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P51670 (CCL9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 9
Alternative name(s):
CCF18
Macrophage inflammatory protein 1-gamma
Short name=MIP-1-gamma
Macrophage inflammatory protein-related protein 2
Short name=MRP-2
Small-inducible cytokine A9

Cleaved into the following 3 chains:

  1. CCL9(29-101)
  2. CCL9(30-101)
  3. CCL9(31-101)
Gene names
Name:Ccl9
Synonyms:Mrp2, Scya10, Scya9
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length122 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Monokine with inflammatory, pyrogenic and chemokinetic properties. Circulates at high concentrations in the blood of healthy animals. Binding to a high-affinity receptor activates calcium release in neutrophils. It also inhibits colony formation of bone marrow myeloid immature progenitors.

Subcellular location

Secreted.

Tissue specificity

Expressed mainly in the liver, lung, and the thymus, although some expression has been detected in a wide variety of tissues except brain.

Induction

By interleukin-4; in the bone marrow macrophage.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell chemotaxis

Inferred from electronic annotation. Source: GOC

immune response

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 122101C-C motif chemokine 9
PRO_0000005192
Chain50 – 12273CCL9(29-101)
PRO_0000041865
Chain51 – 12272CCL9(30-101)
PRO_0000041866
Chain52 – 12271CCL9(31-101)
PRO_0000041867

Amino acid modifications

Disulfide bond57 ↔ 80 By similarity
Disulfide bond58 ↔ 96 By similarity
Disulfide bond67 ↔ 107 By similarity

Experimental info

Sequence conflict1131Q → K in AAB02198. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P51670 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 9075F1FFEEFD30F7

FASTA12213,871
        10         20         30         40         50         60 
MKPFHTALSF LILTTALGIW AQITHATETK EVQSSLKAQQ GLEIEMFHMG FQDSSDCCLS 

        70         80         90        100        110        120 
YNSRIQCSRF IGYFPTSGGC TRPGIIFISK RGFQVCANPS DRRVQRCIER LEQNSQPRTY 


KQ 

« Hide

References

« Hide 'large scale' references
[1]"MIP-1 gamma: molecular cloning, expression, and biological activities of a novel CC chemokine that is constitutively secreted in vivo."
Poltorak A.N., Bazzoni F., Smirnova I.I., Alejos E., Thompson P., Luheshi G., Rothwell N., Beutler B.
J. Inflamm. 45:207-219(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors."
Youn B.-S., Jang I.-K., Broxmeyer H.E., Cooper S., Jenkins N.A., Gilbert D.J., Copeland N.G., Elick T.A., Fraser M.J. Jr., Kwon B.S.
J. Immunol. 155:2661-2667(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Molecular cloning and functional characterization of a novel member of the C-C chemokine family."
Hara T., Bacon K.B., Cho L.C., Yoshimura A., Morikawa Y., Copeland N.G., Gilbert D.J., Jenkins N.A., Schall T.J., Miyajima A.
J. Immunol. 155:5352-5358(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: B10.S/J, BALB/c, DBA/2J, NOD/LtJ and SJL/J.
Tissue: Spleen.
[5]"Organization of the mouse CC chemokine cluster containing the genes for C10, MRP-2 and RANTES."
Nomiyama H.
Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[6]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[7]"Proteolytic activation of alternative CCR1 ligands in inflammation."
Berahovich R.D., Miao Z., Wang Y., Premack B., Howard M.C., Schall T.J.
J. Immunol. 174:7341-7351(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION OF CCL9(29-101); CCL9(30-101) AND CCL9(31-101), PROTEOLYTIC PROCESSING OF N-TERMINUS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U49513 mRNA. Translation: AAB02198.1.
U15209 mRNA. Translation: AAA92583.1.
U19482 mRNA. Translation: AAB17120.1.
AF128195 mRNA. Translation: AAF22536.1.
AF128196 mRNA. Translation: AAF22537.1.
AF128197 mRNA. Translation: AAF22538.1.
AF128198 mRNA. Translation: AAF22539.1.
AF128199 mRNA. Translation: AAF22540.1.
AF128200 mRNA. Translation: AAF22541.1.
AF128201 mRNA. Translation: AAF22542.1.
AF128202 mRNA. Translation: AAF22543.1.
AF128203 mRNA. Translation: AAF22544.1.
AF128204 mRNA. Translation: AAF22545.1.
AB051897 Genomic DNA. Translation: BAB18730.1.
AL596122 Genomic DNA. Translation: CAI25133.1.
RefSeqNP_035468.1. NM_011338.2.
UniGeneMm.416125.

3D structure databases

ProteinModelPortalP51670.
SMRP51670. Positions 57-112.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-5921N.
MINTMINT-123781.

Proteomic databases

PaxDbP51670.
PRIDEP51670.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000019266; ENSMUSP00000019266; ENSMUSG00000019122.
GeneID20308.
KEGGmmu:20308.
UCSCuc007kpj.1. mouse.

Organism-specific databases

CTD20308.
MGIMGI:104533. Ccl9.

Phylogenomic databases

eggNOGNOG136395.
HOGENOMHOG000036685.
HOVERGENHBG017871.
InParanoidP51670.
KOK05510.
OMAFHTALSF.
OrthoDBEOG7RNK2R.
TreeFamTF334888.

Gene expression databases

ArrayExpressP51670.
BgeeP51670.
CleanExMM_CCL9.
GenevestigatorP51670.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio298071.
PROP51670.
SOURCESearch...

Entry information

Entry nameCCL9_MOUSE
AccessionPrimary (citable) accession number: P51670
Secondary accession number(s): Q5QNW2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 19, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot