Reviewed, UniProtKB/Swiss-Prot P51676 (CC1L1_MOUSE)

Names and origin

Protein names

Recommended name:
    C-C chemokine receptor 1-like protein 1
Alternative name(s):
    Macrophage inflammatory protein 1 alpha receptor-like 1

Gene names

Name:	Ccr1l1
Synonyms:	Cmkbr1l1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Probable receptor for a C-C type chemokine.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Detected in the spleen, liver and leukocytes.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	C-C chemokine receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 356	356	C-C chemokine receptor 1-like protein 1		PRO_0000069298
Regions
	Topological domain	1 – 32	32	Extracellular Potential
	Transmembrane	33 – 60	28	1 Potential
	Topological domain	61 – 67	7	Cytoplasmic Potential
	Transmembrane	68 – 92	25	2 Potential
	Topological domain	93 – 108	16	Extracellular Potential
	Transmembrane	109 – 130	22	3 Potential
	Topological domain	131 – 147	17	Cytoplasmic Potential
	Transmembrane	148 – 172	25	4 Potential
	Topological domain	173 – 198	26	Extracellular Potential
	Transmembrane	199 – 224	26	5 Potential
	Topological domain	225 – 240	16	Cytoplasmic Potential
	Transmembrane	241 – 265	25	6 Potential
	Topological domain	266 – 282	17	Extracellular Potential
	Transmembrane	283 – 306	24	7 Potential
	Topological domain	307 – 356	50	Cytoplasmic Potential
Amino acid modifications
	Disulfide bond	107 ↔ 184		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P51676-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 58C01ABA8D7D4B06	FASTA	356	40,934
	10 20 30 40 50 60 MEIPAVTEPS YNTVAKNDFM SGFLCFSINV RAFGITVPTP LYSLVFIIGV IGHVLVVLVL 70 80 90 100 110 120 IQHKRLRNMT SIYLFNLAIS DLVFLSTLPF WVDYIMKGDW IFGNAMCKFV SGFYYLGLYS 130 140 150 160 170 180 DMFFITLLTI DRYLAVVHVV FALRARTVTF GIISSIITWV LAALVSIPCL YVFKSQMEFT 190 200 210 220 230 240 YHTCRAILPR KSLIRFLRFQ ALTMNILGLI LPLLAMIICY TRIINVLHRR PNKKKAKVMR 250 260 270 280 290 300 LIFVITLLFF LLLAPYYLAA FVSAFEDVLF TPSCLRSQQV DLSLMITEAL AYTHCCVNPV 310 320 330 340 350 IYVFVGKRFR KYLWQLFRRH TAITLPQWLP FLSEDRAQRA SARLPSTVEI ETSADL

References

[1]	"Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor." Gao J.-L., Murphy P.M. J. Biol. Chem. 270:17494-17501(1995) [PubMed: 7542241] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/SvJ.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U28405 Genomic DNA. Translation: AAA89154.1.
IPI	IPI00125200.
PIR	I49340.
UniGene	Mm.423532
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Genome annotation databases
Ensembl	ENSMUSG00000064039. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:104617. Ccr1l1.
Phylogenomic databases
HOGENOM	P51676.
HOVERGEN	P51676.
Gene expression databases
ArrayExpress	P51676.
Bgee	P51676.
CleanEx	MM_CCR1L1.
GermOnline	ENSMUSG00000064039. Mus musculus.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR002236. CC_1_rcpt. IPR000355. Chmkine_rcpt. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR01106. CHEMOKINER1. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

CC1L1_MOUSE

Accession

Primary (citable) accession number: P51676

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)