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P51677

- CCR3_HUMAN

UniProt

P51677 - CCR3_HUMAN

Protein

C-C chemokine receptor type 3

Gene

CCR3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.

    GO - Molecular functioni

    1. C-C chemokine receptor activity Source: Ensembl
    2. chemokine receptor activity Source: ProtInc
    3. protein binding Source: IntAct

    GO - Biological processi

    1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: ProtInc
    2. cell adhesion Source: ProtInc
    3. cellular defense response Source: ProtInc
    4. chemokine-mediated signaling pathway Source: GOC
    5. chemotaxis Source: ProtInc
    6. inflammatory response Source: ProtInc
    7. positive regulation of angiogenesis Source: BHF-UCL
    8. positive regulation of cytosolic calcium ion concentration Source: ProtInc
    9. positive regulation of endothelial cell proliferation Source: Ensembl
    10. viral process Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Host-virus interaction

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C chemokine receptor type 3
    Short name:
    C-C CKR-3
    Short name:
    CC-CKR-3
    Short name:
    CCR-3
    Short name:
    CCR3
    Short name:
    CKR3
    Alternative name(s):
    Eosinophil eotaxin receptor
    CD_antigen: CD193
    Gene namesi
    Name:CCR3
    Synonyms:CMKBR3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:1604. CCR3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26168.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 355355C-C chemokine receptor type 3PRO_0000069239Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi106 ↔ 183PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP51677.
    PRIDEiP51677.

    Expressioni

    Tissue specificityi

    In eosinophils as well as trace amounts in neutrophils and monocytes.

    Gene expression databases

    ArrayExpressiP51677.
    BgeeiP51677.
    CleanExiHS_CCR3.
    GenevestigatoriP51677.

    Organism-specific databases

    HPAiCAB003795.

    Interactioni

    Subunit structurei

    Binds to HIV-1 Tat.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CCL11P516712EBI-6625120,EBI-727357

    Protein-protein interaction databases

    BioGridi107637. 7 interactions.
    DIPiDIP-5846N.
    IntActiP51677. 1 interaction.
    MINTiMINT-105239.
    STRINGi9606.ENSP00000350003.

    Structurei

    3D structure databases

    ProteinModelPortaliP51677.
    SMRiP51677. Positions 24-317.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini63 – 7210CytoplasmicSequence Analysis
    Topological domaini94 – 10714ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini130 – 14617CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini172 – 20332ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini224 – 23916CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini265 – 28117ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini306 – 35550CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 6228Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei73 – 9321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei108 – 12922Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei147 – 17125Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei204 – 22320Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei240 – 26425Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei282 – 30524Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148353.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiP51677.
    KOiK04178.
    OMAiYIPFLPS.
    OrthoDBiEOG738051.
    PhylomeDBiP51677.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR002238. Chemokine_CCR3.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF13. PTHR24227:SF13. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR01108. CHEMOKINER3.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P51677-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTTSLDTVET FGTTSYYDDV GLLCEKADTR ALMAQFVPPL YSLVFTVGLL    50
    GNVVVVMILI KYRRLRIMTN IYLLNLAISD LLFLVTLPFW IHYVRGHNWV 100
    FGHGMCKLLS GFYHTGLYSE IFFIILLTID RYLAIVHAVF ALRARTVTFG 150
    VITSIVTWGL AVLAALPEFI FYETEELFEE TLCSALYPED TVYSWRHFHT 200
    LRMTIFCLVL PLLVMAICYT GIIKTLLRCP SKKKYKAIRL IFVIMAVFFI 250
    FWTPYNVAIL LSSYQSILFG NDCERSKHLD LVMLVTEVIA YSHCCMNPVI 300
    YAFVGERFRK YLRHFFHRHL LMHLGRYIPF LPSEKLERTS SVSPSTAEPE 350
    LSIVF 355
    Length:355
    Mass (Da):41,044
    Last modified:October 1, 1996 - v1
    Checksum:iE95DCD7A6C643874
    GO
    Isoform 2 (identifier: P51677-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MPFGIRMLLRAHKPGSSRRSEM

    Note: Gene prediction based on EST data.

    Show »
    Length:376
    Mass (Da):43,453
    Checksum:i422D094FF3497FE4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti81 – 822LL → QG in AAL85630. (PubMed:12079287)Curated
    Sequence conflicti205 – 2051I → V in BAG53863. (PubMed:14702039)Curated
    Sequence conflicti276 – 2761S → T in AAB09726. (PubMed:8676064)Curated
    Sequence conflicti276 – 2761S → T in BAA86964. (PubMed:11196669)Curated
    Sequence conflicti277 – 2771K → R in BAG53863. (PubMed:14702039)Curated
    Sequence conflicti349 – 3491P → R in BAG53863. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti21 – 211G → D.
    Corresponds to variant rs4987125 [ dbSNP | Ensembl ].
    VAR_020067
    Natural varianti39 – 391P → L.
    Corresponds to variant rs5742906 [ dbSNP | Ensembl ].
    VAR_049382
    Natural varianti218 – 2181C → S Polymorphism found in about 7% of the population; may show reduced activity. 1 Publication
    VAR_010668

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MPFGIRMLLRAHKPGSSRRS EM in isoform 2. CuratedVSP_046704

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28694 mRNA. Translation: AAC50469.1.
    U51241 Genomic DNA. Translation: AAB16831.1.
    U49727 Genomic DNA. Translation: AAB09726.1.
    AF026535 mRNA. Translation: AAB82589.1.
    AB023887 Genomic DNA. Translation: BAA86964.1.
    AF262301 mRNA. Translation: AAL85630.1.
    AF247361 Genomic DNA. Translation: AAL85154.1.
    AY221092 Genomic DNA. Translation: AAO65970.2.
    EF064760 Genomic DNA. Translation: ABK41943.1.
    AK123050 mRNA. Translation: BAG53863.1.
    AC104439 Genomic DNA. No translation available.
    BC110297 mRNA. Translation: AAI10298.1.
    BC130318 mRNA. Translation: AAI30319.1.
    BC130320 mRNA. Translation: AAI30321.1.
    CCDSiCCDS2738.1. [P51677-1]
    CCDS54574.1. [P51677-2]
    PIRiG02436.
    RefSeqiNP_001828.1. NM_001837.3. [P51677-1]
    NP_847898.1. NM_178328.1. [P51677-2]
    NP_847899.1. NM_178329.2. [P51677-1]
    XP_006713023.1. XM_006712960.1. [P51677-1]
    UniGeneiHs.506190.

    Genome annotation databases

    EnsembliENST00000357422; ENSP00000350003; ENSG00000183625. [P51677-1]
    ENST00000395940; ENSP00000379271; ENSG00000183625. [P51677-1]
    ENST00000395942; ENSP00000379273; ENSG00000183625. [P51677-1]
    ENST00000545097; ENSP00000441600; ENSG00000183625. [P51677-2]
    GeneIDi1232.
    KEGGihsa:1232.
    UCSCiuc003cpg.2. human. [P51677-1]

    Polymorphism databases

    DMDMi1705892.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CC chemokine receptors entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28694 mRNA. Translation: AAC50469.1 .
    U51241 Genomic DNA. Translation: AAB16831.1 .
    U49727 Genomic DNA. Translation: AAB09726.1 .
    AF026535 mRNA. Translation: AAB82589.1 .
    AB023887 Genomic DNA. Translation: BAA86964.1 .
    AF262301 mRNA. Translation: AAL85630.1 .
    AF247361 Genomic DNA. Translation: AAL85154.1 .
    AY221092 Genomic DNA. Translation: AAO65970.2 .
    EF064760 Genomic DNA. Translation: ABK41943.1 .
    AK123050 mRNA. Translation: BAG53863.1 .
    AC104439 Genomic DNA. No translation available.
    BC110297 mRNA. Translation: AAI10298.1 .
    BC130318 mRNA. Translation: AAI30319.1 .
    BC130320 mRNA. Translation: AAI30321.1 .
    CCDSi CCDS2738.1. [P51677-1 ]
    CCDS54574.1. [P51677-2 ]
    PIRi G02436.
    RefSeqi NP_001828.1. NM_001837.3. [P51677-1 ]
    NP_847898.1. NM_178328.1. [P51677-2 ]
    NP_847899.1. NM_178329.2. [P51677-1 ]
    XP_006713023.1. XM_006712960.1. [P51677-1 ]
    UniGenei Hs.506190.

    3D structure databases

    ProteinModelPortali P51677.
    SMRi P51677. Positions 24-317.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107637. 7 interactions.
    DIPi DIP-5846N.
    IntActi P51677. 1 interaction.
    MINTi MINT-105239.
    STRINGi 9606.ENSP00000350003.

    Chemistry

    BindingDBi P51677.
    ChEMBLi CHEMBL3473.
    GuidetoPHARMACOLOGYi 60.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 1705892.

    Proteomic databases

    PaxDbi P51677.
    PRIDEi P51677.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357422 ; ENSP00000350003 ; ENSG00000183625 . [P51677-1 ]
    ENST00000395940 ; ENSP00000379271 ; ENSG00000183625 . [P51677-1 ]
    ENST00000395942 ; ENSP00000379273 ; ENSG00000183625 . [P51677-1 ]
    ENST00000545097 ; ENSP00000441600 ; ENSG00000183625 . [P51677-2 ]
    GeneIDi 1232.
    KEGGi hsa:1232.
    UCSCi uc003cpg.2. human. [P51677-1 ]

    Organism-specific databases

    CTDi 1232.
    GeneCardsi GC03P046227.
    HGNCi HGNC:1604. CCR3.
    HPAi CAB003795.
    MIMi 601268. gene.
    neXtProti NX_P51677.
    PharmGKBi PA26168.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG148353.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi P51677.
    KOi K04178.
    OMAi YIPFLPS.
    OrthoDBi EOG738051.
    PhylomeDBi P51677.
    TreeFami TF330966.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GenomeRNAii 1232.
    NextBioi 5025.
    PROi P51677.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51677.
    Bgeei P51677.
    CleanExi HS_CCR3.
    Genevestigatori P51677.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR002238. Chemokine_CCR3.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF13. PTHR24227:SF13. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR01108. CHEMOKINER3.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and functional expression of a human eosinophil CC chemokine receptor."
      Combadiere C., Ahuja S.K., Murphy P.M.
      J. Biol. Chem. 270:16491-16494(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Monocyte.
    2. Erratum
      Combadiere C., Ahuja S.K., Murphy P.M.
      J. Biol. Chem. 270:30235-30235(1995)
    3. "Cloning, expression, and characterization of the human eosinophil eotaxin receptor."
      Daugherty B.L., Siciliano S.J., Demartino J.A., Malkowitz L., Sirotina A., Springer M.S.
      J. Exp. Med. 183:2349-2354(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    4. "Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils."
      Ponath P.D., Qin S., Post T.W., Wang J., Wu L., Gerard N.P., Newman W., Gerard C., Mackay C.R.
      J. Exp. Med. 183:2437-2448(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    5. "Partial resistance to infection by syncytium-inducing primary HIV-1 in exposed uninfected individuals homozygous for CCR5 32bp deletion."
      Xiao L., Weiss S., Qari S., Rudolph D., Hodge T., Lal R.
      Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    6. "New variations of human CC-chemokine receptors CCR3 and CCR4."
      Kato H., Tsuchiya N., Izumi S., Miyamasu M., Nakajima T., Kawasaki H., Hirai K., Tokunaga K.
      Genes Immun. 1:97-104(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANT SER-218.
    7. "Transcription regulation of human chemokine receptor CCR3: evidence for a rare TATA-less promoter structure conserved between Drosophila and humans."
      Vijh S., Dayhoff D.E., Wang C.E., Imam Z., Ehrenberg P.K., Michael N.L.
      Genomics 80:86-95(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    8. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    9. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    10. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Synovium.
    11. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Blood.
    13. Cited for: INTERACTION WITH HIV-1 TAT.
    14. "Increased expression of chemokine receptor CCR3 and its ligands in ulcerative colitis: the role of colonic epithelial cells in in vitro studies."
      Manousou P., Kolios G., Valatas V., Drygiannakis I., Bourikas L., Pyrovolaki K., Koutroubakis I., Papadaki H.A., Kouroumalis E.
      Clin. Exp. Immunol. 162:337-347(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: OVEREXPRESSION.

    Entry informationi

    Entry nameiCCR3_HUMAN
    AccessioniPrimary (citable) accession number: P51677
    Secondary accession number(s): B3KVQ1
    , F5GWL6, Q15748, Q2YDB9, Q86WD2, Q8TDP6, Q9ULY8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 141 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Overexpression of CCR3 together with its ligands appears to be a characteristic of ulcerative colitis (UC). The production of CCR3 ligands by human colonic epithelial cells suggests further that the epithelium can play a role in modulating pathological T-cell-mediated mucosal inflammation (PubMed:21077277).1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    3. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    4. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3