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Protein

C-C chemokine receptor type 9

Gene

CCR9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level.2 Publications
(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.

Miscellaneous

EC50 of SCYA25/TECK for isoform 1 is lower than for isoform 2.

GO - Molecular functioni

  • C-C chemokine receptor activity Source: Ensembl
  • chemokine receptor activity Source: ProtInc

GO - Biological processi

  • CD8-positive, gamma-delta intraepithelial T cell differentiation Source: Ensembl
  • cellular defense response Source: ProtInc
  • chemotaxis Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • immune response Source: ProtInc
  • positive regulation of cytosolic calcium ion concentration Source: ProtInc

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP51686.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 9
Short name:
C-C CKR-9
Short name:
CC-CKR-9
Short name:
CCR-9
Alternative name(s):
G-protein coupled receptor 28
GPR-9-6
CD_antigen: CDw199
Gene namesi
Name:CCR9
Synonyms:GPR28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:1610. CCR9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 48Extracellular1 PublicationAdd BLAST48
Transmembranei49 – 74Helical; Name=11 PublicationAdd BLAST26
Topological domaini75 – 85Cytoplasmic1 PublicationAdd BLAST11
Transmembranei86 – 109Helical; Name=21 PublicationAdd BLAST24
Topological domaini110 – 120Extracellular1 PublicationAdd BLAST11
Transmembranei121 – 150Helical; Name=31 PublicationAdd BLAST30
Topological domaini151 – 159Cytoplasmic1 Publication9
Transmembranei160 – 185Helical; Name=41 PublicationAdd BLAST26
Topological domaini186 – 208Extracellular1 PublicationAdd BLAST23
Transmembranei209 – 243Helical; Name=51 PublicationAdd BLAST35
Topological domaini244 – 248Cytoplasmic1 Publication5
Transmembranei249 – 283Helical; Name=61 PublicationAdd BLAST35
Topological domaini284 – 290Extracellular1 Publication7
Transmembranei291 – 321Helical; Name=71 PublicationAdd BLAST31
Topological domaini322 – 369CytoplasmicSequence analysis1 PublicationAdd BLAST48

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10803.
OpenTargetsiENSG00000173585.
PharmGKBiPA26174.

Chemistry databases

ChEMBLiCHEMBL5815.
DrugBankiDB05005. CCX282.
GuidetoPHARMACOLOGYi66.

Polymorphism and mutation databases

BioMutaiCCR9.
DMDMi114152781.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692911 – 369C-C chemokine receptor type 9Add BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi32N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi38 ↔ 2891 Publication
Disulfide bondi119 ↔ 198PROSITE-ProRule annotationCombined sources1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP51686.
PeptideAtlasiP51686.
PRIDEiP51686.

PTM databases

iPTMnetiP51686.
PhosphoSitePlusiP51686.

Expressioni

Tissue specificityi

Highly expressed in the thymus and low in lymph nodes and spleen.2 Publications

Gene expression databases

BgeeiENSG00000173585.
CleanExiHS_CCR9.
ExpressionAtlasiP51686. baseline and differential.
GenevisibleiP51686. HS.

Organism-specific databases

HPAiCAB006839.

Interactioni

Protein-protein interaction databases

DIPiDIP-5884N.
MINTiMINT-106203.
STRINGi9606.ENSP00000350256.

Chemistry databases

BindingDBiP51686.

Structurei

Secondary structure

1369
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi33 – 37Combined sources5
Helixi45 – 75Combined sources31
Helixi82 – 106Combined sources25
Helixi117 – 148Combined sources32
Helixi151 – 154Combined sources4
Helixi155 – 157Combined sources3
Helixi158 – 179Combined sources22
Helixi181 – 185Combined sources5
Helixi209 – 222Combined sources14
Helixi224 – 243Combined sources20
Helixi249 – 252Combined sources4
Helixi254 – 282Combined sources29
Helixi289 – 307Combined sources19
Helixi308 – 311Combined sources4
Helixi313 – 320Combined sources8
Helixi324 – 341Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LWEX-ray2.80A/B24-341[»]
ProteinModelPortaliP51686.
SMRiP51686.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP51686.
KOiK04184.
OMAiTWRQKRL.
OrthoDBiEOG091G093O.
PhylomeDBiP51686.
TreeFamiTF330966.

Family and domain databases

InterProiView protein in InterPro
IPR004069. Chemokine_CCR9.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00657. CCCHEMOKINER.
PR01531. CHEMOKINER9.
PR00237. GPCRRHODOPSN.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P51686-1) [UniParc]FASTAAdd to basket
Also known as: CCR9A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPTDFTSPI PNMADDYGSE STSSMEDYVN FNFTDFYCEK NNVRQFASHF
60 70 80 90 100
LPPLYWLVFI VGALGNSLVI LVYWYCTRVK TMTDMFLLNL AIADLLFLVT
110 120 130 140 150
LPFWAIAAAD QWKFQTFMCK VVNSMYKMNF YSCVLLIMCI SVDRYIAIAQ
160 170 180 190 200
AMRAHTWREK RLLYSKMVCF TIWVLAAALC IPEILYSQIK EESGIAICTM
210 220 230 240 250
VYPSDESTKL KSAVLTLKVI LGFFLPFVVM ACCYTIIIHT LIQAKKSSKH
260 270 280 290 300
KALKVTITVL TVFVLSQFPY NCILLVQTID AYAMFISNCA VSTNIDICFQ
310 320 330 340 350
VTQTIAFFHS CLNPVLYVFV GERFRRDLVK TLKNLGCISQ AQWVSFTRRE
360
GSLKLSSMLL ETTSGALSL
Length:369
Mass (Da):42,016
Last modified:September 5, 2006 - v2
Checksum:iF27CEA0CFB66B44C
GO
Isoform 2 (identifier: P51686-2) [UniParc]FASTAAdd to basket
Also known as: CCR9B

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.

Show »
Length:357
Mass (Da):40,713
Checksum:i96982E0B922F6B31
GO

Sequence cautioni

The sequence AAH95516 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02920892I → V. Corresponds to variant dbSNP:rs45530037Ensembl.1
Natural variantiVAR_020068284M → V. Corresponds to variant dbSNP:rs12721497Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0202861 – 12Missing in isoform 2. 3 PublicationsAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132337 mRNA. Translation: CAB43477.1.
AF145439 mRNA. Translation: AAF66699.1.
AF145440 mRNA. Translation: AAF66700.1.
U45982 Genomic DNA. Translation: AAA93319.1.
AY242127 Genomic DNA. Translation: AAO92294.1.
BC069678 mRNA. Translation: AAH69678.1.
BC095516 mRNA. Translation: AAH95516.1. Different initiation.
CCDSiCCDS2732.1. [P51686-1]
CCDS2733.1. [P51686-2]
RefSeqiNP_001243298.1. NM_001256369.1. [P51686-2]
NP_006632.2. NM_006641.3. [P51686-2]
NP_112477.1. NM_031200.2. [P51686-1]
XP_011531614.1. XM_011533312.2. [P51686-1]
UniGeneiHs.225946.

Genome annotation databases

EnsembliENST00000355983; ENSP00000348260; ENSG00000173585. [P51686-2]
ENST00000357632; ENSP00000350256; ENSG00000173585. [P51686-1]
ENST00000395963; ENSP00000379292; ENSG00000173585. [P51686-2]
GeneIDi10803.
KEGGihsa:10803.
UCSCiuc003coz.3. human. [P51686-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCCR9_HUMAN
AccessioniPrimary (citable) accession number: P51686
Secondary accession number(s): Q4VBM3, Q549E0, Q9UQQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 5, 2006
Last modified: August 30, 2017
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  8. SIMILARITY comments
    Index of protein domains and families