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P51678

- CCR3_MOUSE

UniProt

P51678 - CCR3_MOUSE

Protein

Probable C-C chemokine receptor type 3

Gene

Ccr3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Receptor for a C-C type chemokine. Binds to eotaxin, MCP-3, MCP-4 and RANTES and subsequently transduces a signal by increasing the intracellular calcium ions level.

    GO - Molecular functioni

    1. C-C chemokine receptor activity Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. chemokine-mediated signaling pathway Source: GOC
    2. chemotaxis Source: MGI
    3. inflammatory response Source: InterPro
    4. positive regulation of angiogenesis Source: BHF-UCL
    5. positive regulation of endothelial cell proliferation Source: BHF-UCL

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable C-C chemokine receptor type 3
    Short name:
    C-C CKR-3
    Short name:
    CC-CKR-3
    Short name:
    CCR-3
    Short name:
    CCR3
    Short name:
    CKR3
    Alternative name(s):
    Macrophage inflammatory protein 1-alpha receptor-like 2
    Short name:
    MIP-1 alpha RL2
    CD_antigen: CD193
    Gene namesi
    Name:Ccr3
    Synonyms:Cmkbr1l2, Cmkbr3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:104616. Ccr3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Probable C-C chemokine receptor type 3PRO_0000069242Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi110 ↔ 187PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP51678.

    Expressioni

    Tissue specificityi

    Detected in skeletal muscle and in trace amounts in leukocytes.

    Gene expression databases

    BgeeiP51678.
    CleanExiMM_CCR3.
    GenevestigatoriP51678.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliP51678.
    SMRiP51678. Positions 4-324.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3838ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini65 – 684CytoplasmicSequence Analysis
    Topological domaini96 – 11116ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini134 – 15017CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini176 – 20126ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini228 – 24316CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini269 – 28517ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini310 – 35950CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei39 – 6426Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei69 – 9527Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei112 – 13322Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei151 – 17525Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei202 – 22726Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei244 – 26825Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei286 – 30924Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148353.
    GeneTreeiENSGT00700000104407.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiQ8K3M7.
    KOiK04178.
    OMAiYIPFLPS.
    OrthoDBiEOG738051.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR002238. Chemokine_CCR3.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF13. PTHR24227:SF13. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR01108. CHEMOKINER3.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51678-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFNTDEIKT VVESFETTPY EYEWAPPCEK VRIKELGSWL LPPLYSLVFI    50
    IGLLGNMMVV LILIKYRKLQ IMTNIYLFNL AISDLLFLFT VPFWIHYVLW 100
    NEWGFGHYMC KMLSGFYYLA LYSEIFFIIL LTIDRYLAIV HAVFALRART 150
    VTFATITSII TWGLAGLAAL PEFIFHESQD SFGEFSCSPR YPEGEEDSWK 200
    RFHALRMNIF GLALPLLIMV ICYSGIIKTL LRCPNKKKHK AIRLIFVVMI 250
    VFFIFWTPYN LVLLFSAFHS TFLETSCQQS KHLDLAMQVT EVIAYTHCCI 300
    NPVIYAFVGE RFRKHLRLFF HRNVAVYLGK YIPFLPGEKM ERTSSVSPST 350
    GEQEISVVF 359
    Length:359
    Mass (Da):41,783
    Last modified:July 27, 2011 - v2
    Checksum:i40DA3C745B8C05A9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti218 – 2181I → V in AAA86118. (PubMed:7594543)Curated
    Sequence conflicti218 – 2181I → V in AAA89155. (PubMed:7542241)Curated
    Sequence conflicti270 – 2701S → R in AAA86118. (PubMed:7594543)Curated
    Sequence conflicti278 – 2781Q → E in AAA86118. (PubMed:7594543)Curated
    Sequence conflicti278 – 2781Q → E in AAA89155. (PubMed:7542241)Curated
    Sequence conflicti300 – 3001I → V in AAA86118. (PubMed:7594543)Curated
    Sequence conflicti300 – 3001I → V in AAA89155. (PubMed:7542241)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U29677 Genomic DNA. Translation: AAA86118.1.
    U28406 Genomic DNA. Translation: AAA89155.1.
    AY049018 Genomic DNA. Translation: AAL13085.1.
    AK041106 mRNA. Translation: BAC30823.1.
    CH466671 Genomic DNA. Translation: EDL37175.1.
    BC108967 mRNA. Translation: AAI08968.1.
    BC108968 mRNA. Translation: AAI08969.1.
    CCDSiCCDS23668.1.
    PIRiI49341.
    RefSeqiNP_034044.3. NM_009914.4.
    XP_006512487.1. XM_006512424.1.
    XP_006512488.1. XM_006512425.1.
    UniGeneiMm.57050.

    Genome annotation databases

    EnsembliENSMUST00000039171; ENSMUSP00000039107; ENSMUSG00000035448.
    GeneIDi12771.
    KEGGimmu:12771.
    UCSCiuc009sha.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U29677 Genomic DNA. Translation: AAA86118.1 .
    U28406 Genomic DNA. Translation: AAA89155.1 .
    AY049018 Genomic DNA. Translation: AAL13085.1 .
    AK041106 mRNA. Translation: BAC30823.1 .
    CH466671 Genomic DNA. Translation: EDL37175.1 .
    BC108967 mRNA. Translation: AAI08968.1 .
    BC108968 mRNA. Translation: AAI08969.1 .
    CCDSi CCDS23668.1.
    PIRi I49341.
    RefSeqi NP_034044.3. NM_009914.4.
    XP_006512487.1. XM_006512424.1.
    XP_006512488.1. XM_006512425.1.
    UniGenei Mm.57050.

    3D structure databases

    ProteinModelPortali P51678.
    SMRi P51678. Positions 4-324.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P51678.
    ChEMBLi CHEMBL3406.
    GuidetoPHARMACOLOGYi 60.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi P51678.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000039171 ; ENSMUSP00000039107 ; ENSMUSG00000035448 .
    GeneIDi 12771.
    KEGGi mmu:12771.
    UCSCi uc009sha.2. mouse.

    Organism-specific databases

    CTDi 1232.
    MGIi MGI:104616. Ccr3.

    Phylogenomic databases

    eggNOGi NOG148353.
    GeneTreei ENSGT00700000104407.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi Q8K3M7.
    KOi K04178.
    OMAi YIPFLPS.
    OrthoDBi EOG738051.
    TreeFami TF330966.

    Miscellaneous databases

    NextBioi 282146.
    PROi P51678.
    SOURCEi Search...

    Gene expression databases

    Bgeei P51678.
    CleanExi MM_CCR3.
    Genevestigatori P51678.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR002238. Chemokine_CCR3.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF13. PTHR24227:SF13. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR01108. CHEMOKINER3.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of two murine eosinophil beta chemokine receptors."
      Post T.W., Bozic C.R., Rothenberg M.E., Luster A.D., Gerard N., Gerard C.
      J. Immunol. 155:5299-5305(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    2. "Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor."
      Gao J.-L., Murphy P.M.
      J. Biol. Chem. 270:17494-17501(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
    3. "Molecular Cloning of the Murine BALB/C CCR3 Gene."
      Daugherty B.L.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Aorta and Vein.
    5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiCCR3_MOUSE
    AccessioniPrimary (citable) accession number: P51678
    Secondary accession number(s): Q8K3M7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3