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P51674

- GPM6A_HUMAN

UniProt

P51674 - GPM6A_HUMAN

Protein

Neuronal membrane glycoprotein M6-a

Gene

GPM6A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca2+ influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.1 Publication

    GO - Molecular functioni

    1. calcium channel activity Source: Ensembl
    2. protein binding Source: IntAct

    GO - Biological processi

    1. neural retina development Source: UniProtKB
    2. neuron migration Source: UniProtKB
    3. neuron projection morphogenesis Source: UniProtKB
    4. positive regulation of filopodium assembly Source: UniProtKB
    5. stem cell differentiation Source: UniProtKB
    6. synapse assembly Source: UniProtKB

    Keywords - Biological processi

    Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuronal membrane glycoprotein M6-a
    Short name:
    M6a
    Gene namesi
    Name:GPM6A
    Synonyms:M6A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:4460. GPM6A.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity. Cell projectionaxon By similarity. Cell projectiondendritic spine By similarity. Cell projectionfilopodium By similarity
    Note: Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons. Localized to the growth cone edge membrane of elongating axons By similarity.By similarity

    GO - Cellular componenti

    1. axonal growth cone Source: UniProtKB
    2. dendritic spine Source: UniProtKB-SubCell
    3. extracellular vesicular exosome Source: UniProt
    4. filopodium Source: UniProtKB
    5. integral component of membrane Source: UniProtKB-KW
    6. neuronal cell body Source: UniProtKB
    7. neuron projection Source: UniProtKB
    8. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28843.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 278278Neuronal membrane glycoprotein M6-aPRO_0000159018Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi174 ↔ 192By similarity
    Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Acetylation, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP51674.
    PRIDEiP51674.

    PTM databases

    PhosphoSiteiP51674.

    Expressioni

    Gene expression databases

    ArrayExpressiP51674.
    BgeeiP51674.
    CleanExiHS_GPM6A.
    GenevestigatoriP51674.

    Organism-specific databases

    HPAiHPA017338.

    Interactioni

    Subunit structurei

    Interacts with OPRM1.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ZDHHC17Q8IUH55EBI-7187133,EBI-524753

    Protein-protein interaction databases

    BioGridi109084. 3 interactions.
    IntActiP51674. 3 interactions.
    STRINGi9606.ENSP00000280187.

    Structurei

    3D structure databases

    ProteinModelPortaliP51674.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2222CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini44 – 8441ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini106 – 12722CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini149 – 21365ExtracellularBy similarityAdd
    BLAST
    Topological domaini235 – 27844CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei85 – 10521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei128 – 14821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei214 – 23421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the myelin proteolipid protein family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG322245.
    HOGENOMiHOG000231338.
    HOVERGENiHBG000096.
    InParanoidiP51674.
    OMAiEEKKVCT.
    OrthoDBiEOG7X3QRG.
    PhylomeDBiP51674.
    TreeFamiTF315162.

    Family and domain databases

    InterProiIPR001614. Myelin_PLP.
    IPR018237. Myelin_PLP_CS.
    [Graphical view]
    PANTHERiPTHR11683. PTHR11683. 1 hit.
    PfamiPF01275. Myelin_PLP. 1 hit.
    [Graphical view]
    PRINTSiPR00214. MYELINPLP.
    SMARTiSM00002. PLP. 1 hit.
    [Graphical view]
    PROSITEiPS00575. MYELIN_PLP_1. 1 hit.
    PS01004. MYELIN_PLP_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P51674-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEENMEEGQT QKGCFECCIK CLGGIPYASL IATILLYAGV ALFCGCGHEA    50
    LSGTVNILQT YFEMARTAGD TLDVFTMIDI FKYVIYGIAA AFFVYGILLM 100
    VEGFFTTGAI KDLYGDFKIT TCGRCVSAWF IMLTYLFMLA WLGVTAFTSL 150
    PVYMYFNLWT ICRNTTLVEG ANLCLDLRQF GIVTIGEEKK ICTVSENFLR 200
    MCESTELNMT FHLFIVALAG AGAAVIAMVH YLMVLSANWA YVKDACRMQK 250
    YEDIKSKEEQ ELHDIHSTRS KERLNAYT 278
    Length:278
    Mass (Da):31,210
    Last modified:November 1, 1997 - v2
    Checksum:iDD0DB598C0E86B5D
    GO
    Isoform 2 (identifier: P51674-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-12: MEENMEEGQTQK → MTDLE

    Show »
    Length:271
    Mass (Da):30,364
    Checksum:iAA2999D92620BD4A
    GO
    Isoform 3 (identifier: P51674-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-12: MEENMEEGQTQK → M

    Note: No experimental confirmation available.

    Show »
    Length:267
    Mass (Da):29,905
    Checksum:i94DD2BD6AFADEA61
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti102 – 1021E → A in AAB16889. (PubMed:8661015)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti242 – 2421V → L.
    Corresponds to variant rs1049820 [ dbSNP | Ensembl ].
    VAR_014895

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1212MEENM…GQTQK → MTDLE in isoform 2. 1 PublicationVSP_045109Add
    BLAST
    Alternative sequencei1 – 1212MEENM…GQTQK → M in isoform 3. 1 PublicationVSP_046098Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49958 mRNA. Translation: BAA08712.1.
    AK299788 mRNA. Translation: BAH13128.1.
    AK226176 mRNA. No translation available.
    AC093819 Genomic DNA. No translation available.
    AC097537 Genomic DNA. No translation available.
    AC110794 Genomic DNA. No translation available.
    BC022508 mRNA. Translation: AAH22508.1.
    BC022528 mRNA. Translation: AAH22528.1.
    U45956 mRNA. Translation: AAB16889.1.
    CCDSiCCDS3824.1. [P51674-1]
    CCDS54822.1. [P51674-3]
    CCDS58936.1. [P51674-2]
    RefSeqiNP_001248377.1. NM_001261448.1. [P51674-2]
    NP_005268.1. NM_005277.4. [P51674-1]
    NP_963885.1. NM_201591.2. [P51674-1]
    NP_963886.1. NM_201592.2. [P51674-3]
    UniGeneiHs.75819.

    Genome annotation databases

    EnsembliENST00000280187; ENSP00000280187; ENSG00000150625. [P51674-1]
    ENST00000393658; ENSP00000377268; ENSG00000150625. [P51674-1]
    ENST00000506894; ENSP00000421578; ENSG00000150625. [P51674-3]
    ENST00000515090; ENSP00000423984; ENSG00000150625. [P51674-2]
    GeneIDi2823.
    KEGGihsa:2823.
    UCSCiuc003iuf.4. human. [P51674-1]
    uc011ckj.2. human.

    Polymorphism databases

    DMDMi2506889.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49958 mRNA. Translation: BAA08712.1 .
    AK299788 mRNA. Translation: BAH13128.1 .
    AK226176 mRNA. No translation available.
    AC093819 Genomic DNA. No translation available.
    AC097537 Genomic DNA. No translation available.
    AC110794 Genomic DNA. No translation available.
    BC022508 mRNA. Translation: AAH22508.1 .
    BC022528 mRNA. Translation: AAH22528.1 .
    U45956 mRNA. Translation: AAB16889.1 .
    CCDSi CCDS3824.1. [P51674-1 ]
    CCDS54822.1. [P51674-3 ]
    CCDS58936.1. [P51674-2 ]
    RefSeqi NP_001248377.1. NM_001261448.1. [P51674-2 ]
    NP_005268.1. NM_005277.4. [P51674-1 ]
    NP_963885.1. NM_201591.2. [P51674-1 ]
    NP_963886.1. NM_201592.2. [P51674-3 ]
    UniGenei Hs.75819.

    3D structure databases

    ProteinModelPortali P51674.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109084. 3 interactions.
    IntActi P51674. 3 interactions.
    STRINGi 9606.ENSP00000280187.

    PTM databases

    PhosphoSitei P51674.

    Polymorphism databases

    DMDMi 2506889.

    Proteomic databases

    PaxDbi P51674.
    PRIDEi P51674.

    Protocols and materials databases

    DNASUi 2823.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000280187 ; ENSP00000280187 ; ENSG00000150625 . [P51674-1 ]
    ENST00000393658 ; ENSP00000377268 ; ENSG00000150625 . [P51674-1 ]
    ENST00000506894 ; ENSP00000421578 ; ENSG00000150625 . [P51674-3 ]
    ENST00000515090 ; ENSP00000423984 ; ENSG00000150625 . [P51674-2 ]
    GeneIDi 2823.
    KEGGi hsa:2823.
    UCSCi uc003iuf.4. human. [P51674-1 ]
    uc011ckj.2. human.

    Organism-specific databases

    CTDi 2823.
    GeneCardsi GC04M176554.
    HGNCi HGNC:4460. GPM6A.
    HPAi HPA017338.
    MIMi 601275. gene.
    neXtProti NX_P51674.
    PharmGKBi PA28843.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG322245.
    HOGENOMi HOG000231338.
    HOVERGENi HBG000096.
    InParanoidi P51674.
    OMAi EEKKVCT.
    OrthoDBi EOG7X3QRG.
    PhylomeDBi P51674.
    TreeFami TF315162.

    Miscellaneous databases

    ChiTaRSi GPM6A. human.
    GeneWikii GPM6A.
    GenomeRNAii 2823.
    NextBioi 11127.
    PROi P51674.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51674.
    Bgeei P51674.
    CleanExi HS_GPM6A.
    Genevestigatori P51674.

    Family and domain databases

    InterProi IPR001614. Myelin_PLP.
    IPR018237. Myelin_PLP_CS.
    [Graphical view ]
    PANTHERi PTHR11683. PTHR11683. 1 hit.
    Pfami PF01275. Myelin_PLP. 1 hit.
    [Graphical view ]
    PRINTSi PR00214. MYELINPLP.
    SMARTi SM00002. PLP. 1 hit.
    [Graphical view ]
    PROSITEi PS00575. MYELIN_PLP_1. 1 hit.
    PS01004. MYELIN_PLP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and mapping of the human glycoprotein M6 gene (GPM6A) to 4q33-->q34."
      Shimizu F., Watanabe T.K., Fujiwara T., Takahashi E., Nakamura Y., Maekawa H.
      Cytogenet. Cell Genet. 74:138-139(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Fetal brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 100-278.
      Tissue: Spinal cord.
    7. "Human GPM6A is associated with differentiation and neuronal migration of neurons derived from human embryonic stem cells."
      Michibata H., Okuno T., Konishi N., Kyono K., Wakimoto K., Aoki K., Kondo Y., Takata K., Kitamura Y., Taniguchi T.
      Stem Cells Dev. 18:629-639(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGPM6A_HUMAN
    AccessioniPrimary (citable) accession number: P51674
    Secondary accession number(s): B7Z642, E9PHI5, Q92602
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3