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Protein

Probable C-C chemokine receptor type 3

Gene

Ccr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for a C-C type chemokine. Binds to eotaxin, MCP-3, MCP-4 and RANTES and subsequently transduces a signal by increasing the intracellular calcium ions level.

GO - Molecular functioni

  • C-C chemokine binding Source: UniProtKB
  • C-C chemokine receptor activity Source: MGI

GO - Biological processi

  • chemotaxis Source: MGI
  • inflammatory response Source: InterPro
  • positive regulation of angiogenesis Source: BHF-UCL
  • positive regulation of endothelial cell proliferation Source: BHF-UCL

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable C-C chemokine receptor type 3
Short name:
C-C CKR-3
Short name:
CC-CKR-3
Short name:
CCR-3
Short name:
CCR3
Short name:
CKR3
Alternative name(s):
Macrophage inflammatory protein 1-alpha receptor-like 2
Short name:
MIP-1 alpha RL2
CD_antigen: CD193
Gene namesi
Name:Ccr3
Synonyms:Cmkbr1l2, Cmkbr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:104616. Ccr3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 64Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini65 – 68CytoplasmicSequence analysis4
Transmembranei69 – 95Helical; Name=2Sequence analysisAdd BLAST27
Topological domaini96 – 111ExtracellularSequence analysisAdd BLAST16
Transmembranei112 – 133Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini134 – 150CytoplasmicSequence analysisAdd BLAST17
Transmembranei151 – 175Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini176 – 201ExtracellularSequence analysisAdd BLAST26
Transmembranei202 – 227Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini228 – 243CytoplasmicSequence analysisAdd BLAST16
Transmembranei244 – 268Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini269 – 285ExtracellularSequence analysisAdd BLAST17
Transmembranei286 – 309Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini310 – 359CytoplasmicSequence analysisAdd BLAST50

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3406.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692421 – 359Probable C-C chemokine receptor type 3Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi110 ↔ 187PROSITE-ProRule annotation
Modified residuei136PhosphotyrosineBy similarity1
Modified residuei344PhosphoserineBy similarity1
Modified residuei345PhosphoserineBy similarity1
Modified residuei349PhosphoserineBy similarity1
Modified residuei356PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP51678.
PRIDEiP51678.

PTM databases

iPTMnetiP51678.
PhosphoSitePlusiP51678.

Expressioni

Tissue specificityi

Detected in skeletal muscle and in trace amounts in leukocytes.

Gene expression databases

BgeeiENSMUSG00000035448.
CleanExiMM_CCR3.
GenevisibleiP51678. MM.

Interactioni

GO - Molecular functioni

  • C-C chemokine binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039107.

Chemistry databases

BindingDBiP51678.

Structurei

3D structure databases

ProteinModelPortaliP51678.
SMRiP51678.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP51678.
KOiK04178.
OMAiLLRCPSK.
OrthoDBiEOG091G0B7A.
TreeFamiTF330966.

Family and domain databases

InterProiView protein in InterPro
IPR002238. Chemokine_CCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00657. CCCHEMOKINER.
PR01108. CHEMOKINER3.
PR00237. GPCRRHODOPSN.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P51678-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFNTDEIKT VVESFETTPY EYEWAPPCEK VRIKELGSWL LPPLYSLVFI
60 70 80 90 100
IGLLGNMMVV LILIKYRKLQ IMTNIYLFNL AISDLLFLFT VPFWIHYVLW
110 120 130 140 150
NEWGFGHYMC KMLSGFYYLA LYSEIFFIIL LTIDRYLAIV HAVFALRART
160 170 180 190 200
VTFATITSII TWGLAGLAAL PEFIFHESQD SFGEFSCSPR YPEGEEDSWK
210 220 230 240 250
RFHALRMNIF GLALPLLIMV ICYSGIIKTL LRCPNKKKHK AIRLIFVVMI
260 270 280 290 300
VFFIFWTPYN LVLLFSAFHS TFLETSCQQS KHLDLAMQVT EVIAYTHCCI
310 320 330 340 350
NPVIYAFVGE RFRKHLRLFF HRNVAVYLGK YIPFLPGEKM ERTSSVSPST

GEQEISVVF
Length:359
Mass (Da):41,783
Last modified:July 27, 2011 - v2
Checksum:i40DA3C745B8C05A9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti218I → V in AAA86118 (PubMed:7594543).Curated1
Sequence conflicti218I → V in AAA89155 (PubMed:7542241).Curated1
Sequence conflicti270S → R in AAA86118 (PubMed:7594543).Curated1
Sequence conflicti278Q → E in AAA86118 (PubMed:7594543).Curated1
Sequence conflicti278Q → E in AAA89155 (PubMed:7542241).Curated1
Sequence conflicti300I → V in AAA86118 (PubMed:7594543).Curated1
Sequence conflicti300I → V in AAA89155 (PubMed:7542241).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29677 Genomic DNA. Translation: AAA86118.1.
U28406 Genomic DNA. Translation: AAA89155.1.
AY049018 Genomic DNA. Translation: AAL13085.1.
AK041106 mRNA. Translation: BAC30823.1.
CH466671 Genomic DNA. Translation: EDL37175.1.
BC108967 mRNA. Translation: AAI08968.1.
BC108968 mRNA. Translation: AAI08969.1.
CCDSiCCDS23668.1.
PIRiI49341.
RefSeqiNP_034044.3. NM_009914.4.
XP_017168608.1. XM_017313119.1.
XP_017168609.1. XM_017313120.1.
UniGeneiMm.57050.

Genome annotation databases

EnsembliENSMUST00000039171; ENSMUSP00000039107; ENSMUSG00000035448.
GeneIDi12771.
KEGGimmu:12771.
UCSCiuc009sha.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiCCR3_MOUSE
AccessioniPrimary (citable) accession number: P51678
Secondary accession number(s): Q8K3M7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: August 30, 2017
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families