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P51674

- GPM6A_HUMAN

UniProt

P51674 - GPM6A_HUMAN

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Protein

Neuronal membrane glycoprotein M6-a

Gene
GPM6A, M6A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca2+ influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.1 Publication

GO - Molecular functioni

  1. calcium channel activity Source: Ensembl
  2. protein binding Source: IntAct

GO - Biological processi

  1. neural retina development Source: UniProtKB
  2. neuron migration Source: UniProtKB
  3. neuron projection morphogenesis Source: UniProtKB
  4. positive regulation of filopodium assembly Source: UniProtKB
  5. stem cell differentiation Source: UniProtKB
  6. synapse assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal membrane glycoprotein M6-a
Short name:
M6a
Gene namesi
Name:GPM6A
Synonyms:M6A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:4460. GPM6A.

Subcellular locationi

Cell membrane; Multi-pass membrane protein By similarity. Cell projectionaxon By similarity. Cell projectiondendritic spine By similarity. Cell projectionfilopodium By similarity
Note: Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons. Localized to the growth cone edge membrane of elongating axons By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei23 – 4321Helical; Reviewed predictionAdd
BLAST
Topological domaini44 – 8441Extracellular Reviewed predictionAdd
BLAST
Transmembranei85 – 10521Helical; Reviewed predictionAdd
BLAST
Topological domaini106 – 12722Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei128 – 14821Helical; Reviewed predictionAdd
BLAST
Topological domaini149 – 21365Extracellular By similarityAdd
BLAST
Transmembranei214 – 23421Helical; Reviewed predictionAdd
BLAST
Topological domaini235 – 27844Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. axonal growth cone Source: UniProtKB
  2. dendritic spine Source: UniProtKB-SubCell
  3. extracellular vesicular exosome Source: UniProt
  4. filopodium Source: UniProtKB
  5. integral component of membrane Source: UniProtKB-KW
  6. neuronal cell body Source: UniProtKB
  7. neuron projection Source: UniProtKB
  8. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28843.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Neuronal membrane glycoprotein M6-aPRO_0000159018Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Glycosylationi164 – 1641N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi174 ↔ 192 By similarity
Glycosylationi208 – 2081N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP51674.
PRIDEiP51674.

PTM databases

PhosphoSiteiP51674.

Expressioni

Gene expression databases

ArrayExpressiP51674.
BgeeiP51674.
CleanExiHS_GPM6A.
GenevestigatoriP51674.

Organism-specific databases

HPAiHPA017338.

Interactioni

Subunit structurei

Interacts with OPRM1 By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
ZDHHC17Q8IUH55EBI-7187133,EBI-524753

Protein-protein interaction databases

BioGridi109084. 3 interactions.
IntActiP51674. 3 interactions.
STRINGi9606.ENSP00000280187.

Structurei

3D structure databases

ProteinModelPortaliP51674.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG322245.
HOGENOMiHOG000231338.
HOVERGENiHBG000096.
InParanoidiP51674.
OMAiEEKKVCT.
OrthoDBiEOG7X3QRG.
PhylomeDBiP51674.
TreeFamiTF315162.

Family and domain databases

InterProiIPR001614. Myelin_PLP.
IPR018237. Myelin_PLP_CS.
[Graphical view]
PANTHERiPTHR11683. PTHR11683. 1 hit.
PfamiPF01275. Myelin_PLP. 1 hit.
[Graphical view]
PRINTSiPR00214. MYELINPLP.
SMARTiSM00002. PLP. 1 hit.
[Graphical view]
PROSITEiPS00575. MYELIN_PLP_1. 1 hit.
PS01004. MYELIN_PLP_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P51674-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEENMEEGQT QKGCFECCIK CLGGIPYASL IATILLYAGV ALFCGCGHEA    50
LSGTVNILQT YFEMARTAGD TLDVFTMIDI FKYVIYGIAA AFFVYGILLM 100
VEGFFTTGAI KDLYGDFKIT TCGRCVSAWF IMLTYLFMLA WLGVTAFTSL 150
PVYMYFNLWT ICRNTTLVEG ANLCLDLRQF GIVTIGEEKK ICTVSENFLR 200
MCESTELNMT FHLFIVALAG AGAAVIAMVH YLMVLSANWA YVKDACRMQK 250
YEDIKSKEEQ ELHDIHSTRS KERLNAYT 278
Length:278
Mass (Da):31,210
Last modified:November 1, 1997 - v2
Checksum:iDD0DB598C0E86B5D
GO
Isoform 2 (identifier: P51674-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MEENMEEGQTQK → MTDLE

Show »
Length:271
Mass (Da):30,364
Checksum:iAA2999D92620BD4A
GO
Isoform 3 (identifier: P51674-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MEENMEEGQTQK → M

Note: No experimental confirmation available.

Show »
Length:267
Mass (Da):29,905
Checksum:i94DD2BD6AFADEA61
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti242 – 2421V → L.
Corresponds to variant rs1049820 [ dbSNP | Ensembl ].
VAR_014895

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1212MEENM…GQTQK → MTDLE in isoform 2. VSP_045109Add
BLAST
Alternative sequencei1 – 1212MEENM…GQTQK → M in isoform 3. VSP_046098Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021E → A in AAB16889. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D49958 mRNA. Translation: BAA08712.1.
AK299788 mRNA. Translation: BAH13128.1.
AK226176 mRNA. No translation available.
AC093819 Genomic DNA. No translation available.
AC097537 Genomic DNA. No translation available.
AC110794 Genomic DNA. No translation available.
BC022508 mRNA. Translation: AAH22508.1.
BC022528 mRNA. Translation: AAH22528.1.
U45956 mRNA. Translation: AAB16889.1.
CCDSiCCDS3824.1. [P51674-1]
CCDS54822.1. [P51674-3]
CCDS58936.1. [P51674-2]
RefSeqiNP_001248377.1. NM_001261448.1. [P51674-2]
NP_005268.1. NM_005277.4. [P51674-1]
NP_963885.1. NM_201591.2. [P51674-1]
NP_963886.1. NM_201592.2. [P51674-3]
UniGeneiHs.75819.

Genome annotation databases

EnsembliENST00000280187; ENSP00000280187; ENSG00000150625. [P51674-1]
ENST00000393658; ENSP00000377268; ENSG00000150625. [P51674-1]
ENST00000506894; ENSP00000421578; ENSG00000150625. [P51674-3]
ENST00000515090; ENSP00000423984; ENSG00000150625. [P51674-2]
GeneIDi2823.
KEGGihsa:2823.
UCSCiuc003iuf.4. human. [P51674-1]
uc011ckj.2. human.

Polymorphism databases

DMDMi2506889.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D49958 mRNA. Translation: BAA08712.1 .
AK299788 mRNA. Translation: BAH13128.1 .
AK226176 mRNA. No translation available.
AC093819 Genomic DNA. No translation available.
AC097537 Genomic DNA. No translation available.
AC110794 Genomic DNA. No translation available.
BC022508 mRNA. Translation: AAH22508.1 .
BC022528 mRNA. Translation: AAH22528.1 .
U45956 mRNA. Translation: AAB16889.1 .
CCDSi CCDS3824.1. [P51674-1 ]
CCDS54822.1. [P51674-3 ]
CCDS58936.1. [P51674-2 ]
RefSeqi NP_001248377.1. NM_001261448.1. [P51674-2 ]
NP_005268.1. NM_005277.4. [P51674-1 ]
NP_963885.1. NM_201591.2. [P51674-1 ]
NP_963886.1. NM_201592.2. [P51674-3 ]
UniGenei Hs.75819.

3D structure databases

ProteinModelPortali P51674.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109084. 3 interactions.
IntActi P51674. 3 interactions.
STRINGi 9606.ENSP00000280187.

PTM databases

PhosphoSitei P51674.

Polymorphism databases

DMDMi 2506889.

Proteomic databases

PaxDbi P51674.
PRIDEi P51674.

Protocols and materials databases

DNASUi 2823.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000280187 ; ENSP00000280187 ; ENSG00000150625 . [P51674-1 ]
ENST00000393658 ; ENSP00000377268 ; ENSG00000150625 . [P51674-1 ]
ENST00000506894 ; ENSP00000421578 ; ENSG00000150625 . [P51674-3 ]
ENST00000515090 ; ENSP00000423984 ; ENSG00000150625 . [P51674-2 ]
GeneIDi 2823.
KEGGi hsa:2823.
UCSCi uc003iuf.4. human. [P51674-1 ]
uc011ckj.2. human.

Organism-specific databases

CTDi 2823.
GeneCardsi GC04M176554.
HGNCi HGNC:4460. GPM6A.
HPAi HPA017338.
MIMi 601275. gene.
neXtProti NX_P51674.
PharmGKBi PA28843.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG322245.
HOGENOMi HOG000231338.
HOVERGENi HBG000096.
InParanoidi P51674.
OMAi EEKKVCT.
OrthoDBi EOG7X3QRG.
PhylomeDBi P51674.
TreeFami TF315162.

Miscellaneous databases

ChiTaRSi GPM6A. human.
GeneWikii GPM6A.
GenomeRNAii 2823.
NextBioi 11127.
PROi P51674.
SOURCEi Search...

Gene expression databases

ArrayExpressi P51674.
Bgeei P51674.
CleanExi HS_GPM6A.
Genevestigatori P51674.

Family and domain databases

InterProi IPR001614. Myelin_PLP.
IPR018237. Myelin_PLP_CS.
[Graphical view ]
PANTHERi PTHR11683. PTHR11683. 1 hit.
Pfami PF01275. Myelin_PLP. 1 hit.
[Graphical view ]
PRINTSi PR00214. MYELINPLP.
SMARTi SM00002. PLP. 1 hit.
[Graphical view ]
PROSITEi PS00575. MYELIN_PLP_1. 1 hit.
PS01004. MYELIN_PLP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and mapping of the human glycoprotein M6 gene (GPM6A) to 4q33-->q34."
    Shimizu F., Watanabe T.K., Fujiwara T., Takahashi E., Nakamura Y., Maekawa H.
    Cytogenet. Cell Genet. 74:138-139(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Fetal brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 100-278.
    Tissue: Spinal cord.
  7. "Human GPM6A is associated with differentiation and neuronal migration of neurons derived from human embryonic stem cells."
    Michibata H., Okuno T., Konishi N., Kyono K., Wakimoto K., Aoki K., Kondo Y., Takata K., Kitamura Y., Taniguchi T.
    Stem Cells Dev. 18:629-639(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGPM6A_HUMAN
AccessioniPrimary (citable) accession number: P51674
Secondary accession number(s): B7Z642, E9PHI5, Q92602
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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