Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-C chemokine receptor type 6

Gene

CCR6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level.1 Publication

GO - Molecular functioni

  • C-C chemokine receptor activity Source: InterPro
  • chemokine receptor activity Source: ProtInc
  • receptor activity Source: ProtInc

GO - Biological processi

  • cellular defense response Source: ProtInc
  • chemokine-mediated signaling pathway Source: GOC
  • chemotaxis Source: ProtInc
  • dendritic cell chemotaxis Source: BHF-UCL
  • humoral immune response Source: ProtInc
  • immune response Source: ProtInc
  • innate immune response Source: Reactome
  • movement of cell or subcellular component Source: ProtInc
  • positive regulation of cytosolic calcium ion concentration Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_115897. Beta defensins.
REACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 6
Short name:
C-C CKR-6
Short name:
CC-CKR-6
Short name:
CCR-6
Alternative name(s):
Chemokine receptor-like 3
Short name:
CKR-L3
DRY6
G-protein coupled receptor 29
GPR-CY4
Short name:
GPRCY4
LARC receptor
CD_antigen: CD196
Gene namesi
Name:CCR6
Synonyms:CKRL3, CMKBR6, GPR29, STRL22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:1607. CCR6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747ExtracellularSequence AnalysisAdd
BLAST
Transmembranei48 – 7427Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini75 – 839CytoplasmicSequence Analysis
Transmembranei84 – 10421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini105 – 11915ExtracellularSequence AnalysisAdd
BLAST
Transmembranei120 – 14122Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini142 – 15918CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei160 – 18021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini181 – 21131ExtracellularSequence AnalysisAdd
BLAST
Transmembranei212 – 23827Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini239 – 25416CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei255 – 27925Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini280 – 30324ExtracellularSequence AnalysisAdd
BLAST
Transmembranei304 – 32118Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini322 – 37453CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: Ensembl
  • cytosol Source: GOC
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti220393. Diffuse cutaneous systemic sclerosis.
220402. Limited cutaneous systemic sclerosis.
PharmGKBiPA26171.

Polymorphism and mutation databases

BioMutaiCCR6.
DMDMi2851567.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374C-C chemokine receptor type 6PRO_0000069286Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi118 ↔ 197PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP51684.
PRIDEiP51684.

PTM databases

PhosphoSiteiP51684.

Expressioni

Tissue specificityi

Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.

Inductioni

By IL2/interleukin-2.

Gene expression databases

BgeeiP51684.
CleanExiHS_CCR6.
GenevisibleiP51684. HS.

Organism-specific databases

HPAiCAB006820.
HPA014488.

Interactioni

Protein-protein interaction databases

BioGridi107640. 1 interaction.
DIPiDIP-5865N.
MINTiMINT-1525119.
STRINGi9606.ENSP00000339393.

Structurei

3D structure databases

ProteinModelPortaliP51684.
SMRiP51684. Positions 40-331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG147813.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP51684.
KOiK04181.
OMAiCYMFIVK.
OrthoDBiEOG7PP57J.
PhylomeDBiP51684.
TreeFamiTF330966.

Family and domain databases

InterProiIPR004067. Chemokine_CCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF24. PTHR24227:SF24. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01529. CHEMOKINER6.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51684-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGESMNFSD VFDSSEDYFV SVNTSYYSVD SEMLLCSLQE VRQFSRLFVP
60 70 80 90 100
IAYSLICVFG LLGNILVVIT FAFYKKARSM TDVYLLNMAI ADILFVLTLP
110 120 130 140 150
FWAVSHATGA WVFSNATCKL LKGIYAINFN CGMLLLTCIS MDRYIAIVQA
160 170 180 190 200
TKSFRLRSRT LPRSKIICLV VWGLSVIISS STFVFNQKYN TQGSDVCEPK
210 220 230 240 250
YQTVSEPIRW KLLMLGLELL FGFFIPLMFM IFCYTFIVKT LVQAQNSKRH
260 270 280 290 300
KAIRVIIAVV LVFLACQIPH NMVLLVTAAN LGKMNRSCQS EKLIGYTKTV
310 320 330 340 350
TEVLAFLHCC LNPVLYAFIG QKFRNYFLKI LKDLWCVRRK YKSSGFSCAG
360 370
RYSENISRQT SETADNDNAS SFTM
Length:374
Mass (Da):42,494
Last modified:July 15, 1998 - v2
Checksum:iD7F963534E990BC4
GO

Sequence cautioni

The sequence CAB02144.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601G → A in AAB06949 (Ref. 4) Curated
Sequence conflicti74 – 741Y → N in AAB06949 (Ref. 4) Curated
Sequence conflicti86 – 861L → V in AAB06949 (Ref. 4) Curated
Sequence conflicti164 – 1641S → T in AAC51124 (PubMed:9070937).Curated
Sequence conflicti164 – 1641S → T in AAC51125 (PubMed:9070937).Curated
Sequence conflicti182 – 1821T → S in AAB06949 (Ref. 4) Curated
Sequence conflicti192 – 1921Q → L in AAB06949 (Ref. 4) Curated
Sequence conflicti206 – 2061E → V in AAB06949 (Ref. 4) Curated
Sequence conflicti225 – 2251I → F in AAB06949 (Ref. 4) Curated
Sequence conflicti370 – 3745SSFTM → VVLHYVIES in AAB06949 (Ref. 4) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U45984 Genomic DNA. Translation: AAB62714.1.
Z79784 Genomic DNA. Translation: CAB02144.1. Different initiation.
U60000 mRNA. Translation: AAB06949.1.
U68030 mRNA. Translation: AAC51124.1.
U68032 Genomic DNA. Translation: AAC51125.1.
AY242126 mRNA. Translation: AAO92293.1.
AL121935 Genomic DNA. Translation: CAB99328.1.
CH471051 Genomic DNA. Translation: EAW47506.1.
CH471051 Genomic DNA. Translation: EAW47507.1.
BC037960 mRNA. Translation: AAH37960.1.
CCDSiCCDS5298.1.
PIRiJC5068.
RefSeqiNP_004358.2. NM_004367.5.
NP_113597.2. NM_031409.3.
UniGeneiHs.46468.

Genome annotation databases

EnsembliENST00000341935; ENSP00000343952; ENSG00000112486.
ENST00000349984; ENSP00000339393; ENSG00000112486.
ENST00000400926; ENSP00000383715; ENSG00000112486.
GeneIDi1235.
KEGGihsa:1235.
UCSCiuc003qvl.3. human.

Cross-referencesi

Web resourcesi

Wikipedia

CC chemokine receptors entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U45984 Genomic DNA. Translation: AAB62714.1.
Z79784 Genomic DNA. Translation: CAB02144.1. Different initiation.
U60000 mRNA. Translation: AAB06949.1.
U68030 mRNA. Translation: AAC51124.1.
U68032 Genomic DNA. Translation: AAC51125.1.
AY242126 mRNA. Translation: AAO92293.1.
AL121935 Genomic DNA. Translation: CAB99328.1.
CH471051 Genomic DNA. Translation: EAW47506.1.
CH471051 Genomic DNA. Translation: EAW47507.1.
BC037960 mRNA. Translation: AAH37960.1.
CCDSiCCDS5298.1.
PIRiJC5068.
RefSeqiNP_004358.2. NM_004367.5.
NP_113597.2. NM_031409.3.
UniGeneiHs.46468.

3D structure databases

ProteinModelPortaliP51684.
SMRiP51684. Positions 40-331.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107640. 1 interaction.
DIPiDIP-5865N.
MINTiMINT-1525119.
STRINGi9606.ENSP00000339393.

Chemistry

BindingDBiP51684.
ChEMBLiCHEMBL4423.
GuidetoPHARMACOLOGYi63.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP51684.

Polymorphism and mutation databases

BioMutaiCCR6.
DMDMi2851567.

Proteomic databases

PaxDbiP51684.
PRIDEiP51684.

Protocols and materials databases

DNASUi1235.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341935; ENSP00000343952; ENSG00000112486.
ENST00000349984; ENSP00000339393; ENSG00000112486.
ENST00000400926; ENSP00000383715; ENSG00000112486.
GeneIDi1235.
KEGGihsa:1235.
UCSCiuc003qvl.3. human.

Organism-specific databases

CTDi1235.
GeneCardsiGC06P167525.
HGNCiHGNC:1607. CCR6.
HPAiCAB006820.
HPA014488.
MIMi601835. gene.
neXtProtiNX_P51684.
Orphaneti220393. Diffuse cutaneous systemic sclerosis.
220402. Limited cutaneous systemic sclerosis.
PharmGKBiPA26171.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG147813.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP51684.
KOiK04181.
OMAiCYMFIVK.
OrthoDBiEOG7PP57J.
PhylomeDBiP51684.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiREACT_115897. Beta defensins.
REACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSiCCR6. human.
GeneWikiiC-C_chemokine_receptor_type_6.
GenomeRNAii1235.
NextBioi5043.
PROiP51684.
SOURCEiSearch...

Gene expression databases

BgeeiP51684.
CleanExiHS_CCR6.
GenevisibleiP51684. HS.

Family and domain databases

InterProiIPR004067. Chemokine_CCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF24. PTHR24227:SF24. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01529. CHEMOKINER6.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC."
    Baba M., Imai T., Nishimura M., Kakizaki M., Takagi S., Hieshima K., Nomiyama H., Yoshie O.
    J. Biol. Chem. 272:14893-14898(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  2. Lautens L.L., Modi W., Bonner T.I.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Molecular cloning and RNA expression of two new human chemokine receptor-like genes."
    Zaballos A., Varona R., Gutierrez J., Lind P., Marquez G.
    Biochem. Biophys. Res. Commun. 227:846-853(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. McCoy R., Perlmutter D.H.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Cloning of STRL22, a new human gene encoding a G-protein-coupled receptor related to chemokine receptors and located on chromosome 6q27."
    Liao F., Lee H.-H., Farber J.M.
    Genomics 40:175-180(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Warren C.N., Aronstam R.S., Sharma S.V.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.

Entry informationi

Entry nameiCCR6_HUMAN
AccessioniPrimary (citable) accession number: P51684
Secondary accession number(s): E1P5C6, P78553, Q92846
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1998
Last modified: June 24, 2015
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-6 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.