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P51686

- CCR9_HUMAN

UniProt

P51686 - CCR9_HUMAN

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Protein

C-C chemokine receptor type 9

Gene

CCR9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.

GO - Molecular functioni

  1. C-C chemokine receptor activity Source: Ensembl
  2. chemokine receptor activity Source: ProtInc

GO - Biological processi

  1. cellular defense response Source: ProtInc
  2. chemokine-mediated signaling pathway Source: GOC
  3. chemotaxis Source: ProtInc
  4. G-protein coupled receptor signaling pathway Source: ProtInc
  5. immune response Source: ProtInc
  6. positive regulation of cytosolic calcium ion concentration Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 9
Short name:
C-C CKR-9
Short name:
CC-CKR-9
Short name:
CCR-9
Alternative name(s):
G-protein coupled receptor 28
GPR-9-6
CD_antigen: CDw199
Gene namesi
Name:CCR9
Synonyms:GPR28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:1610. CCR9.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26174.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369C-C chemokine receptor type 9PRO_0000069291Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi119 ↔ 198PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP51686.
PRIDEiP51686.

PTM databases

PhosphoSiteiP51686.

Expressioni

Tissue specificityi

Highly expressed in the thymus and low in lymph nodes and spleen.2 Publications

Gene expression databases

BgeeiP51686.
CleanExiHS_CCR9.
ExpressionAtlasiP51686. baseline and differential.
GenevestigatoriP51686.

Organism-specific databases

HPAiCAB006839.

Interactioni

Protein-protein interaction databases

DIPiDIP-5884N.
MINTiMINT-106203.
STRINGi9606.ENSP00000350256.

Structurei

3D structure databases

ProteinModelPortaliP51686.
SMRiP51686. Positions 44-332.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5353ExtracellularSequence AnalysisAdd
BLAST
Topological domaini75 – 8511CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini107 – 12721ExtracellularSequence AnalysisAdd
BLAST
Topological domaini149 – 16618CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini188 – 21831ExtracellularSequence AnalysisAdd
BLAST
Topological domaini240 – 25415CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini276 – 30025ExtracellularSequence AnalysisAdd
BLAST
Topological domaini322 – 36948CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei54 – 7421Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei86 – 10621Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei128 – 14821Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei167 – 18721Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei219 – 23921Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei255 – 27521Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei301 – 32121Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG268585.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP51686.
KOiK04184.
OMAiISTNIDI.
OrthoDBiEOG77WWD0.
PhylomeDBiP51686.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR004069. Chemokine_CCR9.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01531. CHEMOKINER9.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P51686) [UniParc]FASTAAdd to Basket

Also known as: CCR9A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPTDFTSPI PNMADDYGSE STSSMEDYVN FNFTDFYCEK NNVRQFASHF
60 70 80 90 100
LPPLYWLVFI VGALGNSLVI LVYWYCTRVK TMTDMFLLNL AIADLLFLVT
110 120 130 140 150
LPFWAIAAAD QWKFQTFMCK VVNSMYKMNF YSCVLLIMCI SVDRYIAIAQ
160 170 180 190 200
AMRAHTWREK RLLYSKMVCF TIWVLAAALC IPEILYSQIK EESGIAICTM
210 220 230 240 250
VYPSDESTKL KSAVLTLKVI LGFFLPFVVM ACCYTIIIHT LIQAKKSSKH
260 270 280 290 300
KALKVTITVL TVFVLSQFPY NCILLVQTID AYAMFISNCA VSTNIDICFQ
310 320 330 340 350
VTQTIAFFHS CLNPVLYVFV GERFRRDLVK TLKNLGCISQ AQWVSFTRRE
360
GSLKLSSMLL ETTSGALSL
Length:369
Mass (Da):42,016
Last modified:September 5, 2006 - v2
Checksum:iF27CEA0CFB66B44C
GO
Isoform 2 (identifier: P51686-2) [UniParc]FASTAAdd to Basket

Also known as: CCR9B

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.

Show »
Length:357
Mass (Da):40,713
Checksum:i96982E0B922F6B31
GO

Sequence cautioni

The sequence AAH95516.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti92 – 921I → V.
Corresponds to variant rs45530037 [ dbSNP | Ensembl ].
VAR_029208
Natural varianti284 – 2841M → V.
Corresponds to variant rs12721497 [ dbSNP | Ensembl ].
VAR_020068

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1212Missing in isoform 2. 3 PublicationsVSP_020286Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ132337 mRNA. Translation: CAB43477.1.
AF145439 mRNA. Translation: AAF66699.1.
AF145440 mRNA. Translation: AAF66700.1.
U45982 Genomic DNA. Translation: AAA93319.1.
AY242127 Genomic DNA. Translation: AAO92294.1.
BC069678 mRNA. Translation: AAH69678.1.
BC095516 mRNA. Translation: AAH95516.1. Different initiation.
CCDSiCCDS2732.1. [P51686-1]
CCDS2733.1. [P51686-2]
RefSeqiNP_001243298.1. NM_001256369.1. [P51686-2]
NP_006632.2. NM_006641.3. [P51686-2]
NP_112477.1. NM_031200.2. [P51686-1]
UniGeneiHs.225946.

Genome annotation databases

EnsembliENST00000355983; ENSP00000348260; ENSG00000173585. [P51686-2]
ENST00000357632; ENSP00000350256; ENSG00000173585. [P51686-1]
ENST00000395963; ENSP00000379292; ENSG00000173585. [P51686-2]
GeneIDi10803.
KEGGihsa:10803.
UCSCiuc003coz.2. human. [P51686-1]

Polymorphism databases

DMDMi114152781.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CC chemokine receptors entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ132337 mRNA. Translation: CAB43477.1 .
AF145439 mRNA. Translation: AAF66699.1 .
AF145440 mRNA. Translation: AAF66700.1 .
U45982 Genomic DNA. Translation: AAA93319.1 .
AY242127 Genomic DNA. Translation: AAO92294.1 .
BC069678 mRNA. Translation: AAH69678.1 .
BC095516 mRNA. Translation: AAH95516.1 . Different initiation.
CCDSi CCDS2732.1. [P51686-1 ]
CCDS2733.1. [P51686-2 ]
RefSeqi NP_001243298.1. NM_001256369.1. [P51686-2 ]
NP_006632.2. NM_006641.3. [P51686-2 ]
NP_112477.1. NM_031200.2. [P51686-1 ]
UniGenei Hs.225946.

3D structure databases

ProteinModelPortali P51686.
SMRi P51686. Positions 44-332.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-5884N.
MINTi MINT-106203.
STRINGi 9606.ENSP00000350256.

Chemistry

BindingDBi P51686.
ChEMBLi CHEMBL5815.
GuidetoPHARMACOLOGYi 66.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P51686.

Polymorphism databases

DMDMi 114152781.

Proteomic databases

PaxDbi P51686.
PRIDEi P51686.

Protocols and materials databases

DNASUi 10803.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000355983 ; ENSP00000348260 ; ENSG00000173585 . [P51686-2 ]
ENST00000357632 ; ENSP00000350256 ; ENSG00000173585 . [P51686-1 ]
ENST00000395963 ; ENSP00000379292 ; ENSG00000173585 . [P51686-2 ]
GeneIDi 10803.
KEGGi hsa:10803.
UCSCi uc003coz.2. human. [P51686-1 ]

Organism-specific databases

CTDi 10803.
GeneCardsi GC03P045903.
HGNCi HGNC:1610. CCR9.
HPAi CAB006839.
MIMi 604738. gene.
neXtProti NX_P51686.
PharmGKBi PA26174.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG268585.
GeneTreei ENSGT00760000118785.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi P51686.
KOi K04184.
OMAi ISTNIDI.
OrthoDBi EOG77WWD0.
PhylomeDBi P51686.
TreeFami TF330966.

Enzyme and pathway databases

Reactomei REACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii CCR9.
GenomeRNAii 10803.
NextBioi 41035.
PROi P51686.
SOURCEi Search...

Gene expression databases

Bgeei P51686.
CleanExi HS_CCR9.
ExpressionAtlasi P51686. baseline and differential.
Genevestigatori P51686.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR004069. Chemokine_CCR9.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00657. CCCHEMOKINER.
PR01531. CHEMOKINER9.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK."
    Zaballos A., Gutierrez J., Varona R., Ardavin C., Marquez G.
    J. Immunol. 162:5671-5675(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION, TISSUE SPECIFICITY.
  2. "CCR9A and CCR9B: two receptors for the chemokine CCL25/TECK/Ck beta-15 that differ in their sensitivities to ligand."
    Yu C.-R., Peden K.W.C., Zaitseva M.B., Golding H., Farber J.M.
    J. Immunol. 164:1293-1305(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), CHARACTERIZATION, TISSUE SPECIFICITY.
  3. "Cloning, tissue distribution and chromosomal localization of two potential G-protein-linked chemokine receptors."
    Lautens L.L., Tiffany H.L., Gao J.-L., Modi W., Murphy P.M., Bonner T.I.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
  4. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Warren C.N., Aronstam R.S., Sharma S.V.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).

Entry informationi

Entry nameiCCR9_HUMAN
AccessioniPrimary (citable) accession number: P51686
Secondary accession number(s): Q4VBM3, Q549E0, Q9UQQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

EC50 of SCYA25/TECK for isoform 1 is lower than for isoform 2.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3