47655. SSF47655. 1 hit.
    SSF48092. SSF48092. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and cloning of STAT5 from IM-9 cells and its activation by growth hormone."
      Silva C.M., Lu H., Day R.N.
      Mol. Endocrinol. 10:508-518(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Silva C.M., Lu H.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 628; 717 AND 720.
    3. "Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells."
      Lin J.-X., Mietz J., Modi W.S., John S., Leonard W.J.
      J. Biol. Chem. 271:10738-10744(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The structure of human STAT5A and B genes reveals two regions of nearly identical sequence and an alternative tissue specific STAT5B promoter."
      Ambrosio R., Fimiani G., Monfregola J., Sanzari E., De Felice N., Salerno M.C., Pignata C., D'Urso M., Ursini M.V.
      Gene 285:311-318(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lymph.
    6. Cited for: PHOSPHORYLATION BY INSR, INTERACTION WITH INSR, MUTAGENESIS OF THR-684.
    7. "Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling."
      Zhu M.-H., John S., Berg M., Leonard W.J.
      Cell 96:121-130(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NMI.
    8. "The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells."
      Klejman A., Schreiner S.J., Nieborowska-Skorska M., Slupianek A., Wilson M., Smithgall T.E., Skorski T.
      EMBO J. 21:5766-5774(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT TYR-699, MUTAGENESIS OF TYR-699.
    9. "A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus."
      Aoki N., Matsuda T.
      Mol. Endocrinol. 16:58-69(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PROLACTIN SIGNALING PATHWAY, PHOSPHORYLATION, DEPHOSPHORYLATION BY PTPN2.
    10. "NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain."
      Litterst C.M., Kliem S., Marilley D., Pfitzner E.
      J. Biol. Chem. 278:45340-45351(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NCOA1.
    11. "FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy."
      Taketani T., Taki T., Sugita K., Furuichi Y., Ishii E., Hanada R., Tsuchida M., Sugita K., Ida K., Hayashi Y.
      Blood 103:1085-1088(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION IN RESPONSE TO FLT3 SIGNALING.
    12. "Signal transduction via the stem cell factor receptor/c-Kit."
      Ronnstrand L.
      Cell. Mol. Life Sci. 61:2535-2548(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON ROLE IN KIT SIGNALING.
    13. "Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta."
      Kurzer J.H., Argetsinger L.S., Zhou Y.J., Kouadio J.L., O'Shea J.J., Carter-Su C.
      Mol. Cell. Biol. 24:4557-4570(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION BY JAK2.
    14. "Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation."
      Martens N., Uzan G., Wery M., Hooghe R., Hooghe-Peters E.L., Gertler A.
      J. Biol. Chem. 280:13817-13823(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SOCS7.
    15. "Severe growth hormone insensitivity resulting from total absence of signal transducer and activator of transcription 5b."
      Hwa V., Little B., Adiyaman P., Kofoed E.M., Pratt K.L., Ocal G., Berberoglu M., Rosenfeld R.G.
      J. Clin. Endocrinol. Metab. 90:4260-4266(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN GHII.
    16. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. "Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6."
      Weaver A.M., Silva C.M.
      Breast Cancer Res. 9:R79-R79(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT TYR-699 BY PTK6.
    18. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    20. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    21. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    22. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    23. "Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells."
      Chaix A., Lopez S., Voisset E., Gros L., Dubreuil P., De Sepulveda P.
      J. Biol. Chem. 286:5956-5966(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION IN RESPONSE TO KIT SIGNALING.
    24. Cited for: VARIANT GHII PRO-630.
    25. "A Novel Missense Mutation in the SH2 Domain of the STAT5B Gene Results in a transcriptionally inactive STAT5b associated with severe IGF-I deficiency, immune dysfunction, and lack of pulmonary disease."
      Scaglia P.A., Martinez A.S., Feigerlova E., Bezrodnik L., Gaillard M.I., Di Giovanni D., Ballerini M.G., Jasper H.G., Heinrich J.J., Fang P., Domene H.M., Rosenfeld R.G., Hwa V.
      J. Clin. Endocrinol. Metab. 97:E830-839(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT GHII SER-646, CHARACTERIZATION OF VARIANT GHII SER-646.

    Entry informationi

    Entry nameiSTA5B_HUMAN
    AccessioniPrimary (citable) accession number: P51692
    Secondary accession number(s): Q8WWS8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 16, 2004
    Last modified: October 1, 2014
    This is version 151 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3