Probable C-C chemokine receptor type 3

Contribute

Send feedback

Read comments (?) or add your own

P51678 (CCR3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 101. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Probable C-C chemokine receptor type 3
Short name=C-C CKR-3
Short name=CC-CKR-3
Short name=CCR-3
Short name=CCR3
Short name=CKR3

Alternative name(s):
Macrophage inflammatory protein 1-alpha receptor-like 2
Short name=MIP-1 alpha RL2
CD_antigen=CD193

Gene names

Name:	Ccr3
Synonyms:	Cmkbr1l2, Cmkbr3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for a C-C type chemokine. Binds to eotaxin, MCP-3, MCP-4 and RANTES and subsequently transduces a signal by increasing the intracellular calcium ions level.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Detected in skeletal muscle and in trace amounts in leukocytes.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ERK1 and ERK2 cascade Inferred from electronic annotation. Source: Compara activation of MAPK activity Inferred from electronic annotation. Source: InterPro angioblast cell migration Inferred from electronic annotation. Source: Compara chemotaxis Inferred from direct assay Ref.1. Source: MGI elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: InterPro eosinophil chemotaxis Inferred from electronic annotation. Source: Compara mast cell chemotaxis Inferred from electronic annotation. Source: Compara positive regulation of angiogenesis Inferred from mutant phenotype PubMed 19525930. Source: BHF-UCL positive regulation of endothelial cell proliferation Inferred from mutant phenotype PubMed 19525930. Source: BHF-UCL
Cellular_component	endosome Inferred from electronic annotation. Source: Compara extracellular space Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	C-C chemokine receptor activity Inferred from direct assay Ref.1. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 359

359

Probable C-C chemokine receptor type 3

PRO_0000069242

Regions

Topological domain

1 – 38

Extracellular Potential

Transmembrane

39 – 64

Helical; Name=1; Potential

Topological domain

65 – 68

Cytoplasmic Potential

Transmembrane

69 – 95

Helical; Name=2; Potential

Topological domain

96 – 111

Extracellular Potential

Transmembrane

112 – 133

Helical; Name=3; Potential

Topological domain

134 – 150

Cytoplasmic Potential

Transmembrane

151 – 175

Helical; Name=4; Potential

Topological domain

176 – 201

Extracellular Potential

Transmembrane

202 – 227

Helical; Name=5; Potential

Topological domain

228 – 243

Cytoplasmic Potential

Transmembrane

244 – 268

Helical; Name=6; Potential

Topological domain

269 – 285

Extracellular Potential

Transmembrane

286 – 309

Helical; Name=7; Potential

Topological domain

310 – 359

Cytoplasmic Potential

Amino acid modifications

Disulfide bond

110 ↔ 187

By similarity

Experimental info

Sequence conflict

218

I → V in AAA86118. Ref.1

Sequence conflict

218

I → V in AAA89155. Ref.2

Sequence conflict

270

S → R in AAA86118. Ref.1

Sequence conflict

278

Q → E in AAA86118. Ref.1

Sequence conflict

278

Q → E in AAA89155. Ref.2

Sequence conflict

300

I → V in AAA86118. Ref.1

Sequence conflict

300

I → V in AAA89155. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

P51678 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 40DA3C745B8C05A9
Show »

FASTA

359

41,783

        10         20         30         40         50         60 
MAFNTDEIKT VVESFETTPY EYEWAPPCEK VRIKELGSWL LPPLYSLVFI IGLLGNMMVV 

        70         80         90        100        110        120 
LILIKYRKLQ IMTNIYLFNL AISDLLFLFT VPFWIHYVLW NEWGFGHYMC KMLSGFYYLA 

       130        140        150        160        170        180 
LYSEIFFIIL LTIDRYLAIV HAVFALRART VTFATITSII TWGLAGLAAL PEFIFHESQD 

       190        200        210        220        230        240 
SFGEFSCSPR YPEGEEDSWK RFHALRMNIF GLALPLLIMV ICYSGIIKTL LRCPNKKKHK 

       250        260        270        280        290        300 
AIRLIFVVMI VFFIFWTPYN LVLLFSAFHS TFLETSCQQS KHLDLAMQVT EVIAYTHCCI 

       310        320        330        340        350 
NPVIYAFVGE RFRKHLRLFF HRNVAVYLGK YIPFLPGEKM ERTSSVSPST GEQEISVVF

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of two murine eosinophil beta chemokine receptors." Post T.W., Bozic C.R., Rothenberg M.E., Luster A.D., Gerard N., Gerard C. J. Immunol. 155:5299-5305(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv.
[2]	"Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor." Gao J.-L., Murphy P.M. J. Biol. Chem. 270:17494-17501(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/SvJ.
[3]	"Molecular Cloning of the Murine BALB/C CCR3 Gene." Daugherty B.L. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BALB/c.
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Aorta and Vein.
[5]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U29677 Genomic DNA. Translation: AAA86118.1. U28406 Genomic DNA. Translation: AAA89155.1. AY049018 Genomic DNA. Translation: AAL13085.1. AK041106 mRNA. Translation: BAC30823.1. CH466671 Genomic DNA. Translation: EDL37175.1. BC108967 mRNA. Translation: AAI08968.1. BC108968 mRNA. Translation: AAI08969.1.
IPI	IPI00312471.
PIR	I49341.
RefSeq	NP_034044.3. NM_009914.4.
UniGene	Mm.57050.
3D structure databases
ProteinModelPortal	P51678.
SMR	P51678. Positions 40-324.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	P51678.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000039171; ENSMUSP00000039107; ENSMUSG00000035448.
GeneID	12771.
KEGG	mmu:12771.
Organism-specific databases
CTD	1232.
MGI	MGI:104616. Ccr3.
Phylogenomic databases
eggNOG	NOG148353.
GeneTree	ENSGT00700000104407.
HOGENOM	HOG000234122.
HOVERGEN	HBG106917.
InParanoid	Q8K3M7.
KO	K04178.
OMA	YIPFLPS.
OrthoDB	EOG4S1T7D.
Gene expression databases
Bgee	P51678.
CleanEx	MM_CCR3.
Genevestigator	P51678.
GermOnline	ENSMUSG00000035448. Mus musculus.
Family and domain databases
InterPro	IPR002238. Chemokine_CCR3. IPR000355. Chemokine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR01108. CHEMOKINER3. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P51678.
ChEMBL	CHEMBL3406.
NextBio	282146.
SOURCE	Search...

Entry information

Entry name

CCR3_MOUSE

Accession

Primary (citable) accession number: P51678
Secondary accession number(s): Q8K3M7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents