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P51675

- CCR1_MOUSE

UniProt

P51675 - CCR1_MOUSE

Protein

C-C chemokine receptor type 1

Gene

Ccr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Receptor for a C-C type chemokine. Binds to MIP-1-alpha, RANTES, and less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.

    GO - Molecular functioni

    1. C-C chemokine receptor activity Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. cerebellum development Source: Ensembl
    2. chemokine-mediated signaling pathway Source: GOC
    3. immune response Source: InterPro
    4. inflammatory response Source: MGI
    5. leukocyte chemotaxis Source: MGI
    6. myeloid cell differentiation Source: MGI
    7. negative regulation of innate immune response Source: BHF-UCL
    8. positive regulation of monocyte chemotaxis Source: UniProtKB
    9. regulation of fever generation Source: Ensembl
    10. response to lipopolysaccharide Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C chemokine receptor type 1
    Short name:
    C-C CKR-1
    Short name:
    CC-CKR-1
    Short name:
    CCR-1
    Short name:
    CCR1
    Alternative name(s):
    Macrophage inflammatory protein 1-alpha receptor
    Short name:
    MIP-1alpha-R
    RANTES-R
    CD_antigen: CD191
    Gene namesi
    Name:Ccr1
    Synonyms:Cmkbr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:104618. Ccr1.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. neuronal cell body Source: Ensembl
    4. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 355355C-C chemokine receptor type 1PRO_0000069231Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi106 ↔ 183PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP51675.

    PTM databases

    PhosphoSiteiP51675.

    Expressioni

    Tissue specificityi

    Detected in the heart, spleen, lung, peritoneal exudate cells and leukocytes.

    Gene expression databases

    BgeeiP51675.
    CleanExiMM_CCR1.
    GenevestigatoriP51675.

    Interactioni

    Subunit structurei

    Interacts with CREB3.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP51675.
    SMRiP51675. Positions 23-317.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini61 – 644CytoplasmicSequence Analysis
    Topological domaini92 – 10716ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini130 – 14617CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini172 – 19726ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini224 – 23916CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini265 – 28117ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini306 – 35550CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 6026Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei65 – 9127Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei108 – 12922Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei147 – 17125Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei198 – 22326Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei240 – 26425Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei282 – 30524Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148353.
    GeneTreeiENSGT00700000104407.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiQ6ZWR7.
    KOiK04176.
    OMAiFWIDYKL.
    OrthoDBiEOG738051.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR002236. Chemokine_CCR1.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR01106. CHEMOKINER1.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51675-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEISDFTEAY PTTTEFDYGD STPCQKTAVR AFGAGLLPPL YSLVFIIGVV    50
    GNVLVILVLM QHRRLQSMTS IYLFNLAVSD LVFLFTLPFW IDYKLKDDWI 100
    FGDAMCKLLS GFYYLGLYSE IFFIILLTID RYLAIVHAVF ALRARTVTFG 150
    IITSIITWAL AILASMPALY FFKAQWEFTH RTCSPHFPYK SLKQWKRFQA 200
    LKLNLLGLIL PLLVMIICYA GIIRILLRRP SEKKVKAVRL IFAITLLFFL 250
    LWTPYNLSVF VSAFQDVLFT NQCEQSKQLD LAMQVTEVIA YTHCCVNPII 300
    YVFVGERFWK YLRQLFQRHV AIPLAKWLPF LSVDQLERTS SISPSTGEHE 350
    LSAGF 355
    Length:355
    Mass (Da):40,895
    Last modified:July 27, 2011 - v2
    Checksum:i41B0D566A56BC4F7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti55 – 551V → M in AAA86119. (PubMed:7594543)Curated
    Sequence conflicti149 – 1491F → L in AAA86119. (PubMed:7594543)Curated
    Sequence conflicti149 – 1491F → L in AAA89153. (PubMed:7542241)Curated
    Sequence conflicti278 – 2781Q → H in AAA86119. (PubMed:7594543)Curated
    Sequence conflicti278 – 2781Q → H in AAA89153. (PubMed:7542241)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U29678 mRNA. Translation: AAA86119.1.
    U28404 Genomic DNA. Translation: AAA89153.1.
    AK036597 mRNA. Translation: BAC29500.1.
    AK036690 mRNA. Translation: BAC29535.1.
    CH466671 Genomic DNA. Translation: EDL37173.1.
    BC011092 mRNA. Translation: AAH11092.1.
    CCDSiCCDS23666.1.
    PIRiI49339.
    RefSeqiNP_034042.3. NM_009912.4.
    UniGeneiMm.274927.

    Genome annotation databases

    EnsembliENSMUST00000026911; ENSMUSP00000026911; ENSMUSG00000025804.
    GeneIDi12768.
    KEGGimmu:12768.
    UCSCiuc009sgy.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U29678 mRNA. Translation: AAA86119.1 .
    U28404 Genomic DNA. Translation: AAA89153.1 .
    AK036597 mRNA. Translation: BAC29500.1 .
    AK036690 mRNA. Translation: BAC29535.1 .
    CH466671 Genomic DNA. Translation: EDL37173.1 .
    BC011092 mRNA. Translation: AAH11092.1 .
    CCDSi CCDS23666.1.
    PIRi I49339.
    RefSeqi NP_034042.3. NM_009912.4.
    UniGenei Mm.274927.

    3D structure databases

    ProteinModelPortali P51675.
    SMRi P51675. Positions 23-317.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P51675.
    ChEMBLi CHEMBL3872.
    GuidetoPHARMACOLOGYi 58.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P51675.

    Proteomic databases

    PRIDEi P51675.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026911 ; ENSMUSP00000026911 ; ENSMUSG00000025804 .
    GeneIDi 12768.
    KEGGi mmu:12768.
    UCSCi uc009sgy.2. mouse.

    Organism-specific databases

    CTDi 1230.
    MGIi MGI:104618. Ccr1.

    Phylogenomic databases

    eggNOGi NOG148353.
    GeneTreei ENSGT00700000104407.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi Q6ZWR7.
    KOi K04176.
    OMAi FWIDYKL.
    OrthoDBi EOG738051.
    TreeFami TF330966.

    Miscellaneous databases

    NextBioi 282134.
    PROi P51675.
    SOURCEi Search...

    Gene expression databases

    Bgeei P51675.
    CleanExi MM_CCR1.
    Genevestigatori P51675.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR002236. Chemokine_CCR1.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR01106. CHEMOKINER1.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of two murine eosinophil beta chemokine receptors."
      Post T.W., Bozic C.R., Rothenberg M.E., Luster A.D., Gerard N., Gerard C.
      J. Immunol. 155:5299-5305(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/Sv.
      Tissue: Peritoneal macrophage.
    2. "Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor."
      Gao J.-L., Murphy P.M.
      J. Biol. Chem. 270:17494-17501(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiCCR1_MOUSE
    AccessioniPrimary (citable) accession number: P51675
    Secondary accession number(s): Q6ZWR7, Q91VP9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3