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P51682

- CCR5_MOUSE

UniProt

P51682 - CCR5_MOUSE

Protein

C-C chemokine receptor type 5

Gene

Ccr5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation By similarity.By similarity

    GO - Molecular functioni

    1. C-C chemokine binding Source: BHF-UCL
    2. C-C chemokine receptor activity Source: MGI

    GO - Biological processi

    1. chemokine-mediated signaling pathway Source: GOC
    2. chemotaxis Source: InterPro
    3. defense response Source: MGI
    4. immune response Source: InterPro
    5. inflammatory response Source: InterPro
    6. negative regulation of macrophage apoptotic process Source: BHF-UCL

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C chemokine receptor type 5
    Short name:
    C-C CKR-5
    Short name:
    CC-CKR-5
    Short name:
    CCR-5
    Alternative name(s):
    MIP-1 alpha receptor
    CD_antigen: CD195
    Gene namesi
    Name:Ccr5
    Synonyms:Cmkbr5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:107182. Ccr5.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: MGI
    2. external side of plasma membrane Source: MGI
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 354354C-C chemokine receptor type 5PRO_0000069269Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61O-linked (GalNAc...)By similarity
    Modified residuei10 – 101SulfotyrosineSequence Analysis
    Modified residuei12 – 121SulfotyrosineSequence Analysis
    Modified residuei16 – 161SulfotyrosineSequence Analysis
    Disulfide bondi103 ↔ 180PROSITE-ProRule annotation
    Lipidationi323 – 3231S-palmitoyl cysteineBy similarity
    Lipidationi326 – 3261S-palmitoyl cysteineBy similarity
    Modified residuei338 – 3381Phosphoserine; by BARK1By similarity
    Modified residuei339 – 3391Phosphoserine; by BARK1By similarity
    Modified residuei344 – 3441Phosphoserine; by BARK1By similarity
    Modified residuei351 – 3511Phosphoserine; by BARK1By similarity

    Post-translational modificationi

    Sulfated on at least 2 of the N-terminal tyrosines. Sulfation is required for efficient binding of the chemokines, CCL3 and CCL4 By similarity.By similarity
    O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which contribute to chemokine binding By similarity.By similarity
    Palmitoylation in the C-terminal is important for cell surface expression.By similarity
    Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein, Sulfation

    Proteomic databases

    PRIDEiP51682.

    PTM databases

    PhosphoSiteiP51682.

    Expressioni

    Gene expression databases

    ArrayExpressiP51682.
    BgeeiP51682.
    CleanExiMM_CCR5.
    GenevestigatoriP51682.

    Interactioni

    Subunit structurei

    Interacts with PRAF2. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with ADRBK1. Interacts with ARRB1 and ARRB2 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP51682.
    SMRiP51682. Positions 21-315.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini61 – 7010CytoplasmicSequence Analysis
    Topological domaini92 – 10413ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini127 – 14317CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini169 – 20032ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini221 – 23717CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini263 – 27917ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini304 – 35451CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 6028Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei71 – 9121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei105 – 12622Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei144 – 16825Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei201 – 22020Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 26225Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei280 – 30324Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148353.
    GeneTreeiENSGT00700000104407.
    HOVERGENiHBG106917.
    InParanoidiQ3ZAZ8.
    KOiK04180.
    OMAiIIFTRSQ.
    OrthoDBiEOG738051.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR002240. Chemokine_CCR5.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR01110. CHEMOKINER5.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51682-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFQGSVPTY SYDIDYGMSA PCQKINVKQI AAQLLPPLYS LVFIFGFVGN    50
    MMVFLILISC KKLKSVTDIY LLNLAISDLL FLLTLPFWAH YAANEWVFGN 100
    IMCKVFTGLY HIGYFGGIFF IILLTIDRYL AIVHAVFALK VRTVNFGVIT 150
    SVVTWAVAVF ASLPEIIFTR SQKEGFHYTC SPHFPHTQYH FWKSFQTLKM 200
    VILSLILPLL VMVICYSGIL HTLFRCRNEK KRHRAVRLIF AIMIVYFLFW 250
    TPYNIVLLLT TFQEFFGLNN CSSSNRLDQA MQATETLGMT HCCLNPVIYA 300
    FVGEKFRSYL SVFFRKHMVK RFCKRCSIFQ QDNPDRASSV YTRSTGEHEV 350
    STGL 354
    Length:354
    Mass (Da):40,785
    Last modified:July 27, 2011 - v3
    Checksum:iD91F50EC9C956795
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31F → L in CAA63867. (PubMed:8662890)Curated
    Sequence conflicti62 – 621K → R in AAC53386. (PubMed:9343222)Curated
    Sequence conflicti66 – 661V → M in AAC53386. (PubMed:9343222)Curated
    Sequence conflicti80 – 801L → F in CAA63867. (PubMed:8662890)Curated
    Sequence conflicti145 – 1451N → I in AAB71183. (PubMed:9261347)Curated
    Sequence conflicti160 – 1601F → S in AAC53386. (PubMed:9343222)Curated
    Sequence conflicti185 – 1851P → L in AAC53386. (PubMed:9343222)Curated
    Sequence conflicti190 – 1901H → Y in AAB37273. 1 PublicationCurated
    Sequence conflicti208 – 2081P → S in AAC52454. (PubMed:8631787)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti11 – 111S → I.
    Natural varianti97 – 971V → I.
    Natural varianti109 – 1091L → V.
    Natural varianti156 – 1561A → V.
    Natural varianti213 – 2131V → I.
    Natural varianti318 – 3181M → I.
    Natural varianti337 – 3371A → V.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U47036 mRNA. Translation: AAC52454.1.
    X94151 mRNA. Translation: CAA63867.1.
    U68565 Genomic DNA. Translation: AAB37273.1.
    U83327 Genomic DNA. Translation: AAC53386.1.
    AF022990 Genomic DNA. Translation: AAC53389.1.
    AF019772 Genomic DNA. Translation: AAB71183.1.
    D83648 mRNA. Translation: BAA12024.1.
    AK141906 mRNA. Translation: BAE24879.1.
    AK154595 mRNA. Translation: BAE32698.1.
    AK155628 mRNA. Translation: BAE33354.1.
    AK155867 mRNA. Translation: BAE33471.1.
    CH466671 Genomic DNA. Translation: EDL37177.1.
    BC103574 mRNA. Translation: AAI03575.1.
    BC103586 mRNA. Translation: AAI03587.1.
    BC103587 mRNA. Translation: AAI03588.1.
    CCDSiCCDS40821.1.
    RefSeqiNP_034047.2. NM_009917.5.
    UniGeneiMm.14302.

    Genome annotation databases

    EnsembliENSMUST00000111442; ENSMUSP00000107069; ENSMUSG00000079227.
    GeneIDi12774.
    KEGGimmu:12774.
    UCSCiuc009shd.2. mouse.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U47036 mRNA. Translation: AAC52454.1 .
    X94151 mRNA. Translation: CAA63867.1 .
    U68565 Genomic DNA. Translation: AAB37273.1 .
    U83327 Genomic DNA. Translation: AAC53386.1 .
    AF022990 Genomic DNA. Translation: AAC53389.1 .
    AF019772 Genomic DNA. Translation: AAB71183.1 .
    D83648 mRNA. Translation: BAA12024.1 .
    AK141906 mRNA. Translation: BAE24879.1 .
    AK154595 mRNA. Translation: BAE32698.1 .
    AK155628 mRNA. Translation: BAE33354.1 .
    AK155867 mRNA. Translation: BAE33471.1 .
    CH466671 Genomic DNA. Translation: EDL37177.1 .
    BC103574 mRNA. Translation: AAI03575.1 .
    BC103586 mRNA. Translation: AAI03587.1 .
    BC103587 mRNA. Translation: AAI03588.1 .
    CCDSi CCDS40821.1.
    RefSeqi NP_034047.2. NM_009917.5.
    UniGenei Mm.14302.

    3D structure databases

    ProteinModelPortali P51682.
    SMRi P51682. Positions 21-315.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P51682.
    ChEMBLi CHEMBL3676.
    GuidetoPHARMACOLOGYi 62.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P51682.

    Proteomic databases

    PRIDEi P51682.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000111442 ; ENSMUSP00000107069 ; ENSMUSG00000079227 .
    GeneIDi 12774.
    KEGGi mmu:12774.
    UCSCi uc009shd.2. mouse.

    Organism-specific databases

    CTDi 1234.
    MGIi MGI:107182. Ccr5.

    Phylogenomic databases

    eggNOGi NOG148353.
    GeneTreei ENSGT00700000104407.
    HOVERGENi HBG106917.
    InParanoidi Q3ZAZ8.
    KOi K04180.
    OMAi IIFTRSQ.
    OrthoDBi EOG738051.
    TreeFami TF330966.

    Miscellaneous databases

    NextBioi 282158.
    PROi P51682.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51682.
    Bgeei P51682.
    CleanExi MM_CCR5.
    Genevestigatori P51682.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR002240. Chemokine_CCR5.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR01110. CHEMOKINER5.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9."
      Boring L., Gosling J., Monteclaro F.S., Lusis A.J., Tsou C.-L., Charo I.F.
      J. Biol. Chem. 271:7551-7558(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/SvJ.
      Tissue: Spleen.
    2. "Cloning and characterization of a novel murine macrophage inflammatory protein-1 alpha receptor."
      Meyer A., Coyle A.J., Proudfoot A.E.I., Wells T.N.C., Power C.A.
      J. Biol. Chem. 271:14445-14451(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X CBA.
      Tissue: Thymus.
    3. Kuziel W.A., Beck M.A., Dawson T.C., Maeda N.
      Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Ola.
    4. "Polymorphisms in the CCR5 genes of African green monkeys and mice implicate specific amino acids in infections by simian and human immunodeficiency viruses."
      Kuhmann S.E., Platt E.J., Kozak S.L., Kabat D.
      J. Virol. 71:8642-8656(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C57BL/6 and NIH Swiss.
      Tissue: Kidney, Liver and Spleen.
    5. "Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1."
      Doranz B.J., Lu Z.H., Rucker J., Zhang T.Y., Sharron M., Cen Y.H., Wang Z.X., Guo H.H., Du J.G., Accavitti M.A., Doms R.W., Peiper S.C.
      J. Virol. 71:6305-6314(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129.
    6. Guo B., Kuno K., Harada A., Matsushima K.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    7. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Spinal ganglion.
    8. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiCCR5_MOUSE
    AccessioniPrimary (citable) accession number: P51682
    Secondary accession number(s): O35313
    , O35891, P97308, P97405, Q3ZAZ8, Q61867
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 127 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3