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P51677

- CCR3_HUMAN

UniProt

P51677 - CCR3_HUMAN

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Protein

C-C chemokine receptor type 3

Gene

CCR3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.

GO - Molecular functioni

  1. C-C chemokine receptor activity Source: Ensembl
  2. chemokine receptor activity Source: ProtInc

GO - Biological processi

  1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: ProtInc
  2. cell adhesion Source: ProtInc
  3. cellular defense response Source: ProtInc
  4. chemokine-mediated signaling pathway Source: GOC
  5. chemotaxis Source: ProtInc
  6. inflammatory response Source: ProtInc
  7. positive regulation of angiogenesis Source: BHF-UCL
  8. positive regulation of cytosolic calcium ion concentration Source: ProtInc
  9. positive regulation of endothelial cell proliferation Source: Ensembl
  10. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 3
Short name:
C-C CKR-3
Short name:
CC-CKR-3
Short name:
CCR-3
Short name:
CCR3
Short name:
CKR3
Alternative name(s):
Eosinophil eotaxin receptor
CD_antigen: CD193
Gene namesi
Name:CCR3
Synonyms:CMKBR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:1604. CCR3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434ExtracellularSequence AnalysisAdd
BLAST
Transmembranei35 – 6228Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini63 – 7210CytoplasmicSequence Analysis
Transmembranei73 – 9321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini94 – 10714ExtracellularSequence AnalysisAdd
BLAST
Transmembranei108 – 12922Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini130 – 14617CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei147 – 17125Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini172 – 20332ExtracellularSequence AnalysisAdd
BLAST
Transmembranei204 – 22320Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini224 – 23916CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei240 – 26425Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini265 – 28117ExtracellularSequence AnalysisAdd
BLAST
Transmembranei282 – 30524Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini306 – 35550CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26168.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355C-C chemokine receptor type 3PRO_0000069239Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi106 ↔ 183PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP51677.
PRIDEiP51677.

Expressioni

Tissue specificityi

In eosinophils as well as trace amounts in neutrophils and monocytes.

Gene expression databases

BgeeiP51677.
CleanExiHS_CCR3.
ExpressionAtlasiP51677. baseline and differential.
GenevestigatoriP51677.

Organism-specific databases

HPAiCAB003795.

Interactioni

Subunit structurei

Binds to HIV-1 Tat.

Binary interactionsi

WithEntry#Exp.IntActNotes
CCL11P516712EBI-6625120,EBI-727357

Protein-protein interaction databases

BioGridi107637. 7 interactions.
DIPiDIP-5846N.
IntActiP51677. 1 interaction.
MINTiMINT-105239.
STRINGi9606.ENSP00000350003.

Structurei

3D structure databases

ProteinModelPortaliP51677.
SMRiP51677. Positions 24-317.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148353.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP51677.
KOiK04178.
OMAiYIPFLPS.
OrthoDBiEOG738051.
PhylomeDBiP51677.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR002238. Chemokine_CCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF13. PTHR24227:SF13. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01108. CHEMOKINER3.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P51677-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTSLDTVET FGTTSYYDDV GLLCEKADTR ALMAQFVPPL YSLVFTVGLL
60 70 80 90 100
GNVVVVMILI KYRRLRIMTN IYLLNLAISD LLFLVTLPFW IHYVRGHNWV
110 120 130 140 150
FGHGMCKLLS GFYHTGLYSE IFFIILLTID RYLAIVHAVF ALRARTVTFG
160 170 180 190 200
VITSIVTWGL AVLAALPEFI FYETEELFEE TLCSALYPED TVYSWRHFHT
210 220 230 240 250
LRMTIFCLVL PLLVMAICYT GIIKTLLRCP SKKKYKAIRL IFVIMAVFFI
260 270 280 290 300
FWTPYNVAIL LSSYQSILFG NDCERSKHLD LVMLVTEVIA YSHCCMNPVI
310 320 330 340 350
YAFVGERFRK YLRHFFHRHL LMHLGRYIPF LPSEKLERTS SVSPSTAEPE

LSIVF
Length:355
Mass (Da):41,044
Last modified:October 1, 1996 - v1
Checksum:iE95DCD7A6C643874
GO
Isoform 2 (identifier: P51677-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPFGIRMLLRAHKPGSSRRSEM

Note: Gene prediction based on EST data.

Show »
Length:376
Mass (Da):43,453
Checksum:i422D094FF3497FE4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 822LL → QG in AAL85630. (PubMed:12079287)Curated
Sequence conflicti205 – 2051I → V in BAG53863. (PubMed:14702039)Curated
Sequence conflicti276 – 2761S → T in AAB09726. (PubMed:8676064)Curated
Sequence conflicti276 – 2761S → T in BAA86964. (PubMed:11196669)Curated
Sequence conflicti277 – 2771K → R in BAG53863. (PubMed:14702039)Curated
Sequence conflicti349 – 3491P → R in BAG53863. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211G → D.
Corresponds to variant rs4987125 [ dbSNP | Ensembl ].
VAR_020067
Natural varianti39 – 391P → L.
Corresponds to variant rs5742906 [ dbSNP | Ensembl ].
VAR_049382
Natural varianti218 – 2181C → S Polymorphism found in about 7% of the population; may show reduced activity. 1 Publication
VAR_010668

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MPFGIRMLLRAHKPGSSRRS EM in isoform 2. CuratedVSP_046704

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28694 mRNA. Translation: AAC50469.1.
U51241 Genomic DNA. Translation: AAB16831.1.
U49727 Genomic DNA. Translation: AAB09726.1.
AF026535 mRNA. Translation: AAB82589.1.
AB023887 Genomic DNA. Translation: BAA86964.1.
AF262301 mRNA. Translation: AAL85630.1.
AF247361 Genomic DNA. Translation: AAL85154.1.
AY221092 Genomic DNA. Translation: AAO65970.2.
EF064760 Genomic DNA. Translation: ABK41943.1.
AK123050 mRNA. Translation: BAG53863.1.
AC104439 Genomic DNA. No translation available.
BC110297 mRNA. Translation: AAI10298.1.
BC130318 mRNA. Translation: AAI30319.1.
BC130320 mRNA. Translation: AAI30321.1.
CCDSiCCDS2738.1. [P51677-1]
CCDS54574.1. [P51677-2]
PIRiG02436.
RefSeqiNP_001828.1. NM_001837.3. [P51677-1]
NP_847898.1. NM_178328.1. [P51677-2]
NP_847899.1. NM_178329.2. [P51677-1]
XP_006713023.1. XM_006712960.1. [P51677-1]
UniGeneiHs.506190.

Genome annotation databases

EnsembliENST00000357422; ENSP00000350003; ENSG00000183625. [P51677-1]
ENST00000395940; ENSP00000379271; ENSG00000183625. [P51677-1]
ENST00000395942; ENSP00000379273; ENSG00000183625. [P51677-1]
ENST00000545097; ENSP00000441600; ENSG00000183625. [P51677-2]
GeneIDi1232.
KEGGihsa:1232.
UCSCiuc003cpg.2. human. [P51677-1]

Polymorphism databases

DMDMi1705892.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CC chemokine receptors entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28694 mRNA. Translation: AAC50469.1 .
U51241 Genomic DNA. Translation: AAB16831.1 .
U49727 Genomic DNA. Translation: AAB09726.1 .
AF026535 mRNA. Translation: AAB82589.1 .
AB023887 Genomic DNA. Translation: BAA86964.1 .
AF262301 mRNA. Translation: AAL85630.1 .
AF247361 Genomic DNA. Translation: AAL85154.1 .
AY221092 Genomic DNA. Translation: AAO65970.2 .
EF064760 Genomic DNA. Translation: ABK41943.1 .
AK123050 mRNA. Translation: BAG53863.1 .
AC104439 Genomic DNA. No translation available.
BC110297 mRNA. Translation: AAI10298.1 .
BC130318 mRNA. Translation: AAI30319.1 .
BC130320 mRNA. Translation: AAI30321.1 .
CCDSi CCDS2738.1. [P51677-1 ]
CCDS54574.1. [P51677-2 ]
PIRi G02436.
RefSeqi NP_001828.1. NM_001837.3. [P51677-1 ]
NP_847898.1. NM_178328.1. [P51677-2 ]
NP_847899.1. NM_178329.2. [P51677-1 ]
XP_006713023.1. XM_006712960.1. [P51677-1 ]
UniGenei Hs.506190.

3D structure databases

ProteinModelPortali P51677.
SMRi P51677. Positions 24-317.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107637. 7 interactions.
DIPi DIP-5846N.
IntActi P51677. 1 interaction.
MINTi MINT-105239.
STRINGi 9606.ENSP00000350003.

Chemistry

BindingDBi P51677.
ChEMBLi CHEMBL3473.
GuidetoPHARMACOLOGYi 60.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 1705892.

Proteomic databases

PaxDbi P51677.
PRIDEi P51677.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000357422 ; ENSP00000350003 ; ENSG00000183625 . [P51677-1 ]
ENST00000395940 ; ENSP00000379271 ; ENSG00000183625 . [P51677-1 ]
ENST00000395942 ; ENSP00000379273 ; ENSG00000183625 . [P51677-1 ]
ENST00000545097 ; ENSP00000441600 ; ENSG00000183625 . [P51677-2 ]
GeneIDi 1232.
KEGGi hsa:1232.
UCSCi uc003cpg.2. human. [P51677-1 ]

Organism-specific databases

CTDi 1232.
GeneCardsi GC03P046227.
HGNCi HGNC:1604. CCR3.
HPAi CAB003795.
MIMi 601268. gene.
neXtProti NX_P51677.
PharmGKBi PA26168.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG148353.
GeneTreei ENSGT00760000118785.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi P51677.
KOi K04178.
OMAi YIPFLPS.
OrthoDBi EOG738051.
PhylomeDBi P51677.
TreeFami TF330966.

Enzyme and pathway databases

Reactomei REACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GenomeRNAii 1232.
NextBioi 5025.
PROi P51677.
SOURCEi Search...

Gene expression databases

Bgeei P51677.
CleanExi HS_CCR3.
ExpressionAtlasi P51677. baseline and differential.
Genevestigatori P51677.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR002238. Chemokine_CCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
PTHR24227:SF13. PTHR24227:SF13. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00657. CCCHEMOKINER.
PR01108. CHEMOKINER3.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional expression of a human eosinophil CC chemokine receptor."
    Combadiere C., Ahuja S.K., Murphy P.M.
    J. Biol. Chem. 270:16491-16494(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Monocyte.
  2. Erratum
    Combadiere C., Ahuja S.K., Murphy P.M.
    J. Biol. Chem. 270:30235-30235(1995)
  3. "Cloning, expression, and characterization of the human eosinophil eotaxin receptor."
    Daugherty B.L., Siciliano S.J., Demartino J.A., Malkowitz L., Sirotina A., Springer M.S.
    J. Exp. Med. 183:2349-2354(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  4. "Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils."
    Ponath P.D., Qin S., Post T.W., Wang J., Wu L., Gerard N.P., Newman W., Gerard C., Mackay C.R.
    J. Exp. Med. 183:2437-2448(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  5. "Partial resistance to infection by syncytium-inducing primary HIV-1 in exposed uninfected individuals homozygous for CCR5 32bp deletion."
    Xiao L., Weiss S., Qari S., Rudolph D., Hodge T., Lal R.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  6. "New variations of human CC-chemokine receptors CCR3 and CCR4."
    Kato H., Tsuchiya N., Izumi S., Miyamasu M., Nakajima T., Kawasaki H., Hirai K., Tokunaga K.
    Genes Immun. 1:97-104(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANT SER-218.
  7. "Transcription regulation of human chemokine receptor CCR3: evidence for a rare TATA-less promoter structure conserved between Drosophila and humans."
    Vijh S., Dayhoff D.E., Wang C.E., Imam Z., Ehrenberg P.K., Michael N.L.
    Genomics 80:86-95(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  8. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  9. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  10. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Synovium.
  11. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Blood.
  13. Cited for: INTERACTION WITH HIV-1 TAT.
  14. "Increased expression of chemokine receptor CCR3 and its ligands in ulcerative colitis: the role of colonic epithelial cells in in vitro studies."
    Manousou P., Kolios G., Valatas V., Drygiannakis I., Bourikas L., Pyrovolaki K., Koutroubakis I., Papadaki H.A., Kouroumalis E.
    Clin. Exp. Immunol. 162:337-347(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: OVEREXPRESSION.

Entry informationi

Entry nameiCCR3_HUMAN
AccessioniPrimary (citable) accession number: P51677
Secondary accession number(s): B3KVQ1
, F5GWL6, Q15748, Q2YDB9, Q86WD2, Q8TDP6, Q9ULY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Overexpression of CCR3 together with its ligands appears to be a characteristic of ulcerative colitis (UC). The production of CCR3 ligands by human colonic epithelial cells suggests further that the epithelium can play a role in modulating pathological T-cell-mediated mucosal inflammation (PubMed:21077277).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3