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Protein

C-C chemokine receptor type 3

Gene

CCR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.

GO - Molecular functioni

  • C-C chemokine receptor activity Source: Ensembl
  • chemokine receptor activity Source: ProtInc

GO - Biological processi

  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: ProtInc
  • cell adhesion Source: ProtInc
  • cellular defense response Source: ProtInc
  • chemotaxis Source: ProtInc
  • inflammatory response Source: ProtInc
  • positive regulation of angiogenesis Source: BHF-UCL
  • positive regulation of cytosolic calcium ion concentration Source: ProtInc
  • positive regulation of endothelial cell proliferation Source: Ensembl
  • viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

BioCyciZFISH:G66-30657-MONOMER.
ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 3
Short name:
C-C CKR-3
Short name:
CC-CKR-3
Short name:
CCR-3
Short name:
CCR3
Short name:
CKR3
Alternative name(s):
Eosinophil eotaxin receptor
CD_antigen: CD193
Gene namesi
Name:CCR3
Synonyms:CMKBR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:1604. CCR3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularSequence analysisAdd BLAST34
Transmembranei35 – 62Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini63 – 72CytoplasmicSequence analysis10
Transmembranei73 – 93Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini94 – 107ExtracellularSequence analysisAdd BLAST14
Transmembranei108 – 129Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini130 – 146CytoplasmicSequence analysisAdd BLAST17
Transmembranei147 – 171Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini172 – 203ExtracellularSequence analysisAdd BLAST32
Transmembranei204 – 223Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini224 – 239CytoplasmicSequence analysisAdd BLAST16
Transmembranei240 – 264Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini265 – 281ExtracellularSequence analysisAdd BLAST17
Transmembranei282 – 305Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini306 – 355CytoplasmicSequence analysisAdd BLAST50

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1232.
OpenTargetsiENSG00000183625.
PharmGKBiPA26168.

Chemistry databases

ChEMBLiCHEMBL3473.
GuidetoPHARMACOLOGYi60.

Polymorphism and mutation databases

BioMutaiCCR3.
DMDMi1705892.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692391 – 355C-C chemokine receptor type 3Add BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi106 ↔ 183PROSITE-ProRule annotation
Modified residuei132PhosphotyrosineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP51677.
PRIDEiP51677.

PTM databases

PhosphoSitePlusiP51677.

Expressioni

Tissue specificityi

In eosinophils as well as trace amounts in neutrophils and monocytes.

Gene expression databases

BgeeiENSG00000183625.
CleanExiHS_CCR3.
ExpressionAtlasiP51677. baseline and differential.
GenevisibleiP51677. HS.

Organism-specific databases

HPAiCAB003795.

Interactioni

Subunit structurei

Binds to HIV-1 Tat.

Binary interactionsi

WithEntry#Exp.IntActNotes
CCL11P516712EBI-6625120,EBI-727357

Protein-protein interaction databases

BioGridi107637. 7 interactors.
DIPiDIP-5846N.
IntActiP51677. 1 interactor.
MINTiMINT-105239.
STRINGi9606.ENSP00000441600.

Chemistry databases

BindingDBiP51677.

Structurei

3D structure databases

ProteinModelPortaliP51677.
SMRiP51677.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP51677.
KOiK04178.
OMAiLLRCPSK.
OrthoDBiEOG091G0B7A.
PhylomeDBiP51677.
TreeFamiTF330966.

Family and domain databases

InterProiIPR002238. Chemokine_CCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01108. CHEMOKINER3.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P51677-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTSLDTVET FGTTSYYDDV GLLCEKADTR ALMAQFVPPL YSLVFTVGLL
60 70 80 90 100
GNVVVVMILI KYRRLRIMTN IYLLNLAISD LLFLVTLPFW IHYVRGHNWV
110 120 130 140 150
FGHGMCKLLS GFYHTGLYSE IFFIILLTID RYLAIVHAVF ALRARTVTFG
160 170 180 190 200
VITSIVTWGL AVLAALPEFI FYETEELFEE TLCSALYPED TVYSWRHFHT
210 220 230 240 250
LRMTIFCLVL PLLVMAICYT GIIKTLLRCP SKKKYKAIRL IFVIMAVFFI
260 270 280 290 300
FWTPYNVAIL LSSYQSILFG NDCERSKHLD LVMLVTEVIA YSHCCMNPVI
310 320 330 340 350
YAFVGERFRK YLRHFFHRHL LMHLGRYIPF LPSEKLERTS SVSPSTAEPE

LSIVF
Length:355
Mass (Da):41,044
Last modified:October 1, 1996 - v1
Checksum:iE95DCD7A6C643874
GO
Isoform 2 (identifier: P51677-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPFGIRMLLRAHKPGSSRRSEM

Note: Gene prediction based on EST data.
Show »
Length:376
Mass (Da):43,453
Checksum:i422D094FF3497FE4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81 – 82LL → QG in AAL85630 (PubMed:12079287).Curated2
Sequence conflicti205I → V in BAG53863 (PubMed:14702039).Curated1
Sequence conflicti276S → T in AAB09726 (PubMed:8676064).Curated1
Sequence conflicti276S → T in BAA86964 (PubMed:11196669).Curated1
Sequence conflicti277K → R in BAG53863 (PubMed:14702039).Curated1
Sequence conflicti349P → R in BAG53863 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02006721G → D.Corresponds to variant rs4987125dbSNPEnsembl.1
Natural variantiVAR_04938239P → L.Corresponds to variant rs5742906dbSNPEnsembl.1
Natural variantiVAR_010668218C → S Polymorphism found in about 7% of the population; may show reduced activity. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0467041M → MPFGIRMLLRAHKPGSSRRS EM in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28694 mRNA. Translation: AAC50469.1.
U51241 Genomic DNA. Translation: AAB16831.1.
U49727 Genomic DNA. Translation: AAB09726.1.
AF026535 mRNA. Translation: AAB82589.1.
AB023887 Genomic DNA. Translation: BAA86964.1.
AF262301 mRNA. Translation: AAL85630.1.
AF247361 Genomic DNA. Translation: AAL85154.1.
AY221092 Genomic DNA. Translation: AAO65970.2.
EF064760 Genomic DNA. Translation: ABK41943.1.
AK123050 mRNA. Translation: BAG53863.1.
AC104439 Genomic DNA. No translation available.
BC110297 mRNA. Translation: AAI10298.1.
BC130318 mRNA. Translation: AAI30319.1.
BC130320 mRNA. Translation: AAI30321.1.
CCDSiCCDS2738.1. [P51677-1]
CCDS54574.1. [P51677-2]
PIRiG02436.
RefSeqiNP_001828.1. NM_001837.3. [P51677-1]
NP_847898.1. NM_178328.1. [P51677-2]
NP_847899.1. NM_178329.2. [P51677-1]
XP_006713023.1. XM_006712960.3. [P51677-1]
XP_011531637.1. XM_011533335.2. [P51677-1]
UniGeneiHs.506190.

Genome annotation databases

EnsembliENST00000357422; ENSP00000350003; ENSG00000183625. [P51677-1]
ENST00000395940; ENSP00000379271; ENSG00000183625. [P51677-1]
ENST00000395942; ENSP00000379273; ENSG00000183625. [P51677-1]
ENST00000545097; ENSP00000441600; ENSG00000183625. [P51677-2]
GeneIDi1232.
KEGGihsa:1232.
UCSCiuc003cpg.3. human. [P51677-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CC chemokine receptors entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28694 mRNA. Translation: AAC50469.1.
U51241 Genomic DNA. Translation: AAB16831.1.
U49727 Genomic DNA. Translation: AAB09726.1.
AF026535 mRNA. Translation: AAB82589.1.
AB023887 Genomic DNA. Translation: BAA86964.1.
AF262301 mRNA. Translation: AAL85630.1.
AF247361 Genomic DNA. Translation: AAL85154.1.
AY221092 Genomic DNA. Translation: AAO65970.2.
EF064760 Genomic DNA. Translation: ABK41943.1.
AK123050 mRNA. Translation: BAG53863.1.
AC104439 Genomic DNA. No translation available.
BC110297 mRNA. Translation: AAI10298.1.
BC130318 mRNA. Translation: AAI30319.1.
BC130320 mRNA. Translation: AAI30321.1.
CCDSiCCDS2738.1. [P51677-1]
CCDS54574.1. [P51677-2]
PIRiG02436.
RefSeqiNP_001828.1. NM_001837.3. [P51677-1]
NP_847898.1. NM_178328.1. [P51677-2]
NP_847899.1. NM_178329.2. [P51677-1]
XP_006713023.1. XM_006712960.3. [P51677-1]
XP_011531637.1. XM_011533335.2. [P51677-1]
UniGeneiHs.506190.

3D structure databases

ProteinModelPortaliP51677.
SMRiP51677.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107637. 7 interactors.
DIPiDIP-5846N.
IntActiP51677. 1 interactor.
MINTiMINT-105239.
STRINGi9606.ENSP00000441600.

Chemistry databases

BindingDBiP51677.
ChEMBLiCHEMBL3473.
GuidetoPHARMACOLOGYi60.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP51677.

Polymorphism and mutation databases

BioMutaiCCR3.
DMDMi1705892.

Proteomic databases

PaxDbiP51677.
PRIDEiP51677.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357422; ENSP00000350003; ENSG00000183625. [P51677-1]
ENST00000395940; ENSP00000379271; ENSG00000183625. [P51677-1]
ENST00000395942; ENSP00000379273; ENSG00000183625. [P51677-1]
ENST00000545097; ENSP00000441600; ENSG00000183625. [P51677-2]
GeneIDi1232.
KEGGihsa:1232.
UCSCiuc003cpg.3. human. [P51677-1]

Organism-specific databases

CTDi1232.
DisGeNETi1232.
GeneCardsiCCR3.
HGNCiHGNC:1604. CCR3.
HPAiCAB003795.
MIMi601268. gene.
neXtProtiNX_P51677.
OpenTargetsiENSG00000183625.
PharmGKBiPA26168.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP51677.
KOiK04178.
OMAiLLRCPSK.
OrthoDBiEOG091G0B7A.
PhylomeDBiP51677.
TreeFamiTF330966.

Enzyme and pathway databases

BioCyciZFISH:G66-30657-MONOMER.
ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

GenomeRNAii1232.
PROiP51677.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183625.
CleanExiHS_CCR3.
ExpressionAtlasiP51677. baseline and differential.
GenevisibleiP51677. HS.

Family and domain databases

InterProiIPR002238. Chemokine_CCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01108. CHEMOKINER3.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCR3_HUMAN
AccessioniPrimary (citable) accession number: P51677
Secondary accession number(s): B3KVQ1
, F5GWL6, Q15748, Q2YDB9, Q86WD2, Q8TDP6, Q9ULY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Overexpression of CCR3 together with its ligands appears to be a characteristic of ulcerative colitis (UC). The production of CCR3 ligands by human colonic epithelial cells suggests further that the epithelium can play a role in modulating pathological T-cell-mediated mucosal inflammation (PubMed:21077277).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.