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P51674 (GPM6A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuronal membrane glycoprotein M6-a

Short name=M6a
Gene names
Name:GPM6A
Synonyms:M6A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca2+ influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor. Ref.7

Subunit structure

Interacts with OPRM1 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Cell projectionaxon By similarity. Cell projectiondendritic spine By similarity. Cell projectionfilopodium By similarity. Note: Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons. Localized to the growth cone edge membrane of elongating axons By similarity.

Sequence similarities

Belongs to the myelin proteolipid protein family.

Ontologies

Keywords
   Biological processNeurogenesis
   Cellular componentCell membrane
Cell projection
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   PTMAcetylation
Disulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processneural retina development

Inferred from sequence or structural similarity. Source: UniProtKB

neuron migration

Inferred from direct assay Ref.7. Source: UniProtKB

neuron projection morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of filopodium assembly

Inferred from sequence or structural similarity. Source: UniProtKB

stem cell differentiation

Inferred from direct assay Ref.7. Source: UniProtKB

synapse assembly

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentaxonal growth cone

Inferred from sequence or structural similarity. Source: UniProtKB

dendritic spine

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular vesicular exosome

Inferred from direct assay PubMed 19056867. Source: UniProt

filopodium

Inferred from sequence or structural similarity. Source: UniProtKB

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

neuronal cell body

Inferred from sequence or structural similarity. Source: UniProtKB

plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functioncalcium channel activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P51674-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P51674-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MEENMEEGQTQK → MTDLE
Isoform 3 (identifier: P51674-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MEENMEEGQTQK → M
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 278278Neuronal membrane glycoprotein M6-a
PRO_0000159018

Regions

Topological domain1 – 2222Cytoplasmic Potential
Transmembrane23 – 4321Helical; Potential
Topological domain44 – 8441Extracellular Potential
Transmembrane85 – 10521Helical; Potential
Topological domain106 – 12722Cytoplasmic Potential
Transmembrane128 – 14821Helical; Potential
Topological domain149 – 21365Extracellular By similarity
Transmembrane214 – 23421Helical; Potential
Topological domain235 – 27844Cytoplasmic Potential

Amino acid modifications

Modified residue11N-acetylmethionine
Glycosylation1641N-linked (GlcNAc...) Potential
Glycosylation2081N-linked (GlcNAc...) Potential
Disulfide bond174 ↔ 192 By similarity

Natural variations

Alternative sequence1 – 1212MEENM…GQTQK → MTDLE in isoform 2.
VSP_045109
Alternative sequence1 – 1212MEENM…GQTQK → M in isoform 3.
VSP_046098
Natural variant2421V → L.
Corresponds to variant rs1049820 [ dbSNP | Ensembl ].
VAR_014895

Experimental info

Sequence conflict1021E → A in AAB16889. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: DD0DB598C0E86B5D

FASTA27831,210
        10         20         30         40         50         60 
MEENMEEGQT QKGCFECCIK CLGGIPYASL IATILLYAGV ALFCGCGHEA LSGTVNILQT 

        70         80         90        100        110        120 
YFEMARTAGD TLDVFTMIDI FKYVIYGIAA AFFVYGILLM VEGFFTTGAI KDLYGDFKIT 

       130        140        150        160        170        180 
TCGRCVSAWF IMLTYLFMLA WLGVTAFTSL PVYMYFNLWT ICRNTTLVEG ANLCLDLRQF 

       190        200        210        220        230        240 
GIVTIGEEKK ICTVSENFLR MCESTELNMT FHLFIVALAG AGAAVIAMVH YLMVLSANWA 

       250        260        270 
YVKDACRMQK YEDIKSKEEQ ELHDIHSTRS KERLNAYT 

« Hide

Isoform 2 [UniParc].

Checksum: AA2999D92620BD4A
Show »

FASTA27130,364
Isoform 3 [UniParc].

Checksum: 94DD2BD6AFADEA61
Show »

FASTA26729,905

References

« Hide 'large scale' references
[1]"Isolation and mapping of the human glycoprotein M6 gene (GPM6A) to 4q33-->q34."
Shimizu F., Watanabe T.K., Fujiwara T., Takahashi E., Nakamura Y., Maekawa H.
Cytogenet. Cell Genet. 74:138-139(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Fetal brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[3]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Brain.
[4]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[6]"Chromosomal mapping of the human M6 genes."
Olinsky S., Loop B.T., Dekosky A., Ripepi B., Weng W., Cummins J., Wenger S.L., Yan Y., Lagenaur C., Narayanan V.
Genomics 33:532-536(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 100-278.
Tissue: Spinal cord.
[7]"Human GPM6A is associated with differentiation and neuronal migration of neurons derived from human embryonic stem cells."
Michibata H., Okuno T., Konishi N., Kyono K., Wakimoto K., Aoki K., Kondo Y., Takata K., Kitamura Y., Taniguchi T.
Stem Cells Dev. 18:629-639(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[8]"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D49958 mRNA. Translation: BAA08712.1.
AK299788 mRNA. Translation: BAH13128.1.
AK226176 mRNA. No translation available.
AC093819 Genomic DNA. No translation available.
AC097537 Genomic DNA. No translation available.
AC110794 Genomic DNA. No translation available.
BC022508 mRNA. Translation: AAH22508.1.
BC022528 mRNA. Translation: AAH22528.1.
U45956 mRNA. Translation: AAB16889.1.
RefSeqNP_001248377.1. NM_001261448.1.
NP_005268.1. NM_005277.4.
NP_963885.1. NM_201591.2.
NP_963886.1. NM_201592.2.
UniGeneHs.75819.

3D structure databases

ProteinModelPortalP51674.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109084. 3 interactions.
IntActP51674. 1 interaction.
STRING9606.ENSP00000280187.

PTM databases

PhosphoSiteP51674.

Polymorphism databases

DMDM2506889.

Proteomic databases

PaxDbP51674.
PRIDEP51674.

Protocols and materials databases

DNASU2823.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000280187; ENSP00000280187; ENSG00000150625. [P51674-1]
ENST00000393658; ENSP00000377268; ENSG00000150625. [P51674-1]
ENST00000506894; ENSP00000421578; ENSG00000150625. [P51674-3]
ENST00000515090; ENSP00000423984; ENSG00000150625. [P51674-2]
GeneID2823.
KEGGhsa:2823.
UCSCuc003iuf.4. human. [P51674-1]
uc011ckj.2. human.

Organism-specific databases

CTD2823.
GeneCardsGC04M176554.
HGNCHGNC:4460. GPM6A.
HPAHPA017338.
MIM601275. gene.
neXtProtNX_P51674.
PharmGKBPA28843.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG322245.
HOGENOMHOG000231338.
HOVERGENHBG000096.
InParanoidP51674.
OMAGIFCGTM.
OrthoDBEOG7X3QRG.
TreeFamTF315162.

Gene expression databases

ArrayExpressP51674.
BgeeP51674.
CleanExHS_GPM6A.
GenevestigatorP51674.

Family and domain databases

InterProIPR001614. Myelin_PLP.
IPR018237. Myelin_PLP_CS.
[Graphical view]
PANTHERPTHR11683. PTHR11683. 1 hit.
PfamPF01275. Myelin_PLP. 1 hit.
[Graphical view]
PRINTSPR00214. MYELINPLP.
SMARTSM00002. PLP. 1 hit.
[Graphical view]
PROSITEPS00575. MYELIN_PLP_1. 1 hit.
PS01004. MYELIN_PLP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGPM6A. human.
GeneWikiGPM6A.
GenomeRNAi2823.
NextBio11127.
PROP51674.
SOURCESearch...

Entry information

Entry nameGPM6A_HUMAN
AccessionPrimary (citable) accession number: P51674
Secondary accession number(s): B7Z642, E9PHI5, Q92602
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: March 19, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM