Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-C chemokine receptor type 9

Gene

CCR9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.

GO - Molecular functioni

  • C-C chemokine receptor activity Source: Ensembl
  • chemokine receptor activity Source: ProtInc

GO - Biological processi

  • CD8-positive, gamma-delta intraepithelial T cell differentiation Source: Ensembl
  • cellular defense response Source: ProtInc
  • chemotaxis Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • immune response Source: ProtInc
  • positive regulation of cytosolic calcium ion concentration Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173585-MONOMER.
ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP51686.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 9
Short name:
C-C CKR-9
Short name:
CC-CKR-9
Short name:
CCR-9
Alternative name(s):
G-protein coupled receptor 28
GPR-9-6
CD_antigen: CDw199
Gene namesi
Name:CCR9
Synonyms:GPR28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:1610. CCR9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 53ExtracellularSequence analysisAdd BLAST53
Transmembranei54 – 74Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini75 – 85CytoplasmicSequence analysisAdd BLAST11
Transmembranei86 – 106Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini107 – 127ExtracellularSequence analysisAdd BLAST21
Transmembranei128 – 148Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini149 – 166CytoplasmicSequence analysisAdd BLAST18
Transmembranei167 – 187Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini188 – 218ExtracellularSequence analysisAdd BLAST31
Transmembranei219 – 239Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini240 – 254CytoplasmicSequence analysisAdd BLAST15
Transmembranei255 – 275Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini276 – 300ExtracellularSequence analysisAdd BLAST25
Transmembranei301 – 321Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini322 – 369CytoplasmicSequence analysisAdd BLAST48

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10803.
OpenTargetsiENSG00000173585.
PharmGKBiPA26174.

Chemistry databases

ChEMBLiCHEMBL5815.
GuidetoPHARMACOLOGYi66.

Polymorphism and mutation databases

BioMutaiCCR9.
DMDMi114152781.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692911 – 369C-C chemokine receptor type 9Add BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi32N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi119 ↔ 198PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP51686.
PRIDEiP51686.

PTM databases

iPTMnetiP51686.
PhosphoSitePlusiP51686.

Expressioni

Tissue specificityi

Highly expressed in the thymus and low in lymph nodes and spleen.2 Publications

Gene expression databases

BgeeiENSG00000173585.
CleanExiHS_CCR9.
ExpressionAtlasiP51686. baseline and differential.
GenevisibleiP51686. HS.

Organism-specific databases

HPAiCAB006839.

Interactioni

Protein-protein interaction databases

DIPiDIP-5884N.
MINTiMINT-106203.
STRINGi9606.ENSP00000350256.

Chemistry databases

BindingDBiP51686.

Structurei

3D structure databases

ProteinModelPortaliP51686.
SMRiP51686.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP51686.
KOiK04184.
OMAiTWRQKRL.
OrthoDBiEOG091G093O.
PhylomeDBiP51686.
TreeFamiTF330966.

Family and domain databases

InterProiIPR004069. Chemokine_CCR9.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01531. CHEMOKINER9.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P51686-1) [UniParc]FASTAAdd to basket
Also known as: CCR9A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPTDFTSPI PNMADDYGSE STSSMEDYVN FNFTDFYCEK NNVRQFASHF
60 70 80 90 100
LPPLYWLVFI VGALGNSLVI LVYWYCTRVK TMTDMFLLNL AIADLLFLVT
110 120 130 140 150
LPFWAIAAAD QWKFQTFMCK VVNSMYKMNF YSCVLLIMCI SVDRYIAIAQ
160 170 180 190 200
AMRAHTWREK RLLYSKMVCF TIWVLAAALC IPEILYSQIK EESGIAICTM
210 220 230 240 250
VYPSDESTKL KSAVLTLKVI LGFFLPFVVM ACCYTIIIHT LIQAKKSSKH
260 270 280 290 300
KALKVTITVL TVFVLSQFPY NCILLVQTID AYAMFISNCA VSTNIDICFQ
310 320 330 340 350
VTQTIAFFHS CLNPVLYVFV GERFRRDLVK TLKNLGCISQ AQWVSFTRRE
360
GSLKLSSMLL ETTSGALSL
Length:369
Mass (Da):42,016
Last modified:September 5, 2006 - v2
Checksum:iF27CEA0CFB66B44C
GO
Isoform 2 (identifier: P51686-2) [UniParc]FASTAAdd to basket
Also known as: CCR9B

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.

Show »
Length:357
Mass (Da):40,713
Checksum:i96982E0B922F6B31
GO

Sequence cautioni

The sequence AAH95516 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02920892I → V.Corresponds to variant rs45530037dbSNPEnsembl.1
Natural variantiVAR_020068284M → V.Corresponds to variant rs12721497dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0202861 – 12Missing in isoform 2. 3 PublicationsAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132337 mRNA. Translation: CAB43477.1.
AF145439 mRNA. Translation: AAF66699.1.
AF145440 mRNA. Translation: AAF66700.1.
U45982 Genomic DNA. Translation: AAA93319.1.
AY242127 Genomic DNA. Translation: AAO92294.1.
BC069678 mRNA. Translation: AAH69678.1.
BC095516 mRNA. Translation: AAH95516.1. Different initiation.
CCDSiCCDS2732.1. [P51686-1]
CCDS2733.1. [P51686-2]
RefSeqiNP_001243298.1. NM_001256369.1. [P51686-2]
NP_006632.2. NM_006641.3. [P51686-2]
NP_112477.1. NM_031200.2. [P51686-1]
XP_011531614.1. XM_011533312.2. [P51686-1]
UniGeneiHs.225946.

Genome annotation databases

EnsembliENST00000355983; ENSP00000348260; ENSG00000173585. [P51686-2]
ENST00000357632; ENSP00000350256; ENSG00000173585. [P51686-1]
ENST00000395963; ENSP00000379292; ENSG00000173585. [P51686-2]
GeneIDi10803.
KEGGihsa:10803.
UCSCiuc003coz.3. human. [P51686-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CC chemokine receptors entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132337 mRNA. Translation: CAB43477.1.
AF145439 mRNA. Translation: AAF66699.1.
AF145440 mRNA. Translation: AAF66700.1.
U45982 Genomic DNA. Translation: AAA93319.1.
AY242127 Genomic DNA. Translation: AAO92294.1.
BC069678 mRNA. Translation: AAH69678.1.
BC095516 mRNA. Translation: AAH95516.1. Different initiation.
CCDSiCCDS2732.1. [P51686-1]
CCDS2733.1. [P51686-2]
RefSeqiNP_001243298.1. NM_001256369.1. [P51686-2]
NP_006632.2. NM_006641.3. [P51686-2]
NP_112477.1. NM_031200.2. [P51686-1]
XP_011531614.1. XM_011533312.2. [P51686-1]
UniGeneiHs.225946.

3D structure databases

ProteinModelPortaliP51686.
SMRiP51686.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5884N.
MINTiMINT-106203.
STRINGi9606.ENSP00000350256.

Chemistry databases

BindingDBiP51686.
ChEMBLiCHEMBL5815.
GuidetoPHARMACOLOGYi66.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP51686.
PhosphoSitePlusiP51686.

Polymorphism and mutation databases

BioMutaiCCR9.
DMDMi114152781.

Proteomic databases

PaxDbiP51686.
PRIDEiP51686.

Protocols and materials databases

DNASUi10803.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355983; ENSP00000348260; ENSG00000173585. [P51686-2]
ENST00000357632; ENSP00000350256; ENSG00000173585. [P51686-1]
ENST00000395963; ENSP00000379292; ENSG00000173585. [P51686-2]
GeneIDi10803.
KEGGihsa:10803.
UCSCiuc003coz.3. human. [P51686-1]

Organism-specific databases

CTDi10803.
DisGeNETi10803.
GeneCardsiCCR9.
HGNCiHGNC:1610. CCR9.
HPAiCAB006839.
MIMi604738. gene.
neXtProtiNX_P51686.
OpenTargetsiENSG00000173585.
PharmGKBiPA26174.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP51686.
KOiK04184.
OMAiTWRQKRL.
OrthoDBiEOG091G093O.
PhylomeDBiP51686.
TreeFamiTF330966.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173585-MONOMER.
ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP51686.

Miscellaneous databases

GeneWikiiCCR9.
GenomeRNAii10803.
PROiP51686.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173585.
CleanExiHS_CCR9.
ExpressionAtlasiP51686. baseline and differential.
GenevisibleiP51686. HS.

Family and domain databases

InterProiIPR004069. Chemokine_CCR9.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01531. CHEMOKINER9.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCR9_HUMAN
AccessioniPrimary (citable) accession number: P51686
Secondary accession number(s): Q4VBM3, Q549E0, Q9UQQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 5, 2006
Last modified: November 2, 2016
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

EC50 of SCYA25/TECK for isoform 1 is lower than for isoform 2.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.