C-C chemokine receptor type 3 - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot P51677 (CCR3_HUMAN)

Last modified November 3, 2009. Version 92. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    C-C chemokine receptor type 3
      Short name=C-C CKR-3
      Short name=CC-CKR-3
      Short name=CCR-3
      Short name=CCR3
      Short name=CKR3
Alternative name(s):
    Eosinophil eotaxin receptor
    CD_antigen=CD193

Gene names

Name:	CCR3
Synonyms:	CMKBR3

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	355 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
Subunit structure	Binds to HIV-1 Tat. Ref.11
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	In eosinophils as well as trace amounts in neutrophils and monocytes.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

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Ontologies

Keywords
Biological process	Host-virus interaction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	G-protein signaling, coupled to cAMP nucleotide second messenger Traceable author statement. Source: ProtInc cell adhesion Traceable author statement. Source: ProtInc cellular defense response Traceable author statement. Source: ProtInc chemotaxis Traceable author statement. Source: ProtInc elevation of cytosolic calcium ion concentration Traceable author statement. Source: ProtInc inflammatory response Traceable author statement. Source: ProtInc interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 355

355

C-C chemokine receptor type 3

PRO_0000069239

Regions

Topological domain

1 – 34

Extracellular Potential

Transmembrane

35 – 62

1 Potential

Topological domain

63 – 72

Cytoplasmic Potential

Transmembrane

73 – 93

2 Potential

Topological domain

94 – 107

Extracellular Potential

Transmembrane

108 – 129

3 Potential

Topological domain

130 – 146

Cytoplasmic Potential

Transmembrane

147 – 171

4 Potential

Topological domain

172 – 203

Extracellular Potential

Transmembrane

204 – 223

5 Potential

Topological domain

224 – 239

Cytoplasmic Potential

Transmembrane

240 – 264

6 Potential

Topological domain

265 – 281

Extracellular Potential

Transmembrane

282 – 305

7 Potential

Topological domain

306 – 355

Cytoplasmic Potential

Amino acid modifications

Disulfide bond

106 ↔ 183

By similarity

Natural variations

Natural variant

G → D: dbSNP rs4987125.

VAR_020067

Natural variant

P → L: dbSNP rs5742906.

VAR_049382

Natural variant

218

C → S Polymorphism found in about 7% of the population; may show reduced activity. Ref.6

VAR_010668

Experimental info

Sequence conflict

276

S → T Ref.4

Sequence conflict

276

S → T Ref.5

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Sequences

Sequence

Length

Mass (Da)

Tools

P51677-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: E95DCD7A6C643874
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FASTA

355

41,044

        10         20         30         40         50         60 
MTTSLDTVET FGTTSYYDDV GLLCEKADTR ALMAQFVPPL YSLVFTVGLL GNVVVVMILI 

        70         80         90        100        110        120 
KYRRLRIMTN IYLLNLAISD LLFLVTLPFW IHYVRGHNWV FGHGMCKLLS GFYHTGLYSE 

       130        140        150        160        170        180 
IFFIILLTID RYLAIVHAVF ALRARTVTFG VITSIVTWGL AVLAALPEFI FYETEELFEE 

       190        200        210        220        230        240 
TLCSALYPED TVYSWRHFHT LRMTIFCLVL PLLVMAICYT GIIKTLLRCP SKKKYKAIRL 

       250        260        270        280        290        300 
IFVIMAVFFI FWTPYNVAIL LSSYQSILFG NDCERSKHLD LVMLVTEVIA YSHCCMNPVI 

       310        320        330        340        350 
YAFVGERFRK YLRHFFHRHL LMHLGRYIPF LPSEKLERTS SVSPSTAEPE LSIVF

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and functional expression of a human eosinophil CC chemokine receptor." Combadiere C., Ahuja S.K., Murphy P.M. J. Biol. Chem. 270:16491-16494(1995) [PubMed: 7622448] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Monocyte.
[2]	Erratum Combadiere C., Ahuja S.K., Murphy P.M. J. Biol. Chem. 270:30235-30235(1995)
[3]	"Cloning, expression, and characterization of the human eosinophil eotaxin receptor." Daugherty B.L., Siciliano S.J., Demartino J.A., Malkowitz L., Sirotina A., Springer M.S. J. Exp. Med. 183:2349-2354(1996) [PubMed: 8642344] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils." Ponath P.D., Qin S., Post T.W., Wang J., Wu L., Gerard N.P., Newman W., Gerard C., Mackay C.R. J. Exp. Med. 183:2437-2448(1996) [PubMed: 8676064] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"Partial resistance to infection by syncytium-inducing primary HIV-1 in exposed uninfected individuals homozygous for CCR5 32bp deletion." Xiao L., Weiss S., Qari S., Rudolph D., Hodge T., Lal R. Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]	"New variations of human CC-chemokine receptors CCR3 and CCR4." Kato H., Tsuchiya N., Izumi S., Miyamasu M., Nakajima T., Kawasaki H., Hirai K., Tokunaga K. Genes Immun. 1:97-104(1999) [PubMed: 11196669] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-218.
[7]	"Transcription regulation of human chemokine receptor CCR3: evidence for a rare TATA-less promoter structure conserved between Drosophila and humans." Vijh S., Dayhoff D.E., Wang C.E., Imam Z., Ehrenberg P.K., Michael N.L. Genomics 80:86-95(2002) [PubMed: 12079287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[8]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[9]	Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., Nickerson D.A. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[10]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood.
[11]	"HIV-1 Tat protein mimicry of chemokines." Albini A., Ferrini S., Benelli R., Sforzini S., Giunciuglio D., Aluigi M.G., Proudfoot A.E.I., Alouani S., Wells T.N.C., Mariani G., Rabin R.L., Farber J.M., Noonan D.M. Proc. Natl. Acad. Sci. U.S.A. 95:13153-13158(1998) [PubMed: 9789057] [Abstract] Cited for: INTERACTION WITH HIV-1 TAT.
+	Additional computationally mapped references.

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Web resources

Wikipedia

CC chemokine receptors entry

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Cross-references

Sequence databases
	U28694 mRNA. Translation: AAC50469.1. U51241 Genomic DNA. Translation: AAB16831.1. U49727 Genomic DNA. Translation: AAB09726.1. AF026535 mRNA. Translation: AAB82589.1. AB023887 Genomic DNA. Translation: BAA86964.1. AF247361 Genomic DNA. Translation: AAL85154.1. AY221092 Genomic DNA. Translation: AAO65970.2. EF064760 Genomic DNA. Translation: ABK41943.1. BC110297 mRNA. Translation: AAI10298.1. BC130318 mRNA. Translation: AAI30319.1. BC130320 mRNA. Translation: AAI30321.1.
IPI	IPI00019957.
PIR	G02436.
RefSeq	NP_001828.1. NP_847899.1.
UniGene	Hs.506190
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:5846N.
STRING	P51677.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	P51677.
Genome annotation databases
Ensembl	ENST00000357422; ENSP00000350003; ENSG00000183625; Homo sapiens. [Genome view] ENST00000395940; ENSP00000379271; ENSG00000183625; Homo sapiens. [Genome view] ENST00000395942; ENSP00000379273; ENSG00000183625; Homo sapiens. [Genome view] ENST00000439250; ENSP00000402205; ENSG00000183625; Homo sapiens. [Genome view] ENST00000452454; ENSP00000389336; ENSG00000183625; Homo sapiens. [Genome view] ENST00000457243; ENSP00000401822; ENSG00000183625; Homo sapiens. [Genome view]
GeneID	1232.
KEGG	hsa:1232.
UCSC	uc003cpg.1. human.
Organism-specific databases
CTD	1232.
GeneCards	GC03P046227.
H-InvDB	HIX0024274.
HGNC	HGNC:1604. CCR3.
HPA	CAB003795.
MIM	601268. gene.
PharmGKB	PA26168.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P51677.
HOVERGEN	P51677.
OMA	KTLLRCP.
Enzyme and pathway databases
Reactome	REACT_14797. Signaling by GPCR.
Gene expression databases
ArrayExpress	P51677.
Bgee	P51677.
CleanEx	HS_CCR3.
Genevestigator	P51677.
GermOnline	ENSG00000183625. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR002238. CC_3_rcpt. IPR000355. Chmkine_rcpt. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR01108. CHEMOKINER3. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	5025.
SOURCE	Search...

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Entry information

Entry name

CCR3_HUMAN

Accession

Primary (citable) accession number: P51677
Secondary accession number(s): Q15748

Q9ULY8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 3, 2009
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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