ID XCL1_RAT Reviewed; 114 AA. AC P51672; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 1. DT 08-NOV-2023, entry version 126. DE RecName: Full=Lymphotactin; DE AltName: Full=C motif chemokine 1; DE AltName: Full=Cytokine SCM-1; DE AltName: Full=Small-inducible cytokine C1; DE Flags: Precursor; GN Name=Xcl1; Synonyms=Ltn, Scyc1; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Long Evans; TISSUE=Lung; RA Jones M.L.; RL Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Chemotactic activity for lymphocytes but not for monocytes or CC neutrophils. In thymus, mediates medullary accumulation of thymic CC dendritic cells and contributes to regulatoy T cell development, CC playing a role in self-tolerance establishment. CC {ECO:0000250|UniProtKB:P47993}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. CC -!- SIMILARITY: Belongs to the intercrine gamma family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U23377; AAA69478.1; -; mRNA. DR RefSeq; NP_599188.1; NM_134361.1. DR AlphaFoldDB; P51672; -. DR SMR; P51672; -. DR STRING; 10116.ENSRNOP00000003976; -. DR PhosphoSitePlus; P51672; -. DR PaxDb; 10116-ENSRNOP00000003976; -. DR GeneID; 171371; -. DR KEGG; rno:171371; -. DR UCSC; RGD:620452; rat. DR AGR; RGD:620452; -. DR CTD; 6375; -. DR RGD; 620452; Xcl1. DR eggNOG; ENOG502S6ZP; Eukaryota. DR InParanoid; P51672; -. DR OrthoDB; 4639980at2759; -. DR PhylomeDB; P51672; -. DR Reactome; R-RNO-380108; Chemokine receptors bind chemokines. DR Reactome; R-RNO-416476; G alpha (q) signalling events. DR PRO; PR:P51672; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005615; C:extracellular space; ISO:RGD. DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central. DR GO; GO:0008009; F:chemokine activity; ISO:RGD. DR GO; GO:0042379; F:chemokine receptor binding; ISO:RGD. DR GO; GO:0042803; F:protein homodimerization activity; ISO:RGD. DR GO; GO:0007267; P:cell-cell signaling; ISO:RGD. DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central. DR GO; GO:0071353; P:cellular response to interleukin-4; ISO:RGD. DR GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; ISO:RGD. DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central. DR GO; GO:0071346; P:cellular response to type II interferon; IBA:GO_Central. DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central. DR GO; GO:0006935; P:chemotaxis; ISO:RGD. DR GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central. DR GO; GO:0051649; P:establishment of localization in cell; ISO:RGD. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central. DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central. DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central. DR GO; GO:0035782; P:mature natural killer cell chemotaxis; ISO:RGD. DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central. DR GO; GO:2000562; P:negative regulation of CD4-positive, alpha-beta T cell proliferation; ISO:RGD. DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; ISO:RGD. DR GO; GO:0032703; P:negative regulation of interleukin-2 production; ISO:RGD. DR GO; GO:0002725; P:negative regulation of T cell cytokine production; ISO:RGD. DR GO; GO:2000518; P:negative regulation of T-helper 1 cell activation; ISO:RGD. DR GO; GO:0032689; P:negative regulation of type II interferon production; ISO:RGD. DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central. DR GO; GO:2000538; P:positive regulation of B cell chemotaxis; ISO:RGD. DR GO; GO:2000563; P:positive regulation of CD4-positive, alpha-beta T cell proliferation; ISO:RGD. DR GO; GO:2000566; P:positive regulation of CD8-positive, alpha-beta T cell proliferation; ISO:RGD. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central. DR GO; GO:2000513; P:positive regulation of granzyme A production; ISO:RGD. DR GO; GO:0071663; P:positive regulation of granzyme B production; ISO:RGD. DR GO; GO:2000558; P:positive regulation of immunoglobulin production in mucosal tissue; ISO:RGD. DR GO; GO:0032733; P:positive regulation of interleukin-10 production; ISO:RGD. DR GO; GO:0002690; P:positive regulation of leukocyte chemotaxis; ISO:RGD. DR GO; GO:2000503; P:positive regulation of natural killer cell chemotaxis; ISO:RGD. DR GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; ISO:RGD. DR GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; ISO:RGD. DR GO; GO:0010820; P:positive regulation of T cell chemotaxis; ISO:RGD. DR GO; GO:0002726; P:positive regulation of T cell cytokine production; ISO:RGD. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; ISO:RGD. DR GO; GO:2000556; P:positive regulation of T-helper 1 cell cytokine production; ISO:RGD. DR GO; GO:2000553; P:positive regulation of T-helper 2 cell cytokine production; ISO:RGD. DR GO; GO:2000412; P:positive regulation of thymocyte migration; ISO:RGD. DR GO; GO:0071636; P:positive regulation of transforming growth factor beta production; ISO:RGD. DR GO; GO:0050727; P:regulation of inflammatory response; ISO:RGD. DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; ISO:RGD. DR GO; GO:0009615; P:response to virus; ISO:RGD. DR CDD; cd00271; Chemokine_C; 1. DR Gene3D; 2.40.50.40; -; 1. DR InterPro; IPR039809; Chemokine_b/g/d. DR InterPro; IPR001811; Chemokine_IL8-like_dom. DR InterPro; IPR008105; Chemokine_XCL1/XCL2. DR InterPro; IPR036048; Interleukin_8-like_sf. DR PANTHER; PTHR12015:SF101; CYTOKINE SCM-1 BETA-RELATED; 1. DR PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1. DR Pfam; PF00048; IL8; 1. DR PRINTS; PR01731; LYMPHOTACTIN. DR SMART; SM00199; SCY; 1. DR SUPFAM; SSF54117; Interleukin 8-like chemokines; 1. PE 3: Inferred from homology; KW Chemotaxis; Cytokine; Disulfide bond; Reference proteome; Secreted; Signal. FT SIGNAL 1..21 FT /evidence="ECO:0000255" FT CHAIN 22..114 FT /note="Lymphotactin" FT /id="PRO_0000005250" FT REGION 87..114 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 93..114 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT DISULFID 32..69 FT /evidence="ECO:0000255" SQ SEQUENCE 114 AA; 12370 MW; 8E171C14F63172B0 CRC64; MRLLLLTFLG VCCFAAWVVE GVGTEVLQES ICVSLRTQRL PVQKIKTYTI KEGAMRAVIF VTKRGLRICA DPQAKWVKTA IKTVDGRASA SKSKAETIPT QAQRSASTAV TLTG //