ID CC1L1_MOUSE Reviewed; 356 AA. AC P51676; A0JP35; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 27-JUL-2011, sequence version 2. DT 24-JAN-2024, entry version 150. DE RecName: Full=C-C chemokine receptor 1-like protein 1; DE AltName: Full=Macrophage inflammatory protein 1 alpha receptor-like 1; GN Name=Ccr1l1; Synonyms=Cmkbr1l1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=129/SvJ; RX PubMed=7542241; DOI=10.1074/jbc.270.29.17494; RA Gao J.-L., Murphy P.M.; RT "Cloning and differential tissue-specific expression of three mouse beta RT chemokine receptor-like genes, including the gene for a functional RT macrophage inflammatory protein-1 alpha receptor."; RL J. Biol. Chem. 270:17494-17501(1995). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Probable receptor for a C-C type chemokine. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Detected in the spleen, liver and leukocytes. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U28405; AAA89154.1; -; Genomic_DNA. DR EMBL; CH466671; EDL37174.1; -; Genomic_DNA. DR EMBL; BC127143; AAI27144.1; -; mRNA. DR EMBL; BC128466; AAI28467.1; -; mRNA. DR CCDS; CCDS23667.1; -. DR PIR; I49340; I49340. DR RefSeq; NP_031744.3; NM_007718.3. DR AlphaFoldDB; P51676; -. DR SMR; P51676; -. DR STRING; 10090.ENSMUSP00000071353; -. DR PaxDb; 10090-ENSMUSP00000071353; -. DR DNASU; 12770; -. DR Ensembl; ENSMUST00000071404.5; ENSMUSP00000071353.4; ENSMUSG00000064039.5. DR GeneID; 12770; -. DR KEGG; mmu:12770; -. DR UCSC; uc009sgz.2; mouse. DR AGR; MGI:104617; -. DR CTD; 12770; -. DR MGI; MGI:104617; Ccr1l1. DR VEuPathDB; HostDB:ENSMUSG00000064039; -. DR eggNOG; KOG3656; Eukaryota. DR GeneTree; ENSGT01020000230359; -. DR HOGENOM; CLU_009579_8_3_1; -. DR InParanoid; P51676; -. DR OMA; HESHQAW; -. DR OrthoDB; 4604454at2759; -. DR PhylomeDB; P51676; -. DR TreeFam; TF330966; -. DR BioGRID-ORCS; 12770; 0 hits in 78 CRISPR screens. DR PRO; PR:P51676; -. DR Proteomes; UP000000589; Chromosome 9. DR RNAct; P51676; Protein. DR Bgee; ENSMUSG00000064039; Expressed in placenta labyrinth and 8 other cell types or tissues. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0009897; C:external side of plasma membrane; ISO:MGI. DR GO; GO:0005886; C:plasma membrane; ISO:MGI. DR GO; GO:0019957; F:C-C chemokine binding; ISO:MGI. DR GO; GO:0016493; F:C-C chemokine receptor activity; ISO:MGI. DR GO; GO:0071791; F:chemokine (C-C motif) ligand 5 binding; ISO:MGI. DR GO; GO:0035717; F:chemokine (C-C motif) ligand 7 binding; ISO:MGI. DR GO; GO:0004950; F:chemokine receptor activity; ISO:MGI. DR GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; ISO:MGI. DR GO; GO:0006816; P:calcium ion transport; ISO:MGI. DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central. DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central. DR GO; GO:0007267; P:cell-cell signaling; ISO:MGI. DR GO; GO:0070098; P:chemokine-mediated signaling pathway; ISO:MGI. DR GO; GO:0006887; P:exocytosis; ISO:MGI. DR GO; GO:0006955; P:immune response; ISO:MGI. DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central. DR GO; GO:0006874; P:intracellular calcium ion homeostasis; ISO:MGI. DR GO; GO:0030502; P:negative regulation of bone mineralization; ISO:MGI. DR GO; GO:0010629; P:negative regulation of gene expression; ISO:MGI. DR GO; GO:0051928; P:positive regulation of calcium ion transport; ISO:MGI. DR GO; GO:0030335; P:positive regulation of cell migration; ISO:MGI. DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:MGI. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:MGI. DR GO; GO:0090026; P:positive regulation of monocyte chemotaxis; ISO:MGI. DR GO; GO:0045672; P:positive regulation of osteoclast differentiation; ISO:MGI. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR002236; Chemokine_CCR1. DR InterPro; IPR000355; Chemokine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR PANTHER; PTHR10489:SF923; C-C CHEMOKINE RECEPTOR 1-LIKE PROTEIN 1; 1. DR PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00657; CCCHEMOKINER. DR PRINTS; PR01106; CHEMOKINER1. DR PRINTS; PR00237; GPCRRHODOPSN. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR Genevisible; P51676; MM. PE 2: Evidence at transcript level; KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane; KW Receptor; Reference proteome; Transducer; Transmembrane; KW Transmembrane helix. FT CHAIN 1..356 FT /note="C-C chemokine receptor 1-like protein 1" FT /id="PRO_0000069298" FT TOPO_DOM 1..32 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 33..60 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 61..67 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 68..92 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 93..108 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 109..130 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 131..147 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 148..172 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 173..198 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 199..224 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 225..240 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 241..265 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 266..282 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 283..306 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 307..356 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT DISULFID 107..184 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" FT CONFLICT 38 FT /note="L -> P (in Ref. 1; AAA89154)" FT /evidence="ECO:0000305" FT CONFLICT 334 FT /note="V -> E (in Ref. 1; AAA89154)" FT /evidence="ECO:0000305" FT CONFLICT 343..344 FT /note="TP -> RL (in Ref. 1; AAA89154)" FT /evidence="ECO:0000305" SQ SEQUENCE 356 AA; 40849 MW; CA84549CFA1DEA9B CRC64; MEIPAVTEPS YNTVAKNDFM SGFLCFSINV RAFGITVLTP LYSLVFIIGV IGHVLVVLVL IQHKRLRNMT SIYLFNLAIS DLVFLSTLPF WVDYIMKGDW IFGNAMCKFV SGFYYLGLYS DMFFITLLTI DRYLAVVHVV FALRARTVTF GIISSIITWV LAALVSIPCL YVFKSQMEFT YHTCRAILPR KSLIRFLRFQ ALTMNILGLI LPLLAMIICY TRIINVLHRR PNKKKAKVMR LIFVITLLFF LLLAPYYLAA FVSAFEDVLF TPSCLRSQQV DLSLMITEAL AYTHCCVNPV IYVFVGKRFR KYLWQLFRRH TAITLPQWLP FLSVDRAQRA SATPPSTVEI ETSADL //