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P51684 (CCR6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 141. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C chemokine receptor type 6

Short name=C-C CKR-6
Short name=CC-CKR-6
Short name=CCR-6
Alternative name(s):
Chemokine receptor-like 3
Short name=CKR-L3
DRY6
G-protein coupled receptor 29
GPR-CY4
Short name=GPRCY4
LARC receptor
CD_antigen=CD196
Gene names
Name:CCR6
Synonyms:CKRL3, CMKBR6, GPR29, STRL22
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length374 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level. Ref.1

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.

Induction

By IL2/interleukin-2.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

It is uncertain whether Met-1 or Met-6 is the initiator.

Sequence caution

The sequence CAB02144.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular component movement

Traceable author statement PubMed 9186513. Source: ProtInc

cellular defense response

Traceable author statement PubMed 10521347. Source: ProtInc

chemokine-mediated signaling pathway

Traceable author statement PubMed 11001880. Source: GOC

chemotaxis

Traceable author statement PubMed 11001880. Source: ProtInc

dendritic cell chemotaxis

Traceable author statement PubMed 16621978. Source: BHF-UCL

humoral immune response

Traceable author statement PubMed 11001880. Source: ProtInc

immune response

Traceable author statement PubMed 9223454. Source: ProtInc

innate immune response

Traceable author statement. Source: Reactome

positive regulation of cytosolic calcium ion concentration

Traceable author statement PubMed 9223454. Source: ProtInc

signal transduction

Traceable author statement PubMed 9186513. Source: ProtInc

   Cellular_componentintegral component of plasma membrane

Traceable author statement PubMed 9186513. Source: ProtInc

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionC-C chemokine receptor activity

Inferred from electronic annotation. Source: InterPro

chemokine receptor activity

Traceable author statement PubMed 11001880. Source: ProtInc

receptor activity

Traceable author statement PubMed 9186513. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 374374C-C chemokine receptor type 6
PRO_0000069286

Regions

Topological domain1 – 4747Extracellular Potential
Transmembrane48 – 7427Helical; Name=1; Potential
Topological domain75 – 839Cytoplasmic Potential
Transmembrane84 – 10421Helical; Name=2; Potential
Topological domain105 – 11915Extracellular Potential
Transmembrane120 – 14122Helical; Name=3; Potential
Topological domain142 – 15918Cytoplasmic Potential
Transmembrane160 – 18021Helical; Name=4; Potential
Topological domain181 – 21131Extracellular Potential
Transmembrane212 – 23827Helical; Name=5; Potential
Topological domain239 – 25416Cytoplasmic Potential
Transmembrane255 – 27925Helical; Name=6; Potential
Topological domain280 – 30324Extracellular Potential
Transmembrane304 – 32118Helical; Name=7; Potential
Topological domain322 – 37453Cytoplasmic Potential

Amino acid modifications

Glycosylation71N-linked (GlcNAc...) Potential
Glycosylation231N-linked (GlcNAc...) Potential
Disulfide bond118 ↔ 197 By similarity

Experimental info

Sequence conflict601G → A in AAB06949. Ref.4
Sequence conflict741Y → N in AAB06949. Ref.4
Sequence conflict861L → V in AAB06949. Ref.4
Sequence conflict1641S → T in AAC51124. Ref.5
Sequence conflict1641S → T in AAC51125. Ref.5
Sequence conflict1821T → S in AAB06949. Ref.4
Sequence conflict1921Q → L in AAB06949. Ref.4
Sequence conflict2061E → V in AAB06949. Ref.4
Sequence conflict2251I → F in AAB06949. Ref.4
Sequence conflict370 – 3745SSFTM → VVLHYVIES in AAB06949. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P51684 [UniParc].

Last modified July 15, 1998. Version 2.
Checksum: D7F963534E990BC4

FASTA37442,494
        10         20         30         40         50         60 
MSGESMNFSD VFDSSEDYFV SVNTSYYSVD SEMLLCSLQE VRQFSRLFVP IAYSLICVFG 

        70         80         90        100        110        120 
LLGNILVVIT FAFYKKARSM TDVYLLNMAI ADILFVLTLP FWAVSHATGA WVFSNATCKL 

       130        140        150        160        170        180 
LKGIYAINFN CGMLLLTCIS MDRYIAIVQA TKSFRLRSRT LPRSKIICLV VWGLSVIISS 

       190        200        210        220        230        240 
STFVFNQKYN TQGSDVCEPK YQTVSEPIRW KLLMLGLELL FGFFIPLMFM IFCYTFIVKT 

       250        260        270        280        290        300 
LVQAQNSKRH KAIRVIIAVV LVFLACQIPH NMVLLVTAAN LGKMNRSCQS EKLIGYTKTV 

       310        320        330        340        350        360 
TEVLAFLHCC LNPVLYAFIG QKFRNYFLKI LKDLWCVRRK YKSSGFSCAG RYSENISRQT 

       370 
SETADNDNAS SFTM 

« Hide

References

« Hide 'large scale' references
[1]"Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC."
Baba M., Imai T., Nishimura M., Kakizaki M., Takagi S., Hieshima K., Nomiyama H., Yoshie O.
J. Biol. Chem. 272:14893-14898(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[2]Lautens L.L., Modi W., Bonner T.I.
Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[3]"Molecular cloning and RNA expression of two new human chemokine receptor-like genes."
Zaballos A., Varona R., Gutierrez J., Lind P., Marquez G.
Biochem. Biophys. Res. Commun. 227:846-853(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]McCoy R., Perlmutter D.H.
Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"Cloning of STRL22, a new human gene encoding a G-protein-coupled receptor related to chemokine receptors and located on chromosome 6q27."
Liao F., Lee H.-H., Farber J.M.
Genomics 40:175-180(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Warren C.N., Aronstam R.S., Sharma S.V.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas.
+Additional computationally mapped references.

Web resources

Wikipedia

CC chemokine receptors entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U45984 Genomic DNA. Translation: AAB62714.1.
Z79784 Genomic DNA. Translation: CAB02144.1. Different initiation.
U60000 mRNA. Translation: AAB06949.1.
U68030 mRNA. Translation: AAC51124.1.
U68032 Genomic DNA. Translation: AAC51125.1.
AY242126 mRNA. Translation: AAO92293.1.
AL121935 Genomic DNA. Translation: CAB99328.1.
CH471051 Genomic DNA. Translation: EAW47506.1.
CH471051 Genomic DNA. Translation: EAW47507.1.
BC037960 mRNA. Translation: AAH37960.1.
PIRJC5068.
RefSeqNP_004358.2. NM_004367.5.
NP_113597.2. NM_031409.3.
UniGeneHs.46468.

3D structure databases

ProteinModelPortalP51684.
SMRP51684. Positions 40-331.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107640. 1 interaction.
DIPDIP-5865N.
MINTMINT-1525119.
STRING9606.ENSP00000339393.

Chemistry

BindingDBP51684.
ChEMBLCHEMBL4423.
GuidetoPHARMACOLOGY63.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP51684.

Polymorphism databases

DMDM2851567.

Proteomic databases

PaxDbP51684.
PRIDEP51684.

Protocols and materials databases

DNASU1235.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000341935; ENSP00000343952; ENSG00000112486.
ENST00000349984; ENSP00000339393; ENSG00000112486.
ENST00000400926; ENSP00000383715; ENSG00000112486.
GeneID1235.
KEGGhsa:1235.
UCSCuc003qvl.3. human.

Organism-specific databases

CTD1235.
GeneCardsGC06P167525.
HGNCHGNC:1607. CCR6.
HPACAB006820.
HPA014488.
MIM601835. gene.
neXtProtNX_P51684.
Orphanet220393. Diffuse cutaneous systemic sclerosis.
220402. Limited cutaneous systemic sclerosis.
PharmGKBPA26171.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG147813.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidP51684.
KOK04181.
OMACYMFIVK.
OrthoDBEOG7PP57J.
PhylomeDBP51684.
TreeFamTF330966.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_6900. Immune System.

Gene expression databases

BgeeP51684.
CleanExHS_CCR6.
GenevestigatorP51684.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR004067. Chemokine_CCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF24. PTHR24227:SF24. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00657. CCCHEMOKINER.
PR01529. CHEMOKINER6.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiC-C_chemokine_receptor_type_6.
GenomeRNAi1235.
NextBio5043.
PROP51684.
SOURCESearch...

Entry information

Entry nameCCR6_HUMAN
AccessionPrimary (citable) accession number: P51684
Secondary accession number(s): E1P5C6, P78553, Q92846
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1998
Last modified: April 16, 2014
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries