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P51684

- CCR6_HUMAN

UniProt

P51684 - CCR6_HUMAN

Protein

C-C chemokine receptor type 6

Gene

CCR6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 2 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level.1 Publication

    GO - Molecular functioni

    1. C-C chemokine receptor activity Source: InterPro
    2. chemokine receptor activity Source: ProtInc
    3. receptor activity Source: ProtInc

    GO - Biological processi

    1. cellular component movement Source: ProtInc
    2. cellular defense response Source: ProtInc
    3. chemokine-mediated signaling pathway Source: GOC
    4. chemotaxis Source: ProtInc
    5. dendritic cell chemotaxis Source: BHF-UCL
    6. humoral immune response Source: ProtInc
    7. immune response Source: ProtInc
    8. innate immune response Source: Reactome
    9. positive regulation of cytosolic calcium ion concentration Source: ProtInc
    10. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_115897. Beta defensins.
    REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C chemokine receptor type 6
    Short name:
    C-C CKR-6
    Short name:
    CC-CKR-6
    Short name:
    CCR-6
    Alternative name(s):
    Chemokine receptor-like 3
    Short name:
    CKR-L3
    DRY6
    G-protein coupled receptor 29
    GPR-CY4
    Short name:
    GPRCY4
    LARC receptor
    CD_antigen: CD196
    Gene namesi
    Name:CCR6
    Synonyms:CKRL3, CMKBR6, GPR29, STRL22
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:1607. CCR6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti220393. Diffuse cutaneous systemic sclerosis.
    220402. Limited cutaneous systemic sclerosis.
    PharmGKBiPA26171.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 374374C-C chemokine receptor type 6PRO_0000069286Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi118 ↔ 197PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP51684.
    PRIDEiP51684.

    PTM databases

    PhosphoSiteiP51684.

    Expressioni

    Tissue specificityi

    Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.

    Inductioni

    By IL2/interleukin-2.

    Gene expression databases

    BgeeiP51684.
    CleanExiHS_CCR6.
    GenevestigatoriP51684.

    Organism-specific databases

    HPAiCAB006820.
    HPA014488.

    Interactioni

    Protein-protein interaction databases

    BioGridi107640. 1 interaction.
    DIPiDIP-5865N.
    MINTiMINT-1525119.
    STRINGi9606.ENSP00000339393.

    Structurei

    3D structure databases

    ProteinModelPortaliP51684.
    SMRiP51684. Positions 40-331.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4747ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini75 – 839CytoplasmicSequence Analysis
    Topological domaini105 – 11915ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini142 – 15918CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini181 – 21131ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini239 – 25416CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini280 – 30324ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini322 – 37453CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei48 – 7427Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei84 – 10421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei120 – 14122Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei160 – 18021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei212 – 23827Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei255 – 27925Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei304 – 32118Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG147813.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiP51684.
    KOiK04181.
    OMAiVVTFAFY.
    OrthoDBiEOG7PP57J.
    PhylomeDBiP51684.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR004067. Chemokine_CCR6.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF24. PTHR24227:SF24. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR01529. CHEMOKINER6.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51684-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGESMNFSD VFDSSEDYFV SVNTSYYSVD SEMLLCSLQE VRQFSRLFVP    50
    IAYSLICVFG LLGNILVVIT FAFYKKARSM TDVYLLNMAI ADILFVLTLP 100
    FWAVSHATGA WVFSNATCKL LKGIYAINFN CGMLLLTCIS MDRYIAIVQA 150
    TKSFRLRSRT LPRSKIICLV VWGLSVIISS STFVFNQKYN TQGSDVCEPK 200
    YQTVSEPIRW KLLMLGLELL FGFFIPLMFM IFCYTFIVKT LVQAQNSKRH 250
    KAIRVIIAVV LVFLACQIPH NMVLLVTAAN LGKMNRSCQS EKLIGYTKTV 300
    TEVLAFLHCC LNPVLYAFIG QKFRNYFLKI LKDLWCVRRK YKSSGFSCAG 350
    RYSENISRQT SETADNDNAS SFTM 374
    Length:374
    Mass (Da):42,494
    Last modified:July 15, 1998 - v2
    Checksum:iD7F963534E990BC4
    GO

    Sequence cautioni

    The sequence CAB02144.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti60 – 601G → A in AAB06949. 1 PublicationCurated
    Sequence conflicti74 – 741Y → N in AAB06949. 1 PublicationCurated
    Sequence conflicti86 – 861L → V in AAB06949. 1 PublicationCurated
    Sequence conflicti164 – 1641S → T in AAC51124. (PubMed:9070937)Curated
    Sequence conflicti164 – 1641S → T in AAC51125. (PubMed:9070937)Curated
    Sequence conflicti182 – 1821T → S in AAB06949. 1 PublicationCurated
    Sequence conflicti192 – 1921Q → L in AAB06949. 1 PublicationCurated
    Sequence conflicti206 – 2061E → V in AAB06949. 1 PublicationCurated
    Sequence conflicti225 – 2251I → F in AAB06949. 1 PublicationCurated
    Sequence conflicti370 – 3745SSFTM → VVLHYVIES in AAB06949. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U45984 Genomic DNA. Translation: AAB62714.1.
    Z79784 Genomic DNA. Translation: CAB02144.1. Different initiation.
    U60000 mRNA. Translation: AAB06949.1.
    U68030 mRNA. Translation: AAC51124.1.
    U68032 Genomic DNA. Translation: AAC51125.1.
    AY242126 mRNA. Translation: AAO92293.1.
    AL121935 Genomic DNA. Translation: CAB99328.1.
    CH471051 Genomic DNA. Translation: EAW47506.1.
    CH471051 Genomic DNA. Translation: EAW47507.1.
    BC037960 mRNA. Translation: AAH37960.1.
    CCDSiCCDS5298.1.
    PIRiJC5068.
    RefSeqiNP_004358.2. NM_004367.5.
    NP_113597.2. NM_031409.3.
    UniGeneiHs.46468.

    Genome annotation databases

    EnsembliENST00000341935; ENSP00000343952; ENSG00000112486.
    ENST00000349984; ENSP00000339393; ENSG00000112486.
    GeneIDi1235.
    KEGGihsa:1235.
    UCSCiuc003qvl.3. human.

    Polymorphism databases

    DMDMi2851567.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CC chemokine receptors entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U45984 Genomic DNA. Translation: AAB62714.1 .
    Z79784 Genomic DNA. Translation: CAB02144.1 . Different initiation.
    U60000 mRNA. Translation: AAB06949.1 .
    U68030 mRNA. Translation: AAC51124.1 .
    U68032 Genomic DNA. Translation: AAC51125.1 .
    AY242126 mRNA. Translation: AAO92293.1 .
    AL121935 Genomic DNA. Translation: CAB99328.1 .
    CH471051 Genomic DNA. Translation: EAW47506.1 .
    CH471051 Genomic DNA. Translation: EAW47507.1 .
    BC037960 mRNA. Translation: AAH37960.1 .
    CCDSi CCDS5298.1.
    PIRi JC5068.
    RefSeqi NP_004358.2. NM_004367.5.
    NP_113597.2. NM_031409.3.
    UniGenei Hs.46468.

    3D structure databases

    ProteinModelPortali P51684.
    SMRi P51684. Positions 40-331.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107640. 1 interaction.
    DIPi DIP-5865N.
    MINTi MINT-1525119.
    STRINGi 9606.ENSP00000339393.

    Chemistry

    BindingDBi P51684.
    ChEMBLi CHEMBL4423.
    GuidetoPHARMACOLOGYi 63.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P51684.

    Polymorphism databases

    DMDMi 2851567.

    Proteomic databases

    PaxDbi P51684.
    PRIDEi P51684.

    Protocols and materials databases

    DNASUi 1235.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000341935 ; ENSP00000343952 ; ENSG00000112486 .
    ENST00000349984 ; ENSP00000339393 ; ENSG00000112486 .
    GeneIDi 1235.
    KEGGi hsa:1235.
    UCSCi uc003qvl.3. human.

    Organism-specific databases

    CTDi 1235.
    GeneCardsi GC06P167525.
    HGNCi HGNC:1607. CCR6.
    HPAi CAB006820.
    HPA014488.
    MIMi 601835. gene.
    neXtProti NX_P51684.
    Orphaneti 220393. Diffuse cutaneous systemic sclerosis.
    220402. Limited cutaneous systemic sclerosis.
    PharmGKBi PA26171.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG147813.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi P51684.
    KOi K04181.
    OMAi VVTFAFY.
    OrthoDBi EOG7PP57J.
    PhylomeDBi P51684.
    TreeFami TF330966.

    Enzyme and pathway databases

    Reactomei REACT_115897. Beta defensins.
    REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii C-C_chemokine_receptor_type_6.
    GenomeRNAii 1235.
    NextBioi 5043.
    PROi P51684.
    SOURCEi Search...

    Gene expression databases

    Bgeei P51684.
    CleanExi HS_CCR6.
    Genevestigatori P51684.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR004067. Chemokine_CCR6.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF24. PTHR24227:SF24. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR01529. CHEMOKINER6.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC."
      Baba M., Imai T., Nishimura M., Kakizaki M., Takagi S., Hieshima K., Nomiyama H., Yoshie O.
      J. Biol. Chem. 272:14893-14898(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    2. Lautens L.L., Modi W., Bonner T.I.
      Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "Molecular cloning and RNA expression of two new human chemokine receptor-like genes."
      Zaballos A., Varona R., Gutierrez J., Lind P., Marquez G.
      Biochem. Biophys. Res. Commun. 227:846-853(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. McCoy R., Perlmutter D.H.
      Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "Cloning of STRL22, a new human gene encoding a G-protein-coupled receptor related to chemokine receptors and located on chromosome 6q27."
      Liao F., Lee H.-H., Farber J.M.
      Genomics 40:175-180(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Warren C.N., Aronstam R.S., Sharma S.V.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.

    Entry informationi

    Entry nameiCCR6_HUMAN
    AccessioniPrimary (citable) accession number: P51684
    Secondary accession number(s): E1P5C6, P78553, Q92846
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 145 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-6 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    3. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3