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Protein

C-C chemokine receptor type 4

Gene

Ccr4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Could play a role in lipopolysaccharide (LPS)-induced endotoxic shock. In the CNS, could mediate hippocampal-neuron survival.1 Publication

GO - Molecular functioni

  • C-C chemokine receptor activity Source: MGI

GO - Biological processi

  • chemotaxis Source: MGI
  • homeostasis of number of cells Source: MGI
  • immune response Source: InterPro
  • inflammatory response Source: MGI
  • neuron migration Source: MGI
  • positive regulation of positive chemotaxis Source: Ensembl
  • response to antibiotic Source: Ensembl
  • response to bacterium Source: Ensembl
  • response to radiation Source: Ensembl
  • tolerance induction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 4
Short name:
C-C CKR-4
Short name:
CC-CKR-4
Short name:
CCR-4
Short name:
CCR4
Alternative name(s):
CD_antigen: CD194
Gene namesi
Name:Ccr4
Synonyms:Cmkbr4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:107824. Ccr4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 67Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini68 – 77CytoplasmicSequence analysis10
Transmembranei78 – 98Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini99 – 111ExtracellularSequence analysisAdd BLAST13
Transmembranei112 – 133Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini134 – 150CytoplasmicSequence analysisAdd BLAST17
Transmembranei151 – 175Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini176 – 206ExtracellularSequence analysisAdd BLAST31
Transmembranei207 – 226Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini227 – 242CytoplasmicSequence analysisAdd BLAST16
Transmembranei243 – 267Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini268 – 284ExtracellularSequence analysisAdd BLAST17
Transmembranei285 – 308Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini309 – 360CytoplasmicSequence analysisAdd BLAST52

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5410.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692461 – 360C-C chemokine receptor type 4Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi110 ↔ 187PROSITE-ProRule annotation
Glycosylationi183N-linked (GlcNAc...)Sequence analysis1
Glycosylationi194N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP51680.
PRIDEiP51680.

PTM databases

PhosphoSitePlusiP51680.

Expressioni

Tissue specificityi

Expressed in the thymus, macrophages and T- and B-cells.

Developmental stagei

Low expression at 7.5 dpc and 12.5 dpc in the yolk sac.

Gene expression databases

BgeeiENSMUSG00000047898.
CleanExiMM_CCR4.
GenevisibleiP51680. MM.

Interactioni

Protein-protein interaction databases

MINTiMINT-4996815.
STRINGi10090.ENSMUSP00000062677.

Chemistry databases

BindingDBiP51680.

Structurei

3D structure databases

ProteinModelPortaliP51680.
SMRiP51680.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi343 – 346Poly-Ser4

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP51680.
KOiK04179.
OMAiKFRKYIV.
OrthoDBiEOG091G0B7A.
TreeFamiTF330966.

Family and domain databases

InterProiIPR002239. Chemokine_CCR4.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01109. CHEMOKINER4.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51680-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNATEVTDTT QDETVYNSYY FYESMPKPCT KEGIKAFGEV FLPPLYSLVF
60 70 80 90 100
LLGLFGNSVV VLVLFKYKRL KSMTDVYLLN LAISDLLFVL SLPFWGYYAA
110 120 130 140 150
DQWVFGLGLC KIVSWMYLVG FYSGIFFIML MSIDRYLAIV HAVFSLKART
160 170 180 190 200
LTYGVITSLI TWSVAVFASL PGLLFSTCYT EHNHTYCKTQ YSVNSTTWKV
210 220 230 240 250
LSSLEINVLG LLIPLGIMLF CYSMIIRTLQ HCKNEKKNRA VRMIFAVVVL
260 270 280 290 300
FLGFWTPYNV VLFLETLVEL EVLQDCTLER YLDYAIQATE TLAFIHCCLN
310 320 330 340 350
PVIYFFLGEK FRKYITQLFR TCRGPLVLCK HCDFLQVYSA DMSSSSYTQS
360
TVDHDFRDAL
Length:360
Mass (Da):41,408
Last modified:July 27, 2011 - v2
Checksum:i8FA760951BE2002B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4T → I in AAA92582 (PubMed:9192769).Curated1
Sequence conflicti145S → T in AAA92582 (PubMed:9192769).Curated1
Sequence conflicti181E → Q in AAA92582 (PubMed:9192769).Curated1
Sequence conflicti205E → D in AAA92582 (PubMed:9192769).Curated1
Sequence conflicti221C → W in CAA62372 (PubMed:8573157).Curated1
Sequence conflicti241V → L in AAA92582 (PubMed:9192769).Curated1
Sequence conflicti246A → G in CAA62372 (PubMed:8573157).Curated1
Sequence conflicti293A → G in CAA62372 (PubMed:8573157).Curated1
Sequence conflicti311F → S in AAA92582 (PubMed:9192769).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90862 mRNA. Translation: CAA62372.1.
U15208 mRNA. Translation: AAA92582.1.
CH466587 Genomic DNA. Translation: EDL09307.1.
CH466587 Genomic DNA. Translation: EDL09308.1.
BC117041 mRNA. Translation: AAI17042.1.
BC119171 mRNA. Translation: AAI19172.1.
CCDSiCCDS23594.1.
PIRiJC4587.
RefSeqiNP_034046.2. NM_009916.2.
XP_006511996.1. XM_006511933.2.
XP_006511997.1. XM_006511934.3.
XP_011241235.1. XM_011242933.2.
UniGeneiMm.1337.

Genome annotation databases

EnsembliENSMUST00000054414; ENSMUSP00000062677; ENSMUSG00000047898.
GeneIDi12773.
KEGGimmu:12773.
UCSCiuc009rxo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90862 mRNA. Translation: CAA62372.1.
U15208 mRNA. Translation: AAA92582.1.
CH466587 Genomic DNA. Translation: EDL09307.1.
CH466587 Genomic DNA. Translation: EDL09308.1.
BC117041 mRNA. Translation: AAI17042.1.
BC119171 mRNA. Translation: AAI19172.1.
CCDSiCCDS23594.1.
PIRiJC4587.
RefSeqiNP_034046.2. NM_009916.2.
XP_006511996.1. XM_006511933.2.
XP_006511997.1. XM_006511934.3.
XP_011241235.1. XM_011242933.2.
UniGeneiMm.1337.

3D structure databases

ProteinModelPortaliP51680.
SMRiP51680.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4996815.
STRINGi10090.ENSMUSP00000062677.

Chemistry databases

BindingDBiP51680.
ChEMBLiCHEMBL5410.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP51680.

Proteomic databases

PaxDbiP51680.
PRIDEiP51680.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054414; ENSMUSP00000062677; ENSMUSG00000047898.
GeneIDi12773.
KEGGimmu:12773.
UCSCiuc009rxo.2. mouse.

Organism-specific databases

CTDi1233.
MGIiMGI:107824. Ccr4.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP51680.
KOiK04179.
OMAiKFRKYIV.
OrthoDBiEOG091G0B7A.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiP51680.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047898.
CleanExiMM_CCR4.
GenevisibleiP51680. MM.

Family and domain databases

InterProiIPR002239. Chemokine_CCR4.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01109. CHEMOKINER4.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCR4_MOUSE
AccessioniPrimary (citable) accession number: P51680
Secondary accession number(s): Q14A03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.