P51686 (CCR9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-C chemokine receptor type 9
Short name=C-C CKR-9
Short name=CC-CKR-9
Short name=CCR-9

Alternative name(s):
G-protein coupled receptor 28
GPR-9-6
CD_antigen=CDw199

Gene names

Name:	CCR9
Synonyms:	GPR28

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	369 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Highly expressed in the thymus and low in lymph nodes and spleen. Ref.1 Ref.2
Miscellaneous	EC50 of SCYA25/TECK for isoform 1 is lower than for isoform 2.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Sequence caution	The sequence AAH95516.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular defense response Traceable author statement PubMed 10544196. Source: ProtInc chemotaxis Traceable author statement Ref.2. Source: ProtInc elevation of cytosolic calcium ion concentration Traceable author statement Ref.1. Source: ProtInc immune response Traceable author statement Ref.1. Source: ProtInc
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	C-C chemokine receptor activity Inferred from electronic annotation. Source: Compara chemokine receptor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P51686-1)

Also known as: CCR9A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P51686-2)

Also known as: CCR9B;

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 369	369	C-C chemokine receptor type 9		PRO_0000069291
Regions
	Topological domain	1 – 53	53	Extracellular Potential
	Transmembrane	54 – 74	21	Helical; Name=1; Potential
	Topological domain	75 – 85	11	Cytoplasmic Potential
	Transmembrane	86 – 106	21	Helical; Name=2; Potential
	Topological domain	107 – 127	21	Extracellular Potential
	Transmembrane	128 – 148	21	Helical; Name=3; Potential
	Topological domain	149 – 166	18	Cytoplasmic Potential
	Transmembrane	167 – 187	21	Helical; Name=4; Potential
	Topological domain	188 – 218	31	Extracellular Potential
	Transmembrane	219 – 239	21	Helical; Name=5; Potential
	Topological domain	240 – 254	15	Cytoplasmic Potential
	Transmembrane	255 – 275	21	Helical; Name=6; Potential
	Topological domain	276 – 300	25	Extracellular Potential
	Transmembrane	301 – 321	21	Helical; Name=7; Potential
	Topological domain	322 – 369	48	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	32	1	N-linked (GlcNAc...) Potential
	Disulfide bond	119 ↔ 198		By similarity
Natural variations
	Alternative sequence	1 – 12	12	Missing in isoform 2.		VSP_020286
	Natural variant	92	1	I → V. Corresponds to variant rs45530037 [ dbSNP | Ensembl ].		VAR_029208
	Natural variant	284	1	M → V. Corresponds to variant rs12721497 [ dbSNP | Ensembl ].		VAR_020068

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (CCR9A) [UniParc]. Last modified September 5, 2006. Version 2. Checksum: F27CEA0CFB66B44C	FASTA	369	42,016
	10 20 30 40 50 60 MTPTDFTSPI PNMADDYGSE STSSMEDYVN FNFTDFYCEK NNVRQFASHF LPPLYWLVFI 70 80 90 100 110 120 VGALGNSLVI LVYWYCTRVK TMTDMFLLNL AIADLLFLVT LPFWAIAAAD QWKFQTFMCK 130 140 150 160 170 180 VVNSMYKMNF YSCVLLIMCI SVDRYIAIAQ AMRAHTWREK RLLYSKMVCF TIWVLAAALC 190 200 210 220 230 240 IPEILYSQIK EESGIAICTM VYPSDESTKL KSAVLTLKVI LGFFLPFVVM ACCYTIIIHT 250 260 270 280 290 300 LIQAKKSSKH KALKVTITVL TVFVLSQFPY NCILLVQTID AYAMFISNCA VSTNIDICFQ 310 320 330 340 350 360 VTQTIAFFHS CLNPVLYVFV GERFRRDLVK TLKNLGCISQ AQWVSFTRRE GSLKLSSMLL ETTSGALSL
	Isoform 2 (CCR9B) [UniParc]. Checksum: 96982E0B922F6B31	FASTA	357	40,713
	10 20 30 40 50 60 MADDYGSEST SSMEDYVNFN FTDFYCEKNN VRQFASHFLP PLYWLVFIVG ALGNSLVILV 70 80 90 100 110 120 YWYCTRVKTM TDMFLLNLAI ADLLFLVTLP FWAIAAADQW KFQTFMCKVV NSMYKMNFYS 130 140 150 160 170 180 CVLLIMCISV DRYIAIAQAM RAHTWREKRL LYSKMVCFTI WVLAAALCIP EILYSQIKEE 190 200 210 220 230 240 SGIAICTMVY PSDESTKLKS AVLTLKVILG FFLPFVVMAC CYTIIIHTLI QAKKSSKHKA 250 260 270 280 290 300 LKVTITVLTV FVLSQFPYNC ILLVQTIDAY AMFISNCAVS TNIDICFQVT QTIAFFHSCL 310 320 330 340 350 NPVLYVFVGE RFRRDLVKTL KNLGCISQAQ WVSFTRREGS LKLSSMLLET TSGALSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK." Zaballos A., Gutierrez J., Varona R., Ardavin C., Marquez G. J. Immunol. 162:5671-5675(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION, TISSUE SPECIFICITY.
[2]	"CCR9A and CCR9B: two receptors for the chemokine CCL25/TECK/Ck beta-15 that differ in their sensitivities to ligand." Yu C.-R., Peden K.W.C., Zaitseva M.B., Golding H., Farber J.M. J. Immunol. 164:1293-1305(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), CHARACTERIZATION, TISSUE SPECIFICITY.
[3]	"Cloning, tissue distribution and chromosomal localization of two potential G-protein-linked chemokine receptors." Lautens L.L., Tiffany H.L., Gao J.-L., Modi W., Murphy P.M., Bonner T.I. Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
[4]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Warren C.N., Aronstam R.S., Sharma S.V. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
+	Additional computationally mapped references.

Web resources

Wikipedia

CC chemokine receptors entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ132337 mRNA. Translation: CAB43477.1. AF145439 mRNA. Translation: AAF66699.1. AF145440 mRNA. Translation: AAF66700.1. U45982 Genomic DNA. Translation: AAA93319.1. AY242127 Genomic DNA. Translation: AAO92294.1. BC069678 mRNA. Translation: AAH69678.1. BC095516 mRNA. Translation: AAH95516.1. Different initiation.
IPI	IPI00009902. IPI00019986.
RefSeq	NP_001243298.1. NM_001256369.1. NP_006632.2. NM_006641.3. NP_112477.1. NM_031200.2.
UniGene	Hs.225946.
3D structure databases
ProteinModelPortal	P51686.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5884N.
STRING	9606.ENSP00000350256.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P51686.
Polymorphism databases
DMDM	114152781.
Proteomic databases
PaxDb	P51686.
PRIDE	P51686.
Protocols and materials databases
DNASU	10803.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000355983; ENSP00000348260; ENSG00000173585. ENST00000357632; ENSP00000350256; ENSG00000173585. ENST00000395963; ENSP00000379292; ENSG00000173585.
GeneID	10803.
KEGG	hsa:10803.
UCSC	uc003coz.2. human.
Organism-specific databases
CTD	10803.
GeneCards	GC03P045903.
HGNC	HGNC:1610. CCR9.
HPA	CAB006839.
MIM	604738. gene.
neXtProt	NX_P51686.
PharmGKB	PA26174.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG268585.
HOGENOM	HOG000234122.
HOVERGEN	HBG106917.
InParanoid	P51686.
KO	K04184.
OMA	ISTNIDI.
OrthoDB	EOG4M65HT.
PhylomeDB	P51686.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P51686.
Bgee	P51686.
CleanEx	HS_CCR9.
Genevestigator	P51686.
GermOnline	ENSG00000173585. Homo sapiens.
Family and domain databases
InterPro	IPR004069. Chemokine_CCR9. IPR000355. Chemokine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR01531. CHEMOKINER9. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P51686.
ChEMBL	CHEMBL5815.
GenomeRNAi	10803.
NextBio	41035.
SOURCE	Search...

Entry information

Entry name

CCR9_HUMAN

Accession

Primary (citable) accession number: P51686
Secondary accession number(s): Q4VBM3, Q549E0, Q9UQQ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	September 5, 2006
Last modified:	May 1, 2013
This is version 122 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.