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Protein

Eotaxin

Gene

CCL11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: UniProtKB

GO - Biological processi

  • actin filament organization Source: Ensembl
  • branching involved in mammary gland duct morphogenesis Source: Ensembl
  • cell adhesion Source: ProtInc
  • cellular calcium ion homeostasis Source: ProtInc
  • cellular response to interferon-gamma Source: GO_Central
  • cellular response to interleukin-1 Source: GO_Central
  • cellular response to tumor necrosis factor Source: GO_Central
  • chemokine-mediated signaling pathway Source: GO_Central
  • chemotaxis Source: ProtInc
  • chronic inflammatory response Source: Ensembl
  • cytoskeleton organization Source: UniProtKB
  • eosinophil chemotaxis Source: UniProtKB
  • ERK1 and ERK2 cascade Source: Ensembl
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • inflammatory response Source: ProtInc
  • lymphocyte chemotaxis Source: GO_Central
  • mammary duct terminal end bud growth Source: Ensembl
  • mast cell chemotaxis Source: Ensembl
  • monocyte chemotaxis Source: GO_Central
  • neutrophil chemotaxis Source: GO_Central
  • positive regulation of actin filament polymerization Source: BHF-UCL
  • positive regulation of angiogenesis Source: Ensembl
  • positive regulation of cell migration Source: BHF-UCL
  • positive regulation of endothelial cell proliferation Source: BHF-UCL
  • positive regulation of ERK1 and ERK2 cascade Source: GO_Central
  • positive regulation of GTPase activity Source: BHF-UCL
  • positive regulation of inflammatory response Source: GO_Central
  • protein phosphorylation Source: ProtInc
  • regulation of cell shape Source: UniProtKB
  • response to interleukin-13 Source: Ensembl
  • response to interleukin-4 Source: Ensembl
  • response to radiation Source: ProtInc
  • response to virus Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172156-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Eotaxin
Alternative name(s):
C-C motif chemokine 11
Eosinophil chemotactic protein
Small-inducible cytokine A11
Gene namesi
Name:CCL11
Synonyms:SCYA11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:10610. CCL11.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: BHF-UCL
  • extracellular space Source: GO_Central
  • intracellular Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6356.
MalaCardsiCCL11.
OpenTargetsiENSG00000172156.
PharmGKBiPA35543.

Chemistry databases

ChEMBLiCHEMBL3286077.

Polymorphism and mutation databases

BioMutaiCCL11.
DMDMi1706661.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Add BLAST23
ChainiPRO_000000519524 – 97EotaxinAdd BLAST74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 57
Disulfide bondi33 ↔ 73
Glycosylationi94O-linked (GalNAc...)1 Publication1

Post-translational modificationi

O-linked glycan consists of a Gal-GalNAc disaccharide which is mofified with up to 2 sialic acid residues.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP51671.
PeptideAtlasiP51671.
PRIDEiP51671.

PTM databases

iPTMnetiP51671.
PhosphoSitePlusiP51671.

Miscellaneous databases

PMAP-CutDBP51671.

Expressioni

Inductioni

By TNF, IL1A/interleukin-1 alpha and IFNG/IFN-gamma.

Gene expression databases

BgeeiENSG00000172156.
CleanExiHS_CCL11.
ExpressionAtlasiP51671. baseline and differential.
GenevisibleiP51671. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCR3P516772EBI-727357,EBI-6625120
DPP4P274872EBI-727357,EBI-2871277

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: UniProtKB

Protein-protein interaction databases

BioGridi112259. 3 interactors.
DIPiDIP-5858N.
IntActiP51671. 4 interactors.
MINTiMINT-103325.
STRINGi9606.ENSP00000302234.

Chemistry databases

BindingDBiP51671.

Structurei

Secondary structure

197
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 29Combined sources4
Turni43 – 45Combined sources3
Beta strandi46 – 52Combined sources7
Beta strandi55 – 59Combined sources5
Beta strandi61 – 66Combined sources6
Beta strandi67 – 70Combined sources4
Beta strandi71 – 74Combined sources4
Helixi79 – 91Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EOTNMR-A24-97[»]
2EOTNMR-A24-97[»]
2MPMNMR-A24-97[»]
DisProtiDP00641.
ProteinModelPortaliP51671.
SMRiP51671.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP51671.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1ST. Eukaryota.
ENOG410YXJU. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP51671.
KOiK16597.
OMAiGSKCPQK.
OrthoDBiEOG091G14KV.
PhylomeDBiP51671.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51671-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSAALLWL LLIAAAFSPQ GLAGPASVPT TCCFNLANRK IPLQRLESYR
60 70 80 90
RITSGKCPQK AVIFKTKLAK DICADPKKKW VQDSMKYLDQ KSPTPKP
Length:97
Mass (Da):10,732
Last modified:October 1, 1996 - v1
Checksum:iB433C30FDA4C71A7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0016347L → P.1
Natural variantiVAR_00163523A → T.Corresponds to variant rs1129844dbSNPEnsembl.1
Natural variantiVAR_00163651R → S.1
Natural variantiVAR_00163779K → R.1
Natural variantiVAR_04870586K → T.Corresponds to variant rs34262946dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46573 mRNA. Translation: AAA98957.1.
U34780 Genomic DNA. Translation: AAC50369.1.
D49372 mRNA. Translation: BAA08370.1.
Z69291 mRNA. Translation: CAA93258.1.
Z75668 mRNA. Translation: CAA99997.1.
Z75669 mRNA. Translation: CAA99998.1.
U46572 Genomic DNA. Translation: AAC51297.1.
Z92709 Genomic DNA. Translation: CAB07027.1.
BC017850 mRNA. Translation: AAH17850.1.
CCDSiCCDS11279.1.
PIRiJC4912.
RefSeqiNP_002977.1. NM_002986.2.
UniGeneiHs.54460.

Genome annotation databases

EnsembliENST00000305869; ENSP00000302234; ENSG00000172156.
GeneIDi6356.
KEGGihsa:6356.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CCL11 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46573 mRNA. Translation: AAA98957.1.
U34780 Genomic DNA. Translation: AAC50369.1.
D49372 mRNA. Translation: BAA08370.1.
Z69291 mRNA. Translation: CAA93258.1.
Z75668 mRNA. Translation: CAA99997.1.
Z75669 mRNA. Translation: CAA99998.1.
U46572 Genomic DNA. Translation: AAC51297.1.
Z92709 Genomic DNA. Translation: CAB07027.1.
BC017850 mRNA. Translation: AAH17850.1.
CCDSiCCDS11279.1.
PIRiJC4912.
RefSeqiNP_002977.1. NM_002986.2.
UniGeneiHs.54460.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EOTNMR-A24-97[»]
2EOTNMR-A24-97[»]
2MPMNMR-A24-97[»]
DisProtiDP00641.
ProteinModelPortaliP51671.
SMRiP51671.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112259. 3 interactors.
DIPiDIP-5858N.
IntActiP51671. 4 interactors.
MINTiMINT-103325.
STRINGi9606.ENSP00000302234.

Chemistry databases

BindingDBiP51671.
ChEMBLiCHEMBL3286077.

PTM databases

iPTMnetiP51671.
PhosphoSitePlusiP51671.

Polymorphism and mutation databases

BioMutaiCCL11.
DMDMi1706661.

Proteomic databases

PaxDbiP51671.
PeptideAtlasiP51671.
PRIDEiP51671.

Protocols and materials databases

DNASUi6356.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305869; ENSP00000302234; ENSG00000172156.
GeneIDi6356.
KEGGihsa:6356.

Organism-specific databases

CTDi6356.
DisGeNETi6356.
GeneCardsiCCL11.
HGNCiHGNC:10610. CCL11.
MalaCardsiCCL11.
MIMi601156. gene.
neXtProtiNX_P51671.
OpenTargetsiENSG00000172156.
PharmGKBiPA35543.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1ST. Eukaryota.
ENOG410YXJU. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP51671.
KOiK16597.
OMAiGSKCPQK.
OrthoDBiEOG091G14KV.
PhylomeDBiP51671.
TreeFamiTF334888.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172156-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP51671.
GeneWikiiCCL11.
GenomeRNAii6356.
PMAP-CutDBP51671.
PROiP51671.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172156.
CleanExiHS_CCL11.
ExpressionAtlasiP51671. baseline and differential.
GenevisibleiP51671. HS.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCL11_HUMAN
AccessioniPrimary (citable) accession number: P51671
Secondary accession number(s): P50877, Q92490, Q92491
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 165 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.