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P51686

- CCR9_HUMAN

UniProt

P51686 - CCR9_HUMAN

Protein

C-C chemokine receptor type 9

Gene

CCR9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 2 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.

    GO - Molecular functioni

    1. C-C chemokine receptor activity Source: Ensembl
    2. chemokine receptor activity Source: ProtInc

    GO - Biological processi

    1. cellular defense response Source: ProtInc
    2. chemokine-mediated signaling pathway Source: GOC
    3. chemotaxis Source: ProtInc
    4. G-protein coupled receptor signaling pathway Source: ProtInc
    5. immune response Source: ProtInc
    6. positive regulation of cytosolic calcium ion concentration Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C chemokine receptor type 9
    Short name:
    C-C CKR-9
    Short name:
    CC-CKR-9
    Short name:
    CCR-9
    Alternative name(s):
    G-protein coupled receptor 28
    GPR-9-6
    CD_antigen: CDw199
    Gene namesi
    Name:CCR9
    Synonyms:GPR28
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:1610. CCR9.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26174.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 369369C-C chemokine receptor type 9PRO_0000069291Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi119 ↔ 198PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP51686.
    PRIDEiP51686.

    PTM databases

    PhosphoSiteiP51686.

    Expressioni

    Tissue specificityi

    Highly expressed in the thymus and low in lymph nodes and spleen.2 Publications

    Gene expression databases

    ArrayExpressiP51686.
    BgeeiP51686.
    CleanExiHS_CCR9.
    GenevestigatoriP51686.

    Organism-specific databases

    HPAiCAB006839.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-5884N.
    MINTiMINT-106203.
    STRINGi9606.ENSP00000350256.

    Structurei

    3D structure databases

    ProteinModelPortaliP51686.
    SMRiP51686. Positions 44-332.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5353ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini75 – 8511CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini107 – 12721ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini149 – 16618CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini188 – 21831ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini240 – 25415CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini276 – 30025ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini322 – 36948CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei54 – 7421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei86 – 10621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei128 – 14821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei167 – 18721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei219 – 23921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei255 – 27521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei301 – 32121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG268585.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiP51686.
    KOiK04184.
    OMAiISTNIDI.
    OrthoDBiEOG77WWD0.
    PhylomeDBiP51686.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR004069. Chemokine_CCR9.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR01531. CHEMOKINER9.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P51686-1) [UniParc]FASTAAdd to Basket

    Also known as: CCR9A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTPTDFTSPI PNMADDYGSE STSSMEDYVN FNFTDFYCEK NNVRQFASHF    50
    LPPLYWLVFI VGALGNSLVI LVYWYCTRVK TMTDMFLLNL AIADLLFLVT 100
    LPFWAIAAAD QWKFQTFMCK VVNSMYKMNF YSCVLLIMCI SVDRYIAIAQ 150
    AMRAHTWREK RLLYSKMVCF TIWVLAAALC IPEILYSQIK EESGIAICTM 200
    VYPSDESTKL KSAVLTLKVI LGFFLPFVVM ACCYTIIIHT LIQAKKSSKH 250
    KALKVTITVL TVFVLSQFPY NCILLVQTID AYAMFISNCA VSTNIDICFQ 300
    VTQTIAFFHS CLNPVLYVFV GERFRRDLVK TLKNLGCISQ AQWVSFTRRE 350
    GSLKLSSMLL ETTSGALSL 369
    Length:369
    Mass (Da):42,016
    Last modified:September 5, 2006 - v2
    Checksum:iF27CEA0CFB66B44C
    GO
    Isoform 2 (identifier: P51686-2) [UniParc]FASTAAdd to Basket

    Also known as: CCR9B

    The sequence of this isoform differs from the canonical sequence as follows:
         1-12: Missing.

    Show »
    Length:357
    Mass (Da):40,713
    Checksum:i96982E0B922F6B31
    GO

    Sequence cautioni

    The sequence AAH95516.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti92 – 921I → V.
    Corresponds to variant rs45530037 [ dbSNP | Ensembl ].
    VAR_029208
    Natural varianti284 – 2841M → V.
    Corresponds to variant rs12721497 [ dbSNP | Ensembl ].
    VAR_020068

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1212Missing in isoform 2. 3 PublicationsVSP_020286Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ132337 mRNA. Translation: CAB43477.1.
    AF145439 mRNA. Translation: AAF66699.1.
    AF145440 mRNA. Translation: AAF66700.1.
    U45982 Genomic DNA. Translation: AAA93319.1.
    AY242127 Genomic DNA. Translation: AAO92294.1.
    BC069678 mRNA. Translation: AAH69678.1.
    BC095516 mRNA. Translation: AAH95516.1. Different initiation.
    CCDSiCCDS2732.1. [P51686-1]
    CCDS2733.1. [P51686-2]
    RefSeqiNP_001243298.1. NM_001256369.1. [P51686-2]
    NP_006632.2. NM_006641.3. [P51686-2]
    NP_112477.1. NM_031200.2. [P51686-1]
    UniGeneiHs.225946.

    Genome annotation databases

    EnsembliENST00000355983; ENSP00000348260; ENSG00000173585. [P51686-2]
    ENST00000357632; ENSP00000350256; ENSG00000173585. [P51686-1]
    ENST00000395963; ENSP00000379292; ENSG00000173585. [P51686-2]
    GeneIDi10803.
    KEGGihsa:10803.
    UCSCiuc003coz.2. human. [P51686-1]

    Polymorphism databases

    DMDMi114152781.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CC chemokine receptors entry

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ132337 mRNA. Translation: CAB43477.1 .
    AF145439 mRNA. Translation: AAF66699.1 .
    AF145440 mRNA. Translation: AAF66700.1 .
    U45982 Genomic DNA. Translation: AAA93319.1 .
    AY242127 Genomic DNA. Translation: AAO92294.1 .
    BC069678 mRNA. Translation: AAH69678.1 .
    BC095516 mRNA. Translation: AAH95516.1 . Different initiation.
    CCDSi CCDS2732.1. [P51686-1 ]
    CCDS2733.1. [P51686-2 ]
    RefSeqi NP_001243298.1. NM_001256369.1. [P51686-2 ]
    NP_006632.2. NM_006641.3. [P51686-2 ]
    NP_112477.1. NM_031200.2. [P51686-1 ]
    UniGenei Hs.225946.

    3D structure databases

    ProteinModelPortali P51686.
    SMRi P51686. Positions 44-332.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-5884N.
    MINTi MINT-106203.
    STRINGi 9606.ENSP00000350256.

    Chemistry

    BindingDBi P51686.
    ChEMBLi CHEMBL5815.
    GuidetoPHARMACOLOGYi 66.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P51686.

    Polymorphism databases

    DMDMi 114152781.

    Proteomic databases

    PaxDbi P51686.
    PRIDEi P51686.

    Protocols and materials databases

    DNASUi 10803.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000355983 ; ENSP00000348260 ; ENSG00000173585 . [P51686-2 ]
    ENST00000357632 ; ENSP00000350256 ; ENSG00000173585 . [P51686-1 ]
    ENST00000395963 ; ENSP00000379292 ; ENSG00000173585 . [P51686-2 ]
    GeneIDi 10803.
    KEGGi hsa:10803.
    UCSCi uc003coz.2. human. [P51686-1 ]

    Organism-specific databases

    CTDi 10803.
    GeneCardsi GC03P045903.
    HGNCi HGNC:1610. CCR9.
    HPAi CAB006839.
    MIMi 604738. gene.
    neXtProti NX_P51686.
    PharmGKBi PA26174.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG268585.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi P51686.
    KOi K04184.
    OMAi ISTNIDI.
    OrthoDBi EOG77WWD0.
    PhylomeDBi P51686.
    TreeFami TF330966.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii CCR9.
    GenomeRNAii 10803.
    NextBioi 41035.
    PROi P51686.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51686.
    Bgeei P51686.
    CleanExi HS_CCR9.
    Genevestigatori P51686.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR004069. Chemokine_CCR9.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR01531. CHEMOKINER9.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK."
      Zaballos A., Gutierrez J., Varona R., Ardavin C., Marquez G.
      J. Immunol. 162:5671-5675(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION, TISSUE SPECIFICITY.
    2. "CCR9A and CCR9B: two receptors for the chemokine CCL25/TECK/Ck beta-15 that differ in their sensitivities to ligand."
      Yu C.-R., Peden K.W.C., Zaitseva M.B., Golding H., Farber J.M.
      J. Immunol. 164:1293-1305(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), CHARACTERIZATION, TISSUE SPECIFICITY.
    3. "Cloning, tissue distribution and chromosomal localization of two potential G-protein-linked chemokine receptors."
      Lautens L.L., Tiffany H.L., Gao J.-L., Modi W., Murphy P.M., Bonner T.I.
      Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
    4. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Warren C.N., Aronstam R.S., Sharma S.V.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).

    Entry informationi

    Entry nameiCCR9_HUMAN
    AccessioniPrimary (citable) accession number: P51686
    Secondary accession number(s): Q4VBM3, Q549E0, Q9UQQ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 136 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    EC50 of SCYA25/TECK for isoform 1 is lower than for isoform 2.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    3. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    4. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3