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P51680

- CCR4_MOUSE

UniProt

P51680 - CCR4_MOUSE

Protein

C-C chemokine receptor type 4

Gene

Ccr4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Could play a role in lipopolysaccharide (LPS)-induced endotoxic shock. In the CNS, could mediate hippocampal-neuron survival.1 Publication

    GO - Molecular functioni

    1. C-C chemokine receptor activity Source: MGI

    GO - Biological processi

    1. chemokine-mediated signaling pathway Source: GOC
    2. chemotaxis Source: MGI
    3. immune response Source: InterPro
    4. inflammatory response Source: MGI
    5. neuron migration Source: MGI
    6. positive regulation of positive chemotaxis Source: Ensembl
    7. response to antibiotic Source: Ensembl
    8. response to bacterium Source: Ensembl
    9. response to radiation Source: Ensembl
    10. tolerance induction Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C chemokine receptor type 4
    Short name:
    C-C CKR-4
    Short name:
    CC-CKR-4
    Short name:
    CCR-4
    Short name:
    CCR4
    Alternative name(s):
    CD_antigen: CD194
    Gene namesi
    Name:Ccr4
    Synonyms:Cmkbr4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:107824. Ccr4.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. neuronal cell body Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 360360C-C chemokine receptor type 4PRO_0000069246Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi110 ↔ 187PROSITE-ProRule annotation
    Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiP51680.

    Expressioni

    Tissue specificityi

    Expressed in the thymus, macrophages and T- and B-cells.

    Developmental stagei

    Low expression at 7.5 dpc and 12.5 dpc in the yolk sac.

    Gene expression databases

    BgeeiP51680.
    CleanExiMM_CCR4.
    GenevestigatoriP51680.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4996815.
    STRINGi10090.ENSMUSP00000062677.

    Structurei

    3D structure databases

    ProteinModelPortaliP51680.
    SMRiP51680. Positions 28-320.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini68 – 7710CytoplasmicSequence Analysis
    Topological domaini99 – 11113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini134 – 15017CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini176 – 20631ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini227 – 24216CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini268 – 28417ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini309 – 36052CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6728Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei78 – 9821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei112 – 13322Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei151 – 17525Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei207 – 22620Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei243 – 26725Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei285 – 30824Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi343 – 3464Poly-Ser

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148353.
    GeneTreeiENSGT00700000104251.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiQ14A03.
    KOiK04179.
    OMAiLCKIISW.
    OrthoDBiEOG738051.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR002239. Chemokine_CCR4.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF12. PTHR24227:SF12. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR01109. CHEMOKINER4.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51680-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNATEVTDTT QDETVYNSYY FYESMPKPCT KEGIKAFGEV FLPPLYSLVF    50
    LLGLFGNSVV VLVLFKYKRL KSMTDVYLLN LAISDLLFVL SLPFWGYYAA 100
    DQWVFGLGLC KIVSWMYLVG FYSGIFFIML MSIDRYLAIV HAVFSLKART 150
    LTYGVITSLI TWSVAVFASL PGLLFSTCYT EHNHTYCKTQ YSVNSTTWKV 200
    LSSLEINVLG LLIPLGIMLF CYSMIIRTLQ HCKNEKKNRA VRMIFAVVVL 250
    FLGFWTPYNV VLFLETLVEL EVLQDCTLER YLDYAIQATE TLAFIHCCLN 300
    PVIYFFLGEK FRKYITQLFR TCRGPLVLCK HCDFLQVYSA DMSSSSYTQS 350
    TVDHDFRDAL 360
    Length:360
    Mass (Da):41,408
    Last modified:July 27, 2011 - v2
    Checksum:i8FA760951BE2002B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti4 – 41T → I in AAA92582. (PubMed:9192769)Curated
    Sequence conflicti145 – 1451S → T in AAA92582. (PubMed:9192769)Curated
    Sequence conflicti181 – 1811E → Q in AAA92582. (PubMed:9192769)Curated
    Sequence conflicti205 – 2051E → D in AAA92582. (PubMed:9192769)Curated
    Sequence conflicti221 – 2211C → W in CAA62372. (PubMed:8573157)Curated
    Sequence conflicti241 – 2411V → L in AAA92582. (PubMed:9192769)Curated
    Sequence conflicti246 – 2461A → G in CAA62372. (PubMed:8573157)Curated
    Sequence conflicti293 – 2931A → G in CAA62372. (PubMed:8573157)Curated
    Sequence conflicti311 – 3111F → S in AAA92582. (PubMed:9192769)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X90862 mRNA. Translation: CAA62372.1.
    U15208 mRNA. Translation: AAA92582.1.
    CH466587 Genomic DNA. Translation: EDL09307.1.
    CH466587 Genomic DNA. Translation: EDL09308.1.
    BC117041 mRNA. Translation: AAI17042.1.
    BC119171 mRNA. Translation: AAI19172.1.
    CCDSiCCDS23594.1.
    PIRiJC4587.
    RefSeqiNP_034046.2. NM_009916.2.
    XP_006511996.1. XM_006511933.1.
    XP_006511997.1. XM_006511934.1.
    UniGeneiMm.1337.

    Genome annotation databases

    EnsembliENSMUST00000054414; ENSMUSP00000062677; ENSMUSG00000047898.
    GeneIDi12773.
    KEGGimmu:12773.
    UCSCiuc009rxo.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X90862 mRNA. Translation: CAA62372.1 .
    U15208 mRNA. Translation: AAA92582.1 .
    CH466587 Genomic DNA. Translation: EDL09307.1 .
    CH466587 Genomic DNA. Translation: EDL09308.1 .
    BC117041 mRNA. Translation: AAI17042.1 .
    BC119171 mRNA. Translation: AAI19172.1 .
    CCDSi CCDS23594.1.
    PIRi JC4587.
    RefSeqi NP_034046.2. NM_009916.2.
    XP_006511996.1. XM_006511933.1.
    XP_006511997.1. XM_006511934.1.
    UniGenei Mm.1337.

    3D structure databases

    ProteinModelPortali P51680.
    SMRi P51680. Positions 28-320.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4996815.
    STRINGi 10090.ENSMUSP00000062677.

    Chemistry

    BindingDBi P51680.
    ChEMBLi CHEMBL5410.
    GuidetoPHARMACOLOGYi 61.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi P51680.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000054414 ; ENSMUSP00000062677 ; ENSMUSG00000047898 .
    GeneIDi 12773.
    KEGGi mmu:12773.
    UCSCi uc009rxo.2. mouse.

    Organism-specific databases

    CTDi 1233.
    MGIi MGI:107824. Ccr4.

    Phylogenomic databases

    eggNOGi NOG148353.
    GeneTreei ENSGT00700000104251.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi Q14A03.
    KOi K04179.
    OMAi LCKIISW.
    OrthoDBi EOG738051.
    TreeFami TF330966.

    Miscellaneous databases

    NextBioi 282154.
    PROi P51680.
    SOURCEi Search...

    Gene expression databases

    Bgeei P51680.
    CleanExi MM_CCR4.
    Genevestigatori P51680.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR002239. Chemokine_CCR4.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF12. PTHR24227:SF12. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR01109. CHEMOKINER4.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of murine CC CKR-4 and high affinity binding of chemokines to murine and human CC CKR-4."
      Hoogewerf A.J., Black D., Proudfoot A.E.I., Wells T.N.C., Power C.A.
      Biochem. Biophys. Res. Commun. 218:337-343(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X CBA.
      Tissue: Thymus.
    2. "Molecular cloning and characterization of a cDNA, CHEMR1, encoding a chemokine receptor with a homology to the human C-C chemokine receptor, CCR-4."
      Youn B.-S., Kim S.-H., Lyu M.S., Kozak C.A., Taub D.D., Kwon B.S.
      Blood 89:4448-4460(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Cytotoxic T-cell.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus.
    5. "A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock."
      Buser R., Conquet F., Proudfoot A.E.I., Wells T.N.C., Power C.A.
      J. Exp. Med. 191:1755-1764(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiCCR4_MOUSE
    AccessioniPrimary (citable) accession number: P51680
    Secondary accession number(s): Q14A03
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3