P51684 (CCR6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-C chemokine receptor type 6
Short name=C-C CKR-6
Short name=CC-CKR-6
Short name=CCR-6

Alternative name(s):
Chemokine receptor-like 3
Short name=CKR-L3
DRY6
G-protein coupled receptor 29
GPR-CY4
Short name=GPRCY4
LARC receptor
CD_antigen=CD196

Gene names

Name:	CCR6
Synonyms:	CKRL3, CMKBR6, GPR29, STRL22

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	374 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level. Ref.1
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.
Induction	By IL2/interleukin-2.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Caution	It is uncertain whether Met-1 or Met-6 is the initiator.
Sequence caution	The sequence CAB02144.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular defense response Traceable author statement PubMed 10521347. Source: ProtInc dendritic cell chemotaxis Traceable author statement PubMed 16621978. Source: BHF-UCL elevation of cytosolic calcium ion concentration Traceable author statement PubMed 9223454. Source: ProtInc humoral immune response Traceable author statement PubMed 11001880. Source: ProtInc innate immune response Traceable author statement. Source: Reactome negative regulation of cAMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to plasma membrane Traceable author statement PubMed 9186513. Source: ProtInc
Molecular_function	C-C chemokine receptor activity Inferred from electronic annotation. Source: InterPro chemokine receptor activity Traceable author statement PubMed 11001880. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 374	374	C-C chemokine receptor type 6		PRO_0000069286
Regions
	Topological domain	1 – 47	47	Extracellular Potential
	Transmembrane	48 – 74	27	Helical; Name=1; Potential
	Topological domain	75 – 83	9	Cytoplasmic Potential
	Transmembrane	84 – 104	21	Helical; Name=2; Potential
	Topological domain	105 – 119	15	Extracellular Potential
	Transmembrane	120 – 141	22	Helical; Name=3; Potential
	Topological domain	142 – 159	18	Cytoplasmic Potential
	Transmembrane	160 – 180	21	Helical; Name=4; Potential
	Topological domain	181 – 211	31	Extracellular Potential
	Transmembrane	212 – 238	27	Helical; Name=5; Potential
	Topological domain	239 – 254	16	Cytoplasmic Potential
	Transmembrane	255 – 279	25	Helical; Name=6; Potential
	Topological domain	280 – 303	24	Extracellular Potential
	Transmembrane	304 – 321	18	Helical; Name=7; Potential
	Topological domain	322 – 374	53	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	7	1	N-linked (GlcNAc...) Potential
	Glycosylation	23	1	N-linked (GlcNAc...) Potential
	Disulfide bond	118 ↔ 197		By similarity
Experimental info
	Sequence conflict	60	1	G → A in AAB06949. Ref.4
	Sequence conflict	74	1	Y → N in AAB06949. Ref.4
	Sequence conflict	86	1	L → V in AAB06949. Ref.4
	Sequence conflict	164	1	S → T in AAC51124. Ref.5
	Sequence conflict	164	1	S → T in AAC51125. Ref.5
	Sequence conflict	182	1	T → S in AAB06949. Ref.4
	Sequence conflict	192	1	Q → L in AAB06949. Ref.4
	Sequence conflict	206	1	E → V in AAB06949. Ref.4
	Sequence conflict	225	1	I → F in AAB06949. Ref.4
	Sequence conflict	370 – 374	5	SSFTM → VVLHYVIES in AAB06949. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P51684 [UniParc]. Last modified July 15, 1998. Version 2. Checksum: D7F963534E990BC4	FASTA	374	42,494
	10 20 30 40 50 60 MSGESMNFSD VFDSSEDYFV SVNTSYYSVD SEMLLCSLQE VRQFSRLFVP IAYSLICVFG 70 80 90 100 110 120 LLGNILVVIT FAFYKKARSM TDVYLLNMAI ADILFVLTLP FWAVSHATGA WVFSNATCKL 130 140 150 160 170 180 LKGIYAINFN CGMLLLTCIS MDRYIAIVQA TKSFRLRSRT LPRSKIICLV VWGLSVIISS 190 200 210 220 230 240 STFVFNQKYN TQGSDVCEPK YQTVSEPIRW KLLMLGLELL FGFFIPLMFM IFCYTFIVKT 250 260 270 280 290 300 LVQAQNSKRH KAIRVIIAVV LVFLACQIPH NMVLLVTAAN LGKMNRSCQS EKLIGYTKTV 310 320 330 340 350 360 TEVLAFLHCC LNPVLYAFIG QKFRNYFLKI LKDLWCVRRK YKSSGFSCAG RYSENISRQT 370 SETADNDNAS SFTM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC." Baba M., Imai T., Nishimura M., Kakizaki M., Takagi S., Hieshima K., Nomiyama H., Yoshie O. J. Biol. Chem. 272:14893-14898(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[2]	Lautens L.L., Modi W., Bonner T.I. Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Molecular cloning and RNA expression of two new human chemokine receptor-like genes." Zaballos A., Varona R., Gutierrez J., Lind P., Marquez G. Biochem. Biophys. Res. Commun. 227:846-853(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	McCoy R., Perlmutter D.H. Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]	"Cloning of STRL22, a new human gene encoding a G-protein-coupled receptor related to chemokine receptors and located on chromosome 6q27." Liao F., Lee H.-H., Farber J.M. Genomics 40:175-180(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Warren C.N., Aronstam R.S., Sharma S.V. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
+	Additional computationally mapped references.

Web resources

Wikipedia

CC chemokine receptors entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	U45984 Genomic DNA. Translation: AAB62714.1. Z79784 Genomic DNA. Translation: CAB02144.1. Different initiation. U60000 mRNA. Translation: AAB06949.1. U68030 mRNA. Translation: AAC51124.1. U68032 Genomic DNA. Translation: AAC51125.1. AY242126 mRNA. Translation: AAO92293.1. AL121935 Genomic DNA. Translation: CAB99328.1. CH471051 Genomic DNA. Translation: EAW47506.1. CH471051 Genomic DNA. Translation: EAW47507.1. BC037960 mRNA. Translation: AAH37960.1.
IPI	IPI00293730.
PIR	JC5068.
RefSeq	NP_004358.2. NM_004367.5. NP_113597.2. NM_031409.3.
UniGene	Hs.46468.
3D structure databases
ProteinModelPortal	P51684.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5865N.
MINT	MINT-1525119.
STRING	9606.ENSP00000339393.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P51684.
Polymorphism databases
DMDM	2851567.
Proteomic databases
PaxDb	P51684.
PRIDE	P51684.
Protocols and materials databases
DNASU	1235.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000341935; ENSP00000343952; ENSG00000112486. ENST00000349984; ENSP00000339393; ENSG00000112486. ENST00000400926; ENSP00000383715; ENSG00000112486.
GeneID	1235.
KEGG	hsa:1235.
UCSC	uc003qvl.3. human.
Organism-specific databases
CTD	1235.
GeneCards	GC06P167525.
HGNC	HGNC:1607. CCR6.
HPA	CAB006820. HPA014488.
MIM	601835. gene.
neXtProt	NX_P51684.
PharmGKB	PA26171.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG147813.
HOGENOM	HOG000234122.
HOVERGEN	HBG106917.
InParanoid	P51684.
KO	K04181.
OMA	YFLKIMK.
OrthoDB	EOG4640CT.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction. REACT_6900. Immune System.
Gene expression databases
Bgee	P51684.
CleanEx	HS_CCR6.
Genevestigator	P51684.
GermOnline	ENSG00000112486. Homo sapiens.
Family and domain databases
InterPro	IPR004067. Chemokine_CCR6. IPR000355. Chemokine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
PANTHER	PTHR24227. PTHR24227. 1 hit. PTHR24227:SF24. PTHR24227:SF24. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR01529. CHEMOKINER6. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P51684.
ChEMBL	CHEMBL4423.
GenomeRNAi	1235.
NextBio	5043.
SOURCE	Search...

Entry information

Entry name

CCR6_HUMAN

Accession

Primary (citable) accession number: P51684
Secondary accession number(s): E1P5C6, P78553, Q92846

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	July 15, 1998
Last modified:	May 29, 2013
This is version 132 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.