C-C chemokine receptor 1-like protein 1

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P51676 (CC1L1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 94. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
C-C chemokine receptor 1-like protein 1

Alternative name(s):
Macrophage inflammatory protein 1 alpha receptor-like 1

Gene names

Name:	Ccr1l1
Synonyms:	Cmkbr1l1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable receptor for a C-C type chemokine.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Detected in the spleen, liver and leukocytes.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemokine-mediated signaling pathway Inferred from electronic annotation. Source: GOC chemotaxis Inferred from electronic annotation. Source: InterPro elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: InterPro immune response Inferred from electronic annotation. Source: InterPro inflammatory response Inferred from electronic annotation. Source: InterPro positive regulation of monocyte chemotaxis Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	C-C chemokine receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 356

356

C-C chemokine receptor 1-like protein 1

PRO_0000069298

Regions

Topological domain

1 – 32

Extracellular Potential

Transmembrane

33 – 60

Helical; Name=1; Potential

Topological domain

61 – 67

Cytoplasmic Potential

Transmembrane

68 – 92

Helical; Name=2; Potential

Topological domain

93 – 108

Extracellular Potential

Transmembrane

109 – 130

Helical; Name=3; Potential

Topological domain

131 – 147

Cytoplasmic Potential

Transmembrane

148 – 172

Helical; Name=4; Potential

Topological domain

173 – 198

Extracellular Potential

Transmembrane

199 – 224

Helical; Name=5; Potential

Topological domain

225 – 240

Cytoplasmic Potential

Transmembrane

241 – 265

Helical; Name=6; Potential

Topological domain

266 – 282

Extracellular Potential

Transmembrane

283 – 306

Helical; Name=7; Potential

Topological domain

307 – 356

Cytoplasmic Potential

Amino acid modifications

Disulfide bond

107 ↔ 184

By similarity

Experimental info

Sequence conflict

L → P in AAA89154. Ref.1

Sequence conflict

334

V → E in AAA89154. Ref.1

Sequence conflict

343 – 344

TP → RL in AAA89154. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P51676 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: CA84549CFA1DEA9B
Show »

FASTA

356

40,849

        10         20         30         40         50         60 
MEIPAVTEPS YNTVAKNDFM SGFLCFSINV RAFGITVLTP LYSLVFIIGV IGHVLVVLVL 

        70         80         90        100        110        120 
IQHKRLRNMT SIYLFNLAIS DLVFLSTLPF WVDYIMKGDW IFGNAMCKFV SGFYYLGLYS 

       130        140        150        160        170        180 
DMFFITLLTI DRYLAVVHVV FALRARTVTF GIISSIITWV LAALVSIPCL YVFKSQMEFT 

       190        200        210        220        230        240 
YHTCRAILPR KSLIRFLRFQ ALTMNILGLI LPLLAMIICY TRIINVLHRR PNKKKAKVMR 

       250        260        270        280        290        300 
LIFVITLLFF LLLAPYYLAA FVSAFEDVLF TPSCLRSQQV DLSLMITEAL AYTHCCVNPV 

       310        320        330        340        350 
IYVFVGKRFR KYLWQLFRRH TAITLPQWLP FLSVDRAQRA SATPPSTVEI ETSADL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor." Gao J.-L., Murphy P.M. J. Biol. Chem. 270:17494-17501(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/SvJ.
[2]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U28405 Genomic DNA. Translation: AAA89154.1. CH466671 Genomic DNA. Translation: EDL37174.1. BC127143 mRNA. Translation: AAI27144.1. BC128466 mRNA. Translation: AAI28467.1.
IPI	IPI00125200.
PIR	I49340.
RefSeq	NP_031744.3. NM_007718.3.
UniGene	Mm.423532.
3D structure databases
ProteinModelPortal	P51676.
SMR	P51676. Positions 33-320.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000071353.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	P51676.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000071404; ENSMUSP00000071353; ENSMUSG00000064039.
GeneID	12770.
KEGG	mmu:12770.
UCSC	uc009sgz.2. mouse.
Organism-specific databases
CTD	12770.
MGI	MGI:104617. Ccr1l1.
Phylogenomic databases
eggNOG	NOG148353.
GeneTree	ENSGT00700000104407.
HOGENOM	HOG000234122.
HOVERGEN	HBG106917.
InParanoid	A0JP35.
KO	K04176.
OMA	ITLLTID.
OrthoDB	EOG4XWG0P.
Gene expression databases
Bgee	P51676.
CleanEx	MM_CCR1L1.
Genevestigator	P51676.
GermOnline	ENSMUSG00000064039. Mus musculus.
Family and domain databases
InterPro	IPR002236. Chemokine_CCR1. IPR000355. Chemokine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
PANTHER	PTHR24227. PTHR24227. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR01106. CHEMOKINER1. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	282142.
SOURCE	Search...

Entry information

Entry name

CC1L1_MOUSE

Accession

Primary (citable) accession number: P51676
Secondary accession number(s): A0JP35

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	July 27, 2011
Last modified:	May 29, 2013
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents