Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neuronal membrane glycoprotein M6-a

Gene

GPM6A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca2+ influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.1 Publication

GO - Molecular functioni

GO - Biological processi

  • neural retina development Source: UniProtKB
  • neuron migration Source: UniProtKB
  • neuron projection morphogenesis Source: UniProtKB
  • positive regulation of filopodium assembly Source: UniProtKB
  • stem cell differentiation Source: UniProtKB
  • synapse assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Neurogenesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000150625-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal membrane glycoprotein M6-a
Short name:
M6a
Gene namesi
Name:GPM6A
Synonyms:M6A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:4460. GPM6A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Topological domaini44 – 84ExtracellularSequence analysisAdd BLAST41
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 127CytoplasmicSequence analysisAdd BLAST22
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Topological domaini149 – 213ExtracellularBy similarityAdd BLAST65
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Topological domaini235 – 278CytoplasmicSequence analysisAdd BLAST44

GO - Cellular componenti

  • axonal growth cone Source: UniProtKB
  • dendritic spine Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • extracellular vesicle Source: UniProtKB
  • filopodium Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • neuronal cell body Source: UniProtKB
  • neuron projection Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2823.
OpenTargetsiENSG00000150625.
PharmGKBiPA28843.

Polymorphism and mutation databases

BioMutaiGPM6A.
DMDMi2506889.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001590181 – 278Neuronal membrane glycoprotein M6-aAdd BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Glycosylationi164N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi174 ↔ 192By similarity
Glycosylationi208N-linked (GlcNAc...)Sequence analysis1
Modified residuei256PhosphoserineBy similarity1
Modified residuei278PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP51674.
PeptideAtlasiP51674.
PRIDEiP51674.

PTM databases

iPTMnetiP51674.
PhosphoSitePlusiP51674.
SwissPalmiP51674.

Expressioni

Gene expression databases

BgeeiENSG00000150625.
CleanExiHS_GPM6A.
ExpressionAtlasiP51674. baseline and differential.
GenevisibleiP51674. HS.

Organism-specific databases

HPAiHPA017338.

Interactioni

Subunit structurei

Interacts with OPRM1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ZDHHC17Q8IUH55EBI-7187133,EBI-524753

Protein-protein interaction databases

BioGridi109084. 33 interactors.
IntActiP51674. 3 interactors.
STRINGi9606.ENSP00000280187.

Structurei

3D structure databases

ProteinModelPortaliP51674.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the myelin proteolipid protein family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4800. Eukaryota.
ENOG4110EPW. LUCA.
GeneTreeiENSGT00390000006915.
HOGENOMiHOG000231338.
HOVERGENiHBG000096.
InParanoidiP51674.
OMAiEEKKVCT.
OrthoDBiEOG091G0IM5.
PhylomeDBiP51674.
TreeFamiTF315162.

Family and domain databases

InterProiIPR001614. Myelin_PLP.
IPR018237. Myelin_PLP_CS.
[Graphical view]
PANTHERiPTHR11683. PTHR11683. 1 hit.
PfamiPF01275. Myelin_PLP. 1 hit.
[Graphical view]
PRINTSiPR00214. MYELINPLP.
SMARTiSM00002. PLP. 1 hit.
[Graphical view]
PROSITEiPS00575. MYELIN_PLP_1. 1 hit.
PS01004. MYELIN_PLP_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P51674-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEENMEEGQT QKGCFECCIK CLGGIPYASL IATILLYAGV ALFCGCGHEA
60 70 80 90 100
LSGTVNILQT YFEMARTAGD TLDVFTMIDI FKYVIYGIAA AFFVYGILLM
110 120 130 140 150
VEGFFTTGAI KDLYGDFKIT TCGRCVSAWF IMLTYLFMLA WLGVTAFTSL
160 170 180 190 200
PVYMYFNLWT ICRNTTLVEG ANLCLDLRQF GIVTIGEEKK ICTVSENFLR
210 220 230 240 250
MCESTELNMT FHLFIVALAG AGAAVIAMVH YLMVLSANWA YVKDACRMQK
260 270
YEDIKSKEEQ ELHDIHSTRS KERLNAYT
Length:278
Mass (Da):31,210
Last modified:November 1, 1997 - v2
Checksum:iDD0DB598C0E86B5D
GO
Isoform 2 (identifier: P51674-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MEENMEEGQTQK → MTDLE

Show »
Length:271
Mass (Da):30,364
Checksum:iAA2999D92620BD4A
GO
Isoform 3 (identifier: P51674-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MEENMEEGQTQK → M

Note: No experimental confirmation available.
Show »
Length:267
Mass (Da):29,905
Checksum:i94DD2BD6AFADEA61
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102E → A in AAB16889 (PubMed:8661015).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014895242V → L.Corresponds to variant rs1049820dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0451091 – 12MEENM…GQTQK → MTDLE in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_0460981 – 12MEENM…GQTQK → M in isoform 3. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49958 mRNA. Translation: BAA08712.1.
AK299788 mRNA. Translation: BAH13128.1.
AK226176 mRNA. No translation available.
AC093819 Genomic DNA. No translation available.
AC097537 Genomic DNA. No translation available.
AC110794 Genomic DNA. No translation available.
BC022508 mRNA. Translation: AAH22508.1.
BC022528 mRNA. Translation: AAH22528.1.
U45956 mRNA. Translation: AAB16889.1.
CCDSiCCDS3824.1. [P51674-1]
CCDS54822.1. [P51674-3]
CCDS58936.1. [P51674-2]
RefSeqiNP_001248377.1. NM_001261448.1. [P51674-2]
NP_005268.1. NM_005277.4. [P51674-1]
NP_963885.1. NM_201591.2. [P51674-1]
NP_963886.1. NM_201592.2. [P51674-3]
UniGeneiHs.75819.

Genome annotation databases

EnsembliENST00000280187; ENSP00000280187; ENSG00000150625. [P51674-1]
ENST00000393658; ENSP00000377268; ENSG00000150625. [P51674-1]
ENST00000506894; ENSP00000421578; ENSG00000150625. [P51674-3]
ENST00000515090; ENSP00000423984; ENSG00000150625. [P51674-2]
GeneIDi2823.
KEGGihsa:2823.
UCSCiuc003iuf.5. human. [P51674-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49958 mRNA. Translation: BAA08712.1.
AK299788 mRNA. Translation: BAH13128.1.
AK226176 mRNA. No translation available.
AC093819 Genomic DNA. No translation available.
AC097537 Genomic DNA. No translation available.
AC110794 Genomic DNA. No translation available.
BC022508 mRNA. Translation: AAH22508.1.
BC022528 mRNA. Translation: AAH22528.1.
U45956 mRNA. Translation: AAB16889.1.
CCDSiCCDS3824.1. [P51674-1]
CCDS54822.1. [P51674-3]
CCDS58936.1. [P51674-2]
RefSeqiNP_001248377.1. NM_001261448.1. [P51674-2]
NP_005268.1. NM_005277.4. [P51674-1]
NP_963885.1. NM_201591.2. [P51674-1]
NP_963886.1. NM_201592.2. [P51674-3]
UniGeneiHs.75819.

3D structure databases

ProteinModelPortaliP51674.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109084. 33 interactors.
IntActiP51674. 3 interactors.
STRINGi9606.ENSP00000280187.

PTM databases

iPTMnetiP51674.
PhosphoSitePlusiP51674.
SwissPalmiP51674.

Polymorphism and mutation databases

BioMutaiGPM6A.
DMDMi2506889.

Proteomic databases

PaxDbiP51674.
PeptideAtlasiP51674.
PRIDEiP51674.

Protocols and materials databases

DNASUi2823.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280187; ENSP00000280187; ENSG00000150625. [P51674-1]
ENST00000393658; ENSP00000377268; ENSG00000150625. [P51674-1]
ENST00000506894; ENSP00000421578; ENSG00000150625. [P51674-3]
ENST00000515090; ENSP00000423984; ENSG00000150625. [P51674-2]
GeneIDi2823.
KEGGihsa:2823.
UCSCiuc003iuf.5. human. [P51674-1]

Organism-specific databases

CTDi2823.
DisGeNETi2823.
GeneCardsiGPM6A.
HGNCiHGNC:4460. GPM6A.
HPAiHPA017338.
MIMi601275. gene.
neXtProtiNX_P51674.
OpenTargetsiENSG00000150625.
PharmGKBiPA28843.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4800. Eukaryota.
ENOG4110EPW. LUCA.
GeneTreeiENSGT00390000006915.
HOGENOMiHOG000231338.
HOVERGENiHBG000096.
InParanoidiP51674.
OMAiEEKKVCT.
OrthoDBiEOG091G0IM5.
PhylomeDBiP51674.
TreeFamiTF315162.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000150625-MONOMER.

Miscellaneous databases

ChiTaRSiGPM6A. human.
GeneWikiiGPM6A.
GenomeRNAii2823.
PROiP51674.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000150625.
CleanExiHS_GPM6A.
ExpressionAtlasiP51674. baseline and differential.
GenevisibleiP51674. HS.

Family and domain databases

InterProiIPR001614. Myelin_PLP.
IPR018237. Myelin_PLP_CS.
[Graphical view]
PANTHERiPTHR11683. PTHR11683. 1 hit.
PfamiPF01275. Myelin_PLP. 1 hit.
[Graphical view]
PRINTSiPR00214. MYELINPLP.
SMARTiSM00002. PLP. 1 hit.
[Graphical view]
PROSITEiPS00575. MYELIN_PLP_1. 1 hit.
PS01004. MYELIN_PLP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPM6A_HUMAN
AccessioniPrimary (citable) accession number: P51674
Secondary accession number(s): B7Z642, E9PHI5, Q92602
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.