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P51670

- CCL9_MOUSE

UniProt

P51670 - CCL9_MOUSE

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Protein
C-C motif chemokine 9
Gene
Ccl9, Mrp2, Scya10, Scya9
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Monokine with inflammatory, pyrogenic and chemokinetic properties. Circulates at high concentrations in the blood of healthy animals. Binding to a high-affinity receptor activates calcium release in neutrophils. It also inhibits colony formation of bone marrow myeloid immature progenitors.

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 9
Alternative name(s):
CCF18
Macrophage inflammatory protein 1-gamma
Short name:
MIP-1-gamma
Macrophage inflammatory protein-related protein 2
Short name:
MRP-2
Small-inducible cytokine A9
Cleaved into the following 3 chains:
Gene namesi
Name:Ccl9
Synonyms:Mrp2, Scya10, Scya9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:104533. Ccl9.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 122101C-C motif chemokine 9
PRO_0000005192Add
BLAST
Chaini50 – 12273CCL9(29-101)
PRO_0000041865Add
BLAST
Chaini51 – 12272CCL9(30-101)
PRO_0000041866Add
BLAST
Chaini52 – 12271CCL9(31-101)
PRO_0000041867Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 80 By similarity
Disulfide bondi58 ↔ 96 By similarity
Disulfide bondi67 ↔ 107 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP51670.
PRIDEiP51670.

Expressioni

Tissue specificityi

Expressed mainly in the liver, lung, and the thymus, although some expression has been detected in a wide variety of tissues except brain.

Inductioni

By interleukin-4; in the bone marrow macrophage.

Gene expression databases

ArrayExpressiP51670.
BgeeiP51670.
CleanExiMM_CCL9.
GenevestigatoriP51670.

Interactioni

Protein-protein interaction databases

DIPiDIP-5921N.
MINTiMINT-123781.

Structurei

3D structure databases

ProteinModelPortaliP51670.
SMRiP51670. Positions 57-112.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG136395.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP51670.
KOiK05510.
OMAiFHTALSF.
OrthoDBiEOG7RNK2R.
PhylomeDBiP51670.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51670-1 [UniParc]FASTAAdd to Basket

« Hide

MKPFHTALSF LILTTALGIW AQITHATETK EVQSSLKAQQ GLEIEMFHMG    50
FQDSSDCCLS YNSRIQCSRF IGYFPTSGGC TRPGIIFISK RGFQVCANPS 100
DRRVQRCIER LEQNSQPRTY KQ 122
Length:122
Mass (Da):13,871
Last modified:October 1, 1996 - v1
Checksum:i9075F1FFEEFD30F7
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti113 – 1131Q → K in AAB02198. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U49513 mRNA. Translation: AAB02198.1.
U15209 mRNA. Translation: AAA92583.1.
U19482 mRNA. Translation: AAB17120.1.
AF128195 mRNA. Translation: AAF22536.1.
AF128196 mRNA. Translation: AAF22537.1.
AF128197 mRNA. Translation: AAF22538.1.
AF128198 mRNA. Translation: AAF22539.1.
AF128199 mRNA. Translation: AAF22540.1.
AF128200 mRNA. Translation: AAF22541.1.
AF128201 mRNA. Translation: AAF22542.1.
AF128202 mRNA. Translation: AAF22543.1.
AF128203 mRNA. Translation: AAF22544.1.
AF128204 mRNA. Translation: AAF22545.1.
AB051897 Genomic DNA. Translation: BAB18730.1.
AL596122 Genomic DNA. Translation: CAI25133.1.
CCDSiCCDS25170.1.
RefSeqiNP_035468.1. NM_011338.2.
UniGeneiMm.416125.

Genome annotation databases

EnsembliENSMUST00000019266; ENSMUSP00000019266; ENSMUSG00000019122.
GeneIDi20308.
KEGGimmu:20308.
UCSCiuc007kpj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U49513 mRNA. Translation: AAB02198.1 .
U15209 mRNA. Translation: AAA92583.1 .
U19482 mRNA. Translation: AAB17120.1 .
AF128195 mRNA. Translation: AAF22536.1 .
AF128196 mRNA. Translation: AAF22537.1 .
AF128197 mRNA. Translation: AAF22538.1 .
AF128198 mRNA. Translation: AAF22539.1 .
AF128199 mRNA. Translation: AAF22540.1 .
AF128200 mRNA. Translation: AAF22541.1 .
AF128201 mRNA. Translation: AAF22542.1 .
AF128202 mRNA. Translation: AAF22543.1 .
AF128203 mRNA. Translation: AAF22544.1 .
AF128204 mRNA. Translation: AAF22545.1 .
AB051897 Genomic DNA. Translation: BAB18730.1 .
AL596122 Genomic DNA. Translation: CAI25133.1 .
CCDSi CCDS25170.1.
RefSeqi NP_035468.1. NM_011338.2.
UniGenei Mm.416125.

3D structure databases

ProteinModelPortali P51670.
SMRi P51670. Positions 57-112.
ModBasei Search...

Protein-protein interaction databases

DIPi DIP-5921N.
MINTi MINT-123781.

Proteomic databases

PaxDbi P51670.
PRIDEi P51670.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019266 ; ENSMUSP00000019266 ; ENSMUSG00000019122 .
GeneIDi 20308.
KEGGi mmu:20308.
UCSCi uc007kpj.1. mouse.

Organism-specific databases

CTDi 20308.
MGIi MGI:104533. Ccl9.

Phylogenomic databases

eggNOGi NOG136395.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi P51670.
KOi K05510.
OMAi FHTALSF.
OrthoDBi EOG7RNK2R.
PhylomeDBi P51670.
TreeFami TF334888.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 298071.
PROi P51670.
SOURCEi Search...

Gene expression databases

ArrayExpressi P51670.
Bgeei P51670.
CleanExi MM_CCL9.
Genevestigatori P51670.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "MIP-1 gamma: molecular cloning, expression, and biological activities of a novel CC chemokine that is constitutively secreted in vivo."
    Poltorak A.N., Bazzoni F., Smirnova I.I., Alejos E., Thompson P., Luheshi G., Rothwell N., Beutler B.
    J. Inflamm. 45:207-219(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors."
    Youn B.-S., Jang I.-K., Broxmeyer H.E., Cooper S., Jenkins N.A., Gilbert D.J., Copeland N.G., Elick T.A., Fraser M.J. Jr., Kwon B.S.
    J. Immunol. 155:2661-2667(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Molecular cloning and functional characterization of a novel member of the C-C chemokine family."
    Hara T., Bacon K.B., Cho L.C., Yoshimura A., Morikawa Y., Copeland N.G., Gilbert D.J., Jenkins N.A., Schall T.J., Miyajima A.
    J. Immunol. 155:5352-5358(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
    Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
    J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: B10.S/J, BALB/c, DBA/2J, NOD/LtJ and SJL/J.
    Tissue: Spleen.
  5. "Organization of the mouse CC chemokine cluster containing the genes for C10, MRP-2 and RANTES."
    Nomiyama H.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  7. "Proteolytic activation of alternative CCR1 ligands in inflammation."
    Berahovich R.D., Miao Z., Wang Y., Premack B., Howard M.C., Schall T.J.
    J. Immunol. 174:7341-7351(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF CCL9(29-101); CCL9(30-101) AND CCL9(31-101), PROTEOLYTIC PROCESSING OF N-TERMINUS.

Entry informationi

Entry nameiCCL9_MOUSE
AccessioniPrimary (citable) accession number: P51670
Secondary accession number(s): Q5QNW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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