ID CCR8_HUMAN Reviewed; 355 AA. AC P51685; B2RC64; Q3KNQ8; Q3KNR3; Q9BYX5; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 1. DT 27-MAR-2024, entry version 187. DE RecName: Full=C-C chemokine receptor type 8; DE Short=C-C CKR-8; DE Short=CC-CKR-8; DE Short=CCR-8; DE AltName: Full=CC chemokine receptor CHEMR1; DE AltName: Full=CMKBRL2; DE AltName: Full=Chemokine receptor-like 1; DE Short=CKR-L1; DE AltName: Full=GPR-CY6; DE Short=GPRCY6; DE AltName: Full=TER1; DE AltName: CD_antigen=CDw198; GN Name=CCR8; Synonyms=CKRL1, CMKBR8, CMKBRL2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=8886020; DOI=10.1006/bbrc.1996.1595; RA Zaballos A., Varona R., Gutierrez J., Lind P., Marquez G.; RT "Molecular cloning and RNA expression of two new human chemokine receptor- RT like genes."; RL Biochem. Biophys. Res. Commun. 227:846-853(1996). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=8977299; DOI=10.1002/eji.1830261230; RA Samson M., Stordeur P., Labbe O., Soularue P., Vassart G., Parmentier M.; RT "Molecular cloning and chromosomal mapping of a novel human gene, ChemR1, RT expressed in T lymphocytes and polymorphonuclear cells and encoding a RT putative chemokine receptor."; RL Eur. J. Immunol. 26:3021-3028(1996). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), AND FUNCTION AS A RP RECEPTOR FOR CCL1. RC TISSUE=Thymus; RX PubMed=9207005; DOI=10.1084/jem.186.1.165; RA Tiffany H.L., Lautens L.L., Gao J.-L., Pease J., Locati M., Combadiere C., RA Modi W., Bonner T.I., Murphy P.M.; RT "Identification of CCR8: a human monocyte and thymus receptor for the CC RT chemokine I-309."; RL J. Exp. Med. 186:165-170(1997). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=8816377; RA Napolitano M., Zingoni A., Bernardini G., Spinetti G., Nista A., RA Storlazzi C.T., Rocchi M., Santoni A.; RT "Molecular cloning of TER1, a chemokine receptor-like gene expressed by RT lymphoid tissues."; RL J. Immunol. 157:2759-2763(1996). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RA Nakajima T., Yoshida R., Harada S.; RT "Molecular cloning of a human novel C-C chemokine receptor."; RL Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLY-27. RX PubMed=12551893; DOI=10.1074/jbc.m211422200; RA DeVries M.E., Cao H., Wang J., Xu L., Kelvin A.A., Ran L., Chau L.A., RA Madrenas J., Hegele R.A., Kelvin D.J.; RT "Genomic organization and evolution of the CX3CR1/CCR8 chemokine receptor RT locus."; RL J. Biol. Chem. 278:11985-11994(2003). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16641997; DOI=10.1038/nature04728; RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.; RT "The DNA sequence, annotation and analysis of human chromosome 3."; RL Nature 440:1194-1198(2006). RN [9] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [10] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [11] RP FUNCTION. RX PubMed=9521068; RX DOI=10.1002/(sici)1521-4141(199802)28:02<582::aid-immu582>3.0.co;2-a; RA Bernardini G., Hedrick J., Sozzani S., Luini W., Spinetti G., Weiss M., RA Menon S., Zlotnik A., Mantovani A., Santoni A., Napolitano M.; RT "Identification of the CC chemokines TARC and macrophage inflammatory RT protein-1 beta as novel functional ligands for the CCR8 receptor."; RL Eur. J. Immunol. 28:582-588(1998). RN [12] RP FUNCTION AS A RECEPTOR FOR CCL1. RX PubMed=9469461; RA Goya I., Gutierrez J., Varona R., Kremer L., Zaballos A., Marquez G.; RT "Identification of CCR8 as the specific receptor for the human beta- RT chemokine I-309: cloning and molecular characterization of murine CCR8 as RT the receptor for TCA-3."; RL J. Immunol. 160:1975-1981(1998). RN [13] RP FUNCTION. RX PubMed=10540332; RX DOI=10.1002/(sici)1521-4141(199910)29:10<3210::aid-immu3210>3.0.co;2-w; RA Garlisi C.G., Xiao H., Tian F., Hedrick J.A., Billah M.M., Egan R.W., RA Umland S.P.; RT "The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta RT are not ligands for human CC-chemokine receptor 8."; RL Eur. J. Immunol. 29:3210-3215(1999). CC -!- FUNCTION: Receptor for the chemokine CCL1/SCYA1/I-309. May regulate CC monocyte chemotaxis and thymic cell line apoptosis. Alternative CC coreceptor with CD4 for HIV-1 infection. {ECO:0000269|PubMed:10540332, CC ECO:0000269|PubMed:9207005, ECO:0000269|PubMed:9469461, CC ECO:0000269|PubMed:9521068}. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=P51685-1; Sequence=Displayed; CC Name=2; CC IsoId=P51685-2; Sequence=VSP_056340; CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC -!- CAUTION: Was originally thought to be a receptor for SCYA3 and SCYA17. CC {ECO:0000305|PubMed:9521068}. CC -!- WEB RESOURCE: Name=Wikipedia; Note=CC chemokine receptors entry; CC URL="https://en.wikipedia.org/wiki/CC_chemokine_receptors"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z79782; CAB02142.1; -; Genomic_DNA. DR EMBL; Y08456; CAA69712.1; -; Genomic_DNA. DR EMBL; U45983; AAB61962.1; -; Genomic_DNA. DR EMBL; AF005210; AAB62547.1; -; mRNA. DR EMBL; U62556; AAB05542.1; -; Genomic_DNA. DR EMBL; D49919; BAA23387.1; -; mRNA. DR EMBL; AY016370; AAK08628.1; -; Genomic_DNA. DR EMBL; AK314957; BAG37461.1; -; mRNA. DR EMBL; AC104850; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471055; EAW64577.1; -; Genomic_DNA. DR EMBL; BC069067; AAH69067.1; -; mRNA. DR EMBL; BC074743; AAH74743.1; -; mRNA. DR EMBL; BC107152; AAI07153.1; -; mRNA. DR EMBL; BC107159; AAI07160.1; -; mRNA. DR CCDS; CCDS2684.1; -. [P51685-1] DR PIR; JC5067; JC5067. DR RefSeq; NP_005192.1; NM_005201.3. [P51685-1] DR AlphaFoldDB; P51685; -. DR SMR; P51685; -. DR BioGRID; 107642; 14. DR DIP; DIP-5836N; -. DR IntAct; P51685; 13. DR MINT; P51685; -. DR STRING; 9606.ENSP00000326432; -. DR BindingDB; P51685; -. DR ChEMBL; CHEMBL4596; -. DR GuidetoPHARMACOLOGY; 65; -. DR iPTMnet; P51685; -. DR PhosphoSitePlus; P51685; -. DR BioMuta; CCR8; -. DR DMDM; 1707884; -. DR MassIVE; P51685; -. DR PaxDb; 9606-ENSP00000326432; -. DR PeptideAtlas; P51685; -. DR Antibodypedia; 12174; 588 antibodies from 39 providers. DR DNASU; 1237; -. DR Ensembl; ENST00000326306.5; ENSP00000326432.4; ENSG00000179934.7. [P51685-1] DR GeneID; 1237; -. DR KEGG; hsa:1237; -. DR MANE-Select; ENST00000326306.5; ENSP00000326432.4; NM_005201.4; NP_005192.1. DR UCSC; uc010hhr.3; human. [P51685-1] DR AGR; HGNC:1609; -. DR CTD; 1237; -. DR DisGeNET; 1237; -. DR GeneCards; CCR8; -. DR HGNC; HGNC:1609; CCR8. DR HPA; ENSG00000179934; Tissue enriched (lymphoid). DR MIM; 601834; gene. DR neXtProt; NX_P51685; -. DR OpenTargets; ENSG00000179934; -. DR PharmGKB; PA26173; -. DR VEuPathDB; HostDB:ENSG00000179934; -. DR eggNOG; KOG3656; Eukaryota. DR GeneTree; ENSGT01020000230359; -. DR HOGENOM; CLU_009579_8_3_1; -. DR InParanoid; P51685; -. DR OMA; QLDQWVF; -. DR OrthoDB; 4604454at2759; -. DR PhylomeDB; P51685; -. DR TreeFam; TF330966; -. DR PathwayCommons; P51685; -. DR Reactome; R-HSA-380108; Chemokine receptors bind chemokines. DR Reactome; R-HSA-418594; G alpha (i) signalling events. DR SignaLink; P51685; -. DR SIGNOR; P51685; -. DR BioGRID-ORCS; 1237; 10 hits in 1141 CRISPR screens. DR GeneWiki; CCR8_(gene); -. DR GenomeRNAi; 1237; -. DR Pharos; P51685; Tchem. DR PRO; PR:P51685; -. DR Proteomes; UP000005640; Chromosome 3. DR RNAct; P51685; Protein. DR Bgee; ENSG00000179934; Expressed in primordial germ cell in gonad and 32 other cell types or tissues. DR ExpressionAtlas; P51685; baseline and differential. DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0019957; F:C-C chemokine binding; IBA:GO_Central. DR GO; GO:0016493; F:C-C chemokine receptor activity; IBA:GO_Central. DR GO; GO:0004950; F:chemokine receptor activity; TAS:ProtInc. DR GO; GO:0015026; F:coreceptor activity; TAS:ProtInc. DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central. DR GO; GO:0007155; P:cell adhesion; TAS:ProtInc. DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central. DR GO; GO:0006935; P:chemotaxis; TAS:ProtInc. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:ProtInc. DR GO; GO:0006955; P:immune response; IBA:GO_Central. DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central. DR CDD; cd15187; 7tmA_CCR8; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR004068; Chemokine_CCR8. DR InterPro; IPR000355; Chemokine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR PANTHER; PTHR10489:SF627; C-C CHEMOKINE RECEPTOR TYPE 8; 1. DR PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00657; CCCHEMOKINER. DR PRINTS; PR01530; CHEMOKINER8. DR PRINTS; PR00237; GPCRRHODOPSN. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR Genevisible; P51685; HS. PE 1: Evidence at protein level; KW Alternative splicing; Cell membrane; Disulfide bond; KW G-protein coupled receptor; Membrane; Receptor; Reference proteome; KW Transducer; Transmembrane; Transmembrane helix. FT CHAIN 1..355 FT /note="C-C chemokine receptor type 8" FT /id="PRO_0000069288" FT TOPO_DOM 1..35 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 36..63 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 64..73 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 74..93 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 94..107 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 108..129 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 130..146 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 147..171 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 172..202 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 203..222 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 223..238 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 239..263 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 264..280 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 281..304 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 305..355 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT DISULFID 106..183 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" FT VAR_SEQ 1..91 FT /note="MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLG FT NSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQ -> MRNLFRQM (in FT isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_056340" FT VARIANT 27 FT /note="A -> G (in dbSNP:rs2853699)" FT /evidence="ECO:0000269|PubMed:12551893" FT /id="VAR_049384" SQ SEQUENCE 355 AA; 40844 MW; BC14A153CF695361 CRC64; MDYTLDLSVT TVTDYYYPDI FSSPCDAELI QTNGKLLLAV FYCLLFVFSL LGNSLVILVL VVCKKLRSIT DVYLLNLALS DLLFVFSFPF QTYYLLDQWV FGTVMCKVVS GFYYIGFYSS MFFITLMSVD RYLAVVHAVY ALKVRTIRMG TTLCLAVWLT AIMATIPLLV FYQVASEDGV LQCYSFYNQQ TLKWKIFTNF KMNILGLLIP FTIFMFCYIK ILHQLKRCQN HNKTKAIRLV LIVVIASLLF WVPFNVVLFL TSLHSMHILD GCSISQQLTY ATHVTEIISF THCCVNPVIY AFVGEKFKKH LSEIFQKSCS QIFNYLGRQM PRESCEKSSS CQQHSSRSSS VDYIL //