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Protein

Lymphotactin

Gene

Xcl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphotactin
Alternative name(s):
C motif chemokine 1
Cytokine SCM-1
Small-inducible cytokine C1
Gene namesi
Name:Xcl1
Synonyms:Ltn, Scyc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620452 Xcl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000525022 – 114LymphotactinAdd BLAST93

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 69Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP51672

PTM databases

PhosphoSitePlusiP51672

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003976

Structurei

3D structure databases

ProteinModelPortaliP51672
SMRiP51672
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the intercrine gamma family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZ5E Eukaryota
ENOG4111C3M LUCA
HOGENOMiHOG000036685
HOVERGENiHBG102118
InParanoidiP51672
KOiK05507
PhylomeDBiP51672

Family and domain databases

CDDicd00271 Chemokine_C, 1 hit
InterProiView protein in InterPro
IPR001811 Chemokine_IL8-like_dom
IPR008105 Chemokine_XCL1/XCL2
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015:SF101 PTHR12015:SF101, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR01731 LYMPHOTACTIN
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51672-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLLLTFLG VCCFAAWVVE GVGTEVLQES ICVSLRTQRL PVQKIKTYTI
60 70 80 90 100
KEGAMRAVIF VTKRGLRICA DPQAKWVKTA IKTVDGRASA SKSKAETIPT
110
QAQRSASTAV TLTG
Length:114
Mass (Da):12,370
Last modified:October 1, 1996 - v1
Checksum:i8E171C14F63172B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23377 mRNA Translation: AAA69478.1
RefSeqiNP_599188.1, NM_134361.1
UniGeneiRn.90962

Genome annotation databases

GeneIDi171371
KEGGirno:171371
UCSCiRGD:620452 rat

Similar proteinsi

Entry informationi

Entry nameiXCL1_RAT
AccessioniPrimary (citable) accession number: P51672
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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