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Protein

Cytochrome P450 11B1, mitochondrial

Gene

CYP11B1

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.

Catalytic activityi

A steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11-beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi450Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processSteroidogenesis
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 11B1, mitochondrial
Alternative name(s):
CYPXIB1
Cytochrome P450C11
Steroid 11-beta-hydroxylase (EC:1.14.15.4)
Gene namesi
Name:CYP11B1
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24MitochondrionAdd BLAST24
ChainiPRO_000000360625 – 503Cytochrome P450 11B1, mitochondrialAdd BLAST479

Structurei

3D structure databases

ProteinModelPortaliP51663
SMRiP51663
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG051098
KOiK00497

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51663-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALWAKARVW MAGPWLSLHR ARPLGTRASA APKAVLPFEA MPRCPGNKWM
60 70 80 90 100
RVLQIWKEQG SENMHLDMHQ TFQELGPIFR YDVGGRHMVF VMLPEDVERL
110 120 130 140 150
QQAESLHPQR MLLEPWLAYR QARGHKCGVF LLNGPQWRLD RLRLNPDVLS
160 170 180 190 200
LPALQKYTPL VDGVARDFSQ TLKARVLQNA RGSLTLDIAP SVFRYTIEAS
210 220 230 240 250
TLVLYGERLG LLTQQPNPDS LNFIHALEAM FKSTVQLMFV PRRLSRWTSS
260 270 280 290 300
SMWREHFEAW DYIFQYANRA IQRIYQELAL GHPWHYSGIV AELLMRADMT
310 320 330 340 350
LDTIKANTID LTAGSVDTTA FPLLMTLFEL ARNPEVQQAL RQESLVAEAR
360 370 380 390 400
ISENPQRATT ELPLLRAALK ETLRLYPVGI TLERQVSSDL VLQNYHIPAG
410 420 430 440 450
TLVKVLLYSL GRNPAVFARP ESYHPQRWLD RQGSGSRFPH LAFGFGMRQC
460 470 480 490 500
LGRRVAEVEM LLLLHHVLKN FLVETLAQED IKMVYRFILM PSTLPLFTFR

AIQ
Length:503
Mass (Da):57,784
Last modified:July 15, 1998 - v2
Checksum:i968F2DF6EE7D595B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99R → S in AAB64248 (PubMed:10728821).Curated1
Sequence conflicti99R → S in AAB64249 (PubMed:10728821).Curated1
Sequence conflicti189A → G in AAA62308 (PubMed:7999785).Curated1
Sequence conflicti439P → R in AAA62308 (PubMed:7999785).Curated1
Sequence conflicti500R → G in AAB64248 (PubMed:10728821).Curated1
Sequence conflicti500R → G in AAB64249 (PubMed:10728821).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34337 mRNA Translation: AAA62308.1
L47569 Genomic DNA Translation: AAA81576.1
U78478 Genomic DNA Translation: AAB64249.1
U78477 mRNA Translation: AAB64248.1
L28716 Genomic DNA Translation: AAA83384.1
PIRiS52085
RefSeqiNP_001068568.1, NM_001075100.2
UniGeneiOar.397

Genome annotation databases

GeneIDi767576
KEGGioas:767576

Similar proteinsi

Entry informationi

Entry nameiC11B1_SHEEP
AccessioniPrimary (citable) accession number: P51663
Secondary accession number(s): O19181
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1998
Last modified: March 28, 2018
This is version 87 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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