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Protein

C-C chemokine receptor 1-like protein 1

Gene

Ccr1l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable receptor for a C-C type chemokine.

GO - Molecular functioni

  1. C-C chemokine receptor activity Source: InterPro

GO - Biological processi

  1. chemotaxis Source: InterPro
  2. immune response Source: InterPro
  3. inflammatory response Source: InterPro
  4. positive regulation of monocyte chemotaxis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_250376. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor 1-like protein 1
Alternative name(s):
Macrophage inflammatory protein 1 alpha receptor-like 1
Gene namesi
Name:Ccr1l1
Synonyms:Cmkbr1l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:104617. Ccr1l1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
BLAST
Transmembranei33 – 6028Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini61 – 677CytoplasmicSequence Analysis
Transmembranei68 – 9225Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini93 – 10816ExtracellularSequence AnalysisAdd
BLAST
Transmembranei109 – 13022Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini131 – 14717CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei148 – 17225Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini173 – 19826ExtracellularSequence AnalysisAdd
BLAST
Transmembranei199 – 22426Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini225 – 24016CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei241 – 26525Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini266 – 28217ExtracellularSequence AnalysisAdd
BLAST
Transmembranei283 – 30624Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini307 – 35650CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356C-C chemokine receptor 1-like protein 1PRO_0000069298Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi107 ↔ 184PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP51676.

Expressioni

Tissue specificityi

Detected in the spleen, liver and leukocytes.

Gene expression databases

BgeeiP51676.
CleanExiMM_CCR1L1.
GenevestigatoriP51676.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071353.

Structurei

3D structure databases

ProteinModelPortaliP51676.
SMRiP51676. Positions 25-318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148353.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP51676.
KOiK04176.
OMAiCYTRIIN.
OrthoDBiEOG738051.
TreeFamiTF330966.

Family and domain databases

InterProiIPR002236. Chemokine_CCR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01106. CHEMOKINER1.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51676-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEIPAVTEPS YNTVAKNDFM SGFLCFSINV RAFGITVLTP LYSLVFIIGV
60 70 80 90 100
IGHVLVVLVL IQHKRLRNMT SIYLFNLAIS DLVFLSTLPF WVDYIMKGDW
110 120 130 140 150
IFGNAMCKFV SGFYYLGLYS DMFFITLLTI DRYLAVVHVV FALRARTVTF
160 170 180 190 200
GIISSIITWV LAALVSIPCL YVFKSQMEFT YHTCRAILPR KSLIRFLRFQ
210 220 230 240 250
ALTMNILGLI LPLLAMIICY TRIINVLHRR PNKKKAKVMR LIFVITLLFF
260 270 280 290 300
LLLAPYYLAA FVSAFEDVLF TPSCLRSQQV DLSLMITEAL AYTHCCVNPV
310 320 330 340 350
IYVFVGKRFR KYLWQLFRRH TAITLPQWLP FLSVDRAQRA SATPPSTVEI

ETSADL
Length:356
Mass (Da):40,849
Last modified:July 27, 2011 - v2
Checksum:iCA84549CFA1DEA9B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381L → P in AAA89154. (PubMed:7542241)Curated
Sequence conflicti334 – 3341V → E in AAA89154. (PubMed:7542241)Curated
Sequence conflicti343 – 3442TP → RL in AAA89154. (PubMed:7542241)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28405 Genomic DNA. Translation: AAA89154.1.
CH466671 Genomic DNA. Translation: EDL37174.1.
BC127143 mRNA. Translation: AAI27144.1.
BC128466 mRNA. Translation: AAI28467.1.
CCDSiCCDS23667.1.
PIRiI49340.
RefSeqiNP_031744.3. NM_007718.3.
UniGeneiMm.423532.

Genome annotation databases

EnsembliENSMUST00000071404; ENSMUSP00000071353; ENSMUSG00000064039.
GeneIDi12770.
KEGGimmu:12770.
UCSCiuc009sgz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28405 Genomic DNA. Translation: AAA89154.1.
CH466671 Genomic DNA. Translation: EDL37174.1.
BC127143 mRNA. Translation: AAI27144.1.
BC128466 mRNA. Translation: AAI28467.1.
CCDSiCCDS23667.1.
PIRiI49340.
RefSeqiNP_031744.3. NM_007718.3.
UniGeneiMm.423532.

3D structure databases

ProteinModelPortaliP51676.
SMRiP51676. Positions 25-318.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071353.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiP51676.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071404; ENSMUSP00000071353; ENSMUSG00000064039.
GeneIDi12770.
KEGGimmu:12770.
UCSCiuc009sgz.2. mouse.

Organism-specific databases

CTDi12770.
MGIiMGI:104617. Ccr1l1.

Phylogenomic databases

eggNOGiNOG148353.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP51676.
KOiK04176.
OMAiCYTRIIN.
OrthoDBiEOG738051.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiREACT_250376. G alpha (i) signalling events.

Miscellaneous databases

NextBioi282142.
PROiP51676.
SOURCEiSearch...

Gene expression databases

BgeeiP51676.
CleanExiMM_CCR1L1.
GenevestigatoriP51676.

Family and domain databases

InterProiIPR002236. Chemokine_CCR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01106. CHEMOKINER1.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor."
    Gao J.-L., Murphy P.M.
    J. Biol. Chem. 270:17494-17501(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCC1L1_MOUSE
AccessioniPrimary (citable) accession number: P51676
Secondary accession number(s): A0JP35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: January 7, 2015
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.