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P51678 (CCR3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable C-C chemokine receptor type 3

Short name=C-C CKR-3
Short name=CC-CKR-3
Short name=CCR-3
Short name=CCR3
Short name=CKR3
Alternative name(s):
Macrophage inflammatory protein 1-alpha receptor-like 2
Short name=MIP-1 alpha RL2
CD_antigen=CD193
Gene names
Name:Ccr3
Synonyms:Cmkbr1l2, Cmkbr3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for a C-C type chemokine. Binds to eotaxin, MCP-3, MCP-4 and RANTES and subsequently transduces a signal by increasing the intracellular calcium ions level.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Detected in skeletal muscle and in trace amounts in leukocytes.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Probable C-C chemokine receptor type 3
PRO_0000069242

Regions

Topological domain1 – 3838Extracellular Potential
Transmembrane39 – 6426Helical; Name=1; Potential
Topological domain65 – 684Cytoplasmic Potential
Transmembrane69 – 9527Helical; Name=2; Potential
Topological domain96 – 11116Extracellular Potential
Transmembrane112 – 13322Helical; Name=3; Potential
Topological domain134 – 15017Cytoplasmic Potential
Transmembrane151 – 17525Helical; Name=4; Potential
Topological domain176 – 20126Extracellular Potential
Transmembrane202 – 22726Helical; Name=5; Potential
Topological domain228 – 24316Cytoplasmic Potential
Transmembrane244 – 26825Helical; Name=6; Potential
Topological domain269 – 28517Extracellular Potential
Transmembrane286 – 30924Helical; Name=7; Potential
Topological domain310 – 35950Cytoplasmic Potential

Amino acid modifications

Disulfide bond110 ↔ 187 By similarity

Experimental info

Sequence conflict2181I → V in AAA86118. Ref.1
Sequence conflict2181I → V in AAA89155. Ref.2
Sequence conflict2701S → R in AAA86118. Ref.1
Sequence conflict2781Q → E in AAA86118. Ref.1
Sequence conflict2781Q → E in AAA89155. Ref.2
Sequence conflict3001I → V in AAA86118. Ref.1
Sequence conflict3001I → V in AAA89155. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P51678 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 40DA3C745B8C05A9

FASTA35941,783
        10         20         30         40         50         60 
MAFNTDEIKT VVESFETTPY EYEWAPPCEK VRIKELGSWL LPPLYSLVFI IGLLGNMMVV 

        70         80         90        100        110        120 
LILIKYRKLQ IMTNIYLFNL AISDLLFLFT VPFWIHYVLW NEWGFGHYMC KMLSGFYYLA 

       130        140        150        160        170        180 
LYSEIFFIIL LTIDRYLAIV HAVFALRART VTFATITSII TWGLAGLAAL PEFIFHESQD 

       190        200        210        220        230        240 
SFGEFSCSPR YPEGEEDSWK RFHALRMNIF GLALPLLIMV ICYSGIIKTL LRCPNKKKHK 

       250        260        270        280        290        300 
AIRLIFVVMI VFFIFWTPYN LVLLFSAFHS TFLETSCQQS KHLDLAMQVT EVIAYTHCCI 

       310        320        330        340        350 
NPVIYAFVGE RFRKHLRLFF HRNVAVYLGK YIPFLPGEKM ERTSSVSPST GEQEISVVF 

« Hide

References

« Hide 'large scale' references
[1]"Molecular characterization of two murine eosinophil beta chemokine receptors."
Post T.W., Bozic C.R., Rothenberg M.E., Luster A.D., Gerard N., Gerard C.
J. Immunol. 155:5299-5305(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[2]"Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor."
Gao J.-L., Murphy P.M.
J. Biol. Chem. 270:17494-17501(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
[3]"Molecular Cloning of the Murine BALB/C CCR3 Gene."
Daugherty B.L.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BALB/c.
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Aorta and Vein.
[5]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U29677 Genomic DNA. Translation: AAA86118.1.
U28406 Genomic DNA. Translation: AAA89155.1.
AY049018 Genomic DNA. Translation: AAL13085.1.
AK041106 mRNA. Translation: BAC30823.1.
CH466671 Genomic DNA. Translation: EDL37175.1.
BC108967 mRNA. Translation: AAI08968.1.
BC108968 mRNA. Translation: AAI08969.1.
PIRI49341.
RefSeqNP_034044.3. NM_009914.4.
XP_006512487.1. XM_006512424.1.
XP_006512488.1. XM_006512425.1.
UniGeneMm.57050.

3D structure databases

ProteinModelPortalP51678.
SMRP51678. Positions 27-321.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP51678.
ChEMBLCHEMBL3406.
GuidetoPHARMACOLOGY60.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEP51678.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000039171; ENSMUSP00000039107; ENSMUSG00000035448.
GeneID12771.
KEGGmmu:12771.
UCSCuc009sha.2. mouse.

Organism-specific databases

CTD1232.
MGIMGI:104616. Ccr3.

Phylogenomic databases

eggNOGNOG148353.
GeneTreeENSGT00700000104407.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidQ8K3M7.
KOK04178.
OMAYIPFLPS.
OrthoDBEOG738051.
TreeFamTF330966.

Gene expression databases

BgeeP51678.
CleanExMM_CCR3.
GenevestigatorP51678.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR002238. Chemokine_CCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF13. PTHR24227:SF13. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00657. CCCHEMOKINER.
PR01108. CHEMOKINER3.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio282146.
PROP51678.
SOURCESearch...

Entry information

Entry nameCCR3_MOUSE
AccessionPrimary (citable) accession number: P51678
Secondary accession number(s): Q8K3M7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries