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P51680 (CCR4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C chemokine receptor type 4

Short name=C-C CKR-4
Short name=CC-CKR-4
Short name=CCR-4
Short name=CCR4
Alternative name(s):
CD_antigen=CD194
Gene names
Name:Ccr4
Synonyms:Cmkbr4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Could play a role in lipopolysaccharide (LPS)-induced endotoxic shock. In the CNS, could mediate hippocampal-neuron survival. Ref.5

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in the thymus, macrophages and T- and B-cells.

Developmental stage

Low expression at 7.5 dpc and 12.5 dpc in the yolk sac.

Post-translational modification

In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2 By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 360360C-C chemokine receptor type 4
PRO_0000069246

Regions

Topological domain1 – 3939Extracellular Potential
Transmembrane40 – 6728Helical; Name=1; Potential
Topological domain68 – 7710Cytoplasmic Potential
Transmembrane78 – 9821Helical; Name=2; Potential
Topological domain99 – 11113Extracellular Potential
Transmembrane112 – 13322Helical; Name=3; Potential
Topological domain134 – 15017Cytoplasmic Potential
Transmembrane151 – 17525Helical; Name=4; Potential
Topological domain176 – 20631Extracellular Potential
Transmembrane207 – 22620Helical; Name=5; Potential
Topological domain227 – 24216Cytoplasmic Potential
Transmembrane243 – 26725Helical; Name=6; Potential
Topological domain268 – 28417Extracellular Potential
Transmembrane285 – 30824Helical; Name=7; Potential
Topological domain309 – 36052Cytoplasmic Potential
Compositional bias343 – 3464Poly-Ser

Amino acid modifications

Glycosylation21N-linked (GlcNAc...) Potential
Glycosylation1831N-linked (GlcNAc...) Potential
Glycosylation1941N-linked (GlcNAc...) Potential
Disulfide bond110 ↔ 187 By similarity

Experimental info

Sequence conflict41T → I in AAA92582. Ref.2
Sequence conflict1451S → T in AAA92582. Ref.2
Sequence conflict1811E → Q in AAA92582. Ref.2
Sequence conflict2051E → D in AAA92582. Ref.2
Sequence conflict2211C → W in CAA62372. Ref.1
Sequence conflict2411V → L in AAA92582. Ref.2
Sequence conflict2461A → G in CAA62372. Ref.1
Sequence conflict2931A → G in CAA62372. Ref.1
Sequence conflict3111F → S in AAA92582. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P51680 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 8FA760951BE2002B

FASTA36041,408
        10         20         30         40         50         60 
MNATEVTDTT QDETVYNSYY FYESMPKPCT KEGIKAFGEV FLPPLYSLVF LLGLFGNSVV 

        70         80         90        100        110        120 
VLVLFKYKRL KSMTDVYLLN LAISDLLFVL SLPFWGYYAA DQWVFGLGLC KIVSWMYLVG 

       130        140        150        160        170        180 
FYSGIFFIML MSIDRYLAIV HAVFSLKART LTYGVITSLI TWSVAVFASL PGLLFSTCYT 

       190        200        210        220        230        240 
EHNHTYCKTQ YSVNSTTWKV LSSLEINVLG LLIPLGIMLF CYSMIIRTLQ HCKNEKKNRA 

       250        260        270        280        290        300 
VRMIFAVVVL FLGFWTPYNV VLFLETLVEL EVLQDCTLER YLDYAIQATE TLAFIHCCLN 

       310        320        330        340        350        360 
PVIYFFLGEK FRKYITQLFR TCRGPLVLCK HCDFLQVYSA DMSSSSYTQS TVDHDFRDAL 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of murine CC CKR-4 and high affinity binding of chemokines to murine and human CC CKR-4."
Hoogewerf A.J., Black D., Proudfoot A.E.I., Wells T.N.C., Power C.A.
Biochem. Biophys. Res. Commun. 218:337-343(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6 X CBA.
Tissue: Thymus.
[2]"Molecular cloning and characterization of a cDNA, CHEMR1, encoding a chemokine receptor with a homology to the human C-C chemokine receptor, CCR-4."
Youn B.-S., Kim S.-H., Lyu M.S., Kozak C.A., Taub D.D., Kwon B.S.
Blood 89:4448-4460(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Cytotoxic T-cell.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thymus.
[5]"A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock."
Buser R., Conquet F., Proudfoot A.E.I., Wells T.N.C., Power C.A.
J. Exp. Med. 191:1755-1764(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X90862 mRNA. Translation: CAA62372.1.
U15208 mRNA. Translation: AAA92582.1.
CH466587 Genomic DNA. Translation: EDL09307.1.
CH466587 Genomic DNA. Translation: EDL09308.1.
BC117041 mRNA. Translation: AAI17042.1.
BC119171 mRNA. Translation: AAI19172.1.
CCDSCCDS23594.1.
PIRJC4587.
RefSeqNP_034046.2. NM_009916.2.
XP_006511996.1. XM_006511933.1.
XP_006511997.1. XM_006511934.1.
UniGeneMm.1337.

3D structure databases

ProteinModelPortalP51680.
SMRP51680. Positions 28-320.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4996815.
STRING10090.ENSMUSP00000062677.

Chemistry

BindingDBP51680.
ChEMBLCHEMBL5410.
GuidetoPHARMACOLOGY61.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEP51680.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000054414; ENSMUSP00000062677; ENSMUSG00000047898.
GeneID12773.
KEGGmmu:12773.
UCSCuc009rxo.2. mouse.

Organism-specific databases

CTD1233.
MGIMGI:107824. Ccr4.

Phylogenomic databases

eggNOGNOG148353.
GeneTreeENSGT00700000104251.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidQ14A03.
KOK04179.
OMALCKIISW.
OrthoDBEOG738051.
TreeFamTF330966.

Gene expression databases

BgeeP51680.
CleanExMM_CCR4.
GenevestigatorP51680.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR002239. Chemokine_CCR4.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF12. PTHR24227:SF12. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00657. CCCHEMOKINER.
PR01109. CHEMOKINER4.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio282154.
PROP51680.
SOURCESearch...

Entry information

Entry nameCCR4_MOUSE
AccessionPrimary (citable) accession number: P51680
Secondary accession number(s): Q14A03
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries