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P51685 - CCR8_HUMAN

UniProt

P51685 - CCR8_HUMAN

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Protein

C-C chemokine receptor type 8

Gene

CCR8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.4 Publications

GO - Molecular functioni

  1. C-C chemokine receptor activity Source: Ensembl
  2. chemokine receptor activity Source: ProtInc
  3. coreceptor activity Source: ProtInc

GO - Biological processi

  1. cell adhesion Source: ProtInc
  2. chemokine-mediated signaling pathway Source: GOC
  3. chemotaxis Source: ProtInc
  4. G-protein coupled receptor signaling pathway Source: ProtInc
  5. immune response Source: ProtInc
  6. positive regulation of cytosolic calcium ion concentration Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 8
Short name:
C-C CKR-8
Short name:
CC-CKR-8
Short name:
CCR-8
Alternative name(s):
CC chemokine receptor CHEMR1
CMKBRL2
Chemokine receptor-like 1
Short name:
CKR-L1
GPR-CY6
Short name:
GPRCY6
TER1
CD_antigen: CDw198
Gene namesi
Name:CCR8
Synonyms:CKRL1, CMKBR8, CMKBRL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:1609. CCR8.

Subcellular locationi

Cell membrane; Multi-pass membrane protein

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
BLAST
Transmembranei36 – 6328Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini64 – 7310CytoplasmicSequence Analysis
Transmembranei74 – 9320Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini94 – 10714ExtracellularSequence AnalysisAdd
BLAST
Transmembranei108 – 12922Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini130 – 14617CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei147 – 17125Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini172 – 20231ExtracellularSequence AnalysisAdd
BLAST
Transmembranei203 – 22220Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini223 – 23816CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei239 – 26325Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini264 – 28017ExtracellularSequence AnalysisAdd
BLAST
Transmembranei281 – 30424Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini305 – 35551CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26173.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355C-C chemokine receptor type 8PRO_0000069288Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi106 ↔ 183PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP51685.
PRIDEiP51685.

PTM databases

PhosphoSiteiP51685.

Expressioni

Gene expression databases

BgeeiP51685.
CleanExiHS_CCR8.
ExpressionAtlasiP51685. baseline.
GenevestigatoriP51685.

Interactioni

Protein-protein interaction databases

DIPiDIP-5836N.
MINTiMINT-140630.
STRINGi9606.ENSP00000326432.

Structurei

3D structure databases

ProteinModelPortaliP51685.
SMRiP51685. Positions 15-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149415.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP51685.
KOiK04183.
OMAiLIYATHV.
OrthoDBiEOG7B5WW3.
PhylomeDBiP51685.
TreeFamiTF330966.

Family and domain databases

InterProiIPR004068. Chemokine_CCR8.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01530. CHEMOKINER8.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P51685-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDYTLDLSVT TVTDYYYPDI FSSPCDAELI QTNGKLLLAV FYCLLFVFSL 
        60         70         80         90        100
LGNSLVILVL VVCKKLRSIT DVYLLNLALS DLLFVFSFPF QTYYLLDQWV 
       110        120        130        140        150
FGTVMCKVVS GFYYIGFYSS MFFITLMSVD RYLAVVHAVY ALKVRTIRMG 
       160        170        180        190        200
TTLCLAVWLT AIMATIPLLV FYQVASEDGV LQCYSFYNQQ TLKWKIFTNF 
       210        220        230        240        250
KMNILGLLIP FTIFMFCYIK ILHQLKRCQN HNKTKAIRLV LIVVIASLLF 
       260        270        280        290        300
WVPFNVVLFL TSLHSMHILD GCSISQQLTY ATHVTEIISF THCCVNPVIY 
       310        320        330        340        350
AFVGEKFKKH LSEIFQKSCS QIFNYLGRQM PRESCEKSSS CQQHSSRSSS 

VDYIL
Length:355
Mass (Da):40,844
Last modified:October 1, 1996 - v1
Checksum:iBC14A153CF695361
GO
Isoform 2 (identifier: P51685-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: MDYTLDLSVT...LLFVFSFPFQ → MRNLFRQM

Note: No experimental confirmation available.

Show »
Length:272
Mass (Da):31,622
Checksum:i1A78F1429FE3A4A3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271A → G.1 Publication
Corresponds to variant rs2853699 [ dbSNP | Ensembl ].		VAR_049384

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9191MDYTL…SFPFQ → MRNLFRQM in isoform 2. 1 PublicationVSP_056340Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z79782 Genomic DNA. Translation: CAB02142.1.
Y08456 Genomic DNA. Translation: CAA69712.1.
U45983 Genomic DNA. Translation: AAB61962.1.
AF005210 mRNA. Translation: AAB62547.1.
U62556 Genomic DNA. Translation: AAB05542.1.
D49919 mRNA. Translation: BAA23387.1.
AY016370 Genomic DNA. Translation: AAK08628.1.
AK314957 mRNA. Translation: BAG37461.1.
AC104850 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64577.1.
BC069067 mRNA. Translation: AAH69067.1.
BC074743 mRNA. Translation: AAH74743.1.
BC107152 mRNA. Translation: AAI07153.1.
BC107159 mRNA. Translation: AAI07160.1.
CCDSiCCDS2684.1. [P51685-1]
PIRiJC5067.
RefSeqiNP_005192.1. NM_005201.3. [P51685-1]
UniGeneiHs.113222.

Genome annotation databases

EnsembliENST00000326306; ENSP00000326432; ENSG00000179934. [P51685-1]
GeneIDi1237.
KEGGihsa:1237.
UCSCiuc010hhr.2. human. [P51685-1]

Polymorphism databases

DMDMi1707884.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CC chemokine receptors entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z79782 Genomic DNA. Translation: CAB02142.1.
Y08456 Genomic DNA. Translation: CAA69712.1.
U45983 Genomic DNA. Translation: AAB61962.1.
AF005210 mRNA. Translation: AAB62547.1.
U62556 Genomic DNA. Translation: AAB05542.1.
D49919 mRNA. Translation: BAA23387.1.
AY016370 Genomic DNA. Translation: AAK08628.1.
AK314957 mRNA. Translation: BAG37461.1.
AC104850 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64577.1.
BC069067 mRNA. Translation: AAH69067.1.
BC074743 mRNA. Translation: AAH74743.1.
BC107152 mRNA. Translation: AAI07153.1.
BC107159 mRNA. Translation: AAI07160.1.
CCDSiCCDS2684.1. [P51685-1]
PIRiJC5067.
RefSeqiNP_005192.1. NM_005201.3. [P51685-1]
UniGeneiHs.113222.

3D structure databases

ProteinModelPortaliP51685.
SMRiP51685. Positions 15-316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5836N.
MINTiMINT-140630.
STRINGi9606.ENSP00000326432.

Chemistry

BindingDBiP51685.
ChEMBLiCHEMBL4596.
GuidetoPHARMACOLOGYi65.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP51685.

Polymorphism databases

DMDMi1707884.

Proteomic databases

PaxDbiP51685.
PRIDEiP51685.

Protocols and materials databases

DNASUi1237.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326306; ENSP00000326432; ENSG00000179934. [P51685-1]
GeneIDi1237.
KEGGihsa:1237.
UCSCiuc010hhr.2. human. [P51685-1]

Organism-specific databases

CTDi1237.
GeneCardsiGC03P039371.
HGNCiHGNC:1609. CCR8.
MIMi601834. gene.
neXtProtiNX_P51685.
PharmGKBiPA26173.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG149415.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP51685.
KOiK04183.
OMAiLIYATHV.
OrthoDBiEOG7B5WW3.
PhylomeDBiP51685.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiCCR8_(gene).
GenomeRNAii1237.
NextBioi5053.
PROiP51685.
SOURCEiSearch...

Gene expression databases

BgeeiP51685.
CleanExiHS_CCR8.
ExpressionAtlasiP51685. baseline.
GenevestigatoriP51685.

Family and domain databases

InterProiIPR004068. Chemokine_CCR8.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01530. CHEMOKINER8.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and RNA expression of two new human chemokine receptor-like genes."
    Zaballos A., Varona R., Gutierrez J., Lind P., Marquez G.
    Biochem. Biophys. Res. Commun. 227:846-853(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Molecular cloning and chromosomal mapping of a novel human gene, ChemR1, expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor."
    Samson M., Stordeur P., Labbe O., Soularue P., Vassart G., Parmentier M.
    Eur. J. Immunol. 26:3021-3028(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309."
    Tiffany H.L., Lautens L.L., Gao J.-L., Pease J., Locati M., Combadiere C., Modi W., Bonner T.I., Murphy P.M.
    J. Exp. Med. 186:165-170(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), FUNCTION AS A RECEPTOR FOR CCL1.
    Tissue: Thymus.
  4. "Molecular cloning of TER1, a chemokine receptor-like gene expressed by lymphoid tissues."
    Napolitano M., Zingoni A., Bernardini G., Spinetti G., Nista A., Storlazzi C.T., Rocchi M., Santoni A.
    J. Immunol. 157:2759-2763(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Molecular cloning of a human novel C-C chemokine receptor."
    Nakajima T., Yoshida R., Harada S.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  6. "Genomic organization and evolution of the CX3CR1/CCR8 chemokine receptor locus."
    DeVries M.E., Cao H., Wang J., Xu L., Kelvin A.A., Ran L., Chau L.A., Madrenas J., Hegele R.A., Kelvin D.J.
    J. Biol. Chem. 278:11985-11994(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-27.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  11. "Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor."
    Bernardini G., Hedrick J., Sozzani S., Luini W., Spinetti G., Weiss M., Menon S., Zlotnik A., Mantovani A., Santoni A., Napolitano M.
    Eur. J. Immunol. 28:582-588(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3."
    Goya I., Gutierrez J., Varona R., Kremer L., Zaballos A., Marquez G.
    J. Immunol. 160:1975-1981(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A RECEPTOR FOR CCL1.
  13. "The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8."
    Garlisi C.G., Xiao H., Tian F., Hedrick J.A., Billah M.M., Egan R.W., Umland S.P.
    Eur. J. Immunol. 29:3210-3215(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
+Additional computationally mapped references.

Entry informationi

Entry nameiCCR8_HUMAN
AccessioniPrimary (citable) accession number: P51685
Secondary accession number(s): B2RC64
, Q3KNQ8, Q3KNR3, Q9BYX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 7, 2015
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.