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P51679

- CCR4_HUMAN

UniProt

P51679 - CCR4_HUMAN

Protein

C-C chemokine receptor type 4

Gene

CCR4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.4 Publications

    GO - Molecular functioni

    1. C-C chemokine receptor activity Source: Ensembl
    2. chemokine receptor activity Source: ProtInc

    GO - Biological processi

    1. chemokine-mediated signaling pathway Source: GOC
    2. chemotaxis Source: ProtInc
    3. immune response Source: ProtInc
    4. inflammatory response Source: ProtInc
    5. neuron migration Source: Ensembl
    6. positive regulation of cytosolic calcium ion concentration Source: ProtInc
    7. positive regulation of positive chemotaxis Source: Ensembl
    8. response to antibiotic Source: Ensembl
    9. response to bacterium Source: Ensembl
    10. response to radiation Source: Ensembl
    11. tolerance induction Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C chemokine receptor type 4
    Short name:
    C-C CKR-4
    Short name:
    CC-CKR-4
    Short name:
    CCR-4
    Short name:
    CCR4
    Alternative name(s):
    K5-5
    CD_antigen: CD194
    Gene namesi
    Name:CCR4
    Synonyms:CMKBR4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:1605. CCR4.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. integral component of plasma membrane Source: ProtInc
    3. neuronal cell body Source: Ensembl
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26169.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 360360C-C chemokine receptor type 4PRO_0000069245Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi110 ↔ 187PROSITE-ProRule annotation
    Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP51679.
    PRIDEiP51679.

    Expressioni

    Tissue specificityi

    Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells.1 Publication

    Gene expression databases

    ArrayExpressiP51679.
    BgeeiP51679.
    CleanExiHS_CCR4.
    GenevestigatoriP51679.

    Organism-specific databases

    HPAiHPA031613.

    Interactioni

    Protein-protein interaction databases

    BioGridi107638. 5 interactions.
    DIPiDIP-5848N.
    IntActiP51679. 1 interaction.
    MINTiMINT-1525168.
    STRINGi9606.ENSP00000332659.

    Structurei

    3D structure databases

    ProteinModelPortaliP51679.
    SMRiP51679. Positions 28-320.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini68 – 7710CytoplasmicSequence Analysis
    Topological domaini99 – 11113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini134 – 15017CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini176 – 20631ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini227 – 24216CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini268 – 28417ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini309 – 36052CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6728Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei78 – 9821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei112 – 13322Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei151 – 17525Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei207 – 22620Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei243 – 26725Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei285 – 30824Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148353.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiP51679.
    KOiK04179.
    OMAiLCKIISW.
    OrthoDBiEOG738051.
    PhylomeDBiP51679.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR002239. Chemokine_CCR4.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF12. PTHR24227:SF12. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR01109. CHEMOKINER4.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51679-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPTDIADTT LDESIYSNYY LYESIPKPCT KEGIKAFGEL FLPPLYSLVF    50
    VFGLLGNSVV VLVLFKYKRL RSMTDVYLLN LAISDLLFVF SLPFWGYYAA 100
    DQWVFGLGLC KMISWMYLVG FYSGIFFVML MSIDRYLAIV HAVFSLRART 150
    LTYGVITSLA TWSVAVFASL PGFLFSTCYT ERNHTYCKTK YSLNSTTWKV 200
    LSSLEINILG LVIPLGIMLF CYSMIIRTLQ HCKNEKKNKA VKMIFAVVVL 250
    FLGFWTPYNI VLFLETLVEL EVLQDCTFER YLDYAIQATE TLAFVHCCLN 300
    PIIYFFLGEK FRKYILQLFK TCRGLFVLCQ YCGLLQIYSA DTPSSSYTQS 350
    TMDHDLHDAL 360
    Length:360
    Mass (Da):41,403
    Last modified:October 1, 1996 - v1
    Checksum:i51EBE12AD1FAFABF
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti130 – 1301L → V.1 Publication
    VAR_010669
    Natural varianti178 – 1781C → S.1 Publication
    VAR_010670

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X85740 mRNA. Translation: CAA59743.1.
    AB023888 Genomic DNA. Translation: BAA86965.1.
    AB023889 Genomic DNA. Translation: BAA86966.1.
    AB023890 Genomic DNA. Translation: BAA86967.1.
    AB023891 Genomic DNA. Translation: BAA86968.1.
    AB023892 Genomic DNA. Translation: BAA86969.1.
    AY322539 Genomic DNA. Translation: AAP84352.1.
    BC069139 mRNA. Translation: AAH69139.1.
    BC071751 mRNA. Translation: AAH71751.1.
    BC074935 mRNA. Translation: AAH74935.1.
    CCDSiCCDS2656.1.
    PIRiA57160.
    RefSeqiNP_005499.1. NM_005508.4.
    UniGeneiHs.184926.

    Genome annotation databases

    EnsembliENST00000330953; ENSP00000332659; ENSG00000183813.
    GeneIDi1233.
    KEGGihsa:1233.
    UCSCiuc003cfg.1. human.

    Polymorphism databases

    DMDMi1705894.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CC chemokine receptors entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X85740 mRNA. Translation: CAA59743.1 .
    AB023888 Genomic DNA. Translation: BAA86965.1 .
    AB023889 Genomic DNA. Translation: BAA86966.1 .
    AB023890 Genomic DNA. Translation: BAA86967.1 .
    AB023891 Genomic DNA. Translation: BAA86968.1 .
    AB023892 Genomic DNA. Translation: BAA86969.1 .
    AY322539 Genomic DNA. Translation: AAP84352.1 .
    BC069139 mRNA. Translation: AAH69139.1 .
    BC071751 mRNA. Translation: AAH71751.1 .
    BC074935 mRNA. Translation: AAH74935.1 .
    CCDSi CCDS2656.1.
    PIRi A57160.
    RefSeqi NP_005499.1. NM_005508.4.
    UniGenei Hs.184926.

    3D structure databases

    ProteinModelPortali P51679.
    SMRi P51679. Positions 28-320.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107638. 5 interactions.
    DIPi DIP-5848N.
    IntActi P51679. 1 interaction.
    MINTi MINT-1525168.
    STRINGi 9606.ENSP00000332659.

    Chemistry

    BindingDBi P51679.
    ChEMBLi CHEMBL2414.
    GuidetoPHARMACOLOGYi 61.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 1705894.

    Proteomic databases

    PaxDbi P51679.
    PRIDEi P51679.

    Protocols and materials databases

    DNASUi 1233.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000330953 ; ENSP00000332659 ; ENSG00000183813 .
    GeneIDi 1233.
    KEGGi hsa:1233.
    UCSCi uc003cfg.1. human.

    Organism-specific databases

    CTDi 1233.
    GeneCardsi GC03P032968.
    HGNCi HGNC:1605. CCR4.
    HPAi HPA031613.
    MIMi 604836. gene.
    neXtProti NX_P51679.
    PharmGKBi PA26169.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG148353.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi P51679.
    KOi K04179.
    OMAi LCKIISW.
    OrthoDBi EOG738051.
    PhylomeDBi P51679.
    TreeFami TF330966.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii CCR4.
    GenomeRNAii 1233.
    NextBioi 5031.
    PROi P51679.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51679.
    Bgeei P51679.
    CleanExi HS_CCR4.
    Genevestigatori P51679.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR002239. Chemokine_CCR4.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF12. PTHR24227:SF12. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR01109. CHEMOKINER4.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line."
      Power C.A., Meyer A., Nemeth K., Bacon K.B., Hoogewerf A.J., Proudfoot A.E.I., Wells T.N.C.
      J. Biol. Chem. 270:19495-19500(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Spleen.
    2. "New variations of human CC-chemokine receptors CCR3 and CCR4."
      Kato H., Tsuchiya N., Izumi S., Miyamasu M., Nakajima T., Kawasaki H., Hirai K., Tokunaga K.
      Genes Immun. 1:97-104(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-130 AND SER-178.
    3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Blood.
    5. "The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4."
      Imai T., Baba M., Nishimura M., Kakizaki M., Takagi S., Yoshie O.
      J. Biol. Chem. 272:15036-15042(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4."
      Imai T., Chantry D., Raport C.J., Wood C.L., Nishimura M., Godiska R., Yoshie O., Gray P.W.
      J. Biol. Chem. 273:1764-1768(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells."
      Campbell J.J., Haraldsen G., Pan J., Rottman J., Qin S., Ponath P., Andrew D.P., Warnke R., Ruffing N., Kassam N., Wu L., Butcher E.C.
      Nature 400:776-780(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309."
      Inngjerdingen M., Damaj B., Maghazachi A.A.
      J. Immunol. 164:4048-4054(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, PHOSPHORYLATION.

    Entry informationi

    Entry nameiCCR4_HUMAN
    AccessioniPrimary (citable) accession number: P51679
    Secondary accession number(s): Q9ULY6, Q9ULY7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    3. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    4. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3