P51677 (CCR3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-C chemokine receptor type 3
Short name=C-C CKR-3
Short name=CC-CKR-3
Short name=CCR-3
Short name=CCR3
Short name=CKR3

Alternative name(s):
Eosinophil eotaxin receptor
CD_antigen=CD193

Gene names

Name:	CCR3
Synonyms:	CMKBR3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	355 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
Subunit structure	Binds to HIV-1 Tat. Ref.12
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	In eosinophils as well as trace amounts in neutrophils and monocytes.
Miscellaneous	Overexpression of CCR3 together with its ligands appears to be a characteristic of ulcerative colitis (UC). The production of CCR3 ligands by human colonic epithelial cells suggests further that the epithelium can play a role in modulating pathological T-cell-mediated mucosal inflammation (Ref.13).
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Host-virus interaction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adenylate cyclase-modulating G-protein coupled receptor signaling pathway Traceable author statement PubMed 10201960. Source: ProtInc cell adhesion Traceable author statement PubMed 10201960. Source: ProtInc cellular defense response Traceable author statement PubMed 10713092. Source: ProtInc chemotaxis Traceable author statement PubMed 10201960. Source: ProtInc elevation of cytosolic calcium ion concentration Traceable author statement PubMed 9302298. Source: ProtInc inflammatory response Traceable author statement PubMed 9302298. Source: ProtInc positive regulation of angiogenesis Inferred from mutant phenotype PubMed 19525930. Source: BHF-UCL virus-host interaction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to plasma membrane Traceable author statement PubMed 9302298. Source: ProtInc
Molecular_function	C-C chemokine receptor activity Inferred from electronic annotation. Source: InterPro chemokine receptor activity Traceable author statement PubMed 10415069. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 355	355	C-C chemokine receptor type 3		PRO_0000069239
Regions
	Topological domain	1 – 34	34	Extracellular Potential
	Transmembrane	35 – 62	28	Helical; Name=1; Potential
	Topological domain	63 – 72	10	Cytoplasmic Potential
	Transmembrane	73 – 93	21	Helical; Name=2; Potential
	Topological domain	94 – 107	14	Extracellular Potential
	Transmembrane	108 – 129	22	Helical; Name=3; Potential
	Topological domain	130 – 146	17	Cytoplasmic Potential
	Transmembrane	147 – 171	25	Helical; Name=4; Potential
	Topological domain	172 – 203	32	Extracellular Potential
	Transmembrane	204 – 223	20	Helical; Name=5; Potential
	Topological domain	224 – 239	16	Cytoplasmic Potential
	Transmembrane	240 – 264	25	Helical; Name=6; Potential
	Topological domain	265 – 281	17	Extracellular Potential
	Transmembrane	282 – 305	24	Helical; Name=7; Potential
	Topological domain	306 – 355	50	Cytoplasmic Potential
Amino acid modifications
	Disulfide bond	106 ↔ 183		By similarity
Natural variations
	Natural variant	21	1	G → D. Corresponds to variant rs4987125 [ dbSNP | Ensembl ].		VAR_020067
	Natural variant	39	1	P → L. Corresponds to variant rs5742906 [ dbSNP | Ensembl ].		VAR_049382
	Natural variant	218	1	C → S Polymorphism found in about 7% of the population; may show reduced activity. Ref.6		VAR_010668
Experimental info
	Sequence conflict	205	1	I → V in BAG53863. Ref.10
	Sequence conflict	276	1	S → T in AAB09726. Ref.4
	Sequence conflict	276	1	S → T in BAA86964. Ref.6
	Sequence conflict	277	1	K → R in BAG53863. Ref.10
	Sequence conflict	349	1	P → R in BAG53863. Ref.10

Sequences

	Sequence		Length	Mass (Da)
	P51677 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: E95DCD7A6C643874	FASTA	355	41,044
	10 20 30 40 50 60 MTTSLDTVET FGTTSYYDDV GLLCEKADTR ALMAQFVPPL YSLVFTVGLL GNVVVVMILI 70 80 90 100 110 120 KYRRLRIMTN IYLLNLAISD LLFLVTLPFW IHYVRGHNWV FGHGMCKLLS GFYHTGLYSE 130 140 150 160 170 180 IFFIILLTID RYLAIVHAVF ALRARTVTFG VITSIVTWGL AVLAALPEFI FYETEELFEE 190 200 210 220 230 240 TLCSALYPED TVYSWRHFHT LRMTIFCLVL PLLVMAICYT GIIKTLLRCP SKKKYKAIRL 250 260 270 280 290 300 IFVIMAVFFI FWTPYNVAIL LSSYQSILFG NDCERSKHLD LVMLVTEVIA YSHCCMNPVI 310 320 330 340 350 YAFVGERFRK YLRHFFHRHL LMHLGRYIPF LPSEKLERTS SVSPSTAEPE LSIVF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and functional expression of a human eosinophil CC chemokine receptor." Combadiere C., Ahuja S.K., Murphy P.M. J. Biol. Chem. 270:16491-16494(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Monocyte.
[2]	Erratum Combadiere C., Ahuja S.K., Murphy P.M. J. Biol. Chem. 270:30235-30235(1995)
[3]	"Cloning, expression, and characterization of the human eosinophil eotaxin receptor." Daugherty B.L., Siciliano S.J., Demartino J.A., Malkowitz L., Sirotina A., Springer M.S. J. Exp. Med. 183:2349-2354(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils." Ponath P.D., Qin S., Post T.W., Wang J., Wu L., Gerard N.P., Newman W., Gerard C., Mackay C.R. J. Exp. Med. 183:2437-2448(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"Partial resistance to infection by syncytium-inducing primary HIV-1 in exposed uninfected individuals homozygous for CCR5 32bp deletion." Xiao L., Weiss S., Qari S., Rudolph D., Hodge T., Lal R. Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]	"New variations of human CC-chemokine receptors CCR3 and CCR4." Kato H., Tsuchiya N., Izumi S., Miyamasu M., Nakajima T., Kawasaki H., Hirai K., Tokunaga K. Genes Immun. 1:97-104(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-218.
[7]	"Transcription regulation of human chemokine receptor CCR3: evidence for a rare TATA-less promoter structure conserved between Drosophila and humans." Vijh S., Dayhoff D.E., Wang C.E., Imam Z., Ehrenberg P.K., Michael N.L. Genomics 80:86-95(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[8]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[9]	Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., Nickerson D.A. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[10]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Synovium.
[11]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood.
[12]	"HIV-1 Tat protein mimicry of chemokines." Albini A., Ferrini S., Benelli R., Sforzini S., Giunciuglio D., Aluigi M.G., Proudfoot A.E.I., Alouani S., Wells T.N.C., Mariani G., Rabin R.L., Farber J.M., Noonan D.M. Proc. Natl. Acad. Sci. U.S.A. 95:13153-13158(1998) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH HIV-1 TAT.
[13]	"Increased expression of chemokine receptor CCR3 and its ligands in ulcerative colitis: the role of colonic epithelial cells in in vitro studies." Manousou P., Kolios G., Valatas V., Drygiannakis I., Bourikas L., Pyrovolaki K., Koutroubakis I., Papadaki H.A., Kouroumalis E. Clin. Exp. Immunol. 162:337-347(2010) [PubMed] [Europe PMC] [Abstract] Cited for: OVEREXPRESSION.
+	Additional computationally mapped references.

Web resources

Wikipedia

CC chemokine receptors entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	U28694 mRNA. Translation: AAC50469.1. U51241 Genomic DNA. Translation: AAB16831.1. U49727 Genomic DNA. Translation: AAB09726.1. AF026535 mRNA. Translation: AAB82589.1. AB023887 Genomic DNA. Translation: BAA86964.1. AF247361 Genomic DNA. Translation: AAL85154.1. AY221092 Genomic DNA. Translation: AAO65970.2. EF064760 Genomic DNA. Translation: ABK41943.1. AK123050 mRNA. Translation: BAG53863.1. BC110297 mRNA. Translation: AAI10298.1. BC130318 mRNA. Translation: AAI30319.1. BC130320 mRNA. Translation: AAI30321.1.
IPI	IPI00019957.
PIR	G02436.
RefSeq	NP_001828.1. NM_001837.3. NP_847899.1. NM_178329.2.
UniGene	Hs.506190.
3D structure databases
ProteinModelPortal	P51677.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5846N.
MINT	MINT-105239.
STRING	9606.ENSP00000350003.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	1705892.
Proteomic databases
PaxDb	P51677.
PRIDE	P51677.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000357422; ENSP00000350003; ENSG00000183625. ENST00000395940; ENSP00000379271; ENSG00000183625. ENST00000395942; ENSP00000379273; ENSG00000183625. ENST00000541018; ENSP00000440097; ENSG00000183625.
GeneID	1232.
KEGG	hsa:1232.
UCSC	uc003cpg.2. human.
Organism-specific databases
CTD	1232.
GeneCards	GC03P046227.
HGNC	HGNC:1604. CCR3.
HPA	CAB003795.
MIM	601268. gene.
neXtProt	NX_P51677.
PharmGKB	PA26168.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG148353.
HOGENOM	HOG000234122.
HOVERGEN	HBG106917.
InParanoid	P51677.
KO	K04178.
OrthoDB	EOG4S1T7D.
PhylomeDB	P51677.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P51677.
Bgee	P51677.
CleanEx	HS_CCR3.
Genevestigator	P51677.
GermOnline	ENSG00000183625. Homo sapiens.
Family and domain databases
InterPro	IPR002238. Chemokine_CCR3. IPR000355. Chemokine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
PANTHER	PTHR24227. PTHR24227. 1 hit. PTHR24227:SF13. PTHR24227:SF13. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR01108. CHEMOKINER3. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P51677.
ChEMBL	CHEMBL3473.
GenomeRNAi	1232.
NextBio	5025.
SOURCE	Search...

Entry information

Entry name

CCR3_HUMAN

Accession

Primary (citable) accession number: P51677
Secondary accession number(s): B3KVQ1 , Q15748, Q2YDB9, Q86WD2, Q9ULY8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 29, 2013
This is version 126 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.