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Protein

C-C chemokine receptor type 5

Gene

Ccr5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).By similarity

GO - Molecular functioni

  • actin binding Source: MGI
  • C-C chemokine binding Source: BHF-UCL
  • C-C chemokine receptor activity Source: MGI
  • chemokine (C-C motif) ligand 5 binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-1461957. Beta defensins.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 5
Short name:
C-C CKR-5
Short name:
CC-CKR-5
Short name:
CCR-5
Alternative name(s):
MIP-1 alpha receptor
CD_antigen: CD195
Gene namesi
Name:Ccr5
Synonyms:Cmkbr5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:107182. Ccr5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 60Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini61 – 70CytoplasmicSequence analysis10
Transmembranei71 – 91Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini92 – 104ExtracellularSequence analysisAdd BLAST13
Transmembranei105 – 126Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini127 – 143CytoplasmicSequence analysisAdd BLAST17
Transmembranei144 – 168Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini169 – 200ExtracellularSequence analysisAdd BLAST32
Transmembranei201 – 220Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini221 – 237CytoplasmicSequence analysisAdd BLAST17
Transmembranei238 – 262Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini263 – 279ExtracellularSequence analysisAdd BLAST17
Transmembranei280 – 303Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini304 – 354CytoplasmicSequence analysisAdd BLAST51

GO - Cellular componenti

  • cell surface Source: MGI
  • endosome Source: MGI
  • external side of plasma membrane Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3676.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692691 – 354C-C chemokine receptor type 5Add BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6O-linked (GalNAc...)By similarity1
Modified residuei10SulfotyrosineSequence analysis1
Modified residuei12SulfotyrosineSequence analysis1
Modified residuei16SulfotyrosineSequence analysis1
Disulfide bondi103 ↔ 180PROSITE-ProRule annotation
Lipidationi323S-palmitoyl cysteineBy similarity1
Lipidationi326S-palmitoyl cysteineBy similarity1
Modified residuei338Phosphoserine; by BARK1By similarity1
Modified residuei339Phosphoserine; by BARK1By similarity1
Modified residuei344Phosphoserine; by BARK1By similarity1
Modified residuei351Phosphoserine; by BARK1By similarity1

Post-translational modificationi

Sulfated on at least 2 of the N-terminal tyrosines. Sulfation is required for efficient binding of the chemokines, CCL3 and CCL4 (By similarity).By similarity
O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which contribute to chemokine binding (By similarity).By similarity
Palmitoylation in the C-terminal is important for cell surface expression.By similarity
Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein, Sulfation

Proteomic databases

EPDiP51682.
PaxDbiP51682.
PRIDEiP51682.

PTM databases

iPTMnetiP51682.
PhosphoSitePlusiP51682.

Expressioni

Gene expression databases

BgeeiENSMUSG00000079227.
CleanExiMM_CCR5.
ExpressionAtlasiP51682. baseline and differential.
GenevisibleiP51682. MM.

Interactioni

Subunit structurei

Interacts with PRAF2. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with GRK2. Interacts with ARRB1 and ARRB2. Interacts with CNIH4.By similarity

GO - Molecular functioni

  • actin binding Source: MGI
  • C-C chemokine binding Source: BHF-UCL
  • chemokine (C-C motif) ligand 5 binding Source: MGI

Protein-protein interaction databases

IntActiP51682. 1 interactor.
STRINGi10090.ENSMUSP00000107069.

Chemistry databases

BindingDBiP51682.

Structurei

3D structure databases

ProteinModelPortaliP51682.
SMRiP51682.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118785.
HOVERGENiHBG106917.
InParanoidiP51682.
KOiK04180.
OMAiGNTMCQL.
OrthoDBiEOG091G0B7A.
TreeFamiTF330966.

Family and domain databases

InterProiIPR002240. Chemokine_CCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01110. CHEMOKINER5.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51682-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFQGSVPTY SYDIDYGMSA PCQKINVKQI AAQLLPPLYS LVFIFGFVGN
60 70 80 90 100
MMVFLILISC KKLKSVTDIY LLNLAISDLL FLLTLPFWAH YAANEWVFGN
110 120 130 140 150
IMCKVFTGLY HIGYFGGIFF IILLTIDRYL AIVHAVFALK VRTVNFGVIT
160 170 180 190 200
SVVTWAVAVF ASLPEIIFTR SQKEGFHYTC SPHFPHTQYH FWKSFQTLKM
210 220 230 240 250
VILSLILPLL VMVICYSGIL HTLFRCRNEK KRHRAVRLIF AIMIVYFLFW
260 270 280 290 300
TPYNIVLLLT TFQEFFGLNN CSSSNRLDQA MQATETLGMT HCCLNPVIYA
310 320 330 340 350
FVGEKFRSYL SVFFRKHMVK RFCKRCSIFQ QDNPDRASSV YTRSTGEHEV

STGL
Length:354
Mass (Da):40,785
Last modified:July 27, 2011 - v3
Checksum:iD91F50EC9C956795
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3F → L in CAA63867 (PubMed:8662890).Curated1
Sequence conflicti62K → R in AAC53386 (PubMed:9343222).Curated1
Sequence conflicti66V → M in AAC53386 (PubMed:9343222).Curated1
Sequence conflicti80L → F in CAA63867 (PubMed:8662890).Curated1
Sequence conflicti145N → I in AAB71183 (PubMed:9261347).Curated1
Sequence conflicti160F → S in AAC53386 (PubMed:9343222).Curated1
Sequence conflicti185P → L in AAC53386 (PubMed:9343222).Curated1
Sequence conflicti190H → Y in AAB37273 (Ref. 3) Curated1
Sequence conflicti208P → S in AAC52454 (PubMed:8631787).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti11S → I.1
Natural varianti97V → I.1
Natural varianti109L → V.1
Natural varianti156A → V.1
Natural varianti213V → I.1
Natural varianti318M → I.1
Natural varianti337A → V.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47036 mRNA. Translation: AAC52454.1.
X94151 mRNA. Translation: CAA63867.1.
U68565 Genomic DNA. Translation: AAB37273.1.
U83327 Genomic DNA. Translation: AAC53386.1.
AF022990 Genomic DNA. Translation: AAC53389.1.
AF019772 Genomic DNA. Translation: AAB71183.1.
D83648 mRNA. Translation: BAA12024.1.
AK141906 mRNA. Translation: BAE24879.1.
AK154595 mRNA. Translation: BAE32698.1.
AK155628 mRNA. Translation: BAE33354.1.
AK155867 mRNA. Translation: BAE33471.1.
CH466671 Genomic DNA. Translation: EDL37177.1.
BC103574 mRNA. Translation: AAI03575.1.
BC103586 mRNA. Translation: AAI03587.1.
BC103587 mRNA. Translation: AAI03588.1.
CCDSiCCDS40821.1.
RefSeqiNP_034047.2. NM_009917.5.
UniGeneiMm.14302.

Genome annotation databases

EnsembliENSMUST00000111442; ENSMUSP00000107069; ENSMUSG00000079227.
GeneIDi12774.
KEGGimmu:12774.
UCSCiuc009shd.2. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47036 mRNA. Translation: AAC52454.1.
X94151 mRNA. Translation: CAA63867.1.
U68565 Genomic DNA. Translation: AAB37273.1.
U83327 Genomic DNA. Translation: AAC53386.1.
AF022990 Genomic DNA. Translation: AAC53389.1.
AF019772 Genomic DNA. Translation: AAB71183.1.
D83648 mRNA. Translation: BAA12024.1.
AK141906 mRNA. Translation: BAE24879.1.
AK154595 mRNA. Translation: BAE32698.1.
AK155628 mRNA. Translation: BAE33354.1.
AK155867 mRNA. Translation: BAE33471.1.
CH466671 Genomic DNA. Translation: EDL37177.1.
BC103574 mRNA. Translation: AAI03575.1.
BC103586 mRNA. Translation: AAI03587.1.
BC103587 mRNA. Translation: AAI03588.1.
CCDSiCCDS40821.1.
RefSeqiNP_034047.2. NM_009917.5.
UniGeneiMm.14302.

3D structure databases

ProteinModelPortaliP51682.
SMRiP51682.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP51682. 1 interactor.
STRINGi10090.ENSMUSP00000107069.

Chemistry databases

BindingDBiP51682.
ChEMBLiCHEMBL3676.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP51682.
PhosphoSitePlusiP51682.

Proteomic databases

EPDiP51682.
PaxDbiP51682.
PRIDEiP51682.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111442; ENSMUSP00000107069; ENSMUSG00000079227.
GeneIDi12774.
KEGGimmu:12774.
UCSCiuc009shd.2. mouse.

Organism-specific databases

CTDi1234.
MGIiMGI:107182. Ccr5.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118785.
HOVERGENiHBG106917.
InParanoidiP51682.
KOiK04180.
OMAiGNTMCQL.
OrthoDBiEOG091G0B7A.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiR-MMU-1461957. Beta defensins.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiP51682.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000079227.
CleanExiMM_CCR5.
ExpressionAtlasiP51682. baseline and differential.
GenevisibleiP51682. MM.

Family and domain databases

InterProiIPR002240. Chemokine_CCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01110. CHEMOKINER5.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCR5_MOUSE
AccessioniPrimary (citable) accession number: P51682
Secondary accession number(s): O35313
, O35891, P97308, P97405, Q3ZAZ8, Q61867
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.