UniProtKB - P51685 (CCR8_HUMAN)
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Protein
C-C chemokine receptor type 8
Gene
CCR8
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.4 Publications
GO - Molecular functioni
- C-C chemokine receptor activity Source: Ensembl
- chemokine receptor activity Source: ProtInc
- coreceptor activity Source: ProtInc
GO - Biological processi
- cell adhesion Source: ProtInc
- chemotaxis Source: ProtInc
- G-protein coupled receptor signaling pathway Source: Reactome
- immune response Source: ProtInc
- positive regulation of cytosolic calcium ion concentration Source: ProtInc
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-HSA-380108. Chemokine receptors bind chemokines. R-HSA-418594. G alpha (i) signalling events. |
SIGNORi | P51685. |
Names & Taxonomyi
Protein namesi | Recommended name: C-C chemokine receptor type 8Short name: C-C CKR-8 Short name: CC-CKR-8 Short name: CCR-8 Alternative name(s): CC chemokine receptor CHEMR1 CMKBRL2 Chemokine receptor-like 1 Short name: CKR-L1 GPR-CY6 Short name: GPRCY6 TER1 CD_antigen: CDw198 |
Gene namesi | Name:CCR8 Synonyms:CKRL1, CMKBR8, CMKBRL2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000179934.6. |
HGNCi | HGNC:1609. CCR8. |
MIMi | 601834. gene. |
neXtProti | NX_P51685. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 35 | ExtracellularSequence analysisAdd BLAST | 35 | |
Transmembranei | 36 – 63 | Helical; Name=1Sequence analysisAdd BLAST | 28 | |
Topological domaini | 64 – 73 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 74 – 93 | Helical; Name=2Sequence analysisAdd BLAST | 20 | |
Topological domaini | 94 – 107 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 108 – 129 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 130 – 146 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 147 – 171 | Helical; Name=4Sequence analysisAdd BLAST | 25 | |
Topological domaini | 172 – 202 | ExtracellularSequence analysisAdd BLAST | 31 | |
Transmembranei | 203 – 222 | Helical; Name=5Sequence analysisAdd BLAST | 20 | |
Topological domaini | 223 – 238 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 239 – 263 | Helical; Name=6Sequence analysisAdd BLAST | 25 | |
Topological domaini | 264 – 280 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 281 – 304 | Helical; Name=7Sequence analysisAdd BLAST | 24 | |
Topological domaini | 305 – 355 | CytoplasmicSequence analysisAdd BLAST | 51 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 1237. |
OpenTargetsi | ENSG00000179934. |
PharmGKBi | PA26173. |
Chemistry databases
ChEMBLi | CHEMBL4596. |
GuidetoPHARMACOLOGYi | 65. |
Polymorphism and mutation databases
BioMutai | CCR8. |
DMDMi | 1707884. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069288 | 1 – 355 | C-C chemokine receptor type 8Add BLAST | 355 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 106 ↔ 183 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | P51685. |
PeptideAtlasi | P51685. |
PRIDEi | P51685. |
PTM databases
iPTMneti | P51685. |
PhosphoSitePlusi | P51685. |
Expressioni
Gene expression databases
Bgeei | ENSG00000179934. |
CleanExi | HS_CCR8. |
ExpressionAtlasi | P51685. baseline and differential. |
Genevisiblei | P51685. HS. |
Interactioni
Protein-protein interaction databases
DIPi | DIP-5836N. |
STRINGi | 9606.ENSP00000326432. |
Chemistry databases
BindingDBi | P51685. |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IJ9D. Eukaryota. ENOG410YUBT. LUCA. |
GeneTreei | ENSGT00760000118785. |
HOGENOMi | HOG000234122. |
HOVERGENi | HBG106917. |
InParanoidi | P51685. |
KOi | K04183. |
OMAi | MFFITLM. |
OrthoDBi | EOG091G0HEN. |
PhylomeDBi | P51685. |
TreeFami | TF330966. |
Family and domain databases
InterProi | View protein in InterPro IPR004068. Chemokine_CCR8. IPR000355. Chemokine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. |
Pfami | View protein in Pfam PF00001. 7tm_1. 1 hit. |
PRINTSi | PR00657. CCCHEMOKINER. PR01530. CHEMOKINER8. PR00237. GPCRRHODOPSN. |
PROSITEi | View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: P51685-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MDYTLDLSVT TVTDYYYPDI FSSPCDAELI QTNGKLLLAV FYCLLFVFSL
60 70 80 90 100
LGNSLVILVL VVCKKLRSIT DVYLLNLALS DLLFVFSFPF QTYYLLDQWV
110 120 130 140 150
FGTVMCKVVS GFYYIGFYSS MFFITLMSVD RYLAVVHAVY ALKVRTIRMG
160 170 180 190 200
TTLCLAVWLT AIMATIPLLV FYQVASEDGV LQCYSFYNQQ TLKWKIFTNF
210 220 230 240 250
KMNILGLLIP FTIFMFCYIK ILHQLKRCQN HNKTKAIRLV LIVVIASLLF
260 270 280 290 300
WVPFNVVLFL TSLHSMHILD GCSISQQLTY ATHVTEIISF THCCVNPVIY
310 320 330 340 350
AFVGEKFKKH LSEIFQKSCS QIFNYLGRQM PRESCEKSSS CQQHSSRSSS
VDYIL
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049384 | 27 | A → G1 PublicationCorresponds to variant dbSNP:rs2853699Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056340 | 1 – 91 | MDYTL…SFPFQ → MRNLFRQM in isoform 2. 1 PublicationAdd BLAST | 91 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z79782 Genomic DNA. Translation: CAB02142.1. Y08456 Genomic DNA. Translation: CAA69712.1. U45983 Genomic DNA. Translation: AAB61962.1. AF005210 mRNA. Translation: AAB62547.1. U62556 Genomic DNA. Translation: AAB05542.1. D49919 mRNA. Translation: BAA23387.1. AY016370 Genomic DNA. Translation: AAK08628.1. AK314957 mRNA. Translation: BAG37461.1. AC104850 Genomic DNA. No translation available. CH471055 Genomic DNA. Translation: EAW64577.1. BC069067 mRNA. Translation: AAH69067.1. BC074743 mRNA. Translation: AAH74743.1. BC107152 mRNA. Translation: AAI07153.1. BC107159 mRNA. Translation: AAI07160.1. |
CCDSi | CCDS2684.1. [P51685-1] |
PIRi | JC5067. |
RefSeqi | NP_005192.1. NM_005201.3. [P51685-1] |
UniGenei | Hs.113222. |
Genome annotation databases
Ensembli | ENST00000326306; ENSP00000326432; ENSG00000179934. [P51685-1] |
GeneIDi | 1237. |
KEGGi | hsa:1237. |
UCSCi | uc010hhr.3. human. [P51685-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | CCR8_HUMAN | |
Accessioni | P51685Primary (citable) accession number: P51685 Secondary accession number(s): B2RC64 Q9BYX5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | March 28, 2018 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Caution
Was originally thought to be a receptor for SCYA3 and SCYA17.1 Publication