C-C chemokine receptor type 4 - Homo sapiens (Human)

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P51679 (CCR4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 113. History...

Clusters with 100%, 90%, 50% identity |

Documents (7) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
C-C chemokine receptor type 4
Short name=C-C CKR-4
Short name=CC-CKR-4
Short name=CCR-4
Short name=CCR4

Alternative name(s):
K5-5
CD_antigen=CD194

Gene names

Name:	CCR4
Synonyms:	CMKBR4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. Ref.5 Ref.6 Ref.7 Ref.8
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells. Ref.8
Post-translational modification	In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemotaxis Traceable author statement Ref.1. Source: ProtInc elevation of cytosolic calcium ion concentration Traceable author statement Ref.1. Source: ProtInc immune response Traceable author statement Ref.1. Source: ProtInc inflammatory response Traceable author statement Ref.1. Source: ProtInc neuron migration Inferred from electronic annotation. Source: Compara tolerance induction Inferred from electronic annotation. Source: Compara
Cellular_component	external side of plasma membrane Inferred from electronic annotation. Source: Compara integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	C-C chemokine receptor activity Inferred from electronic annotation. Source: Compara chemokine receptor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 360

360

C-C chemokine receptor type 4

PRO_0000069245

Regions

Topological domain

1 – 39

Extracellular Potential

Transmembrane

40 – 67

Helical; Name=1; Potential

Topological domain

68 – 77

Cytoplasmic Potential

Transmembrane

78 – 98

Helical; Name=2; Potential

Topological domain

99 – 111

Extracellular Potential

Transmembrane

112 – 133

Helical; Name=3; Potential

Topological domain

134 – 150

Cytoplasmic Potential

Transmembrane

151 – 175

Helical; Name=4; Potential

Topological domain

176 – 206

Extracellular Potential

Transmembrane

207 – 226

Helical; Name=5; Potential

Topological domain

227 – 242

Cytoplasmic Potential

Transmembrane

243 – 267

Helical; Name=6; Potential

Topological domain

268 – 284

Extracellular Potential

Transmembrane

285 – 308

Helical; Name=7; Potential

Topological domain

309 – 360

Cytoplasmic Potential

Amino acid modifications

Glycosylation

183

N-linked (GlcNAc...) Potential

Glycosylation

194

N-linked (GlcNAc...) Potential

Disulfide bond

110 ↔ 187

By similarity

Natural variations

Natural variant

130

L → V. Ref.2

VAR_010669

Natural variant

178

C → S. Ref.2

VAR_010670

Sequences

Sequence

Length

Mass (Da)

Tools

P51679 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 51EBE12AD1FAFABF
Show »

FASTA

360

41,403

        10         20         30         40         50         60 
MNPTDIADTT LDESIYSNYY LYESIPKPCT KEGIKAFGEL FLPPLYSLVF VFGLLGNSVV 

        70         80         90        100        110        120 
VLVLFKYKRL RSMTDVYLLN LAISDLLFVF SLPFWGYYAA DQWVFGLGLC KMISWMYLVG 

       130        140        150        160        170        180 
FYSGIFFVML MSIDRYLAIV HAVFSLRART LTYGVITSLA TWSVAVFASL PGFLFSTCYT 

       190        200        210        220        230        240 
ERNHTYCKTK YSLNSTTWKV LSSLEINILG LVIPLGIMLF CYSMIIRTLQ HCKNEKKNKA 

       250        260        270        280        290        300 
VKMIFAVVVL FLGFWTPYNI VLFLETLVEL EVLQDCTFER YLDYAIQATE TLAFVHCCLN 

       310        320        330        340        350        360 
PIIYFFLGEK FRKYILQLFK TCRGLFVLCQ YCGLLQIYSA DTPSSSYTQS TMDHDLHDAL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line." Power C.A., Meyer A., Nemeth K., Bacon K.B., Hoogewerf A.J., Proudfoot A.E.I., Wells T.N.C. J. Biol. Chem. 270:19495-19500(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Spleen.
[2]	"New variations of human CC-chemokine receptors CCR3 and CCR4." Kato H., Tsuchiya N., Izumi S., Miyamasu M., Nakajima T., Kawasaki H., Hirai K., Tokunaga K. Genes Immun. 1:97-104(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-130 AND SER-178.
[3]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood.
[5]	"The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4." Imai T., Baba M., Nishimura M., Kakizaki M., Takagi S., Yoshie O. J. Biol. Chem. 272:15036-15042(1997) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[6]	"Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4." Imai T., Chantry D., Raport C.J., Wood C.L., Nishimura M., Godiska R., Yoshie O., Gray P.W. J. Biol. Chem. 273:1764-1768(1998) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[7]	"The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells." Campbell J.J., Haraldsen G., Pan J., Rottman J., Qin S., Ponath P., Andrew D.P., Warnke R., Ruffing N., Kassam N., Wu L., Butcher E.C. Nature 400:776-780(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[8]	"Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309." Inngjerdingen M., Damaj B., Maghazachi A.A. J. Immunol. 164:4048-4054(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, PHOSPHORYLATION.
+	Additional computationally mapped references.

Web resources

Wikipedia

CC chemokine receptors entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	X85740 mRNA. Translation: CAA59743.1. AB023888 Genomic DNA. Translation: BAA86965.1. AB023889 Genomic DNA. Translation: BAA86966.1. AB023890 Genomic DNA. Translation: BAA86967.1. AB023891 Genomic DNA. Translation: BAA86968.1. AB023892 Genomic DNA. Translation: BAA86969.1. AY322539 Genomic DNA. Translation: AAP84352.1. BC069139 mRNA. Translation: AAH69139.1. BC071751 mRNA. Translation: AAH71751.1. BC074935 mRNA. Translation: AAH74935.1.
IPI	IPI00019958.
PIR	A57160.
RefSeq	NP_005499.1. NM_005508.4.
UniGene	Hs.184926.
3D structure databases
ProteinModelPortal	P51679.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5848N.
MINT	MINT-1525168.
STRING	9606.ENSP00000332659.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	1705894.
Proteomic databases
PaxDb	P51679.
PRIDE	P51679.
Protocols and materials databases
DNASU	1233.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000330953; ENSP00000332659; ENSG00000183813.
GeneID	1233.
KEGG	hsa:1233.
UCSC	uc003cfg.1. human.
Organism-specific databases
CTD	1233.
GeneCards	GC03P032968.
HGNC	HGNC:1605. CCR4.
HPA	HPA031613.
MIM	604836. gene.
neXtProt	NX_P51679.
PharmGKB	PA26169.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG148353.
HOGENOM	HOG000234122.
HOVERGEN	HBG106917.
InParanoid	P51679.
KO	K04179.
OMA	LCKIISW.
OrthoDB	EOG4JT05S.
PhylomeDB	P51679.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P51679.
Bgee	P51679.
CleanEx	HS_CCR4.
Genevestigator	P51679.
GermOnline	ENSG00000183813. Homo sapiens.
Family and domain databases
InterPro	IPR002239. Chemokine_CCR4. IPR000355. Chemokine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR01109. CHEMOKINER4. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P51679.
ChEMBL	CHEMBL2414.
GenomeRNAi	1233.
NextBio	5031.
SOURCE	Search...

Entry information

Entry name

CCR4_HUMAN

Accession

Primary (citable) accession number: P51679
Secondary accession number(s): Q9ULY6, Q9ULY7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 113 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.