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P51686 (CCR9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 134. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C chemokine receptor type 9

Short name=C-C CKR-9
Short name=CC-CKR-9
Short name=CCR-9
Alternative name(s):
G-protein coupled receptor 28
GPR-9-6
CD_antigen=CDw199
Gene names
Name:CCR9
Synonyms:GPR28
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Highly expressed in the thymus and low in lymph nodes and spleen. Ref.1 Ref.2

Miscellaneous

EC50 of SCYA25/TECK for isoform 1 is lower than for isoform 2.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence AAH95516.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P51686-1)

Also known as: CCR9A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P51686-2)

Also known as: CCR9B;

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 369369C-C chemokine receptor type 9
PRO_0000069291

Regions

Topological domain1 – 5353Extracellular Potential
Transmembrane54 – 7421Helical; Name=1; Potential
Topological domain75 – 8511Cytoplasmic Potential
Transmembrane86 – 10621Helical; Name=2; Potential
Topological domain107 – 12721Extracellular Potential
Transmembrane128 – 14821Helical; Name=3; Potential
Topological domain149 – 16618Cytoplasmic Potential
Transmembrane167 – 18721Helical; Name=4; Potential
Topological domain188 – 21831Extracellular Potential
Transmembrane219 – 23921Helical; Name=5; Potential
Topological domain240 – 25415Cytoplasmic Potential
Transmembrane255 – 27521Helical; Name=6; Potential
Topological domain276 – 30025Extracellular Potential
Transmembrane301 – 32121Helical; Name=7; Potential
Topological domain322 – 36948Cytoplasmic Potential

Amino acid modifications

Glycosylation321N-linked (GlcNAc...) Potential
Disulfide bond119 ↔ 198 By similarity

Natural variations

Alternative sequence1 – 1212Missing in isoform 2.
VSP_020286
Natural variant921I → V.
Corresponds to variant rs45530037 [ dbSNP | Ensembl ].
VAR_029208
Natural variant2841M → V.
Corresponds to variant rs12721497 [ dbSNP | Ensembl ].
VAR_020068

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (CCR9A) [UniParc].

Last modified September 5, 2006. Version 2.
Checksum: F27CEA0CFB66B44C

FASTA36942,016
        10         20         30         40         50         60 
MTPTDFTSPI PNMADDYGSE STSSMEDYVN FNFTDFYCEK NNVRQFASHF LPPLYWLVFI 

        70         80         90        100        110        120 
VGALGNSLVI LVYWYCTRVK TMTDMFLLNL AIADLLFLVT LPFWAIAAAD QWKFQTFMCK 

       130        140        150        160        170        180 
VVNSMYKMNF YSCVLLIMCI SVDRYIAIAQ AMRAHTWREK RLLYSKMVCF TIWVLAAALC 

       190        200        210        220        230        240 
IPEILYSQIK EESGIAICTM VYPSDESTKL KSAVLTLKVI LGFFLPFVVM ACCYTIIIHT 

       250        260        270        280        290        300 
LIQAKKSSKH KALKVTITVL TVFVLSQFPY NCILLVQTID AYAMFISNCA VSTNIDICFQ 

       310        320        330        340        350        360 
VTQTIAFFHS CLNPVLYVFV GERFRRDLVK TLKNLGCISQ AQWVSFTRRE GSLKLSSMLL 


ETTSGALSL 

« Hide

Isoform 2 (CCR9B) [UniParc].

Checksum: 96982E0B922F6B31
Show »

FASTA35740,713

References

« Hide 'large scale' references
[1]"Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK."
Zaballos A., Gutierrez J., Varona R., Ardavin C., Marquez G.
J. Immunol. 162:5671-5675(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION, TISSUE SPECIFICITY.
[2]"CCR9A and CCR9B: two receptors for the chemokine CCL25/TECK/Ck beta-15 that differ in their sensitivities to ligand."
Yu C.-R., Peden K.W.C., Zaitseva M.B., Golding H., Farber J.M.
J. Immunol. 164:1293-1305(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), CHARACTERIZATION, TISSUE SPECIFICITY.
[3]"Cloning, tissue distribution and chromosomal localization of two potential G-protein-linked chemokine receptors."
Lautens L.L., Tiffany H.L., Gao J.-L., Modi W., Murphy P.M., Bonner T.I.
Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
[4]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Warren C.N., Aronstam R.S., Sharma S.V.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ132337 mRNA. Translation: CAB43477.1.
AF145439 mRNA. Translation: AAF66699.1.
AF145440 mRNA. Translation: AAF66700.1.
U45982 Genomic DNA. Translation: AAA93319.1.
AY242127 Genomic DNA. Translation: AAO92294.1.
BC069678 mRNA. Translation: AAH69678.1.
BC095516 mRNA. Translation: AAH95516.1. Different initiation.
CCDSCCDS2732.1. [P51686-1]
CCDS2733.1. [P51686-2]
RefSeqNP_001243298.1. NM_001256369.1. [P51686-2]
NP_006632.2. NM_006641.3. [P51686-2]
NP_112477.1. NM_031200.2. [P51686-1]
UniGeneHs.225946.

3D structure databases

ProteinModelPortalP51686.
SMRP51686. Positions 44-332.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-5884N.
MINTMINT-106203.
STRING9606.ENSP00000350256.

Chemistry

BindingDBP51686.
ChEMBLCHEMBL5815.
GuidetoPHARMACOLOGY66.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP51686.

Polymorphism databases

DMDM114152781.

Proteomic databases

PaxDbP51686.
PRIDEP51686.

Protocols and materials databases

DNASU10803.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000355983; ENSP00000348260; ENSG00000173585. [P51686-2]
ENST00000357632; ENSP00000350256; ENSG00000173585. [P51686-1]
ENST00000395963; ENSP00000379292; ENSG00000173585. [P51686-2]
GeneID10803.
KEGGhsa:10803.
UCSCuc003coz.2. human. [P51686-1]

Organism-specific databases

CTD10803.
GeneCardsGC03P045903.
HGNCHGNC:1610. CCR9.
HPACAB006839.
MIM604738. gene.
neXtProtNX_P51686.
PharmGKBPA26174.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG268585.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidP51686.
KOK04184.
OMAISTNIDI.
OrthoDBEOG77WWD0.
PhylomeDBP51686.
TreeFamTF330966.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP51686.
BgeeP51686.
CleanExHS_CCR9.
GenevestigatorP51686.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR004069. Chemokine_CCR9.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00657. CCCHEMOKINER.
PR01531. CHEMOKINER9.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCCR9.
GenomeRNAi10803.
NextBio41035.
PROP51686.
SOURCESearch...

Entry information

Entry nameCCR9_HUMAN
AccessionPrimary (citable) accession number: P51686
Secondary accession number(s): Q4VBM3, Q549E0, Q9UQQ6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 5, 2006
Last modified: July 9, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries