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Protein

C-C motif chemokine 9

Gene

Ccl9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Monokine with inflammatory, pyrogenic and chemokinetic properties. Circulates at high concentrations in the blood of healthy animals. Binding to a high-affinity receptor activates calcium release in neutrophils. It also inhibits colony formation of bone marrow myeloid immature progenitors.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-444473. Formyl peptide receptors bind formyl peptides and many other ligands.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 9
Alternative name(s):
CCF18
Macrophage inflammatory protein 1-gamma
Short name:
MIP-1-gamma
Macrophage inflammatory protein-related protein 2
Short name:
MRP-2
Small-inducible cytokine A9
Cleaved into the following 3 chains:
Gene namesi
Name:Ccl9
Synonyms:Mrp2, Scya10, Scya9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:104533. Ccl9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000519222 – 122C-C motif chemokine 9Add BLAST101
ChainiPRO_000004186550 – 122CCL9(29-101)Add BLAST73
ChainiPRO_000004186651 – 122CCL9(30-101)Add BLAST72
ChainiPRO_000004186752 – 122CCL9(31-101)Add BLAST71

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi57 ↔ 80By similarity
Disulfide bondi58 ↔ 96By similarity
Disulfide bondi67 ↔ 107By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP51670.
PeptideAtlasiP51670.
PRIDEiP51670.

PTM databases

iPTMnetiP51670.
PhosphoSitePlusiP51670.

Expressioni

Tissue specificityi

Expressed mainly in the liver, lung, and the thymus, although some expression has been detected in a wide variety of tissues except brain.

Inductioni

By interleukin-4; in the bone marrow macrophage.

Gene expression databases

BgeeiENSMUSG00000019122.
CleanExiMM_CCL9.
ExpressionAtlasiP51670. baseline and differential.
GenevisibleiP51670. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-5921N.
MINTiMINT-123781.
STRINGi10090.ENSMUSP00000019266.

Structurei

3D structure databases

ProteinModelPortaliP51670.
SMRiP51670.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4DG. Eukaryota.
ENOG4111C2C. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP51670.
KOiK05510.
OMAiFHTALSF.
OrthoDBiEOG091G14Y2.
PhylomeDBiP51670.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51670-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPFHTALSF LILTTALGIW AQITHATETK EVQSSLKAQQ GLEIEMFHMG
60 70 80 90 100
FQDSSDCCLS YNSRIQCSRF IGYFPTSGGC TRPGIIFISK RGFQVCANPS
110 120
DRRVQRCIER LEQNSQPRTY KQ
Length:122
Mass (Da):13,871
Last modified:October 1, 1996 - v1
Checksum:i9075F1FFEEFD30F7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113Q → K in AAB02198 (PubMed:8597875).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49513 mRNA. Translation: AAB02198.1.
U15209 mRNA. Translation: AAA92583.1.
U19482 mRNA. Translation: AAB17120.1.
AF128195 mRNA. Translation: AAF22536.1.
AF128196 mRNA. Translation: AAF22537.1.
AF128197 mRNA. Translation: AAF22538.1.
AF128198 mRNA. Translation: AAF22539.1.
AF128199 mRNA. Translation: AAF22540.1.
AF128200 mRNA. Translation: AAF22541.1.
AF128201 mRNA. Translation: AAF22542.1.
AF128202 mRNA. Translation: AAF22543.1.
AF128203 mRNA. Translation: AAF22544.1.
AF128204 mRNA. Translation: AAF22545.1.
AB051897 Genomic DNA. Translation: BAB18730.1.
AL596122 Genomic DNA. Translation: CAI25133.1.
CCDSiCCDS25170.1.
RefSeqiNP_035468.1. NM_011338.2.
UniGeneiMm.416125.

Genome annotation databases

EnsembliENSMUST00000019266; ENSMUSP00000019266; ENSMUSG00000019122.
GeneIDi20308.
KEGGimmu:20308.
UCSCiuc007kpj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49513 mRNA. Translation: AAB02198.1.
U15209 mRNA. Translation: AAA92583.1.
U19482 mRNA. Translation: AAB17120.1.
AF128195 mRNA. Translation: AAF22536.1.
AF128196 mRNA. Translation: AAF22537.1.
AF128197 mRNA. Translation: AAF22538.1.
AF128198 mRNA. Translation: AAF22539.1.
AF128199 mRNA. Translation: AAF22540.1.
AF128200 mRNA. Translation: AAF22541.1.
AF128201 mRNA. Translation: AAF22542.1.
AF128202 mRNA. Translation: AAF22543.1.
AF128203 mRNA. Translation: AAF22544.1.
AF128204 mRNA. Translation: AAF22545.1.
AB051897 Genomic DNA. Translation: BAB18730.1.
AL596122 Genomic DNA. Translation: CAI25133.1.
CCDSiCCDS25170.1.
RefSeqiNP_035468.1. NM_011338.2.
UniGeneiMm.416125.

3D structure databases

ProteinModelPortaliP51670.
SMRiP51670.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5921N.
MINTiMINT-123781.
STRINGi10090.ENSMUSP00000019266.

PTM databases

iPTMnetiP51670.
PhosphoSitePlusiP51670.

Proteomic databases

PaxDbiP51670.
PeptideAtlasiP51670.
PRIDEiP51670.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019266; ENSMUSP00000019266; ENSMUSG00000019122.
GeneIDi20308.
KEGGimmu:20308.
UCSCiuc007kpj.1. mouse.

Organism-specific databases

CTDi20308.
MGIiMGI:104533. Ccl9.

Phylogenomic databases

eggNOGiENOG410J4DG. Eukaryota.
ENOG4111C2C. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP51670.
KOiK05510.
OMAiFHTALSF.
OrthoDBiEOG091G14Y2.
PhylomeDBiP51670.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-444473. Formyl peptide receptors bind formyl peptides and many other ligands.

Miscellaneous databases

ChiTaRSiAbcc2. mouse.
PROiP51670.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019122.
CleanExiMM_CCL9.
ExpressionAtlasiP51670. baseline and differential.
GenevisibleiP51670. MM.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCL9_MOUSE
AccessioniPrimary (citable) accession number: P51670
Secondary accession number(s): Q5QNW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.