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P51685 (CCR8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C chemokine receptor type 8

Short name=C-C CKR-8
Short name=CC-CKR-8
Short name=CCR-8
Alternative name(s):
CC chemokine receptor CHEMR1
CMKBRL2
Chemokine receptor-like 1
Short name=CKR-L1
GPR-CY6
Short name=GPRCY6
TER1
CD_antigen=CDw198
Gene names
Name:CCR8
Synonyms:CKRL1, CMKBR8, CMKBRL2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection. Ref.3 Ref.10 Ref.11 Ref.12

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

Was originally (Ref.10) thought to be a receptor for SCYA3 and SCYA17.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 355355C-C chemokine receptor type 8
PRO_0000069288

Regions

Topological domain1 – 3535Extracellular Potential
Transmembrane36 – 6328Helical; Name=1; Potential
Topological domain64 – 7310Cytoplasmic Potential
Transmembrane74 – 9320Helical; Name=2; Potential
Topological domain94 – 10714Extracellular Potential
Transmembrane108 – 12922Helical; Name=3; Potential
Topological domain130 – 14617Cytoplasmic Potential
Transmembrane147 – 17125Helical; Name=4; Potential
Topological domain172 – 20231Extracellular Potential
Transmembrane203 – 22220Helical; Name=5; Potential
Topological domain223 – 23816Cytoplasmic Potential
Transmembrane239 – 26325Helical; Name=6; Potential
Topological domain264 – 28017Extracellular Potential
Transmembrane281 – 30424Helical; Name=7; Potential
Topological domain305 – 35551Cytoplasmic Potential

Amino acid modifications

Disulfide bond106 ↔ 183 By similarity

Natural variations

Natural variant271A → G. Ref.6
Corresponds to variant rs2853699 [ dbSNP | Ensembl ].
VAR_049384

Sequences

Sequence LengthMass (Da)Tools
P51685 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: BC14A153CF695361

FASTA35540,844
        10         20         30         40         50         60 
MDYTLDLSVT TVTDYYYPDI FSSPCDAELI QTNGKLLLAV FYCLLFVFSL LGNSLVILVL 

        70         80         90        100        110        120 
VVCKKLRSIT DVYLLNLALS DLLFVFSFPF QTYYLLDQWV FGTVMCKVVS GFYYIGFYSS 

       130        140        150        160        170        180 
MFFITLMSVD RYLAVVHAVY ALKVRTIRMG TTLCLAVWLT AIMATIPLLV FYQVASEDGV 

       190        200        210        220        230        240 
LQCYSFYNQQ TLKWKIFTNF KMNILGLLIP FTIFMFCYIK ILHQLKRCQN HNKTKAIRLV 

       250        260        270        280        290        300 
LIVVIASLLF WVPFNVVLFL TSLHSMHILD GCSISQQLTY ATHVTEIISF THCCVNPVIY 

       310        320        330        340        350 
AFVGEKFKKH LSEIFQKSCS QIFNYLGRQM PRESCEKSSS CQQHSSRSSS VDYIL 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and RNA expression of two new human chemokine receptor-like genes."
Zaballos A., Varona R., Gutierrez J., Lind P., Marquez G.
Biochem. Biophys. Res. Commun. 227:846-853(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Molecular cloning and chromosomal mapping of a novel human gene, ChemR1, expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor."
Samson M., Stordeur P., Labbe O., Soularue P., Vassart G., Parmentier M.
Eur. J. Immunol. 26:3021-3028(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309."
Tiffany H.L., Lautens L.L., Gao J.-L., Pease J., Locati M., Combadiere C., Modi W., Bonner T.I., Murphy P.M.
J. Exp. Med. 186:165-170(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION AS A RECEPTOR FOR CCL1.
Tissue: Thymus.
[4]"Molecular cloning of TER1, a chemokine receptor-like gene expressed by lymphoid tissues."
Napolitano M., Zingoni A., Bernardini G., Spinetti G., Nista A., Storlazzi C.T., Rocchi M., Santoni A.
J. Immunol. 157:2759-2763(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Molecular cloning of a human novel C-C chemokine receptor."
Nakajima T., Yoshida R., Harada S.
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]"Genomic organization and evolution of the CX3CR1/CCR8 chemokine receptor locus."
DeVries M.E., Cao H., Wang J., Xu L., Kelvin A.A., Ran L., Chau L.A., Madrenas J., Hegele R.A., Kelvin D.J.
J. Biol. Chem. 278:11985-11994(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-27.
[7]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[10]"Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor."
Bernardini G., Hedrick J., Sozzani S., Luini W., Spinetti G., Weiss M., Menon S., Zlotnik A., Mantovani A., Santoni A., Napolitano M.
Eur. J. Immunol. 28:582-588(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[11]"Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3."
Goya I., Gutierrez J., Varona R., Kremer L., Zaballos A., Marquez G.
J. Immunol. 160:1975-1981(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION AS A RECEPTOR FOR CCL1.
[12]"The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8."
Garlisi C.G., Xiao H., Tian F., Hedrick J.A., Billah M.M., Egan R.W., Umland S.P.
Eur. J. Immunol. 29:3210-3215(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Web resources

Wikipedia

CC chemokine receptors entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z79782 Genomic DNA. Translation: CAB02142.1.
Y08456 Genomic DNA. Translation: CAA69712.1.
U45983 Genomic DNA. Translation: AAB61962.1.
AF005210 mRNA. Translation: AAB62547.1.
U62556 Genomic DNA. Translation: AAB05542.1.
D49919 mRNA. Translation: BAA23387.1.
AY016370 Genomic DNA. Translation: AAK08628.1.
AK314957 mRNA. Translation: BAG37461.1.
CH471055 Genomic DNA. Translation: EAW64577.1.
BC069067 mRNA. Translation: AAH69067.1.
BC074743 mRNA. Translation: AAH74743.1.
BC107159 mRNA. Translation: AAI07160.1.
PIRJC5067.
RefSeqNP_005192.1. NM_005201.3.
UniGeneHs.113222.

3D structure databases

ProteinModelPortalP51685.
SMRP51685. Positions 15-316.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-5836N.
MINTMINT-140630.
STRING9606.ENSP00000326432.

Chemistry

BindingDBP51685.
ChEMBLCHEMBL4596.
GuidetoPHARMACOLOGY65.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP51685.

Polymorphism databases

DMDM1707884.

Proteomic databases

PaxDbP51685.
PRIDEP51685.

Protocols and materials databases

DNASU1237.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000326306; ENSP00000326432; ENSG00000179934.
GeneID1237.
KEGGhsa:1237.
UCSCuc010hhr.2. human.

Organism-specific databases

CTD1237.
GeneCardsGC03P039371.
HGNCHGNC:1609. CCR8.
MIM601834. gene.
neXtProtNX_P51685.
PharmGKBPA26173.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG149415.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidP51685.
KOK04183.
OMALIYATHV.
OrthoDBEOG7B5WW3.
PhylomeDBP51685.
TreeFamTF330966.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP51685.
BgeeP51685.
CleanExHS_CCR8.
GenevestigatorP51685.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR004068. Chemokine_CCR8.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF11. PTHR24227:SF11. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00657. CCCHEMOKINER.
PR01530. CHEMOKINER8.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCCR8_(gene).
GenomeRNAi1237.
NextBio5053.
PROP51685.
SOURCESearch...

Entry information

Entry nameCCR8_HUMAN
AccessionPrimary (citable) accession number: P51685
Secondary accession number(s): B2RC64, Q3KNQ8, Q9BYX5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries