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P51676

- CC1L1_MOUSE

UniProt

P51676 - CC1L1_MOUSE

Protein

C-C chemokine receptor 1-like protein 1

Gene

Ccr1l1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Probable receptor for a C-C type chemokine.

    GO - Molecular functioni

    1. C-C chemokine receptor activity Source: InterPro

    GO - Biological processi

    1. chemotaxis Source: InterPro
    2. immune response Source: InterPro
    3. inflammatory response Source: InterPro
    4. positive regulation of monocyte chemotaxis Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C chemokine receptor 1-like protein 1
    Alternative name(s):
    Macrophage inflammatory protein 1 alpha receptor-like 1
    Gene namesi
    Name:Ccr1l1
    Synonyms:Cmkbr1l1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:104617. Ccr1l1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 356356C-C chemokine receptor 1-like protein 1PRO_0000069298Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi107 ↔ 184PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP51676.

    Expressioni

    Tissue specificityi

    Detected in the spleen, liver and leukocytes.

    Gene expression databases

    BgeeiP51676.
    CleanExiMM_CCR1L1.
    GenevestigatoriP51676.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000071353.

    Structurei

    3D structure databases

    ProteinModelPortaliP51676.
    SMRiP51676. Positions 25-318.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini61 – 677CytoplasmicSequence Analysis
    Topological domaini93 – 10816ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini131 – 14717CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini173 – 19826ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini225 – 24016CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini266 – 28217ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini307 – 35650CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 6028Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei68 – 9225Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei109 – 13022Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei148 – 17225Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei199 – 22426Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei241 – 26525Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei283 – 30624Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148353.
    GeneTreeiENSGT00700000104407.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiA0JP35.
    KOiK04176.
    OMAiCYTRIIN.
    OrthoDBiEOG738051.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR002236. Chemokine_CCR1.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR01106. CHEMOKINER1.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51676-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEIPAVTEPS YNTVAKNDFM SGFLCFSINV RAFGITVLTP LYSLVFIIGV    50
    IGHVLVVLVL IQHKRLRNMT SIYLFNLAIS DLVFLSTLPF WVDYIMKGDW 100
    IFGNAMCKFV SGFYYLGLYS DMFFITLLTI DRYLAVVHVV FALRARTVTF 150
    GIISSIITWV LAALVSIPCL YVFKSQMEFT YHTCRAILPR KSLIRFLRFQ 200
    ALTMNILGLI LPLLAMIICY TRIINVLHRR PNKKKAKVMR LIFVITLLFF 250
    LLLAPYYLAA FVSAFEDVLF TPSCLRSQQV DLSLMITEAL AYTHCCVNPV 300
    IYVFVGKRFR KYLWQLFRRH TAITLPQWLP FLSVDRAQRA SATPPSTVEI 350
    ETSADL 356
    Length:356
    Mass (Da):40,849
    Last modified:July 27, 2011 - v2
    Checksum:iCA84549CFA1DEA9B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti38 – 381L → P in AAA89154. (PubMed:7542241)Curated
    Sequence conflicti334 – 3341V → E in AAA89154. (PubMed:7542241)Curated
    Sequence conflicti343 – 3442TP → RL in AAA89154. (PubMed:7542241)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28405 Genomic DNA. Translation: AAA89154.1.
    CH466671 Genomic DNA. Translation: EDL37174.1.
    BC127143 mRNA. Translation: AAI27144.1.
    BC128466 mRNA. Translation: AAI28467.1.
    CCDSiCCDS23667.1.
    PIRiI49340.
    RefSeqiNP_031744.3. NM_007718.3.
    UniGeneiMm.423532.

    Genome annotation databases

    EnsembliENSMUST00000071404; ENSMUSP00000071353; ENSMUSG00000064039.
    GeneIDi12770.
    KEGGimmu:12770.
    UCSCiuc009sgz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28405 Genomic DNA. Translation: AAA89154.1 .
    CH466671 Genomic DNA. Translation: EDL37174.1 .
    BC127143 mRNA. Translation: AAI27144.1 .
    BC128466 mRNA. Translation: AAI28467.1 .
    CCDSi CCDS23667.1.
    PIRi I49340.
    RefSeqi NP_031744.3. NM_007718.3.
    UniGenei Mm.423532.

    3D structure databases

    ProteinModelPortali P51676.
    SMRi P51676. Positions 25-318.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000071353.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi P51676.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000071404 ; ENSMUSP00000071353 ; ENSMUSG00000064039 .
    GeneIDi 12770.
    KEGGi mmu:12770.
    UCSCi uc009sgz.2. mouse.

    Organism-specific databases

    CTDi 12770.
    MGIi MGI:104617. Ccr1l1.

    Phylogenomic databases

    eggNOGi NOG148353.
    GeneTreei ENSGT00700000104407.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi A0JP35.
    KOi K04176.
    OMAi CYTRIIN.
    OrthoDBi EOG738051.
    TreeFami TF330966.

    Miscellaneous databases

    NextBioi 282142.
    PROi P51676.
    SOURCEi Search...

    Gene expression databases

    Bgeei P51676.
    CleanExi MM_CCR1L1.
    Genevestigatori P51676.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR002236. Chemokine_CCR1.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR01106. CHEMOKINER1.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor."
      Gao J.-L., Murphy P.M.
      J. Biol. Chem. 270:17494-17501(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiCC1L1_MOUSE
    AccessioniPrimary (citable) accession number: P51676
    Secondary accession number(s): A0JP35
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3