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Protein

C-C chemokine receptor type 8

Gene

CCR8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.4 Publications

Caution

Was originally thought to be a receptor for SCYA3 and SCYA17.1 Publication

GO - Molecular functioni

  • C-C chemokine receptor activity Source: Ensembl
  • chemokine receptor activity Source: ProtInc
  • coreceptor activity Source: ProtInc

GO - Biological processi

  • cell adhesion Source: ProtInc
  • chemotaxis Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: Reactome
  • immune response Source: ProtInc
  • positive regulation of cytosolic calcium ion concentration Source: ProtInc

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
SIGNORiP51685

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 8
Short name:
C-C CKR-8
Short name:
CC-CKR-8
Short name:
CCR-8
Alternative name(s):
CC chemokine receptor CHEMR1
CMKBRL2
Chemokine receptor-like 1
Short name:
CKR-L1
GPR-CY6
Short name:
GPRCY6
TER1
CD_antigen: CDw198
Gene namesi
Name:CCR8
Synonyms:CKRL1, CMKBR8, CMKBRL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000179934.6
HGNCiHGNC:1609 CCR8
MIMi601834 gene
neXtProtiNX_P51685

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35ExtracellularSequence analysisAdd BLAST35
Transmembranei36 – 63Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini64 – 73CytoplasmicSequence analysis10
Transmembranei74 – 93Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini94 – 107ExtracellularSequence analysisAdd BLAST14
Transmembranei108 – 129Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini130 – 146CytoplasmicSequence analysisAdd BLAST17
Transmembranei147 – 171Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini172 – 202ExtracellularSequence analysisAdd BLAST31
Transmembranei203 – 222Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini223 – 238CytoplasmicSequence analysisAdd BLAST16
Transmembranei239 – 263Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini264 – 280ExtracellularSequence analysisAdd BLAST17
Transmembranei281 – 304Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini305 – 355CytoplasmicSequence analysisAdd BLAST51

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1237
OpenTargetsiENSG00000179934
PharmGKBiPA26173

Chemistry databases

ChEMBLiCHEMBL4596
GuidetoPHARMACOLOGYi65

Polymorphism and mutation databases

BioMutaiCCR8
DMDMi1707884

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692881 – 355C-C chemokine receptor type 8Add BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi106 ↔ 183PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP51685
PeptideAtlasiP51685
PRIDEiP51685

PTM databases

iPTMnetiP51685
PhosphoSitePlusiP51685

Expressioni

Gene expression databases

BgeeiENSG00000179934
CleanExiHS_CCR8
ExpressionAtlasiP51685 baseline and differential
GenevisibleiP51685 HS

Interactioni

Protein-protein interaction databases

DIPiDIP-5836N
STRINGi9606.ENSP00000326432

Chemistry databases

BindingDBiP51685

Structurei

3D structure databases

ProteinModelPortaliP51685
SMRiP51685
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ9D Eukaryota
ENOG410YUBT LUCA
GeneTreeiENSGT00760000118785
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiP51685
KOiK04183
OMAiMFFITLM
OrthoDBiEOG091G0HEN
PhylomeDBiP51685
TreeFamiTF330966

Family and domain databases

InterProiView protein in InterPro
IPR004068 Chemokine_CCR8
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR01530 CHEMOKINER8
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P51685-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDYTLDLSVT TVTDYYYPDI FSSPCDAELI QTNGKLLLAV FYCLLFVFSL
60 70 80 90 100
LGNSLVILVL VVCKKLRSIT DVYLLNLALS DLLFVFSFPF QTYYLLDQWV
110 120 130 140 150
FGTVMCKVVS GFYYIGFYSS MFFITLMSVD RYLAVVHAVY ALKVRTIRMG
160 170 180 190 200
TTLCLAVWLT AIMATIPLLV FYQVASEDGV LQCYSFYNQQ TLKWKIFTNF
210 220 230 240 250
KMNILGLLIP FTIFMFCYIK ILHQLKRCQN HNKTKAIRLV LIVVIASLLF
260 270 280 290 300
WVPFNVVLFL TSLHSMHILD GCSISQQLTY ATHVTEIISF THCCVNPVIY
310 320 330 340 350
AFVGEKFKKH LSEIFQKSCS QIFNYLGRQM PRESCEKSSS CQQHSSRSSS

VDYIL
Length:355
Mass (Da):40,844
Last modified:October 1, 1996 - v1
Checksum:iBC14A153CF695361
GO
Isoform 2 (identifier: P51685-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: MDYTLDLSVT...LLFVFSFPFQ → MRNLFRQM

Note: No experimental confirmation available.
Show »
Length:272
Mass (Da):31,622
Checksum:i1A78F1429FE3A4A3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04938427A → G1 PublicationCorresponds to variant dbSNP:rs2853699Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0563401 – 91MDYTL…SFPFQ → MRNLFRQM in isoform 2. 1 PublicationAdd BLAST91

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z79782 Genomic DNA Translation: CAB02142.1
Y08456 Genomic DNA Translation: CAA69712.1
U45983 Genomic DNA Translation: AAB61962.1
AF005210 mRNA Translation: AAB62547.1
U62556 Genomic DNA Translation: AAB05542.1
D49919 mRNA Translation: BAA23387.1
AY016370 Genomic DNA Translation: AAK08628.1
AK314957 mRNA Translation: BAG37461.1
AC104850 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64577.1
BC069067 mRNA Translation: AAH69067.1
BC074743 mRNA Translation: AAH74743.1
BC107152 mRNA Translation: AAI07153.1
BC107159 mRNA Translation: AAI07160.1
CCDSiCCDS2684.1 [P51685-1]
PIRiJC5067
RefSeqiNP_005192.1, NM_005201.3 [P51685-1]
UniGeneiHs.113222

Genome annotation databases

EnsembliENST00000326306; ENSP00000326432; ENSG00000179934 [P51685-1]
GeneIDi1237
KEGGihsa:1237
UCSCiuc010hhr.3 human [P51685-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCCR8_HUMAN
AccessioniPrimary (citable) accession number: P51685
Secondary accession number(s): B2RC64
, Q3KNQ8, Q3KNR3, Q9BYX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 25, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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