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P51670

- CCL9_MOUSE

UniProt

P51670 - CCL9_MOUSE

Protein

C-C motif chemokine 9

Gene

Ccl9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Monokine with inflammatory, pyrogenic and chemokinetic properties. Circulates at high concentrations in the blood of healthy animals. Binding to a high-affinity receptor activates calcium release in neutrophils. It also inhibits colony formation of bone marrow myeloid immature progenitors.

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 9
    Alternative name(s):
    CCF18
    Macrophage inflammatory protein 1-gamma
    Short name:
    MIP-1-gamma
    Macrophage inflammatory protein-related protein 2
    Short name:
    MRP-2
    Small-inducible cytokine A9
    Cleaved into the following 3 chains:
    Gene namesi
    Name:Ccl9
    Synonyms:Mrp2, Scya10, Scya9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:104533. Ccl9.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 122101C-C motif chemokine 9PRO_0000005192Add
    BLAST
    Chaini50 – 12273CCL9(29-101)PRO_0000041865Add
    BLAST
    Chaini51 – 12272CCL9(30-101)PRO_0000041866Add
    BLAST
    Chaini52 – 12271CCL9(31-101)PRO_0000041867Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi57 ↔ 80By similarity
    Disulfide bondi58 ↔ 96By similarity
    Disulfide bondi67 ↔ 107By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP51670.
    PRIDEiP51670.

    Expressioni

    Tissue specificityi

    Expressed mainly in the liver, lung, and the thymus, although some expression has been detected in a wide variety of tissues except brain.

    Inductioni

    By interleukin-4; in the bone marrow macrophage.

    Gene expression databases

    ArrayExpressiP51670.
    BgeeiP51670.
    CleanExiMM_CCL9.
    GenevestigatoriP51670.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-5921N.
    MINTiMINT-123781.

    Structurei

    3D structure databases

    ProteinModelPortaliP51670.
    SMRiP51670. Positions 57-112.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG136395.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiP51670.
    KOiK05510.
    OMAiFHTALSF.
    OrthoDBiEOG7RNK2R.
    PhylomeDBiP51670.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P51670-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKPFHTALSF LILTTALGIW AQITHATETK EVQSSLKAQQ GLEIEMFHMG    50
    FQDSSDCCLS YNSRIQCSRF IGYFPTSGGC TRPGIIFISK RGFQVCANPS 100
    DRRVQRCIER LEQNSQPRTY KQ 122
    Length:122
    Mass (Da):13,871
    Last modified:October 1, 1996 - v1
    Checksum:i9075F1FFEEFD30F7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti113 – 1131Q → K in AAB02198. (PubMed:8597875)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U49513 mRNA. Translation: AAB02198.1.
    U15209 mRNA. Translation: AAA92583.1.
    U19482 mRNA. Translation: AAB17120.1.
    AF128195 mRNA. Translation: AAF22536.1.
    AF128196 mRNA. Translation: AAF22537.1.
    AF128197 mRNA. Translation: AAF22538.1.
    AF128198 mRNA. Translation: AAF22539.1.
    AF128199 mRNA. Translation: AAF22540.1.
    AF128200 mRNA. Translation: AAF22541.1.
    AF128201 mRNA. Translation: AAF22542.1.
    AF128202 mRNA. Translation: AAF22543.1.
    AF128203 mRNA. Translation: AAF22544.1.
    AF128204 mRNA. Translation: AAF22545.1.
    AB051897 Genomic DNA. Translation: BAB18730.1.
    AL596122 Genomic DNA. Translation: CAI25133.1.
    CCDSiCCDS25170.1.
    RefSeqiNP_035468.1. NM_011338.2.
    UniGeneiMm.416125.

    Genome annotation databases

    EnsembliENSMUST00000019266; ENSMUSP00000019266; ENSMUSG00000019122.
    GeneIDi20308.
    KEGGimmu:20308.
    UCSCiuc007kpj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U49513 mRNA. Translation: AAB02198.1 .
    U15209 mRNA. Translation: AAA92583.1 .
    U19482 mRNA. Translation: AAB17120.1 .
    AF128195 mRNA. Translation: AAF22536.1 .
    AF128196 mRNA. Translation: AAF22537.1 .
    AF128197 mRNA. Translation: AAF22538.1 .
    AF128198 mRNA. Translation: AAF22539.1 .
    AF128199 mRNA. Translation: AAF22540.1 .
    AF128200 mRNA. Translation: AAF22541.1 .
    AF128201 mRNA. Translation: AAF22542.1 .
    AF128202 mRNA. Translation: AAF22543.1 .
    AF128203 mRNA. Translation: AAF22544.1 .
    AF128204 mRNA. Translation: AAF22545.1 .
    AB051897 Genomic DNA. Translation: BAB18730.1 .
    AL596122 Genomic DNA. Translation: CAI25133.1 .
    CCDSi CCDS25170.1.
    RefSeqi NP_035468.1. NM_011338.2.
    UniGenei Mm.416125.

    3D structure databases

    ProteinModelPortali P51670.
    SMRi P51670. Positions 57-112.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-5921N.
    MINTi MINT-123781.

    Proteomic databases

    PaxDbi P51670.
    PRIDEi P51670.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019266 ; ENSMUSP00000019266 ; ENSMUSG00000019122 .
    GeneIDi 20308.
    KEGGi mmu:20308.
    UCSCi uc007kpj.1. mouse.

    Organism-specific databases

    CTDi 20308.
    MGIi MGI:104533. Ccl9.

    Phylogenomic databases

    eggNOGi NOG136395.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi P51670.
    KOi K05510.
    OMAi FHTALSF.
    OrthoDBi EOG7RNK2R.
    PhylomeDBi P51670.
    TreeFami TF334888.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 298071.
    PROi P51670.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51670.
    Bgeei P51670.
    CleanExi MM_CCL9.
    Genevestigatori P51670.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MIP-1 gamma: molecular cloning, expression, and biological activities of a novel CC chemokine that is constitutively secreted in vivo."
      Poltorak A.N., Bazzoni F., Smirnova I.I., Alejos E., Thompson P., Luheshi G., Rothwell N., Beutler B.
      J. Inflamm. 45:207-219(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors."
      Youn B.-S., Jang I.-K., Broxmeyer H.E., Cooper S., Jenkins N.A., Gilbert D.J., Copeland N.G., Elick T.A., Fraser M.J. Jr., Kwon B.S.
      J. Immunol. 155:2661-2667(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Molecular cloning and functional characterization of a novel member of the C-C chemokine family."
      Hara T., Bacon K.B., Cho L.C., Yoshimura A., Morikawa Y., Copeland N.G., Gilbert D.J., Jenkins N.A., Schall T.J., Miyajima A.
      J. Immunol. 155:5352-5358(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
      Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
      J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: B10.S/J, BALB/c, DBA/2J, NOD/LtJ and SJL/J.
      Tissue: Spleen.
    5. "Organization of the mouse CC chemokine cluster containing the genes for C10, MRP-2 and RANTES."
      Nomiyama H.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    7. "Proteolytic activation of alternative CCR1 ligands in inflammation."
      Berahovich R.D., Miao Z., Wang Y., Premack B., Howard M.C., Schall T.J.
      J. Immunol. 174:7341-7351(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF CCL9(29-101); CCL9(30-101) AND CCL9(31-101), PROTEOLYTIC PROCESSING OF N-TERMINUS.

    Entry informationi

    Entry nameiCCL9_MOUSE
    AccessioniPrimary (citable) accession number: P51670
    Secondary accession number(s): Q5QNW2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3