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P51675 (CCR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C chemokine receptor type 1

Short name=C-C CKR-1
Short name=CC-CKR-1
Short name=CCR-1
Short name=CCR1
Alternative name(s):
Macrophage inflammatory protein 1-alpha receptor
Short name=MIP-1alpha-R
RANTES-R
CD_antigen=CD191
Gene names
Name:Ccr1
Synonyms:Cmkbr1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for a C-C type chemokine. Binds to MIP-1-alpha, RANTES, and less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.

Subunit structure

Interacts with CREB3 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Detected in the heart, spleen, lung, peritoneal exudate cells and leukocytes.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcerebellum development

Inferred from electronic annotation. Source: Ensembl

chemokine-mediated signaling pathway

Inferred from direct assay Ref.1. Source: GOC

immune response

Inferred from electronic annotation. Source: InterPro

inflammatory response

Inferred from mutant phenotype PubMed 9166425. Source: MGI

leukocyte chemotaxis

Inferred from direct assay Ref.1. Source: MGI

myeloid cell differentiation

Inferred from mutant phenotype PubMed 9166425. Source: MGI

negative regulation of innate immune response

Inferred from mutant phenotype PubMed 15557190. Source: BHF-UCL

positive regulation of monocyte chemotaxis

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of fever generation

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentexternal side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

neuronal cell body

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionC-C chemokine receptor activity

Inferred from direct assay Ref.1. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 355355C-C chemokine receptor type 1
PRO_0000069231

Regions

Topological domain1 – 3434Extracellular Potential
Transmembrane35 – 6026Helical; Name=1; Potential
Topological domain61 – 644Cytoplasmic Potential
Transmembrane65 – 9127Helical; Name=2; Potential
Topological domain92 – 10716Extracellular Potential
Transmembrane108 – 12922Helical; Name=3; Potential
Topological domain130 – 14617Cytoplasmic Potential
Transmembrane147 – 17125Helical; Name=4; Potential
Topological domain172 – 19726Extracellular Potential
Transmembrane198 – 22326Helical; Name=5; Potential
Topological domain224 – 23916Cytoplasmic Potential
Transmembrane240 – 26425Helical; Name=6; Potential
Topological domain265 – 28117Extracellular Potential
Transmembrane282 – 30524Helical; Name=7; Potential
Topological domain306 – 35550Cytoplasmic Potential

Amino acid modifications

Disulfide bond106 ↔ 183 By similarity

Experimental info

Sequence conflict551V → M in AAA86119. Ref.1
Sequence conflict1491F → L in AAA86119. Ref.1
Sequence conflict1491F → L in AAA89153. Ref.2
Sequence conflict2781Q → H in AAA86119. Ref.1
Sequence conflict2781Q → H in AAA89153. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P51675 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 41B0D566A56BC4F7

FASTA35540,895
        10         20         30         40         50         60 
MEISDFTEAY PTTTEFDYGD STPCQKTAVR AFGAGLLPPL YSLVFIIGVV GNVLVILVLM 

        70         80         90        100        110        120 
QHRRLQSMTS IYLFNLAVSD LVFLFTLPFW IDYKLKDDWI FGDAMCKLLS GFYYLGLYSE 

       130        140        150        160        170        180 
IFFIILLTID RYLAIVHAVF ALRARTVTFG IITSIITWAL AILASMPALY FFKAQWEFTH 

       190        200        210        220        230        240 
RTCSPHFPYK SLKQWKRFQA LKLNLLGLIL PLLVMIICYA GIIRILLRRP SEKKVKAVRL 

       250        260        270        280        290        300 
IFAITLLFFL LWTPYNLSVF VSAFQDVLFT NQCEQSKQLD LAMQVTEVIA YTHCCVNPII 

       310        320        330        340        350 
YVFVGERFWK YLRQLFQRHV AIPLAKWLPF LSVDQLERTS SISPSTGEHE LSAGF 

« Hide

References

« Hide 'large scale' references
[1]"Molecular characterization of two murine eosinophil beta chemokine receptors."
Post T.W., Bozic C.R., Rothenberg M.E., Luster A.D., Gerard N., Gerard C.
J. Immunol. 155:5299-5305(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129/Sv.
Tissue: Peritoneal macrophage.
[2]"Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor."
Gao J.-L., Murphy P.M.
J. Biol. Chem. 270:17494-17501(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U29678 mRNA. Translation: AAA86119.1.
U28404 Genomic DNA. Translation: AAA89153.1.
AK036597 mRNA. Translation: BAC29500.1.
AK036690 mRNA. Translation: BAC29535.1.
CH466671 Genomic DNA. Translation: EDL37173.1.
BC011092 mRNA. Translation: AAH11092.1.
PIRI49339.
RefSeqNP_034042.3. NM_009912.4.
UniGeneMm.274927.

3D structure databases

ProteinModelPortalP51675.
SMRP51675. Positions 23-317.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP51675.
ChEMBLCHEMBL3872.
GuidetoPHARMACOLOGY58.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP51675.

Proteomic databases

PRIDEP51675.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000026911; ENSMUSP00000026911; ENSMUSG00000025804.
GeneID12768.
KEGGmmu:12768.
UCSCuc009sgy.2. mouse.

Organism-specific databases

CTD1230.
MGIMGI:104618. Ccr1.

Phylogenomic databases

eggNOGNOG148353.
GeneTreeENSGT00700000104407.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidQ6ZWR7.
KOK04176.
OMAFWIDYKL.
OrthoDBEOG738051.
TreeFamTF330966.

Gene expression databases

BgeeP51675.
CleanExMM_CCR1.
GenevestigatorP51675.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR002236. Chemokine_CCR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00657. CCCHEMOKINER.
PR01106. CHEMOKINER1.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio282134.
PROP51675.
SOURCESearch...

Entry information

Entry nameCCR1_MOUSE
AccessionPrimary (citable) accession number: P51675
Secondary accession number(s): Q6ZWR7, Q91VP9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries