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P51684

- CCR6_HUMAN

UniProt

P51684 - CCR6_HUMAN

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Protein

C-C chemokine receptor type 6

Gene

CCR6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level.1 Publication

GO - Molecular functioni

  1. C-C chemokine receptor activity Source: InterPro
  2. chemokine receptor activity Source: ProtInc
  3. receptor activity Source: ProtInc

GO - Biological processi

  1. cellular component movement Source: ProtInc
  2. cellular defense response Source: ProtInc
  3. chemokine-mediated signaling pathway Source: GOC
  4. chemotaxis Source: ProtInc
  5. dendritic cell chemotaxis Source: BHF-UCL
  6. humoral immune response Source: ProtInc
  7. immune response Source: ProtInc
  8. innate immune response Source: Reactome
  9. positive regulation of cytosolic calcium ion concentration Source: ProtInc
  10. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_115897. Beta defensins.
REACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 6
Short name:
C-C CKR-6
Short name:
CC-CKR-6
Short name:
CCR-6
Alternative name(s):
Chemokine receptor-like 3
Short name:
CKR-L3
DRY6
G-protein coupled receptor 29
GPR-CY4
Short name:
GPRCY4
LARC receptor
CD_antigen: CD196
Gene namesi
Name:CCR6
Synonyms:CKRL3, CMKBR6, GPR29, STRL22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:1607. CCR6.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti220393. Diffuse cutaneous systemic sclerosis.
220402. Limited cutaneous systemic sclerosis.
PharmGKBiPA26171.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374C-C chemokine receptor type 6PRO_0000069286Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi118 ↔ 197PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP51684.
PRIDEiP51684.

PTM databases

PhosphoSiteiP51684.

Expressioni

Tissue specificityi

Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.

Inductioni

By IL2/interleukin-2.

Gene expression databases

BgeeiP51684.
CleanExiHS_CCR6.
GenevestigatoriP51684.

Organism-specific databases

HPAiCAB006820.
HPA014488.

Interactioni

Protein-protein interaction databases

BioGridi107640. 1 interaction.
DIPiDIP-5865N.
MINTiMINT-1525119.
STRINGi9606.ENSP00000339393.

Structurei

3D structure databases

ProteinModelPortaliP51684.
SMRiP51684. Positions 40-331.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747ExtracellularSequence AnalysisAdd
BLAST
Topological domaini75 – 839CytoplasmicSequence Analysis
Topological domaini105 – 11915ExtracellularSequence AnalysisAdd
BLAST
Topological domaini142 – 15918CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini181 – 21131ExtracellularSequence AnalysisAdd
BLAST
Topological domaini239 – 25416CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini280 – 30324ExtracellularSequence AnalysisAdd
BLAST
Topological domaini322 – 37453CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei48 – 7427Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei84 – 10421Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei120 – 14122Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei160 – 18021Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei212 – 23827Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei255 – 27925Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei304 – 32118Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG147813.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP51684.
KOiK04181.
OMAiVVTFAFY.
OrthoDBiEOG7PP57J.
PhylomeDBiP51684.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR004067. Chemokine_CCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF24. PTHR24227:SF24. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01529. CHEMOKINER6.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51684-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGESMNFSD VFDSSEDYFV SVNTSYYSVD SEMLLCSLQE VRQFSRLFVP
60 70 80 90 100
IAYSLICVFG LLGNILVVIT FAFYKKARSM TDVYLLNMAI ADILFVLTLP
110 120 130 140 150
FWAVSHATGA WVFSNATCKL LKGIYAINFN CGMLLLTCIS MDRYIAIVQA
160 170 180 190 200
TKSFRLRSRT LPRSKIICLV VWGLSVIISS STFVFNQKYN TQGSDVCEPK
210 220 230 240 250
YQTVSEPIRW KLLMLGLELL FGFFIPLMFM IFCYTFIVKT LVQAQNSKRH
260 270 280 290 300
KAIRVIIAVV LVFLACQIPH NMVLLVTAAN LGKMNRSCQS EKLIGYTKTV
310 320 330 340 350
TEVLAFLHCC LNPVLYAFIG QKFRNYFLKI LKDLWCVRRK YKSSGFSCAG
360 370
RYSENISRQT SETADNDNAS SFTM
Length:374
Mass (Da):42,494
Last modified:July 15, 1998 - v2
Checksum:iD7F963534E990BC4
GO

Sequence cautioni

The sequence CAB02144.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601G → A in AAB06949. 1 PublicationCurated
Sequence conflicti74 – 741Y → N in AAB06949. 1 PublicationCurated
Sequence conflicti86 – 861L → V in AAB06949. 1 PublicationCurated
Sequence conflicti164 – 1641S → T in AAC51124. (PubMed:9070937)Curated
Sequence conflicti164 – 1641S → T in AAC51125. (PubMed:9070937)Curated
Sequence conflicti182 – 1821T → S in AAB06949. 1 PublicationCurated
Sequence conflicti192 – 1921Q → L in AAB06949. 1 PublicationCurated
Sequence conflicti206 – 2061E → V in AAB06949. 1 PublicationCurated
Sequence conflicti225 – 2251I → F in AAB06949. 1 PublicationCurated
Sequence conflicti370 – 3745SSFTM → VVLHYVIES in AAB06949. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U45984 Genomic DNA. Translation: AAB62714.1.
Z79784 Genomic DNA. Translation: CAB02144.1. Different initiation.
U60000 mRNA. Translation: AAB06949.1.
U68030 mRNA. Translation: AAC51124.1.
U68032 Genomic DNA. Translation: AAC51125.1.
AY242126 mRNA. Translation: AAO92293.1.
AL121935 Genomic DNA. Translation: CAB99328.1.
CH471051 Genomic DNA. Translation: EAW47506.1.
CH471051 Genomic DNA. Translation: EAW47507.1.
BC037960 mRNA. Translation: AAH37960.1.
CCDSiCCDS5298.1.
PIRiJC5068.
RefSeqiNP_004358.2. NM_004367.5.
NP_113597.2. NM_031409.3.
UniGeneiHs.46468.

Genome annotation databases

EnsembliENST00000341935; ENSP00000343952; ENSG00000112486.
ENST00000349984; ENSP00000339393; ENSG00000112486.
GeneIDi1235.
KEGGihsa:1235.
UCSCiuc003qvl.3. human.

Polymorphism databases

DMDMi2851567.

Cross-referencesi

Web resourcesi

Wikipedia

CC chemokine receptors entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U45984 Genomic DNA. Translation: AAB62714.1 .
Z79784 Genomic DNA. Translation: CAB02144.1 . Different initiation.
U60000 mRNA. Translation: AAB06949.1 .
U68030 mRNA. Translation: AAC51124.1 .
U68032 Genomic DNA. Translation: AAC51125.1 .
AY242126 mRNA. Translation: AAO92293.1 .
AL121935 Genomic DNA. Translation: CAB99328.1 .
CH471051 Genomic DNA. Translation: EAW47506.1 .
CH471051 Genomic DNA. Translation: EAW47507.1 .
BC037960 mRNA. Translation: AAH37960.1 .
CCDSi CCDS5298.1.
PIRi JC5068.
RefSeqi NP_004358.2. NM_004367.5.
NP_113597.2. NM_031409.3.
UniGenei Hs.46468.

3D structure databases

ProteinModelPortali P51684.
SMRi P51684. Positions 40-331.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107640. 1 interaction.
DIPi DIP-5865N.
MINTi MINT-1525119.
STRINGi 9606.ENSP00000339393.

Chemistry

BindingDBi P51684.
ChEMBLi CHEMBL4423.
GuidetoPHARMACOLOGYi 63.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P51684.

Polymorphism databases

DMDMi 2851567.

Proteomic databases

PaxDbi P51684.
PRIDEi P51684.

Protocols and materials databases

DNASUi 1235.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000341935 ; ENSP00000343952 ; ENSG00000112486 .
ENST00000349984 ; ENSP00000339393 ; ENSG00000112486 .
GeneIDi 1235.
KEGGi hsa:1235.
UCSCi uc003qvl.3. human.

Organism-specific databases

CTDi 1235.
GeneCardsi GC06P167525.
HGNCi HGNC:1607. CCR6.
HPAi CAB006820.
HPA014488.
MIMi 601835. gene.
neXtProti NX_P51684.
Orphaneti 220393. Diffuse cutaneous systemic sclerosis.
220402. Limited cutaneous systemic sclerosis.
PharmGKBi PA26171.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG147813.
GeneTreei ENSGT00760000118785.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi P51684.
KOi K04181.
OMAi VVTFAFY.
OrthoDBi EOG7PP57J.
PhylomeDBi P51684.
TreeFami TF330966.

Enzyme and pathway databases

Reactomei REACT_115897. Beta defensins.
REACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii C-C_chemokine_receptor_type_6.
GenomeRNAii 1235.
NextBioi 5043.
PROi P51684.
SOURCEi Search...

Gene expression databases

Bgeei P51684.
CleanExi HS_CCR6.
Genevestigatori P51684.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR004067. Chemokine_CCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
PTHR24227:SF24. PTHR24227:SF24. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00657. CCCHEMOKINER.
PR01529. CHEMOKINER6.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC."
    Baba M., Imai T., Nishimura M., Kakizaki M., Takagi S., Hieshima K., Nomiyama H., Yoshie O.
    J. Biol. Chem. 272:14893-14898(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  2. Lautens L.L., Modi W., Bonner T.I.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Molecular cloning and RNA expression of two new human chemokine receptor-like genes."
    Zaballos A., Varona R., Gutierrez J., Lind P., Marquez G.
    Biochem. Biophys. Res. Commun. 227:846-853(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. McCoy R., Perlmutter D.H.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Cloning of STRL22, a new human gene encoding a G-protein-coupled receptor related to chemokine receptors and located on chromosome 6q27."
    Liao F., Lee H.-H., Farber J.M.
    Genomics 40:175-180(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Warren C.N., Aronstam R.S., Sharma S.V.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.

Entry informationi

Entry nameiCCR6_HUMAN
AccessioniPrimary (citable) accession number: P51684
Secondary accession number(s): E1P5C6, P78553, Q92846
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1998
Last modified: October 29, 2014
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-6 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3