C-C chemokine receptor type 4 - Mus musculus (Mouse)

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P51680 (CCR4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 107. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
C-C chemokine receptor type 4
Short name=C-C CKR-4
Short name=CC-CKR-4
Short name=CCR-4
Short name=CCR4

Alternative name(s):
CD_antigen=CD194

Gene names

Name:	Ccr4
Synonyms:	Cmkbr4

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Could play a role in lipopolysaccharide (LPS)-induced endotoxic shock. In the CNS, could mediate hippocampal-neuron survival. Ref.5
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in the thymus, macrophages and T- and B-cells.
Developmental stage	Low expression at 7.5 dpc and 12.5 dpc in the yolk sac.
Post-translational modification	In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2 By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemotaxis Inferred from mutant phenotype Ref.5. Source: MGI elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: InterPro immune response Inferred from electronic annotation. Source: InterPro inflammatory response Inferred from mutant phenotype Ref.5. Source: MGI neuron migration Inferred from mutant phenotype PubMed 16262623. Source: MGI tolerance induction Inferred from mutant phenotype PubMed 15809349. Source: MGI
Cellular_component	external side of plasma membrane Inferred from direct assay PubMed 19008373. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	C-C chemokine receptor activity Inferred from mutant phenotype Ref.5. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 360

360

C-C chemokine receptor type 4

PRO_0000069246

Regions

Topological domain

1 – 39

Extracellular Potential

Transmembrane

40 – 67

Helical; Name=1; Potential

Topological domain

68 – 77

Cytoplasmic Potential

Transmembrane

78 – 98

Helical; Name=2; Potential

Topological domain

99 – 111

Extracellular Potential

Transmembrane

112 – 133

Helical; Name=3; Potential

Topological domain

134 – 150

Cytoplasmic Potential

Transmembrane

151 – 175

Helical; Name=4; Potential

Topological domain

176 – 206

Extracellular Potential

Transmembrane

207 – 226

Helical; Name=5; Potential

Topological domain

227 – 242

Cytoplasmic Potential

Transmembrane

243 – 267

Helical; Name=6; Potential

Topological domain

268 – 284

Extracellular Potential

Transmembrane

285 – 308

Helical; Name=7; Potential

Topological domain

309 – 360

Cytoplasmic Potential

Compositional bias

343 – 346

Poly-Ser

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

183

N-linked (GlcNAc...) Potential

Glycosylation

194

N-linked (GlcNAc...) Potential

Disulfide bond

110 ↔ 187

By similarity

Experimental info

Sequence conflict

T → I in AAA92582. Ref.2

Sequence conflict

145

S → T in AAA92582. Ref.2

Sequence conflict

181

E → Q in AAA92582. Ref.2

Sequence conflict

205

E → D in AAA92582. Ref.2

Sequence conflict

221

C → W in CAA62372. Ref.1

Sequence conflict

241

V → L in AAA92582. Ref.2

Sequence conflict

246

A → G in CAA62372. Ref.1

Sequence conflict

293

A → G in CAA62372. Ref.1

Sequence conflict

311

F → S in AAA92582. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

P51680 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 8FA760951BE2002B
Show »

FASTA

360

41,408

        10         20         30         40         50         60 
MNATEVTDTT QDETVYNSYY FYESMPKPCT KEGIKAFGEV FLPPLYSLVF LLGLFGNSVV 

        70         80         90        100        110        120 
VLVLFKYKRL KSMTDVYLLN LAISDLLFVL SLPFWGYYAA DQWVFGLGLC KIVSWMYLVG 

       130        140        150        160        170        180 
FYSGIFFIML MSIDRYLAIV HAVFSLKART LTYGVITSLI TWSVAVFASL PGLLFSTCYT 

       190        200        210        220        230        240 
EHNHTYCKTQ YSVNSTTWKV LSSLEINVLG LLIPLGIMLF CYSMIIRTLQ HCKNEKKNRA 

       250        260        270        280        290        300 
VRMIFAVVVL FLGFWTPYNV VLFLETLVEL EVLQDCTLER YLDYAIQATE TLAFIHCCLN 

       310        320        330        340        350        360 
PVIYFFLGEK FRKYITQLFR TCRGPLVLCK HCDFLQVYSA DMSSSSYTQS TVDHDFRDAL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of murine CC CKR-4 and high affinity binding of chemokines to murine and human CC CKR-4." Hoogewerf A.J., Black D., Proudfoot A.E.I., Wells T.N.C., Power C.A. Biochem. Biophys. Res. Commun. 218:337-343(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6 X CBA. Tissue: Thymus.
[2]	"Molecular cloning and characterization of a cDNA, CHEMR1, encoding a chemokine receptor with a homology to the human C-C chemokine receptor, CCR-4." Youn B.-S., Kim S.-H., Lyu M.S., Kozak C.A., Taub D.D., Kwon B.S. Blood 89:4448-4460(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6. Tissue: Cytotoxic T-cell.
[3]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thymus.
[5]	"A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock." Buser R., Conquet F., Proudfoot A.E.I., Wells T.N.C., Power C.A. J. Exp. Med. 191:1755-1764(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X90862 mRNA. Translation: CAA62372.1. U15208 mRNA. Translation: AAA92582.1. CH466587 Genomic DNA. Translation: EDL09307.1. CH466587 Genomic DNA. Translation: EDL09308.1. BC117041 mRNA. Translation: AAI17042.1. BC119171 mRNA. Translation: AAI19172.1.
IPI	IPI00125251.
PIR	JC4587.
RefSeq	NP_034046.2. NM_009916.2.
UniGene	Mm.1337.
3D structure databases
ProteinModelPortal	P51680.
SMR	P51680. Positions 46-312.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000062677.
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000054414; ENSMUSP00000062677; ENSMUSG00000047898.
GeneID	12773.
KEGG	mmu:12773.
Organism-specific databases
CTD	1233.
MGI	MGI:107824. Ccr4.
Phylogenomic databases
eggNOG	NOG148353.
GeneTree	ENSGT00700000104251.
HOGENOM	HOG000234122.
HOVERGEN	HBG106917.
InParanoid	Q14A03.
KO	K04179.
OMA	LCKIISW.
OrthoDB	EOG4JT05S.
Gene expression databases
Bgee	P51680.
CleanEx	MM_CCR4.
Genevestigator	P51680.
GermOnline	ENSMUSG00000047898. Mus musculus.
Family and domain databases
InterPro	IPR002239. Chemokine_CCR4. IPR000355. Chemokine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR01109. CHEMOKINER4. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P51680.
ChEMBL	CHEMBL5410.
NextBio	282154.
SOURCE	Search...

Entry information

Entry name

CCR4_MOUSE

Accession

Primary (citable) accession number: P51680
Secondary accession number(s): Q14A03

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents