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Protein

26S proteasome non-ATPase regulatory subunit 7

Gene

PSMD7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:HS02444-MONOMER.
ReactomeiR-HSA-1169091. Activation of NF-kappaB in B cells.
R-HSA-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-HSA-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-HSA-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-HSA-174154. APC/C:Cdc20 mediated degradation of Securin.
R-HSA-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-HSA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-HSA-180534. Vpu mediated degradation of CD4.
R-HSA-180585. Vif-mediated degradation of APOBEC3G.
R-HSA-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-HSA-195253. Degradation of beta-catenin by the destruction complex.
R-HSA-202424. Downstream TCR signaling.
R-HSA-211733. Regulation of activated PAK-2p34 by proteasome mediated degradation.
R-HSA-2467813. Separation of Sister Chromatids.
R-HSA-2871837. FCERI mediated NF-kB activation.
R-HSA-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-HSA-350562. Regulation of ornithine decarboxylase (ODC).
R-HSA-382556. ABC-family proteins mediated transport.
R-HSA-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-HSA-4608870. Asymmetric localization of PCP proteins.
R-HSA-4641257. Degradation of AXIN.
R-HSA-4641258. Degradation of DVL.
R-HSA-5358346. Hedgehog ligand biogenesis.
R-HSA-5362768. Hh mutants that don't undergo autocatalytic processing are degraded by ERAD.
R-HSA-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-HSA-5607764. CLEC7A (Dectin-1) signaling.
R-HSA-5610780. Degradation of GLI1 by the proteasome.
R-HSA-5610783. Degradation of GLI2 by the proteasome.
R-HSA-5610785. GLI3 is processed to GLI3R by the proteasome.
R-HSA-5632684. Hedgehog 'on' state.
R-HSA-5658442. Regulation of RAS by GAPs.
R-HSA-5668541. TNFR2 non-canonical NF-kB pathway.
R-HSA-5676590. NIK-->noncanonical NF-kB signaling.
R-HSA-5678895. Defective CFTR causes cystic fibrosis.
R-HSA-5687128. MAPK6/MAPK4 signaling.
R-HSA-5689603. UCH proteinases.
R-HSA-5689880. Ub-specific processing proteases.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-68827. CDT1 association with the CDC6:ORC:origin complex.
R-HSA-68949. Orc1 removal from chromatin.
R-HSA-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-HSA-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-HSA-69481. G2/M Checkpoints.
R-HSA-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-HSA-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
R-HSA-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Protein family/group databases

MEROPSiM67.973.

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 7
Alternative name(s):
26S proteasome regulatory subunit RPN8
26S proteasome regulatory subunit S12
Mov34 protein homolog
Proteasome subunit p40
Gene namesi
Name:PSMD7
Synonyms:MOV34L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:9565. PSMD7.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • proteasome complex Source: UniProtKB
  • proteasome regulatory particle Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Proteasome

Pathology & Biotechi

Organism-specific databases

DisGeNETi5713.
OpenTargetsiENSG00000103035.
PharmGKBiPA33911.

Polymorphism and mutation databases

BioMutaiPSMD7.
DMDMi20532412.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002139431 – 32426S proteasome non-ATPase regulatory subunit 7Add BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki180Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Modified residuei204N6-acetyllysineCombined sources1
Modified residuei214N6-acetyllysineCombined sources1
Modified residuei316N6-acetyllysineBy similarity1
Modified residuei317N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP51665.
MaxQBiP51665.
PaxDbiP51665.
PeptideAtlasiP51665.
PRIDEiP51665.

PTM databases

iPTMnetiP51665.
PhosphoSitePlusiP51665.

Expressioni

Gene expression databases

BgeeiENSG00000103035.
CleanExiHS_PSMD7.
ExpressionAtlasiP51665. baseline and differential.
GenevisibleiP51665. HS.

Organism-specific databases

HPAiCAB019379.
HPA049824.
HPA056069.

Interactioni

Subunit structurei

Homodimer. Interacts with TRIM5.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PSMD14O004878EBI-357659,EBI-722193

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi111685. 111 interactors.
DIPiDIP-27572N.
IntActiP51665. 48 interactors.
MINTiMINT-5002613.
STRINGi9606.ENSP00000219313.

Structurei

Secondary structure

1324
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 11Combined sources5
Helixi13 – 28Combined sources16
Beta strandi36 – 56Combined sources21
Beta strandi58 – 60Combined sources3
Beta strandi67 – 70Combined sources4
Helixi72 – 83Combined sources12
Beta strandi86 – 88Combined sources3
Beta strandi90 – 96Combined sources7
Helixi105 – 112Combined sources8
Turni113 – 115Combined sources3
Beta strandi120 – 124Combined sources5
Beta strandi134 – 143Combined sources10
Beta strandi152 – 162Combined sources11
Helixi166 – 178Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2O95X-ray1.95A/B1-186[»]
2O96X-ray3.00A/B1-177[»]
5GJQelectron microscopy4.50U1-324[»]
5GJRelectron microscopy3.508/U1-324[»]
5L4Kelectron microscopy4.50U1-324[»]
5T0Celectron microscopy3.80AZ/BZ1-324[»]
5T0Gelectron microscopy4.40Z1-324[»]
5T0Helectron microscopy6.80Z1-324[»]
5T0Ielectron microscopy8.00Z1-324[»]
5T0Jelectron microscopy8.00Z1-324[»]
ProteinModelPortaliP51665.
SMRiP51665.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP51665.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 118MPNAdd BLAST115

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi286 – 324Glu/Lys-richAdd BLAST39

Sequence similaritiesi

Belongs to the peptidase M67A family.Curated
Contains 1 MPN (JAB/Mov34) domain.Curated

Phylogenomic databases

eggNOGiKOG1556. Eukaryota.
COG1310. LUCA.
GeneTreeiENSGT00530000063075.
HOGENOMiHOG000209236.
HOVERGENiHBG035951.
InParanoidiP51665.
KOiK03038.
OMAiMPVNHQI.
OrthoDBiEOG091G0DX6.
PhylomeDBiP51665.

Family and domain databases

CDDicd08062. MPN_RPN7_8. 1 hit.
InterProiIPR000555. JAMM/MPN+_dom.
IPR033858. MPN_RPN7_8.
IPR024969. Rpn11/EIF3F_C.
[Graphical view]
PfamiPF01398. JAB. 1 hit.
PF13012. MitMem_reg. 1 hit.
[Graphical view]
SMARTiSM00232. JAB_MPN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51665-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPELAVQKVV VHPLVLLSVV DHFNRIGKVG NQKRVVGVLL GSWQKKVLDV
60 70 80 90 100
SNSFAVPFDE DDKDDSVWFL DHDYLENMYG MFKKVNARER IVGWYHTGPK
110 120 130 140 150
LHKNDIAINE LMKRYCPNSV LVIIDVKPKD LGLPTEAYIS VEEVHDDGTP
160 170 180 190 200
TSKTFEHVTS EIGAEEAEEV GVEHLLRDIK DTTVGTLSQR ITNQVHGLKG
210 220 230 240 250
LNSKLLDIRS YLEKVATGKL PINHQIIYQL QDVFNLLPDV SLQEFVKAFY
260 270 280 290 300
LKTNDQMVVV YLASLIRSVV ALHNLINNKI ANRDAEKKEG QEKEESKKDR
310 320
KEDKEKDKDK EKSDVKKEEK KEKK
Length:324
Mass (Da):37,025
Last modified:May 10, 2002 - v2
Checksum:i3F7B343996B102B7
GO

Sequence cautioni

The sequence AAH00338 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27G → V in BAA08780 (PubMed:7755639).Curated1
Sequence conflicti144 – 145VH → DQ in BAA08780 (PubMed:7755639).Curated2
Sequence conflicti216A → G in BAA08780 (PubMed:7755639).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50063 mRNA. Translation: BAA08780.1.
CH471166 Genomic DNA. Translation: EAW59162.1.
CH471166 Genomic DNA. Translation: EAW59163.1.
BC000338 mRNA. Translation: AAH00338.1. Sequence problems.
BC012606 mRNA. Translation: AAH12606.1.
CCDSiCCDS10910.1.
PIRiJC4154.
S65491.
RefSeqiNP_002802.2. NM_002811.4.
UniGeneiHs.440604.

Genome annotation databases

EnsembliENST00000219313; ENSP00000219313; ENSG00000103035.
GeneIDi5713.
KEGGihsa:5713.
UCSCiuc002fcq.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50063 mRNA. Translation: BAA08780.1.
CH471166 Genomic DNA. Translation: EAW59162.1.
CH471166 Genomic DNA. Translation: EAW59163.1.
BC000338 mRNA. Translation: AAH00338.1. Sequence problems.
BC012606 mRNA. Translation: AAH12606.1.
CCDSiCCDS10910.1.
PIRiJC4154.
S65491.
RefSeqiNP_002802.2. NM_002811.4.
UniGeneiHs.440604.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2O95X-ray1.95A/B1-186[»]
2O96X-ray3.00A/B1-177[»]
5GJQelectron microscopy4.50U1-324[»]
5GJRelectron microscopy3.508/U1-324[»]
5L4Kelectron microscopy4.50U1-324[»]
5T0Celectron microscopy3.80AZ/BZ1-324[»]
5T0Gelectron microscopy4.40Z1-324[»]
5T0Helectron microscopy6.80Z1-324[»]
5T0Ielectron microscopy8.00Z1-324[»]
5T0Jelectron microscopy8.00Z1-324[»]
ProteinModelPortaliP51665.
SMRiP51665.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111685. 111 interactors.
DIPiDIP-27572N.
IntActiP51665. 48 interactors.
MINTiMINT-5002613.
STRINGi9606.ENSP00000219313.

Protein family/group databases

MEROPSiM67.973.

PTM databases

iPTMnetiP51665.
PhosphoSitePlusiP51665.

Polymorphism and mutation databases

BioMutaiPSMD7.
DMDMi20532412.

Proteomic databases

EPDiP51665.
MaxQBiP51665.
PaxDbiP51665.
PeptideAtlasiP51665.
PRIDEiP51665.

Protocols and materials databases

DNASUi5713.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219313; ENSP00000219313; ENSG00000103035.
GeneIDi5713.
KEGGihsa:5713.
UCSCiuc002fcq.3. human.

Organism-specific databases

CTDi5713.
DisGeNETi5713.
GeneCardsiPSMD7.
HGNCiHGNC:9565. PSMD7.
HPAiCAB019379.
HPA049824.
HPA056069.
MIMi157970. gene.
neXtProtiNX_P51665.
OpenTargetsiENSG00000103035.
PharmGKBiPA33911.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1556. Eukaryota.
COG1310. LUCA.
GeneTreeiENSGT00530000063075.
HOGENOMiHOG000209236.
HOVERGENiHBG035951.
InParanoidiP51665.
KOiK03038.
OMAiMPVNHQI.
OrthoDBiEOG091G0DX6.
PhylomeDBiP51665.

Enzyme and pathway databases

BioCyciZFISH:HS02444-MONOMER.
ReactomeiR-HSA-1169091. Activation of NF-kappaB in B cells.
R-HSA-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-HSA-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-HSA-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-HSA-174154. APC/C:Cdc20 mediated degradation of Securin.
R-HSA-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-HSA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-HSA-180534. Vpu mediated degradation of CD4.
R-HSA-180585. Vif-mediated degradation of APOBEC3G.
R-HSA-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-HSA-195253. Degradation of beta-catenin by the destruction complex.
R-HSA-202424. Downstream TCR signaling.
R-HSA-211733. Regulation of activated PAK-2p34 by proteasome mediated degradation.
R-HSA-2467813. Separation of Sister Chromatids.
R-HSA-2871837. FCERI mediated NF-kB activation.
R-HSA-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-HSA-350562. Regulation of ornithine decarboxylase (ODC).
R-HSA-382556. ABC-family proteins mediated transport.
R-HSA-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-HSA-4608870. Asymmetric localization of PCP proteins.
R-HSA-4641257. Degradation of AXIN.
R-HSA-4641258. Degradation of DVL.
R-HSA-5358346. Hedgehog ligand biogenesis.
R-HSA-5362768. Hh mutants that don't undergo autocatalytic processing are degraded by ERAD.
R-HSA-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-HSA-5607764. CLEC7A (Dectin-1) signaling.
R-HSA-5610780. Degradation of GLI1 by the proteasome.
R-HSA-5610783. Degradation of GLI2 by the proteasome.
R-HSA-5610785. GLI3 is processed to GLI3R by the proteasome.
R-HSA-5632684. Hedgehog 'on' state.
R-HSA-5658442. Regulation of RAS by GAPs.
R-HSA-5668541. TNFR2 non-canonical NF-kB pathway.
R-HSA-5676590. NIK-->noncanonical NF-kB signaling.
R-HSA-5678895. Defective CFTR causes cystic fibrosis.
R-HSA-5687128. MAPK6/MAPK4 signaling.
R-HSA-5689603. UCH proteinases.
R-HSA-5689880. Ub-specific processing proteases.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-68827. CDT1 association with the CDC6:ORC:origin complex.
R-HSA-68949. Orc1 removal from chromatin.
R-HSA-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-HSA-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-HSA-69481. G2/M Checkpoints.
R-HSA-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-HSA-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
R-HSA-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiPSMD7. human.
EvolutionaryTraceiP51665.
GeneWikiiPSMD7.
GenomeRNAii5713.
PROiP51665.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103035.
CleanExiHS_PSMD7.
ExpressionAtlasiP51665. baseline and differential.
GenevisibleiP51665. HS.

Family and domain databases

CDDicd08062. MPN_RPN7_8. 1 hit.
InterProiIPR000555. JAMM/MPN+_dom.
IPR033858. MPN_RPN7_8.
IPR024969. Rpn11/EIF3F_C.
[Graphical view]
PfamiPF01398. JAB. 1 hit.
PF13012. MitMem_reg. 1 hit.
[Graphical view]
SMARTiSM00232. JAB_MPN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSMD7_HUMAN
AccessioniPrimary (citable) accession number: P51665
Secondary accession number(s): D3DWS9, Q6PKI2, Q96E97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 10, 2002
Last modified: November 30, 2016
This is version 161 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Does not bind a metal ion.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.