P51670 (CCL9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-C motif chemokine 9

Alternative name(s):
CCF18
Macrophage inflammatory protein 1-gamma
Short name=MIP-1-gamma
Macrophage inflammatory protein-related protein 2
Short name=MRP-2
Small-inducible cytokine A9

Cleaved into the following 3 chains:

1. CCL9(29-101)
2. CCL9(30-101)
3. CCL9(31-101)

Gene names

Name:	Ccl9
Synonyms:	Mrp2, Scya10, Scya9

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	122 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Monokine with inflammatory, pyrogenic and chemokinetic properties. Circulates at high concentrations in the blood of healthy animals. Binding to a high-affinity receptor activates calcium release in neutrophils. It also inhibits colony formation of bone marrow myeloid immature progenitors.
Subcellular location	Secreted.
Tissue specificity	Expressed mainly in the liver, lung, and the thymus, although some expression has been detected in a wide variety of tissues except brain.
Induction	By interleukin-4; in the bone marrow macrophage.
Sequence similarities	Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
Biological process	Chemotaxis
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemotaxis Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 122	101	C-C motif chemokine 9		PRO_0000005192
	Chain	50 – 122	73	CCL9(29-101)		PRO_0000041865
	Chain	51 – 122	72	CCL9(30-101)		PRO_0000041866
	Chain	52 – 122	71	CCL9(31-101)		PRO_0000041867
Amino acid modifications
	Disulfide bond	57 ↔ 80		By similarity
	Disulfide bond	58 ↔ 96		By similarity
	Disulfide bond	67 ↔ 107		By similarity
Experimental info
	Sequence conflict	113	1	Q → K in AAB02198. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P51670 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 9075F1FFEEFD30F7	FASTA	122	13,871
	10 20 30 40 50 60 MKPFHTALSF LILTTALGIW AQITHATETK EVQSSLKAQQ GLEIEMFHMG FQDSSDCCLS 70 80 90 100 110 120 YNSRIQCSRF IGYFPTSGGC TRPGIIFISK RGFQVCANPS DRRVQRCIER LEQNSQPRTY KQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"MIP-1 gamma: molecular cloning, expression, and biological activities of a novel CC chemokine that is constitutively secreted in vivo." Poltorak A.N., Bazzoni F., Smirnova I.I., Alejos E., Thompson P., Luheshi G., Rothwell N., Beutler B. J. Inflamm. 45:207-219(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors." Youn B.-S., Jang I.-K., Broxmeyer H.E., Cooper S., Jenkins N.A., Gilbert D.J., Copeland N.G., Elick T.A., Fraser M.J. Jr., Kwon B.S. J. Immunol. 155:2661-2667(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Molecular cloning and functional characterization of a novel member of the C-C chemokine family." Hara T., Bacon K.B., Cho L.C., Yoshimura A., Morikawa Y., Copeland N.G., Gilbert D.J., Jenkins N.A., Schall T.J., Miyajima A. J. Immunol. 155:5352-5358(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis." Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P. J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: B10.S/J, BALB/c, DBA/2J, NOD/LtJ and SJL/J. Tissue: Spleen.
[5]	"Organization of the mouse CC chemokine cluster containing the genes for C10, MRP-2 and RANTES." Nomiyama H. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv.
[6]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[7]	"Proteolytic activation of alternative CCR1 ligands in inflammation." Berahovich R.D., Miao Z., Wang Y., Premack B., Howard M.C., Schall T.J. J. Immunol. 174:7341-7351(2005) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION OF CCL9(29-101); CCL9(30-101) AND CCL9(31-101), PROTEOLYTIC PROCESSING OF N-TERMINUS.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U49513 mRNA. Translation: AAB02198.1. U15209 mRNA. Translation: AAA92583.1. U19482 mRNA. Translation: AAB17120.1. AF128195 mRNA. Translation: AAF22536.1. AF128196 mRNA. Translation: AAF22537.1. AF128197 mRNA. Translation: AAF22538.1. AF128198 mRNA. Translation: AAF22539.1. AF128199 mRNA. Translation: AAF22540.1. AF128200 mRNA. Translation: AAF22541.1. AF128201 mRNA. Translation: AAF22542.1. AF128202 mRNA. Translation: AAF22543.1. AF128203 mRNA. Translation: AAF22544.1. AF128204 mRNA. Translation: AAF22545.1. AB051897 Genomic DNA. Translation: BAB18730.1. AL596122 Genomic DNA. Translation: CAI25133.1.
IPI	IPI00125187.
RefSeq	NP_035468.1. NM_011338.2.
UniGene	Mm.416125.
3D structure databases
ProteinModelPortal	P51670.
SMR	P51670. Positions 57-112.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5921N.
MINT	MINT-123781.
Proteomic databases
PaxDb	P51670.
PRIDE	P51670.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000019266; ENSMUSP00000019266; ENSMUSG00000019122.
GeneID	20308.
KEGG	mmu:20308.
UCSC	uc007kpj.1. mouse.
Organism-specific databases
CTD	20308.
MGI	MGI:104533. Ccl9.
Phylogenomic databases
eggNOG	NOG136395.
HOGENOM	HOG000036685.
HOVERGEN	HBG017871.
InParanoid	P51670.
KO	K05510.
OMA	FHTALSF.
OrthoDB	EOG49PB11.
Gene expression databases
ArrayExpress	P51670.
Bgee	P51670.
CleanEx	MM_CCL9.
Genevestigator	P51670.
GermOnline	ENSMUSG00000019122. Mus musculus.
Family and domain databases
InterPro	IPR000827. Chemokine_CC_CS. IPR001811. Chemokine_IL8-like_dom. [Graphical view]
Pfam	PF00048. IL8. 1 hit. [Graphical view]
SMART	SM00199. SCY. 1 hit. [Graphical view]
SUPFAM	SSF54117. Chemokine_IL8. 1 hit.
PROSITE	PS00472. SMALL_CYTOKINES_CC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	298071.
SOURCE	Search...

Entry information

Entry name

CCL9_MOUSE

Accession

Primary (citable) accession number: P51670
Secondary accession number(s): Q5QNW2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 29, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program