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Protein

C-C chemokine receptor type 1

Gene

Ccr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for a C-C type chemokine. Binds to MIP-1-alpha, RANTES, and less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 1
Short name:
C-C CKR-1
Short name:
CC-CKR-1
Short name:
CCR-1
Short name:
CCR1
Alternative name(s):
Macrophage inflammatory protein 1-alpha receptor
Short name:
MIP-1alpha-R
RANTES-R
CD_antigen: CD191
Gene namesi
Name:Ccr1
Synonyms:Cmkbr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:104618. Ccr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularSequence analysisAdd BLAST34
Transmembranei35 – 60Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini61 – 64CytoplasmicSequence analysis4
Transmembranei65 – 91Helical; Name=2Sequence analysisAdd BLAST27
Topological domaini92 – 107ExtracellularSequence analysisAdd BLAST16
Transmembranei108 – 129Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini130 – 146CytoplasmicSequence analysisAdd BLAST17
Transmembranei147 – 171Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini172 – 197ExtracellularSequence analysisAdd BLAST26
Transmembranei198 – 223Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini224 – 239CytoplasmicSequence analysisAdd BLAST16
Transmembranei240 – 264Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini265 – 281ExtracellularSequence analysisAdd BLAST17
Transmembranei282 – 305Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini306 – 355CytoplasmicSequence analysisAdd BLAST50

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3872.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692311 – 355C-C chemokine receptor type 1Add BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi106 ↔ 183PROSITE-ProRule annotation
Modified residuei132PhosphotyrosineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiP51675.
PaxDbiP51675.
PRIDEiP51675.

PTM databases

iPTMnetiP51675.
PhosphoSitePlusiP51675.

Expressioni

Tissue specificityi

Detected in the heart, spleen, lung, peritoneal exudate cells and leukocytes.

Gene expression databases

BgeeiENSMUSG00000025804.
CleanExiMM_CCR1.
GenevisibleiP51675. MM.

Interactioni

Subunit structurei

Interacts with CREB3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026911.

Chemistry databases

BindingDBiP51675.

Structurei

3D structure databases

ProteinModelPortaliP51675.
SMRiP51675.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP51675.
KOiK04176.
OMAiFWIDYKL.
OrthoDBiEOG091G0B7A.
TreeFamiTF330966.

Family and domain databases

InterProiIPR002236. Chemokine_CCR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR10489:SF711. PTHR10489:SF711. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01106. CHEMOKINER1.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51675-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEISDFTEAY PTTTEFDYGD STPCQKTAVR AFGAGLLPPL YSLVFIIGVV
60 70 80 90 100
GNVLVILVLM QHRRLQSMTS IYLFNLAVSD LVFLFTLPFW IDYKLKDDWI
110 120 130 140 150
FGDAMCKLLS GFYYLGLYSE IFFIILLTID RYLAIVHAVF ALRARTVTFG
160 170 180 190 200
IITSIITWAL AILASMPALY FFKAQWEFTH RTCSPHFPYK SLKQWKRFQA
210 220 230 240 250
LKLNLLGLIL PLLVMIICYA GIIRILLRRP SEKKVKAVRL IFAITLLFFL
260 270 280 290 300
LWTPYNLSVF VSAFQDVLFT NQCEQSKQLD LAMQVTEVIA YTHCCVNPII
310 320 330 340 350
YVFVGERFWK YLRQLFQRHV AIPLAKWLPF LSVDQLERTS SISPSTGEHE

LSAGF
Length:355
Mass (Da):40,895
Last modified:July 27, 2011 - v2
Checksum:i41B0D566A56BC4F7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55V → M in AAA86119 (PubMed:7594543).Curated1
Sequence conflicti149F → L in AAA86119 (PubMed:7594543).Curated1
Sequence conflicti149F → L in AAA89153 (PubMed:7542241).Curated1
Sequence conflicti278Q → H in AAA86119 (PubMed:7594543).Curated1
Sequence conflicti278Q → H in AAA89153 (PubMed:7542241).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29678 mRNA. Translation: AAA86119.1.
U28404 Genomic DNA. Translation: AAA89153.1.
AK036597 mRNA. Translation: BAC29500.1.
AK036690 mRNA. Translation: BAC29535.1.
CH466671 Genomic DNA. Translation: EDL37173.1.
BC011092 mRNA. Translation: AAH11092.1.
CCDSiCCDS23666.1.
PIRiI49339.
RefSeqiNP_034042.3. NM_009912.4.
UniGeneiMm.274927.

Genome annotation databases

EnsembliENSMUST00000026911; ENSMUSP00000026911; ENSMUSG00000025804.
GeneIDi12768.
KEGGimmu:12768.
UCSCiuc009sgy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29678 mRNA. Translation: AAA86119.1.
U28404 Genomic DNA. Translation: AAA89153.1.
AK036597 mRNA. Translation: BAC29500.1.
AK036690 mRNA. Translation: BAC29535.1.
CH466671 Genomic DNA. Translation: EDL37173.1.
BC011092 mRNA. Translation: AAH11092.1.
CCDSiCCDS23666.1.
PIRiI49339.
RefSeqiNP_034042.3. NM_009912.4.
UniGeneiMm.274927.

3D structure databases

ProteinModelPortaliP51675.
SMRiP51675.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026911.

Chemistry databases

BindingDBiP51675.
ChEMBLiCHEMBL3872.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP51675.
PhosphoSitePlusiP51675.

Proteomic databases

MaxQBiP51675.
PaxDbiP51675.
PRIDEiP51675.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026911; ENSMUSP00000026911; ENSMUSG00000025804.
GeneIDi12768.
KEGGimmu:12768.
UCSCiuc009sgy.2. mouse.

Organism-specific databases

CTDi1230.
MGIiMGI:104618. Ccr1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP51675.
KOiK04176.
OMAiFWIDYKL.
OrthoDBiEOG091G0B7A.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiR-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiP51675.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025804.
CleanExiMM_CCR1.
GenevisibleiP51675. MM.

Family and domain databases

InterProiIPR002236. Chemokine_CCR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR10489:SF711. PTHR10489:SF711. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01106. CHEMOKINER1.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCR1_MOUSE
AccessioniPrimary (citable) accession number: P51675
Secondary accession number(s): Q6ZWR7, Q91VP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.