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Protein

Lymphotactin

Gene

Xcl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Chemotactic activity for lymphocytes but not for monocytes or neutrophils.By similarity

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphotactin
Alternative name(s):
C motif chemokine 1
Cytokine SCM-1
Small-inducible cytokine C1
Gene namesi
Name:Xcl1
Synonyms:Ltn, Scyc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620452. Xcl1.

Subcellular locationi

  1. Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 11493LymphotactinPRO_0000005250Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 69Sequence Analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP51672.

Expressioni

Gene expression databases

GenevestigatoriP51672.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003976.

Structurei

3D structure databases

ProteinModelPortaliP51672.
SMRiP51672. Positions 22-114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the intercrine gamma family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47852.
HOGENOMiHOG000036685.
HOVERGENiHBG102118.
InParanoidiP51672.
KOiK05507.
PhylomeDBiP51672.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
IPR008105. Chemokine_XCL1.
[Graphical view]
PANTHERiPTHR12015:SF3. PTHR12015:SF3. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR01731. LYMPHOTACTIN.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51672-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLLLTFLG VCCFAAWVVE GVGTEVLQES ICVSLRTQRL PVQKIKTYTI
60 70 80 90 100
KEGAMRAVIF VTKRGLRICA DPQAKWVKTA IKTVDGRASA SKSKAETIPT
110
QAQRSASTAV TLTG
Length:114
Mass (Da):12,370
Last modified:October 1, 1996 - v1
Checksum:i8E171C14F63172B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23377 mRNA. Translation: AAA69478.1.
RefSeqiNP_599188.1. NM_134361.1.
UniGeneiRn.90962.

Genome annotation databases

GeneIDi171371.
KEGGirno:171371.
UCSCiRGD:620452. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23377 mRNA. Translation: AAA69478.1.
RefSeqiNP_599188.1. NM_134361.1.
UniGeneiRn.90962.

3D structure databases

ProteinModelPortaliP51672.
SMRiP51672. Positions 22-114.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003976.

Proteomic databases

PaxDbiP51672.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi171371.
KEGGirno:171371.
UCSCiRGD:620452. rat.

Organism-specific databases

CTDi6375.
RGDi620452. Xcl1.

Phylogenomic databases

eggNOGiNOG47852.
HOGENOMiHOG000036685.
HOVERGENiHBG102118.
InParanoidiP51672.
KOiK05507.
PhylomeDBiP51672.

Miscellaneous databases

NextBioi622175.
PROiP51672.

Gene expression databases

GenevestigatoriP51672.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
IPR008105. Chemokine_XCL1.
[Graphical view]
PANTHERiPTHR12015:SF3. PTHR12015:SF3. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR01731. LYMPHOTACTIN.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Jones M.L.
    Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Long Evans.
    Tissue: Lung.

Entry informationi

Entry nameiXCL1_RAT
AccessioniPrimary (citable) accession number: P51672
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 1, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.