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Reviewed, UniProtKB/Swiss-Prot P51677 (CCR3_HUMAN)

Last modified November 3, 2009. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    C-C chemokine receptor type 3
      Short name=C-C CKR-3
      Short name=CC-CKR-3
      Short name=CCR-3
      Short name=CCR3
      Short name=CKR3
Alternative name(s):
    Eosinophil eotaxin receptor
    CD_antigen=CD193
Gene names
Name: CCR3
Synonyms: CMKBR3
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.

Subunit structure

Binds to HIV-1 Tat. Ref.11

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

In eosinophils as well as trace amounts in neutrophils and monocytes.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 355355C-C chemokine receptor type 3
PRO_0000069239

Regions

Topological domain1 – 3434Extracellular Potential
Transmembrane35 – 62281 Potential
Topological domain63 – 7210Cytoplasmic Potential
Transmembrane73 – 93212 Potential
Topological domain94 – 10714Extracellular Potential
Transmembrane108 – 129223 Potential
Topological domain130 – 14617Cytoplasmic Potential
Transmembrane147 – 171254 Potential
Topological domain172 – 20332Extracellular Potential
Transmembrane204 – 223205 Potential
Topological domain224 – 23916Cytoplasmic Potential
Transmembrane240 – 264256 Potential
Topological domain265 – 28117Extracellular Potential
Transmembrane282 – 305247 Potential
Topological domain306 – 35550Cytoplasmic Potential

Amino acid modifications

Disulfide bond106 ↔ 183 By similarity

Natural variations

Natural variant211G → D: dbSNP rs4987125.
VAR_020067
Natural variant391P → L: dbSNP rs5742906.
VAR_049382
Natural variant2181C → S Polymorphism found in about 7% of the population; may show reduced activity. Ref.6
VAR_010668

Experimental info

Sequence conflict2761S → T Ref.4
Sequence conflict2761S → T Ref.5

Sequences

Sequence LengthMass (Da)Tools
P51677-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: E95DCD7A6C643874

FASTA35541,044
        10         20         30         40         50         60 
MTTSLDTVET FGTTSYYDDV GLLCEKADTR ALMAQFVPPL YSLVFTVGLL GNVVVVMILI 

        70         80         90        100        110        120 
KYRRLRIMTN IYLLNLAISD LLFLVTLPFW IHYVRGHNWV FGHGMCKLLS GFYHTGLYSE 

       130        140        150        160        170        180 
IFFIILLTID RYLAIVHAVF ALRARTVTFG VITSIVTWGL AVLAALPEFI FYETEELFEE 

       190        200        210        220        230        240 
TLCSALYPED TVYSWRHFHT LRMTIFCLVL PLLVMAICYT GIIKTLLRCP SKKKYKAIRL 

       250        260        270        280        290        300 
IFVIMAVFFI FWTPYNVAIL LSSYQSILFG NDCERSKHLD LVMLVTEVIA YSHCCMNPVI 

       310        320        330        340        350 
YAFVGERFRK YLRHFFHRHL LMHLGRYIPF LPSEKLERTS SVSPSTAEPE LSIVF 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and functional expression of a human eosinophil CC chemokine receptor."
Combadiere C., Ahuja S.K., Murphy P.M.
J. Biol. Chem. 270:16491-16494(1995) [PubMed: 7622448] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Monocyte.
[2]Erratum
Combadiere C., Ahuja S.K., Murphy P.M.
J. Biol. Chem. 270:30235-30235(1995)
[3]"Cloning, expression, and characterization of the human eosinophil eotaxin receptor."
Daugherty B.L., Siciliano S.J., Demartino J.A., Malkowitz L., Sirotina A., Springer M.S.
J. Exp. Med. 183:2349-2354(1996) [PubMed: 8642344] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils."
Ponath P.D., Qin S., Post T.W., Wang J., Wu L., Gerard N.P., Newman W., Gerard C., Mackay C.R.
J. Exp. Med. 183:2437-2448(1996) [PubMed: 8676064] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Partial resistance to infection by syncytium-inducing primary HIV-1 in exposed uninfected individuals homozygous for CCR5 32bp deletion."
Xiao L., Weiss S., Qari S., Rudolph D., Hodge T., Lal R.
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]"New variations of human CC-chemokine receptors CCR3 and CCR4."
Kato H., Tsuchiya N., Izumi S., Miyamasu M., Nakajima T., Kawasaki H., Hirai K., Tokunaga K.
Genes Immun. 1:97-104(1999) [PubMed: 11196669] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-218.
[7]"Transcription regulation of human chemokine receptor CCR3: evidence for a rare TATA-less promoter structure conserved between Drosophila and humans."
Vijh S., Dayhoff D.E., Wang C.E., Imam Z., Ehrenberg P.K., Michael N.L.
Genomics 80:86-95(2002) [PubMed: 12079287] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[8]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[9]Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., Nickerson D.A.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[10]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Blood.
[11]"HIV-1 Tat protein mimicry of chemokines."
Albini A., Ferrini S., Benelli R., Sforzini S., Giunciuglio D., Aluigi M.G., Proudfoot A.E.I., Alouani S., Wells T.N.C., Mariani G., Rabin R.L., Farber J.M., Noonan D.M.
Proc. Natl. Acad. Sci. U.S.A. 95:13153-13158(1998) [PubMed: 9789057] [Abstract]
Cited for: INTERACTION WITH HIV-1 TAT.
+Additional computationally mapped references.

Web resources

Wikipedia

CC chemokine receptors entry

Cross-references

Sequence databases

U28694 mRNA. Translation: AAC50469.1.
U51241 Genomic DNA. Translation: AAB16831.1.
U49727 Genomic DNA. Translation: AAB09726.1.
AF026535 mRNA. Translation: AAB82589.1.
AB023887 Genomic DNA. Translation: BAA86964.1.
AF247361 Genomic DNA. Translation: AAL85154.1.
AY221092 Genomic DNA. Translation: AAO65970.2.
EF064760 Genomic DNA. Translation: ABK41943.1.
BC110297 mRNA. Translation: AAI10298.1.
BC130318 mRNA. Translation: AAI30319.1.
BC130320 mRNA. Translation: AAI30321.1.
IPIIPI00019957.
PIRG02436.
RefSeqNP_001828.1.
NP_847899.1.
UniGeneHs.506190

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:5846N.
STRINGP51677.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEP51677.

Genome annotation databases

EnsemblENST00000357422; ENSP00000350003; ENSG00000183625; Homo sapiens. [Genome view]
ENST00000395940; ENSP00000379271; ENSG00000183625; Homo sapiens. [Genome view]
ENST00000395942; ENSP00000379273; ENSG00000183625; Homo sapiens. [Genome view]
ENST00000439250; ENSP00000402205; ENSG00000183625; Homo sapiens. [Genome view]
ENST00000452454; ENSP00000389336; ENSG00000183625; Homo sapiens. [Genome view]
ENST00000457243; ENSP00000401822; ENSG00000183625; Homo sapiens. [Genome view]
GeneID1232.
KEGGhsa:1232.
UCSCuc003cpg.1. human.

Organism-specific databases

CTD1232.
GeneCardsGC03P046227.
H-InvDBHIX0024274.
HGNCHGNC:1604. CCR3.
HPACAB003795.
MIM601268. gene.
PharmGKBPA26168.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP51677.
HOVERGENP51677.
OMAKTLLRCP.

Enzyme and pathway databases

ReactomeREACT_14797. Signaling by GPCR.

Gene expression databases

ArrayExpressP51677.
BgeeP51677.
CleanExHS_CCR3.
GenevestigatorP51677.
GermOnlineENSG00000183625. Homo sapiens.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR002238. CC_3_rcpt.
IPR000355. Chmkine_rcpt.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00657. CCCHEMOKINER.
PR01108. CHEMOKINER3.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio5025.
SOURCESearch...

Entry information

Entry nameCCR3_HUMAN
AccessionPrimary (citable) accession number: P51677
Secondary accession number(s): Q15748 expand/collapse secondary AC list , Q2YDB9, Q86WD2, Q9ULY8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 3, 2009
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

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List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents