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P51679

- CCR4_HUMAN

UniProt

P51679 - CCR4_HUMAN

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Protein

C-C chemokine receptor type 4

Gene
CCR4, CMKBR4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.4 Publications

GO - Molecular functioni

  1. C-C chemokine receptor activity Source: Ensembl
  2. chemokine receptor activity Source: ProtInc

GO - Biological processi

  1. chemokine-mediated signaling pathway Source: GOC
  2. chemotaxis Source: ProtInc
  3. immune response Source: ProtInc
  4. inflammatory response Source: ProtInc
  5. neuron migration Source: Ensembl
  6. positive regulation of cytosolic calcium ion concentration Source: ProtInc
  7. positive regulation of positive chemotaxis Source: Ensembl
  8. response to antibiotic Source: Ensembl
  9. response to bacterium Source: Ensembl
  10. response to radiation Source: Ensembl
  11. tolerance induction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 4
Short name:
C-C CKR-4
Short name:
CC-CKR-4
Short name:
CCR-4
Short name:
CCR4
Alternative name(s):
K5-5
CD_antigen: CD194
Gene namesi
Name:CCR4
Synonyms:CMKBR4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:1605. CCR4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939Extracellular Reviewed predictionAdd
BLAST
Transmembranei40 – 6728Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini68 – 7710Cytoplasmic Reviewed prediction
Transmembranei78 – 9821Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini99 – 11113Extracellular Reviewed predictionAdd
BLAST
Transmembranei112 – 13322Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini134 – 15017Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei151 – 17525Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini176 – 20631Extracellular Reviewed predictionAdd
BLAST
Transmembranei207 – 22620Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini227 – 24216Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei243 – 26725Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini268 – 28417Extracellular Reviewed predictionAdd
BLAST
Transmembranei285 – 30824Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini309 – 36052Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. integral component of plasma membrane Source: ProtInc
  3. neuronal cell body Source: Ensembl
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26169.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360C-C chemokine receptor type 4PRO_0000069245Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi110 ↔ 187 By similarity
Glycosylationi183 – 1831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi194 – 1941N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP51679.
PRIDEiP51679.

Expressioni

Tissue specificityi

Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells.1 Publication

Gene expression databases

ArrayExpressiP51679.
BgeeiP51679.
CleanExiHS_CCR4.
GenevestigatoriP51679.

Organism-specific databases

HPAiHPA031613.

Interactioni

Protein-protein interaction databases

BioGridi107638. 5 interactions.
DIPiDIP-5848N.
IntActiP51679. 1 interaction.
MINTiMINT-1525168.
STRINGi9606.ENSP00000332659.

Structurei

3D structure databases

ProteinModelPortaliP51679.
SMRiP51679. Positions 28-320.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148353.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP51679.
KOiK04179.
OMAiLCKIISW.
OrthoDBiEOG738051.
PhylomeDBiP51679.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR002239. Chemokine_CCR4.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF12. PTHR24227:SF12. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01109. CHEMOKINER4.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51679-1 [UniParc]FASTAAdd to Basket

« Hide

MNPTDIADTT LDESIYSNYY LYESIPKPCT KEGIKAFGEL FLPPLYSLVF    50
VFGLLGNSVV VLVLFKYKRL RSMTDVYLLN LAISDLLFVF SLPFWGYYAA 100
DQWVFGLGLC KMISWMYLVG FYSGIFFVML MSIDRYLAIV HAVFSLRART 150
LTYGVITSLA TWSVAVFASL PGFLFSTCYT ERNHTYCKTK YSLNSTTWKV 200
LSSLEINILG LVIPLGIMLF CYSMIIRTLQ HCKNEKKNKA VKMIFAVVVL 250
FLGFWTPYNI VLFLETLVEL EVLQDCTFER YLDYAIQATE TLAFVHCCLN 300
PIIYFFLGEK FRKYILQLFK TCRGLFVLCQ YCGLLQIYSA DTPSSSYTQS 350
TMDHDLHDAL 360
Length:360
Mass (Da):41,403
Last modified:October 1, 1996 - v1
Checksum:i51EBE12AD1FAFABF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti130 – 1301L → V.1 Publication
VAR_010669
Natural varianti178 – 1781C → S.1 Publication
VAR_010670

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X85740 mRNA. Translation: CAA59743.1.
AB023888 Genomic DNA. Translation: BAA86965.1.
AB023889 Genomic DNA. Translation: BAA86966.1.
AB023890 Genomic DNA. Translation: BAA86967.1.
AB023891 Genomic DNA. Translation: BAA86968.1.
AB023892 Genomic DNA. Translation: BAA86969.1.
AY322539 Genomic DNA. Translation: AAP84352.1.
BC069139 mRNA. Translation: AAH69139.1.
BC071751 mRNA. Translation: AAH71751.1.
BC074935 mRNA. Translation: AAH74935.1.
CCDSiCCDS2656.1.
PIRiA57160.
RefSeqiNP_005499.1. NM_005508.4.
UniGeneiHs.184926.

Genome annotation databases

EnsembliENST00000330953; ENSP00000332659; ENSG00000183813.
GeneIDi1233.
KEGGihsa:1233.
UCSCiuc003cfg.1. human.

Polymorphism databases

DMDMi1705894.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CC chemokine receptors entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X85740 mRNA. Translation: CAA59743.1 .
AB023888 Genomic DNA. Translation: BAA86965.1 .
AB023889 Genomic DNA. Translation: BAA86966.1 .
AB023890 Genomic DNA. Translation: BAA86967.1 .
AB023891 Genomic DNA. Translation: BAA86968.1 .
AB023892 Genomic DNA. Translation: BAA86969.1 .
AY322539 Genomic DNA. Translation: AAP84352.1 .
BC069139 mRNA. Translation: AAH69139.1 .
BC071751 mRNA. Translation: AAH71751.1 .
BC074935 mRNA. Translation: AAH74935.1 .
CCDSi CCDS2656.1.
PIRi A57160.
RefSeqi NP_005499.1. NM_005508.4.
UniGenei Hs.184926.

3D structure databases

ProteinModelPortali P51679.
SMRi P51679. Positions 28-320.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107638. 5 interactions.
DIPi DIP-5848N.
IntActi P51679. 1 interaction.
MINTi MINT-1525168.
STRINGi 9606.ENSP00000332659.

Chemistry

BindingDBi P51679.
ChEMBLi CHEMBL2414.
GuidetoPHARMACOLOGYi 61.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 1705894.

Proteomic databases

PaxDbi P51679.
PRIDEi P51679.

Protocols and materials databases

DNASUi 1233.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000330953 ; ENSP00000332659 ; ENSG00000183813 .
GeneIDi 1233.
KEGGi hsa:1233.
UCSCi uc003cfg.1. human.

Organism-specific databases

CTDi 1233.
GeneCardsi GC03P032968.
HGNCi HGNC:1605. CCR4.
HPAi HPA031613.
MIMi 604836. gene.
neXtProti NX_P51679.
PharmGKBi PA26169.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG148353.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi P51679.
KOi K04179.
OMAi LCKIISW.
OrthoDBi EOG738051.
PhylomeDBi P51679.
TreeFami TF330966.

Enzyme and pathway databases

Reactomei REACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii CCR4.
GenomeRNAii 1233.
NextBioi 5031.
PROi P51679.
SOURCEi Search...

Gene expression databases

ArrayExpressi P51679.
Bgeei P51679.
CleanExi HS_CCR4.
Genevestigatori P51679.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR002239. Chemokine_CCR4.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
PTHR24227:SF12. PTHR24227:SF12. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00657. CCCHEMOKINER.
PR01109. CHEMOKINER4.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line."
    Power C.A., Meyer A., Nemeth K., Bacon K.B., Hoogewerf A.J., Proudfoot A.E.I., Wells T.N.C.
    J. Biol. Chem. 270:19495-19500(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spleen.
  2. "New variations of human CC-chemokine receptors CCR3 and CCR4."
    Kato H., Tsuchiya N., Izumi S., Miyamasu M., Nakajima T., Kawasaki H., Hirai K., Tokunaga K.
    Genes Immun. 1:97-104(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-130 AND SER-178.
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.
  5. "The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4."
    Imai T., Baba M., Nishimura M., Kakizaki M., Takagi S., Yoshie O.
    J. Biol. Chem. 272:15036-15042(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4."
    Imai T., Chantry D., Raport C.J., Wood C.L., Nishimura M., Godiska R., Yoshie O., Gray P.W.
    J. Biol. Chem. 273:1764-1768(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells."
    Campbell J.J., Haraldsen G., Pan J., Rottman J., Qin S., Ponath P., Andrew D.P., Warnke R., Ruffing N., Kassam N., Wu L., Butcher E.C.
    Nature 400:776-780(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309."
    Inngjerdingen M., Damaj B., Maghazachi A.A.
    J. Immunol. 164:4048-4054(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, PHOSPHORYLATION.

Entry informationi

Entry nameiCCR4_HUMAN
AccessioniPrimary (citable) accession number: P51679
Secondary accession number(s): Q9ULY6, Q9ULY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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