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P51676 (CC1L1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C chemokine receptor 1-like protein 1
Alternative name(s):
Macrophage inflammatory protein 1 alpha receptor-like 1
Gene names
Name:Ccr1l1
Synonyms:Cmkbr1l1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable receptor for a C-C type chemokine.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Detected in the spleen, liver and leukocytes.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 356356C-C chemokine receptor 1-like protein 1
PRO_0000069298

Regions

Topological domain1 – 3232Extracellular Potential
Transmembrane33 – 6028Helical; Name=1; Potential
Topological domain61 – 677Cytoplasmic Potential
Transmembrane68 – 9225Helical; Name=2; Potential
Topological domain93 – 10816Extracellular Potential
Transmembrane109 – 13022Helical; Name=3; Potential
Topological domain131 – 14717Cytoplasmic Potential
Transmembrane148 – 17225Helical; Name=4; Potential
Topological domain173 – 19826Extracellular Potential
Transmembrane199 – 22426Helical; Name=5; Potential
Topological domain225 – 24016Cytoplasmic Potential
Transmembrane241 – 26525Helical; Name=6; Potential
Topological domain266 – 28217Extracellular Potential
Transmembrane283 – 30624Helical; Name=7; Potential
Topological domain307 – 35650Cytoplasmic Potential

Amino acid modifications

Disulfide bond107 ↔ 184 By similarity

Experimental info

Sequence conflict381L → P in AAA89154. Ref.1
Sequence conflict3341V → E in AAA89154. Ref.1
Sequence conflict343 – 3442TP → RL in AAA89154. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P51676 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: CA84549CFA1DEA9B

FASTA35640,849
        10         20         30         40         50         60 
MEIPAVTEPS YNTVAKNDFM SGFLCFSINV RAFGITVLTP LYSLVFIIGV IGHVLVVLVL 

        70         80         90        100        110        120 
IQHKRLRNMT SIYLFNLAIS DLVFLSTLPF WVDYIMKGDW IFGNAMCKFV SGFYYLGLYS 

       130        140        150        160        170        180 
DMFFITLLTI DRYLAVVHVV FALRARTVTF GIISSIITWV LAALVSIPCL YVFKSQMEFT 

       190        200        210        220        230        240 
YHTCRAILPR KSLIRFLRFQ ALTMNILGLI LPLLAMIICY TRIINVLHRR PNKKKAKVMR 

       250        260        270        280        290        300 
LIFVITLLFF LLLAPYYLAA FVSAFEDVLF TPSCLRSQQV DLSLMITEAL AYTHCCVNPV 

       310        320        330        340        350 
IYVFVGKRFR KYLWQLFRRH TAITLPQWLP FLSVDRAQRA SATPPSTVEI ETSADL 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor."
Gao J.-L., Murphy P.M.
J. Biol. Chem. 270:17494-17501(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U28405 Genomic DNA. Translation: AAA89154.1.
CH466671 Genomic DNA. Translation: EDL37174.1.
BC127143 mRNA. Translation: AAI27144.1.
BC128466 mRNA. Translation: AAI28467.1.
PIRI49340.
RefSeqNP_031744.3. NM_007718.3.
UniGeneMm.423532.

3D structure databases

ProteinModelPortalP51676.
SMRP51676. Positions 2-322.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000071353.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEP51676.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000071404; ENSMUSP00000071353; ENSMUSG00000064039.
GeneID12770.
KEGGmmu:12770.
UCSCuc009sgz.2. mouse.

Organism-specific databases

CTD12770.
MGIMGI:104617. Ccr1l1.

Phylogenomic databases

eggNOGNOG148353.
GeneTreeENSGT00700000104407.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidA0JP35.
KOK04176.
OMAITLLTID.
OrthoDBEOG738051.
TreeFamTF330966.

Gene expression databases

BgeeP51676.
CleanExMM_CCR1L1.
GenevestigatorP51676.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR002236. Chemokine_CCR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00657. CCCHEMOKINER.
PR01106. CHEMOKINER1.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio282142.
PROP51676.
SOURCESearch...

Entry information

Entry nameCC1L1_MOUSE
AccessionPrimary (citable) accession number: P51676
Secondary accession number(s): A0JP35
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries