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Protein

C-C chemokine receptor 1-like protein 1

Gene

Ccr1l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable receptor for a C-C type chemokine.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor 1-like protein 1
Alternative name(s):
Macrophage inflammatory protein 1 alpha receptor-like 1
Gene namesi
Name:Ccr1l1
Synonyms:Cmkbr1l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:104617. Ccr1l1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 60Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini61 – 67CytoplasmicSequence analysis7
Transmembranei68 – 92Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini93 – 108ExtracellularSequence analysisAdd BLAST16
Transmembranei109 – 130Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini131 – 147CytoplasmicSequence analysisAdd BLAST17
Transmembranei148 – 172Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini173 – 198ExtracellularSequence analysisAdd BLAST26
Transmembranei199 – 224Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini225 – 240CytoplasmicSequence analysisAdd BLAST16
Transmembranei241 – 265Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini266 – 282ExtracellularSequence analysisAdd BLAST17
Transmembranei283 – 306Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini307 – 356CytoplasmicSequence analysisAdd BLAST50

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692981 – 356C-C chemokine receptor 1-like protein 1Add BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi107 ↔ 184PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP51676.
PRIDEiP51676.

Expressioni

Tissue specificityi

Detected in the spleen, liver and leukocytes.

Gene expression databases

BgeeiENSMUSG00000064039.
CleanExiMM_CCR1L1.
GenevisibleiP51676. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071353.

Structurei

3D structure databases

ProteinModelPortaliP51676.
SMRiP51676.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP51676.
KOiK04176.
OMAiCYTRIIN.
OrthoDBiEOG091G0B7A.
TreeFamiTF330966.

Family and domain databases

InterProiIPR002236. Chemokine_CCR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR10489:SF711. PTHR10489:SF711. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01106. CHEMOKINER1.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51676-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIPAVTEPS YNTVAKNDFM SGFLCFSINV RAFGITVLTP LYSLVFIIGV
60 70 80 90 100
IGHVLVVLVL IQHKRLRNMT SIYLFNLAIS DLVFLSTLPF WVDYIMKGDW
110 120 130 140 150
IFGNAMCKFV SGFYYLGLYS DMFFITLLTI DRYLAVVHVV FALRARTVTF
160 170 180 190 200
GIISSIITWV LAALVSIPCL YVFKSQMEFT YHTCRAILPR KSLIRFLRFQ
210 220 230 240 250
ALTMNILGLI LPLLAMIICY TRIINVLHRR PNKKKAKVMR LIFVITLLFF
260 270 280 290 300
LLLAPYYLAA FVSAFEDVLF TPSCLRSQQV DLSLMITEAL AYTHCCVNPV
310 320 330 340 350
IYVFVGKRFR KYLWQLFRRH TAITLPQWLP FLSVDRAQRA SATPPSTVEI

ETSADL
Length:356
Mass (Da):40,849
Last modified:July 27, 2011 - v2
Checksum:iCA84549CFA1DEA9B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38L → P in AAA89154 (PubMed:7542241).Curated1
Sequence conflicti334V → E in AAA89154 (PubMed:7542241).Curated1
Sequence conflicti343 – 344TP → RL in AAA89154 (PubMed:7542241).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28405 Genomic DNA. Translation: AAA89154.1.
CH466671 Genomic DNA. Translation: EDL37174.1.
BC127143 mRNA. Translation: AAI27144.1.
BC128466 mRNA. Translation: AAI28467.1.
CCDSiCCDS23667.1.
PIRiI49340.
RefSeqiNP_031744.3. NM_007718.3.
UniGeneiMm.423532.

Genome annotation databases

EnsembliENSMUST00000071404; ENSMUSP00000071353; ENSMUSG00000064039.
GeneIDi12770.
KEGGimmu:12770.
UCSCiuc009sgz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28405 Genomic DNA. Translation: AAA89154.1.
CH466671 Genomic DNA. Translation: EDL37174.1.
BC127143 mRNA. Translation: AAI27144.1.
BC128466 mRNA. Translation: AAI28467.1.
CCDSiCCDS23667.1.
PIRiI49340.
RefSeqiNP_031744.3. NM_007718.3.
UniGeneiMm.423532.

3D structure databases

ProteinModelPortaliP51676.
SMRiP51676.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071353.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP51676.
PRIDEiP51676.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071404; ENSMUSP00000071353; ENSMUSG00000064039.
GeneIDi12770.
KEGGimmu:12770.
UCSCiuc009sgz.2. mouse.

Organism-specific databases

CTDi12770.
MGIiMGI:104617. Ccr1l1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP51676.
KOiK04176.
OMAiCYTRIIN.
OrthoDBiEOG091G0B7A.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiR-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiP51676.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000064039.
CleanExiMM_CCR1L1.
GenevisibleiP51676. MM.

Family and domain databases

InterProiIPR002236. Chemokine_CCR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR10489:SF711. PTHR10489:SF711. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01106. CHEMOKINER1.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCC1L1_MOUSE
AccessioniPrimary (citable) accession number: P51676
Secondary accession number(s): A0JP35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.