C-C chemokine receptor type 2 - Mus musculus (Mouse)

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P51683 (CCR2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 106. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
C-C chemokine receptor type 2
Short name=C-C CKR-2
Short name=CC-CKR-2
Short name=CCR-2
Short name=CCR2

Alternative name(s):
JE/FIC receptor
MCP-1 receptor
CD_antigen=CD192

Gene names

Name:	Ccr2
Synonyms:	Cmkbr2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	373 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for the MCP-1 (JE), MCP-3 (FIC) and MCP-5 chemokines. Transduces a signal by increasing the intracellular calcium ions level.
Subunit structure	Interacts with ARRB1 By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Detected in monocyte/macrophage cell lines, but not in nonhematopoietic cell lines.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T-helper 17 cell chemotaxis Inferred from direct assay PubMed 18586982. Source: BHF-UCL angiogenesis Traceable author statement PubMed 18334747. Source: BHF-UCL apoptotic cell clearance Inferred by curator PubMed 20691665. Source: BHF-UCL blood vessel remodeling Inferred from sequence or structural similarity. Source: BHF-UCL cellular calcium ion homeostasis Inferred from sequence or structural similarity. Source: BHF-UCL cellular defense response Inferred from mutant phenotype PubMed 9366570. Source: MGI elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: InterPro hemopoiesis Inferred from mutant phenotype PubMed 9366570. Source: MGI humoral immune response Inferred from mutant phenotype PubMed 10899907. Source: MGI negative regulation of adenylate cyclase activity Inferred from electronic annotation. Source: InterPro negative regulation of angiogenesis Inferred from mutant phenotype PubMed 14566334. Source: BHF-UCL negative regulation of eosinophil degranulation Inferred from mutant phenotype PubMed 14662900. Source: BHF-UCL negative regulation of type 2 immune response Inferred from mutant phenotype PubMed 14662900. Source: BHF-UCL positive regulation of CD8-positive, alpha-beta T cell extravasation Inferred from mutant phenotype PubMed 14662900. Source: BHF-UCL positive regulation of T cell chemotaxis Inferred from direct assay PubMed 18586982. Source: BHF-UCL positive regulation of T-helper 1 cell differentiation Inferred by curator PubMed 14662900. Source: BHF-UCL positive regulation of T-helper 1 type immune response Inferred from mutant phenotype PubMed 10657654. Source: BHF-UCL positive regulation of alpha-beta T cell proliferation Inferred from mutant phenotype PubMed 14662900. Source: BHF-UCL positive regulation of astrocyte chemotaxis Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of hematopoietic stem cell migration Inferred from mutant phenotype PubMed 20234092. Source: BHF-UCL positive regulation of immune complex clearance by monocytes and macrophages Inferred from mutant phenotype PubMed 14566334. Source: BHF-UCL positive regulation of inflammatory response Inferred from direct assay PubMed 20234092. Source: BHF-UCL positive regulation of interferon-gamma production Inferred from mutant phenotype PubMed 14662900. Source: BHF-UCL positive regulation of interleukin-2 production Inferred from mutant phenotype PubMed 14662900. Source: BHF-UCL positive regulation of monocyte chemotaxis Inferred from mutant phenotype PubMed 18832716. Source: BHF-UCL positive regulation of monocyte extravasation Inferred from mutant phenotype PubMed 14566334. Source: BHF-UCL positive regulation of tumor necrosis factor biosynthetic process Inferred from mutant phenotype PubMed 18832716. Source: BHF-UCL regulation of vascular endothelial growth factor production Inferred from mutant phenotype PubMed 14566334. Source: BHF-UCL sensory perception of pain Inferred from mutant phenotype PubMed 12808141. Source: MGI wound healing involved in inflammatory response Non-traceable author statement PubMed 20234092. Source: BHF-UCL
Cellular_component	cytosol Inferred from sequence or structural similarity. Source: BHF-UCL dendrite Inferred from sequence or structural similarity. Source: BHF-UCL integral to plasma membrane Traceable author statement PubMed 20234092. Source: BHF-UCL perikaryon Inferred from sequence or structural similarity. Source: BHF-UCL perinuclear region of cytoplasm Inferred from sequence or structural similarity. Source: BHF-UCL
Molecular_function	C-C chemokine receptor activity Inferred from direct assay Ref.1 Ref.2. Source: MGI protein homodimerization activity Inferred from sequence or structural similarity. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 373

373

C-C chemokine receptor type 2

PRO_0000069234

Regions

Topological domain

1 – 55

Extracellular Potential

Transmembrane

56 – 83

Helical; Name=1; Potential

Topological domain

84 – 93

Cytoplasmic Potential

Transmembrane

94 – 114

Helical; Name=2; Potential

Topological domain

115 – 127

Extracellular Potential

Transmembrane

128 – 149

Helical; Name=3; Potential

Topological domain

150 – 166

Cytoplasmic Potential

Transmembrane

167 – 191

Helical; Name=4; Potential

Topological domain

192 – 219

Extracellular Potential

Transmembrane

220 – 239

Helical; Name=5; Potential

Topological domain

240 – 256

Cytoplasmic Potential

Transmembrane

257 – 281

Helical; Name=6; Potential

Topological domain

282 – 298

Extracellular Potential

Transmembrane

299 – 322

Helical; Name=7; Potential

Topological domain

323 – 373

Cytoplasmic Potential

Amino acid modifications

Modified residue

152

Phosphotyrosine; by JAK2 By similarity

Disulfide bond

45 ↔ 290

By similarity

Disulfide bond

126 ↔ 203

By similarity

Experimental info

Sequence conflict

Y → H in AAC52453. Ref.1

Sequence conflict

184

A → G in AAC52453. Ref.1

Sequence conflict

264

V → G in AAC52453. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P51683 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: FA012C10F4C9325A
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FASTA

373

42,783

        10         20         30         40         50         60 
MEDNNMLPQF IHGILSTSHS LFTRSIQELD EGATTPYDYD DGEPCHKTSV KQIGAWILPP 

        70         80         90        100        110        120 
LYSLVFIFGF VGNMLVIIIL IGCKKLKSMT DIYLLNLAIS DLLFLLTLPF WAHYAANEWV 

       130        140        150        160        170        180 
FGNIMCKVFT GLYHIGYFGG IFFIILLTID RYLAIVHAVF ALKARTVTFG VITSVVTWVV 

       190        200        210        220        230        240 
AVFASLPGII FTKSKQDDHH YTCGPYFTQL WKNFQTIMRN ILSLILPLLV MVICYSGILH 

       250        260        270        280        290        300 
TLFRCRNEKK RHRAVRLIFA IMIVYFLFWT PYNIVLFLTT FQESLGMSNC VIDKHLDQAM 

       310        320        330        340        350        360 
QVTETLGMTH CCINPVIYAF VGEKFRRYLS IFFRKHIAKR LCKQCPVFYR ETADRVSSTF 

       370 
TPSTGEQEVS VGL

« Hide

References

[1]	"Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9." Boring L., Gosling J., Monteclaro F.S., Lusis A.J., Tsou C.-L., Charo I.F. J. Biol. Chem. 271:7551-7558(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning and functional expression of mCCR2, a murine receptor for the C-C chemokines JE and FIC." Kurihara T., Bravo R. J. Biol. Chem. 271:11603-11606(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
[3]	"Mouse astrocytes respond to the chemokines MCP-1 and KC, but reverse transcriptase-polymerase chain reaction does not detect mRNA for the KC or new MCP-1 receptor." Heesen M., Tanabe S., Berman M.A., Yoshizawa I., Luo Y., Kim R., Post T.W., Gerard C., Dorf M.E. J. Neurosci. Res. 45:382-391(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U47035 mRNA. Translation: AAC52453.1. U51717 mRNA. Translation: AAC52557.1. U56819 mRNA. Translation: AAC52784.1.
IPI	IPI00125256.
RefSeq	NP_034045.1. NM_009915.2.
UniGene	Mm.6272.
3D structure databases
ProteinModelPortal	P51683.
SMR	P51683. Positions 51-361.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P51683.
Proteomic databases
PRIDE	P51683.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000055918; ENSMUSP00000049909; ENSMUSG00000049103. ENSMUST00000165984; ENSMUSP00000128734; ENSMUSG00000049103. ENSMUST00000168841; ENSMUSP00000132453; ENSMUSG00000049103. ENSMUST00000171719; ENSMUSP00000130112; ENSMUSG00000049103.
GeneID	12772.
KEGG	mmu:12772.
Organism-specific databases
CTD	729230.
MGI	MGI:106185. Ccr2.
Phylogenomic databases
eggNOG	NOG148353.
HOGENOM	HOG000234122.
HOVERGEN	HBG106917.
InParanoid	P51683.
KO	K04177.
OMA	CPVFYRE.
OrthoDB	EOG40S0GG.
Gene expression databases
ArrayExpress	P51683.
Bgee	P51683.
CleanEx	MM_CCR2.
Genevestigator	P51683.
GermOnline	ENSMUSG00000049103. Mus musculus.
Family and domain databases
InterPro	IPR002237. Chemokine_CCR2. IPR000355. Chemokine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR01107. CHEMOKINER2. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P51683.
ChEMBL	CHEMBL5412.
NextBio	282150.
SOURCE	Search...

Entry information

Entry name

CCR2_MOUSE

Accession

Primary (citable) accession number: P51683
Secondary accession number(s): Q61172

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents