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Protein

Probable C-C chemokine receptor type 3

Gene

Ccr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for a C-C type chemokine. Binds to eotaxin, MCP-3, MCP-4 and RANTES and subsequently transduces a signal by increasing the intracellular calcium ions level.

GO - Molecular functioni

  1. C-C chemokine receptor activity Source: MGI

GO - Biological processi

  1. chemokine-mediated signaling pathway Source: GOC
  2. chemotaxis Source: MGI
  3. inflammatory response Source: InterPro
  4. positive regulation of angiogenesis Source: BHF-UCL
  5. positive regulation of endothelial cell proliferation Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.
REACT_331048. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable C-C chemokine receptor type 3
Short name:
C-C CKR-3
Short name:
CC-CKR-3
Short name:
CCR-3
Short name:
CCR3
Short name:
CKR3
Alternative name(s):
Macrophage inflammatory protein 1-alpha receptor-like 2
Short name:
MIP-1 alpha RL2
CD_antigen: CD193
Gene namesi
Name:Ccr3
Synonyms:Cmkbr1l2, Cmkbr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:104616. Ccr3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838ExtracellularSequence AnalysisAdd
BLAST
Transmembranei39 – 6426Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini65 – 684CytoplasmicSequence Analysis
Transmembranei69 – 9527Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini96 – 11116ExtracellularSequence AnalysisAdd
BLAST
Transmembranei112 – 13322Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini134 – 15017CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei151 – 17525Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini176 – 20126ExtracellularSequence AnalysisAdd
BLAST
Transmembranei202 – 22726Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini228 – 24316CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei244 – 26825Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini269 – 28517ExtracellularSequence AnalysisAdd
BLAST
Transmembranei286 – 30924Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini310 – 35950CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Probable C-C chemokine receptor type 3PRO_0000069242Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi110 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP51678.

Expressioni

Tissue specificityi

Detected in skeletal muscle and in trace amounts in leukocytes.

Gene expression databases

BgeeiP51678.
CleanExiMM_CCR3.
GenevestigatoriP51678.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliP51678.
SMRiP51678. Positions 27-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148353.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP51678.
KOiK04178.
OMAiKKKYKAI.
OrthoDBiEOG738051.
TreeFamiTF330966.

Family and domain databases

InterProiIPR002238. Chemokine_CCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF13. PTHR24227:SF13. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01108. CHEMOKINER3.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51678-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFNTDEIKT VVESFETTPY EYEWAPPCEK VRIKELGSWL LPPLYSLVFI
60 70 80 90 100
IGLLGNMMVV LILIKYRKLQ IMTNIYLFNL AISDLLFLFT VPFWIHYVLW
110 120 130 140 150
NEWGFGHYMC KMLSGFYYLA LYSEIFFIIL LTIDRYLAIV HAVFALRART
160 170 180 190 200
VTFATITSII TWGLAGLAAL PEFIFHESQD SFGEFSCSPR YPEGEEDSWK
210 220 230 240 250
RFHALRMNIF GLALPLLIMV ICYSGIIKTL LRCPNKKKHK AIRLIFVVMI
260 270 280 290 300
VFFIFWTPYN LVLLFSAFHS TFLETSCQQS KHLDLAMQVT EVIAYTHCCI
310 320 330 340 350
NPVIYAFVGE RFRKHLRLFF HRNVAVYLGK YIPFLPGEKM ERTSSVSPST

GEQEISVVF
Length:359
Mass (Da):41,783
Last modified:July 27, 2011 - v2
Checksum:i40DA3C745B8C05A9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti218 – 2181I → V in AAA86118 (PubMed:7594543).Curated
Sequence conflicti218 – 2181I → V in AAA89155 (PubMed:7542241).Curated
Sequence conflicti270 – 2701S → R in AAA86118 (PubMed:7594543).Curated
Sequence conflicti278 – 2781Q → E in AAA86118 (PubMed:7594543).Curated
Sequence conflicti278 – 2781Q → E in AAA89155 (PubMed:7542241).Curated
Sequence conflicti300 – 3001I → V in AAA86118 (PubMed:7594543).Curated
Sequence conflicti300 – 3001I → V in AAA89155 (PubMed:7542241).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29677 Genomic DNA. Translation: AAA86118.1.
U28406 Genomic DNA. Translation: AAA89155.1.
AY049018 Genomic DNA. Translation: AAL13085.1.
AK041106 mRNA. Translation: BAC30823.1.
CH466671 Genomic DNA. Translation: EDL37175.1.
BC108967 mRNA. Translation: AAI08968.1.
BC108968 mRNA. Translation: AAI08969.1.
CCDSiCCDS23668.1.
PIRiI49341.
RefSeqiNP_034044.3. NM_009914.4.
XP_006512487.1. XM_006512424.2.
XP_006512488.1. XM_006512425.2.
UniGeneiMm.57050.

Genome annotation databases

EnsembliENSMUST00000039171; ENSMUSP00000039107; ENSMUSG00000035448.
GeneIDi12771.
KEGGimmu:12771.
UCSCiuc009sha.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29677 Genomic DNA. Translation: AAA86118.1.
U28406 Genomic DNA. Translation: AAA89155.1.
AY049018 Genomic DNA. Translation: AAL13085.1.
AK041106 mRNA. Translation: BAC30823.1.
CH466671 Genomic DNA. Translation: EDL37175.1.
BC108967 mRNA. Translation: AAI08968.1.
BC108968 mRNA. Translation: AAI08969.1.
CCDSiCCDS23668.1.
PIRiI49341.
RefSeqiNP_034044.3. NM_009914.4.
XP_006512487.1. XM_006512424.2.
XP_006512488.1. XM_006512425.2.
UniGeneiMm.57050.

3D structure databases

ProteinModelPortaliP51678.
SMRiP51678. Positions 27-321.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiP51678.
ChEMBLiCHEMBL3406.
GuidetoPHARMACOLOGYi60.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiP51678.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039171; ENSMUSP00000039107; ENSMUSG00000035448.
GeneIDi12771.
KEGGimmu:12771.
UCSCiuc009sha.2. mouse.

Organism-specific databases

CTDi1232.
MGIiMGI:104616. Ccr3.

Phylogenomic databases

eggNOGiNOG148353.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP51678.
KOiK04178.
OMAiKKKYKAI.
OrthoDBiEOG738051.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.
REACT_331048. G alpha (i) signalling events.

Miscellaneous databases

NextBioi282146.
PROiP51678.
SOURCEiSearch...

Gene expression databases

BgeeiP51678.
CleanExiMM_CCR3.
GenevestigatoriP51678.

Family and domain databases

InterProiIPR002238. Chemokine_CCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF13. PTHR24227:SF13. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01108. CHEMOKINER3.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of two murine eosinophil beta chemokine receptors."
    Post T.W., Bozic C.R., Rothenberg M.E., Luster A.D., Gerard N., Gerard C.
    J. Immunol. 155:5299-5305(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  2. "Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor."
    Gao J.-L., Murphy P.M.
    J. Biol. Chem. 270:17494-17501(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  3. "Molecular Cloning of the Murine BALB/C CCR3 Gene."
    Daugherty B.L.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Aorta and Vein.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCCR3_MOUSE
AccessioniPrimary (citable) accession number: P51678
Secondary accession number(s): Q8K3M7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: April 1, 2015
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.