P51672 (XCL1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lymphotactin

Alternative name(s):
C motif chemokine 1
Cytokine SCM-1
Small-inducible cytokine C1

Gene names

Name:	Xcl1
Synonyms:	Ltn, Scyc1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	114 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Chemotactic activity for lymphocytes but not for monocytes or neutrophils By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the intercrine gamma family.

Ontologies

Keywords
Biological process	Chemotaxis
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemotaxis Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 114	93	Lymphotactin		PRO_0000005250
Amino acid modifications
	Disulfide bond	32 ↔ 69		Potential

Sequences

	Sequence		Length	Mass (Da)
	P51672 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 8E171C14F63172B0	FASTA	114	12,370
	10 20 30 40 50 60 MRLLLLTFLG VCCFAAWVVE GVGTEVLQES ICVSLRTQRL PVQKIKTYTI KEGAMRAVIF 70 80 90 100 110 VTKRGLRICA DPQAKWVKTA IKTVDGRASA SKSKAETIPT QAQRSASTAV TLTG

References

[1]	Jones M.L. Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Long Evans. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U23377 mRNA. Translation: AAA69478.1.
IPI	IPI00204352.
RefSeq	NP_599188.1. NM_134361.1.
UniGene	Rn.90962.
3D structure databases
ProteinModelPortal	P51672.
SMR	P51672. Positions 22-114.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000003976.
Proteomic databases
PaxDb	P51672.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	171371.
KEGG	rno:171371.
UCSC	RGD:620452. rat.
Organism-specific databases
CTD	6375.
RGD	620452. Xcl1.
Phylogenomic databases
eggNOG	NOG47852.
HOGENOM	HOG000036685.
HOVERGEN	HBG102118.
InParanoid	P51672.
KO	K05507.
OrthoDB	EOG4XSKRH.
Gene expression databases
Genevestigator	P51672.
GermOnline	ENSRNOG00000002964. Rattus norvegicus.
Family and domain databases
InterPro	IPR001811. Chemokine_IL8-like_dom. IPR008105. Chemokine_XCL1. [Graphical view]
Pfam	PF00048. IL8. 1 hit. [Graphical view]
PRINTS	PR01731. LYMPHOTACTIN.
SMART	SM00199. SCY. 1 hit. [Graphical view]
SUPFAM	SSF54117. Chemokine_IL8. 1 hit.
ProtoNet	Search...
Other
NextBio	622175.

Entry information

Entry name

XCL1_RAT

Accession

Primary (citable) accession number: P51672

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program