Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-C chemokine receptor type 1

Gene

Ccr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for a C-C type chemokine. Binds to MIP-1-alpha, RANTES, and less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.

GO - Molecular functioni

  1. C-C chemokine binding Source: MGI
  2. C-C chemokine receptor activity Source: MGI
  3. chemokine (C-C motif) ligand 5 binding Source: MGI
  4. chemokine (C-C motif) ligand 7 binding Source: MGI
  5. chemokine receptor activity Source: MGI
  6. phosphatidylinositol phospholipase C activity Source: MGI

GO - Biological processi

  1. calcium ion transport Source: MGI
  2. cell-cell signaling Source: MGI
  3. cellular calcium ion homeostasis Source: MGI
  4. cerebellum development Source: Ensembl
  5. chemokine-mediated signaling pathway Source: MGI
  6. exocytosis Source: MGI
  7. immune response Source: MGI
  8. inflammatory response Source: MGI
  9. leukocyte chemotaxis Source: MGI
  10. metabolic process Source: MGI
  11. myeloid cell differentiation Source: MGI
  12. negative regulation of bone mineralization Source: MGI
  13. negative regulation of gene expression Source: MGI
  14. negative regulation of innate immune response Source: BHF-UCL
  15. positive regulation of calcium ion transport Source: MGI
  16. positive regulation of cytosolic calcium ion concentration Source: MGI
  17. positive regulation of ERK1 and ERK2 cascade Source: MGI
  18. positive regulation of monocyte chemotaxis Source: UniProtKB
  19. positive regulation of osteoclast differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_250376. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 1
Short name:
C-C CKR-1
Short name:
CC-CKR-1
Short name:
CCR-1
Short name:
CCR1
Alternative name(s):
Macrophage inflammatory protein 1-alpha receptor
Short name:
MIP-1alpha-R
RANTES-R
CD_antigen: CD191
Gene namesi
Name:Ccr1
Synonyms:Cmkbr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:104618. Ccr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434ExtracellularSequence AnalysisAdd
BLAST
Transmembranei35 – 6026Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini61 – 644CytoplasmicSequence Analysis
Transmembranei65 – 9127Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini92 – 10716ExtracellularSequence AnalysisAdd
BLAST
Transmembranei108 – 12922Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini130 – 14617CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei147 – 17125Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini172 – 19726ExtracellularSequence AnalysisAdd
BLAST
Transmembranei198 – 22326Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini224 – 23916CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei240 – 26425Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini265 – 28117ExtracellularSequence AnalysisAdd
BLAST
Transmembranei282 – 30524Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini306 – 35550CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. neuronal cell body Source: Ensembl
  4. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355C-C chemokine receptor type 1PRO_0000069231Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi106 ↔ 183PROSITE-ProRule annotation
Modified residuei340 – 3401PhosphoserineBy similarity
Modified residuei341 – 3411PhosphoserineBy similarity
Modified residuei345 – 3451PhosphoserineBy similarity
Modified residuei352 – 3521PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PRIDEiP51675.

PTM databases

PhosphoSiteiP51675.

Expressioni

Tissue specificityi

Detected in the heart, spleen, lung, peritoneal exudate cells and leukocytes.

Gene expression databases

BgeeiP51675.
CleanExiMM_CCR1.
GenevestigatoriP51675.

Interactioni

Subunit structurei

Interacts with CREB3.By similarity

Structurei

3D structure databases

ProteinModelPortaliP51675.
SMRiP51675. Positions 23-317.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148353.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP51675.
KOiK04176.
OMAiFWIDYKL.
OrthoDBiEOG738051.
TreeFamiTF330966.

Family and domain databases

InterProiIPR002236. Chemokine_CCR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01106. CHEMOKINER1.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51675-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEISDFTEAY PTTTEFDYGD STPCQKTAVR AFGAGLLPPL YSLVFIIGVV
60 70 80 90 100
GNVLVILVLM QHRRLQSMTS IYLFNLAVSD LVFLFTLPFW IDYKLKDDWI
110 120 130 140 150
FGDAMCKLLS GFYYLGLYSE IFFIILLTID RYLAIVHAVF ALRARTVTFG
160 170 180 190 200
IITSIITWAL AILASMPALY FFKAQWEFTH RTCSPHFPYK SLKQWKRFQA
210 220 230 240 250
LKLNLLGLIL PLLVMIICYA GIIRILLRRP SEKKVKAVRL IFAITLLFFL
260 270 280 290 300
LWTPYNLSVF VSAFQDVLFT NQCEQSKQLD LAMQVTEVIA YTHCCVNPII
310 320 330 340 350
YVFVGERFWK YLRQLFQRHV AIPLAKWLPF LSVDQLERTS SISPSTGEHE

LSAGF
Length:355
Mass (Da):40,895
Last modified:July 27, 2011 - v2
Checksum:i41B0D566A56BC4F7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551V → M in AAA86119 (PubMed:7594543).Curated
Sequence conflicti149 – 1491F → L in AAA86119 (PubMed:7594543).Curated
Sequence conflicti149 – 1491F → L in AAA89153 (PubMed:7542241).Curated
Sequence conflicti278 – 2781Q → H in AAA86119 (PubMed:7594543).Curated
Sequence conflicti278 – 2781Q → H in AAA89153 (PubMed:7542241).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29678 mRNA. Translation: AAA86119.1.
U28404 Genomic DNA. Translation: AAA89153.1.
AK036597 mRNA. Translation: BAC29500.1.
AK036690 mRNA. Translation: BAC29535.1.
CH466671 Genomic DNA. Translation: EDL37173.1.
BC011092 mRNA. Translation: AAH11092.1.
CCDSiCCDS23666.1.
PIRiI49339.
RefSeqiNP_034042.3. NM_009912.4.
UniGeneiMm.274927.

Genome annotation databases

EnsembliENSMUST00000026911; ENSMUSP00000026911; ENSMUSG00000025804.
GeneIDi12768.
KEGGimmu:12768.
UCSCiuc009sgy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29678 mRNA. Translation: AAA86119.1.
U28404 Genomic DNA. Translation: AAA89153.1.
AK036597 mRNA. Translation: BAC29500.1.
AK036690 mRNA. Translation: BAC29535.1.
CH466671 Genomic DNA. Translation: EDL37173.1.
BC011092 mRNA. Translation: AAH11092.1.
CCDSiCCDS23666.1.
PIRiI49339.
RefSeqiNP_034042.3. NM_009912.4.
UniGeneiMm.274927.

3D structure databases

ProteinModelPortaliP51675.
SMRiP51675. Positions 23-317.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiP51675.
ChEMBLiCHEMBL3872.
GuidetoPHARMACOLOGYi58.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP51675.

Proteomic databases

PRIDEiP51675.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026911; ENSMUSP00000026911; ENSMUSG00000025804.
GeneIDi12768.
KEGGimmu:12768.
UCSCiuc009sgy.2. mouse.

Organism-specific databases

CTDi1230.
MGIiMGI:104618. Ccr1.

Phylogenomic databases

eggNOGiNOG148353.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP51675.
KOiK04176.
OMAiFWIDYKL.
OrthoDBiEOG738051.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiREACT_250376. G alpha (i) signalling events.

Miscellaneous databases

NextBioi282134.
PROiP51675.
SOURCEiSearch...

Gene expression databases

BgeeiP51675.
CleanExiMM_CCR1.
GenevestigatoriP51675.

Family and domain databases

InterProiIPR002236. Chemokine_CCR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01106. CHEMOKINER1.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of two murine eosinophil beta chemokine receptors."
    Post T.W., Bozic C.R., Rothenberg M.E., Luster A.D., Gerard N., Gerard C.
    J. Immunol. 155:5299-5305(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/Sv.
    Tissue: Peritoneal macrophage.
  2. "Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor."
    Gao J.-L., Murphy P.M.
    J. Biol. Chem. 270:17494-17501(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.

Entry informationi

Entry nameiCCR1_MOUSE
AccessioniPrimary (citable) accession number: P51675
Secondary accession number(s): Q6ZWR7, Q91VP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: March 4, 2015
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.