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Protein

Cellular retinoic acid-binding protein 2

Gene

Crabp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors (By similarity).By similarity

GO - Molecular functioni

  • lipid binding Source: RGD
  • retinal binding Source: UniProtKB-KW
  • retinoic acid binding Source: RGD
  • retinol binding Source: UniProtKB-KW

GO - Biological processi

  • lipid transport Source: RGD
  • regulation of retinoic acid receptor signaling pathway Source: InterPro
  • retinoic acid biosynthetic process Source: RGD
  • retinoic acid metabolic process Source: RGD

Keywordsi

Biological processTransport
LigandRetinol-binding, Vitamin A

Enzyme and pathway databases

ReactomeiR-RNO-5362517 Signaling by Retinoic Acid

Names & Taxonomyi

Protein namesi
Recommended name:
Cellular retinoic acid-binding protein 2
Alternative name(s):
Cellular retinoic acid-binding protein II
Short name:
CRABP-II
Gene namesi
Name:Crabp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi62070 Crabp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4345

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000674171 – 139Cellular retinoic acid-binding protein 2Add BLAST139

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki103Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Post-translational modificationi

Sumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent nuclear translocation.

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiP51673
PRIDEiP51673

PTM databases

PhosphoSitePlusiP51673

Expressioni

Gene expression databases

BgeeiENSRNOG00000022101
GenevisibleiP51673 RN

Interactioni

Subunit structurei

Interacts with importin alpha, RXR and RARA.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015134

Structurei

3D structure databases

ProteinModelPortaliP51673
SMRiP51673
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni134 – 136Retinoic acid bindingBy similarity3

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi21 – 31Nuclear localization signalBy similarityAdd BLAST11

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOGENOMiHOG000004831
HOVERGENiHBG005633
InParanoidiP51673
KOiK17289
OMAiFPKWETD
OrthoDBiEOG091G0QSV
PhylomeDBiP51673
TreeFamiTF316894

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR031281 CRABP2
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF60 PTHR11955:SF60, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit

Sequencei

Sequence statusi: Complete.

P51673-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNFSGNWKI IRSENFEEML KALGVNMMMR KIAVAAASKP AVEIKQENDD
60 70 80 90 100
TFYIKTSTTV RTTEINFKIG EEFEEQTVDG RPCKSLVKWE SENKMVCEQR
110 120 130
LLKGEGPKTS WSRELTNDGE LILTMTADDV VCTRVYVRE
Length:139
Mass (Da):15,933
Last modified:January 23, 2007 - v2
Checksum:iC32B812D6DC57841
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23407 mRNA Translation: AAA80225.1
PIRiI53298
RefSeqiNP_058940.1, NM_017244.1
UniGeneiRn.11333

Genome annotation databases

EnsembliENSRNOT00000025183; ENSRNOP00000015134; ENSRNOG00000022101
GeneIDi29563
KEGGirno:29563
UCSCiRGD:62070 rat

Similar proteinsi

Entry informationi

Entry nameiRABP2_RAT
AccessioniPrimary (citable) accession number: P51673
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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