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Protein

Arylsulfatase D

Gene

ARSD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi49CalciumBy similarity1
Metal bindingi50CalciumBy similarity1
Active sitei89NucleophileBy similarity1
Metal bindingi89Calcium; via 3-oxoalanineBy similarity1
Binding sitei148SubstrateBy similarity1
Active sitei150By similarity1
Binding sitei304SubstrateBy similarity1
Metal bindingi356CalciumBy similarity1
Metal bindingi357CalciumBy similarity1
Binding sitei381SubstrateBy similarity1

GO - Molecular functioni

  • arylsulfatase activity Source: ProtInc
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-1660662 Glycosphingolipid metabolism
R-HSA-1663150 The activation of arylsulfatases

Names & Taxonomyi

Protein namesi
Recommended name:
Arylsulfatase D (EC:3.1.6.-)
Short name:
ASD
Gene namesi
Name:ARSD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000006756.15
HGNCiHGNC:717 ARSD
MIMi300002 gene
neXtProtiNX_P51689

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi414
OpenTargetsiENSG00000006756
PharmGKBiPA25008

Polymorphism and mutation databases

BioMutaiARSD
DMDMi212276422

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000003342434 – 593Arylsulfatase DAdd BLAST560

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei893-oxoalanine (Cys)By similarity1
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi347N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP51689
PeptideAtlasiP51689
PRIDEiP51689

PTM databases

iPTMnetiP51689
PhosphoSitePlusiP51689

Expressioni

Tissue specificityi

Expressed in the pancreas, kidney, liver, lung, placenta, brain and heart.

Gene expression databases

BgeeiENSG00000006756
CleanExiHS_ARSD
ExpressionAtlasiP51689 baseline and differential
GenevisibleiP51689 HS

Organism-specific databases

HPAiHPA004694
HPA063835

Interactioni

Protein-protein interaction databases

BioGridi106907, 1 interactor
STRINGi9606.ENSP00000370546

Structurei

3D structure databases

ProteinModelPortaliP51689
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3867 Eukaryota
COG3119 LUCA
GeneTreeiENSGT00760000119062
HOGENOMiHOG000135352
HOVERGENiHBG004283
InParanoidiP51689
KOiK12374
OMAiDSGRLWK
OrthoDBiEOG091G07AL
PhylomeDBiP51689
TreeFamiTF314186

Family and domain databases

Gene3Di3.40.720.10, 3 hits
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR024607 Sulfatase_CS
IPR000917 Sulfatase_N
PfamiView protein in Pfam
PF00884 Sulfatase, 1 hit
SUPFAMiSSF53649 SSF53649, 1 hit
PROSITEiView protein in PROSITE
PS00523 SULFATASE_1, 1 hit
PS00149 SULFATASE_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P51689-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRSAARRGRA APAARDSLPV LLFLCLLLKT CEPKTANAFK PNILLIMADD
60 70 80 90 100
LGTGDLGCYG NNTLRTPNID QLAEEGVRLT QHLAAAPLCT PSRAAFLTGR
110 120 130 140 150
HSFRSGMDAS NGYRALQWNA GSGGLPENET TFARILQQHG YATGLIGKWH
160 170 180 190 200
QGVNCASRGD HCHHPLNHGF DYFYGMPFTL TNDCDPGRPP EVDAALRAQL
210 220 230 240 250
WGYTQFLALG ILTLAAGQTC GFFSVSARAV TGMAGVGCLF FISWYSSFGF
260 270 280 290 300
VRRWNCILMR NHDVTEQPMV LEKTASLMLK EAVSYIERHK HGPFLLFLSL
310 320 330 340 350
LHVHIPLVTT SAFLGKSQHG LYGDNVEEMD WLIGKVLNAI EDNGLKNSTF
360 370 380 390 400
TYFTSDHGGH LEARDGHSQL GGWNGIYKGG KGMGGWEGGI RVPGIFHWPG
410 420 430 440 450
VLPAGRVIGE PTSLMDVFPT VVQLVGGEVP QDRVIDGHSL VPLLQGAEAR
460 470 480 490 500
SAHEFLFHYC GQHLHAARWH QKDSGSVWKV HYTTPQFHPE GAGACYGRGV
510 520 530 540 550
CPCSGEGVTH HRPPLLFDLS RDPSEARPLT PDSEPLYHAV IARVGAAVSE
560 570 580 590
HRQTLSPVPQ QFSMSNILWK PWLQPCCGHF PFCSCHEDGD GTP
Length:593
Mass (Da):64,860
Last modified:November 4, 2008 - v2
Checksum:i982B29D0FCEF9D34
GO
Isoform 2 (identifier: P51689-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     334-382: GKVLNAIEDN...WNGIYKGGKG → ASDFMSSSEV...PVRLQILKRA
     383-593: Missing.

Show »
Length:382
Mass (Da):42,315
Checksum:iC9A8FFBE567654DD
GO
Isoform 3 (identifier: P51689-3) [UniParc]FASTAAdd to basket
Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     504-593: Missing.

Show »
Length:503
Mass (Da):54,934
Checksum:iCC4F3F8C7D201877
GO

Sequence cautioni

The sequence CAA58555 differs from that shown. Reason: Frameshift at several positions.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052508224S → C1 PublicationCorresponds to variant dbSNP:rs211653Ensembl.1
Natural variantiVAR_052509500V → I. Corresponds to variant dbSNP:rs2229557Ensembl.1
Natural variantiVAR_052510564M → T. Corresponds to variant dbSNP:rs2228431Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015798334 – 382GKVLN…KGGKG → ASDFMSSSEVTESEAIKLMF RTMQRRCLPSMAFKKPWRGP VRLQILKRA in isoform 2. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_015799383 – 593Missing in isoform 2. 1 PublicationAdd BLAST211
Alternative sequenceiVSP_035667504 – 593Missing in isoform 3. 1 PublicationAdd BLAST90

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83572 mRNA Translation: CAA58555.1 Frameshift.
AF160499 mRNA Translation: AAF22253.1
AC005295 Genomic DNA No translation available.
BC020229 mRNA No translation available.
CCDSiCCDS35196.1 [P51689-1]
PIRiI37186
RefSeqiNP_001660.2, NM_001669.3 [P51689-1]
NP_033667.2, NM_009589.3
UniGeneiHs.528631

Genome annotation databases

EnsembliENST00000381154; ENSP00000370546; ENSG00000006756 [P51689-1]
GeneIDi414
KEGGihsa:414
UCSCiuc004cqy.4 human [P51689-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiARSD_HUMAN
AccessioniPrimary (citable) accession number: P51689
Secondary accession number(s): Q9UHJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 4, 2008
Last modified: May 23, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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