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P51676

- CC1L1_MOUSE

UniProt

P51676 - CC1L1_MOUSE

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Protein
C-C chemokine receptor 1-like protein 1
Gene
Ccr1l1, Cmkbr1l1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable receptor for a C-C type chemokine.

GO - Molecular functioni

  1. C-C chemokine receptor activity Source: InterPro

GO - Biological processi

  1. chemotaxis Source: InterPro
  2. immune response Source: InterPro
  3. inflammatory response Source: InterPro
  4. positive regulation of monocyte chemotaxis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor 1-like protein 1
Alternative name(s):
Macrophage inflammatory protein 1 alpha receptor-like 1
Gene namesi
Name:Ccr1l1
Synonyms:Cmkbr1l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:104617. Ccr1l1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232Extracellular Reviewed prediction
Add
BLAST
Transmembranei33 – 6028Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini61 – 677Cytoplasmic Reviewed prediction
Transmembranei68 – 9225Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini93 – 10816Extracellular Reviewed prediction
Add
BLAST
Transmembranei109 – 13022Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini131 – 14717Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei148 – 17225Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini173 – 19826Extracellular Reviewed prediction
Add
BLAST
Transmembranei199 – 22426Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini225 – 24016Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei241 – 26525Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini266 – 28217Extracellular Reviewed prediction
Add
BLAST
Transmembranei283 – 30624Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini307 – 35650Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356C-C chemokine receptor 1-like protein 1
PRO_0000069298Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi107 ↔ 184 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP51676.

Expressioni

Tissue specificityi

Detected in the spleen, liver and leukocytes.

Gene expression databases

BgeeiP51676.
CleanExiMM_CCR1L1.
GenevestigatoriP51676.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071353.

Structurei

3D structure databases

ProteinModelPortaliP51676.
SMRiP51676. Positions 25-318.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148353.
GeneTreeiENSGT00700000104407.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiA0JP35.
KOiK04176.
OMAiCYTRIIN.
OrthoDBiEOG738051.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR002236. Chemokine_CCR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01106. CHEMOKINER1.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51676-1 [UniParc]FASTAAdd to Basket

« Hide

MEIPAVTEPS YNTVAKNDFM SGFLCFSINV RAFGITVLTP LYSLVFIIGV    50
IGHVLVVLVL IQHKRLRNMT SIYLFNLAIS DLVFLSTLPF WVDYIMKGDW 100
IFGNAMCKFV SGFYYLGLYS DMFFITLLTI DRYLAVVHVV FALRARTVTF 150
GIISSIITWV LAALVSIPCL YVFKSQMEFT YHTCRAILPR KSLIRFLRFQ 200
ALTMNILGLI LPLLAMIICY TRIINVLHRR PNKKKAKVMR LIFVITLLFF 250
LLLAPYYLAA FVSAFEDVLF TPSCLRSQQV DLSLMITEAL AYTHCCVNPV 300
IYVFVGKRFR KYLWQLFRRH TAITLPQWLP FLSVDRAQRA SATPPSTVEI 350
ETSADL 356
Length:356
Mass (Da):40,849
Last modified:July 27, 2011 - v2
Checksum:iCA84549CFA1DEA9B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381L → P in AAA89154. 1 Publication
Sequence conflicti334 – 3341V → E in AAA89154. 1 Publication
Sequence conflicti343 – 3442TP → RL in AAA89154. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U28405 Genomic DNA. Translation: AAA89154.1.
CH466671 Genomic DNA. Translation: EDL37174.1.
BC127143 mRNA. Translation: AAI27144.1.
BC128466 mRNA. Translation: AAI28467.1.
CCDSiCCDS23667.1.
PIRiI49340.
RefSeqiNP_031744.3. NM_007718.3.
UniGeneiMm.423532.

Genome annotation databases

EnsembliENSMUST00000071404; ENSMUSP00000071353; ENSMUSG00000064039.
GeneIDi12770.
KEGGimmu:12770.
UCSCiuc009sgz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U28405 Genomic DNA. Translation: AAA89154.1 .
CH466671 Genomic DNA. Translation: EDL37174.1 .
BC127143 mRNA. Translation: AAI27144.1 .
BC128466 mRNA. Translation: AAI28467.1 .
CCDSi CCDS23667.1.
PIRi I49340.
RefSeqi NP_031744.3. NM_007718.3.
UniGenei Mm.423532.

3D structure databases

ProteinModelPortali P51676.
SMRi P51676. Positions 25-318.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000071353.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi P51676.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000071404 ; ENSMUSP00000071353 ; ENSMUSG00000064039 .
GeneIDi 12770.
KEGGi mmu:12770.
UCSCi uc009sgz.2. mouse.

Organism-specific databases

CTDi 12770.
MGIi MGI:104617. Ccr1l1.

Phylogenomic databases

eggNOGi NOG148353.
GeneTreei ENSGT00700000104407.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi A0JP35.
KOi K04176.
OMAi CYTRIIN.
OrthoDBi EOG738051.
TreeFami TF330966.

Miscellaneous databases

NextBioi 282142.
PROi P51676.
SOURCEi Search...

Gene expression databases

Bgeei P51676.
CleanExi MM_CCR1L1.
Genevestigatori P51676.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR002236. Chemokine_CCR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00657. CCCHEMOKINER.
PR01106. CHEMOKINER1.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor."
    Gao J.-L., Murphy P.M.
    J. Biol. Chem. 270:17494-17501(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCC1L1_MOUSE
AccessioniPrimary (citable) accession number: P51676
Secondary accession number(s): A0JP35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3