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Protein

Neuronal membrane glycoprotein M6-a

Gene

GPM6A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca2+ influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.1 Publication

GO - Molecular functioni

GO - Biological processi

  • neural retina development Source: UniProtKB
  • neuron migration Source: UniProtKB
  • neuron projection morphogenesis Source: UniProtKB
  • positive regulation of filopodium assembly Source: UniProtKB
  • stem cell differentiation Source: UniProtKB
  • synapse assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal membrane glycoprotein M6-a
Short name:
M6a
Gene namesi
Name:GPM6A
Synonyms:M6A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:4460. GPM6A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei23 – 4321HelicalSequence AnalysisAdd
BLAST
Topological domaini44 – 8441ExtracellularSequence AnalysisAdd
BLAST
Transmembranei85 – 10521HelicalSequence AnalysisAdd
BLAST
Topological domaini106 – 12722CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei128 – 14821HelicalSequence AnalysisAdd
BLAST
Topological domaini149 – 21365ExtracellularBy similarityAdd
BLAST
Transmembranei214 – 23421HelicalSequence AnalysisAdd
BLAST
Topological domaini235 – 27844CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • axonal growth cone Source: UniProtKB
  • dendritic spine Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • extracellular vesicle Source: UniProtKB
  • filopodium Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • neuronal cell body Source: UniProtKB
  • neuron projection Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28843.

Polymorphism and mutation databases

BioMutaiGPM6A.
DMDMi2506889.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Neuronal membrane glycoprotein M6-aPRO_0000159018Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi174 ↔ 192By similarity
Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP51674.
PRIDEiP51674.

PTM databases

PhosphoSiteiP51674.

Expressioni

Gene expression databases

BgeeiP51674.
CleanExiHS_GPM6A.
ExpressionAtlasiP51674. baseline and differential.
GenevisibleiP51674. HS.

Organism-specific databases

HPAiHPA017338.

Interactioni

Subunit structurei

Interacts with OPRM1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ZDHHC17Q8IUH55EBI-7187133,EBI-524753

Protein-protein interaction databases

BioGridi109084. 25 interactions.
IntActiP51674. 3 interactions.
STRINGi9606.ENSP00000280187.

Structurei

3D structure databases

ProteinModelPortaliP51674.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the myelin proteolipid protein family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG322245.
GeneTreeiENSGT00390000006915.
HOGENOMiHOG000231338.
HOVERGENiHBG000096.
InParanoidiP51674.
OMAiWIEAVQM.
OrthoDBiEOG7X3QRG.
PhylomeDBiP51674.
TreeFamiTF315162.

Family and domain databases

InterProiIPR001614. Myelin_PLP.
IPR018237. Myelin_PLP_CS.
[Graphical view]
PANTHERiPTHR11683. PTHR11683. 1 hit.
PfamiPF01275. Myelin_PLP. 1 hit.
[Graphical view]
PRINTSiPR00214. MYELINPLP.
SMARTiSM00002. PLP. 1 hit.
[Graphical view]
PROSITEiPS00575. MYELIN_PLP_1. 1 hit.
PS01004. MYELIN_PLP_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P51674-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEENMEEGQT QKGCFECCIK CLGGIPYASL IATILLYAGV ALFCGCGHEA
60 70 80 90 100
LSGTVNILQT YFEMARTAGD TLDVFTMIDI FKYVIYGIAA AFFVYGILLM
110 120 130 140 150
VEGFFTTGAI KDLYGDFKIT TCGRCVSAWF IMLTYLFMLA WLGVTAFTSL
160 170 180 190 200
PVYMYFNLWT ICRNTTLVEG ANLCLDLRQF GIVTIGEEKK ICTVSENFLR
210 220 230 240 250
MCESTELNMT FHLFIVALAG AGAAVIAMVH YLMVLSANWA YVKDACRMQK
260 270
YEDIKSKEEQ ELHDIHSTRS KERLNAYT
Length:278
Mass (Da):31,210
Last modified:November 1, 1997 - v2
Checksum:iDD0DB598C0E86B5D
GO
Isoform 2 (identifier: P51674-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MEENMEEGQTQK → MTDLE

Show »
Length:271
Mass (Da):30,364
Checksum:iAA2999D92620BD4A
GO
Isoform 3 (identifier: P51674-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MEENMEEGQTQK → M

Note: No experimental confirmation available.
Show »
Length:267
Mass (Da):29,905
Checksum:i94DD2BD6AFADEA61
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021E → A in AAB16889 (PubMed:8661015).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti242 – 2421V → L.
Corresponds to variant rs1049820 [ dbSNP | Ensembl ].
VAR_014895

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1212MEENM…GQTQK → MTDLE in isoform 2. 1 PublicationVSP_045109Add
BLAST
Alternative sequencei1 – 1212MEENM…GQTQK → M in isoform 3. 1 PublicationVSP_046098Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49958 mRNA. Translation: BAA08712.1.
AK299788 mRNA. Translation: BAH13128.1.
AK226176 mRNA. No translation available.
AC093819 Genomic DNA. No translation available.
AC097537 Genomic DNA. No translation available.
AC110794 Genomic DNA. No translation available.
BC022508 mRNA. Translation: AAH22508.1.
BC022528 mRNA. Translation: AAH22528.1.
U45956 mRNA. Translation: AAB16889.1.
CCDSiCCDS3824.1. [P51674-1]
CCDS54822.1. [P51674-3]
CCDS58936.1. [P51674-2]
RefSeqiNP_001248377.1. NM_001261448.1. [P51674-2]
NP_005268.1. NM_005277.4. [P51674-1]
NP_963885.1. NM_201591.2. [P51674-1]
NP_963886.1. NM_201592.2. [P51674-3]
UniGeneiHs.75819.

Genome annotation databases

EnsembliENST00000280187; ENSP00000280187; ENSG00000150625. [P51674-1]
ENST00000393658; ENSP00000377268; ENSG00000150625. [P51674-1]
ENST00000506894; ENSP00000421578; ENSG00000150625. [P51674-3]
ENST00000515090; ENSP00000423984; ENSG00000150625. [P51674-2]
GeneIDi2823.
KEGGihsa:2823.
UCSCiuc003iuf.4. human. [P51674-1]
uc011ckj.2. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49958 mRNA. Translation: BAA08712.1.
AK299788 mRNA. Translation: BAH13128.1.
AK226176 mRNA. No translation available.
AC093819 Genomic DNA. No translation available.
AC097537 Genomic DNA. No translation available.
AC110794 Genomic DNA. No translation available.
BC022508 mRNA. Translation: AAH22508.1.
BC022528 mRNA. Translation: AAH22528.1.
U45956 mRNA. Translation: AAB16889.1.
CCDSiCCDS3824.1. [P51674-1]
CCDS54822.1. [P51674-3]
CCDS58936.1. [P51674-2]
RefSeqiNP_001248377.1. NM_001261448.1. [P51674-2]
NP_005268.1. NM_005277.4. [P51674-1]
NP_963885.1. NM_201591.2. [P51674-1]
NP_963886.1. NM_201592.2. [P51674-3]
UniGeneiHs.75819.

3D structure databases

ProteinModelPortaliP51674.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109084. 25 interactions.
IntActiP51674. 3 interactions.
STRINGi9606.ENSP00000280187.

PTM databases

PhosphoSiteiP51674.

Polymorphism and mutation databases

BioMutaiGPM6A.
DMDMi2506889.

Proteomic databases

PaxDbiP51674.
PRIDEiP51674.

Protocols and materials databases

DNASUi2823.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280187; ENSP00000280187; ENSG00000150625. [P51674-1]
ENST00000393658; ENSP00000377268; ENSG00000150625. [P51674-1]
ENST00000506894; ENSP00000421578; ENSG00000150625. [P51674-3]
ENST00000515090; ENSP00000423984; ENSG00000150625. [P51674-2]
GeneIDi2823.
KEGGihsa:2823.
UCSCiuc003iuf.4. human. [P51674-1]
uc011ckj.2. human.

Organism-specific databases

CTDi2823.
GeneCardsiGC04M176554.
HGNCiHGNC:4460. GPM6A.
HPAiHPA017338.
MIMi601275. gene.
neXtProtiNX_P51674.
PharmGKBiPA28843.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG322245.
GeneTreeiENSGT00390000006915.
HOGENOMiHOG000231338.
HOVERGENiHBG000096.
InParanoidiP51674.
OMAiWIEAVQM.
OrthoDBiEOG7X3QRG.
PhylomeDBiP51674.
TreeFamiTF315162.

Miscellaneous databases

ChiTaRSiGPM6A. human.
GeneWikiiGPM6A.
GenomeRNAii2823.
NextBioi11127.
PROiP51674.
SOURCEiSearch...

Gene expression databases

BgeeiP51674.
CleanExiHS_GPM6A.
ExpressionAtlasiP51674. baseline and differential.
GenevisibleiP51674. HS.

Family and domain databases

InterProiIPR001614. Myelin_PLP.
IPR018237. Myelin_PLP_CS.
[Graphical view]
PANTHERiPTHR11683. PTHR11683. 1 hit.
PfamiPF01275. Myelin_PLP. 1 hit.
[Graphical view]
PRINTSiPR00214. MYELINPLP.
SMARTiSM00002. PLP. 1 hit.
[Graphical view]
PROSITEiPS00575. MYELIN_PLP_1. 1 hit.
PS01004. MYELIN_PLP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and mapping of the human glycoprotein M6 gene (GPM6A) to 4q33-->q34."
    Shimizu F., Watanabe T.K., Fujiwara T., Takahashi E., Nakamura Y., Maekawa H.
    Cytogenet. Cell Genet. 74:138-139(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Fetal brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 100-278.
    Tissue: Spinal cord.
  7. "Human GPM6A is associated with differentiation and neuronal migration of neurons derived from human embryonic stem cells."
    Michibata H., Okuno T., Konishi N., Kyono K., Wakimoto K., Aoki K., Kondo Y., Takata K., Kitamura Y., Taniguchi T.
    Stem Cells Dev. 18:629-639(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGPM6A_HUMAN
AccessioniPrimary (citable) accession number: P51674
Secondary accession number(s): B7Z642, E9PHI5, Q92602
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: June 24, 2015
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.