P51685 (CCR8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-C chemokine receptor type 8
Short name=C-C CKR-8
Short name=CC-CKR-8
Short name=CCR-8

Alternative name(s):
CC chemokine receptor CHEMR1
CMKBRL2
Chemokine receptor-like 1
Short name=CKR-L1
GPR-CY6
Short name=GPRCY6
TER1
CD_antigen=CDw198

Gene names

Name:	CCR8
Synonyms:	CKRL1, CMKBR8, CMKBRL2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	355 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection. Ref.3 Ref.10 Ref.11 Ref.12
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Caution	Was originally (Ref.10) thought to be a receptor for SCYA3 and SCYA17.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Traceable author statement Ref.4. Source: ProtInc cell adhesion Traceable author statement PubMed 10910894. Source: ProtInc chemokine-mediated signaling pathway Traceable author statement PubMed 9417093. Source: GOC chemotaxis Traceable author statement PubMed 10910894. Source: ProtInc immune response Traceable author statement PubMed 9670926. Source: ProtInc positive regulation of cytosolic calcium ion concentration Traceable author statement PubMed 9417093. Source: ProtInc
Cellular_component	integral component of plasma membrane Traceable author statement Ref.4. Source: ProtInc plasma membrane Traceable author statement. Source: Reactome
Molecular_function	C-C chemokine receptor activity Inferred from electronic annotation. Source: Ensembl chemokine receptor activity Traceable author statement PubMed 9417093. Source: ProtInc coreceptor activity Traceable author statement PubMed 9417093. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 355	355	C-C chemokine receptor type 8		PRO_0000069288
Regions
	Topological domain	1 – 35	35	Extracellular Potential
	Transmembrane	36 – 63	28	Helical; Name=1; Potential
	Topological domain	64 – 73	10	Cytoplasmic Potential
	Transmembrane	74 – 93	20	Helical; Name=2; Potential
	Topological domain	94 – 107	14	Extracellular Potential
	Transmembrane	108 – 129	22	Helical; Name=3; Potential
	Topological domain	130 – 146	17	Cytoplasmic Potential
	Transmembrane	147 – 171	25	Helical; Name=4; Potential
	Topological domain	172 – 202	31	Extracellular Potential
	Transmembrane	203 – 222	20	Helical; Name=5; Potential
	Topological domain	223 – 238	16	Cytoplasmic Potential
	Transmembrane	239 – 263	25	Helical; Name=6; Potential
	Topological domain	264 – 280	17	Extracellular Potential
	Transmembrane	281 – 304	24	Helical; Name=7; Potential
	Topological domain	305 – 355	51	Cytoplasmic Potential
Amino acid modifications
	Disulfide bond	106 ↔ 183		By similarity
Natural variations
	Natural variant	27	1	A → G. Ref.6 Corresponds to variant rs2853699 [ dbSNP | Ensembl ].		VAR_049384

Sequences

	Sequence		Length	Mass (Da)
	P51685 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: BC14A153CF695361	FASTA	355	40,844
	10 20 30 40 50 60 MDYTLDLSVT TVTDYYYPDI FSSPCDAELI QTNGKLLLAV FYCLLFVFSL LGNSLVILVL 70 80 90 100 110 120 VVCKKLRSIT DVYLLNLALS DLLFVFSFPF QTYYLLDQWV FGTVMCKVVS GFYYIGFYSS 130 140 150 160 170 180 MFFITLMSVD RYLAVVHAVY ALKVRTIRMG TTLCLAVWLT AIMATIPLLV FYQVASEDGV 190 200 210 220 230 240 LQCYSFYNQQ TLKWKIFTNF KMNILGLLIP FTIFMFCYIK ILHQLKRCQN HNKTKAIRLV 250 260 270 280 290 300 LIVVIASLLF WVPFNVVLFL TSLHSMHILD GCSISQQLTY ATHVTEIISF THCCVNPVIY 310 320 330 340 350 AFVGEKFKKH LSEIFQKSCS QIFNYLGRQM PRESCEKSSS CQQHSSRSSS VDYIL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and RNA expression of two new human chemokine receptor-like genes." Zaballos A., Varona R., Gutierrez J., Lind P., Marquez G. Biochem. Biophys. Res. Commun. 227:846-853(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Molecular cloning and chromosomal mapping of a novel human gene, ChemR1, expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor." Samson M., Stordeur P., Labbe O., Soularue P., Vassart G., Parmentier M. Eur. J. Immunol. 26:3021-3028(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309." Tiffany H.L., Lautens L.L., Gao J.-L., Pease J., Locati M., Combadiere C., Modi W., Bonner T.I., Murphy P.M. J. Exp. Med. 186:165-170(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION AS A RECEPTOR FOR CCL1. Tissue: Thymus.
[4]	"Molecular cloning of TER1, a chemokine receptor-like gene expressed by lymphoid tissues." Napolitano M., Zingoni A., Bernardini G., Spinetti G., Nista A., Storlazzi C.T., Rocchi M., Santoni A. J. Immunol. 157:2759-2763(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"Molecular cloning of a human novel C-C chemokine receptor." Nakajima T., Yoshida R., Harada S. Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]	"Genomic organization and evolution of the CX3CR1/CCR8 chemokine receptor locus." DeVries M.E., Cao H., Wang J., Xu L., Kelvin A.A., Ran L., Chau L.A., Madrenas J., Hegele R.A., Kelvin D.J. J. Biol. Chem. 278:11985-11994(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-27.
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[10]	"Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor." Bernardini G., Hedrick J., Sozzani S., Luini W., Spinetti G., Weiss M., Menon S., Zlotnik A., Mantovani A., Santoni A., Napolitano M. Eur. J. Immunol. 28:582-588(1998) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[11]	"Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3." Goya I., Gutierrez J., Varona R., Kremer L., Zaballos A., Marquez G. J. Immunol. 160:1975-1981(1998) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION AS A RECEPTOR FOR CCL1.
[12]	"The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8." Garlisi C.G., Xiao H., Tian F., Hedrick J.A., Billah M.M., Egan R.W., Umland S.P. Eur. J. Immunol. 29:3210-3215(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Web resources

Wikipedia

CC chemokine receptors entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z79782 Genomic DNA. Translation: CAB02142.1. Y08456 Genomic DNA. Translation: CAA69712.1. U45983 Genomic DNA. Translation: AAB61962.1. AF005210 mRNA. Translation: AAB62547.1. U62556 Genomic DNA. Translation: AAB05542.1. D49919 mRNA. Translation: BAA23387.1. AY016370 Genomic DNA. Translation: AAK08628.1. AK314957 mRNA. Translation: BAG37461.1. CH471055 Genomic DNA. Translation: EAW64577.1. BC069067 mRNA. Translation: AAH69067.1. BC074743 mRNA. Translation: AAH74743.1. BC107159 mRNA. Translation: AAI07160.1.
CCDS	CCDS2684.1.
PIR	JC5067.
RefSeq	NP_005192.1. NM_005201.3.
UniGene	Hs.113222.
3D structure databases
ProteinModelPortal	P51685.
SMR	P51685. Positions 15-316.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
DIP	DIP-5836N.
MINT	MINT-140630.
STRING	9606.ENSP00000326432.
Chemistry
BindingDB	P51685.
ChEMBL	CHEMBL4596.
GuidetoPHARMACOLOGY	65.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P51685.
Polymorphism databases
DMDM	1707884.
Proteomic databases
PaxDb	P51685.
PRIDE	P51685.
Protocols and materials databases
DNASU	1237.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000326306; ENSP00000326432; ENSG00000179934.
GeneID	1237.
KEGG	hsa:1237.
UCSC	uc010hhr.2. human.
Organism-specific databases
CTD	1237.
GeneCards	GC03P039371.
HGNC	HGNC:1609. CCR8.
MIM	601834. gene.
neXtProt	NX_P51685.
PharmGKB	PA26173.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG149415.
HOGENOM	HOG000234122.
HOVERGEN	HBG106917.
InParanoid	P51685.
KO	K04183.
OMA	LIYATHV.
OrthoDB	EOG7B5WW3.
PhylomeDB	P51685.
TreeFam	TF330966.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P51685.
Bgee	P51685.
CleanEx	HS_CCR8.
Genevestigator	P51685.
Family and domain databases
Gene3D	1.20.1070.10. 1 hit.
InterPro	IPR004068. Chemokine_CCR8. IPR000355. Chemokine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
PANTHER	PTHR24227. PTHR24227. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR01530. CHEMOKINER8. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GeneWiki	CCR8_(gene).
GenomeRNAi	1237.
NextBio	5053.
PRO	P51685.
SOURCE	Search...

Entry information

Entry name

CCR8_HUMAN

Accession

Primary (citable) accession number: P51685
Secondary accession number(s): B2RC64, Q3KNQ8, Q9BYX5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	July 9, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.