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P51663

- C11B1_SHEEP

UniProt

P51663 - C11B1_SHEEP

Protein

Cytochrome P450 11B1, mitochondrial

Gene

CYP11B1

Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 2 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.

    Catalytic activityi

    A steroid + reduced adrenodoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenodoxin + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi450 – 4501Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. steroid 11-beta-monooxygenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. steroid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Steroidogenesis

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 11B1, mitochondrial
    Alternative name(s):
    CYPXIB1
    Cytochrome P450C11
    Steroid 11-beta-hydroxylase (EC:1.14.15.4)
    Gene namesi
    Name:CYP11B1
    OrganismiOvis aries (Sheep)
    Taxonomic identifieri9940 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
    ProteomesiUP000002356: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2424MitochondrionAdd
    BLAST
    Chaini25 – 503479Cytochrome P450 11B1, mitochondrialPRO_0000003606Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP51663.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG051098.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P51663-1 [UniParc]FASTAAdd to Basket

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    MALWAKARVW MAGPWLSLHR ARPLGTRASA APKAVLPFEA MPRCPGNKWM    50
    RVLQIWKEQG SENMHLDMHQ TFQELGPIFR YDVGGRHMVF VMLPEDVERL 100
    QQAESLHPQR MLLEPWLAYR QARGHKCGVF LLNGPQWRLD RLRLNPDVLS 150
    LPALQKYTPL VDGVARDFSQ TLKARVLQNA RGSLTLDIAP SVFRYTIEAS 200
    TLVLYGERLG LLTQQPNPDS LNFIHALEAM FKSTVQLMFV PRRLSRWTSS 250
    SMWREHFEAW DYIFQYANRA IQRIYQELAL GHPWHYSGIV AELLMRADMT 300
    LDTIKANTID LTAGSVDTTA FPLLMTLFEL ARNPEVQQAL RQESLVAEAR 350
    ISENPQRATT ELPLLRAALK ETLRLYPVGI TLERQVSSDL VLQNYHIPAG 400
    TLVKVLLYSL GRNPAVFARP ESYHPQRWLD RQGSGSRFPH LAFGFGMRQC 450
    LGRRVAEVEM LLLLHHVLKN FLVETLAQED IKMVYRFILM PSTLPLFTFR 500
    AIQ 503
    Length:503
    Mass (Da):57,784
    Last modified:July 15, 1998 - v2
    Checksum:i968F2DF6EE7D595B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti99 – 991R → S in AAB64248. (PubMed:10728821)Curated
    Sequence conflicti99 – 991R → S in AAB64249. (PubMed:10728821)Curated
    Sequence conflicti189 – 1891A → G in AAA62308. (PubMed:7999785)Curated
    Sequence conflicti439 – 4391P → R in AAA62308. (PubMed:7999785)Curated
    Sequence conflicti500 – 5001R → G in AAB64248. (PubMed:10728821)Curated
    Sequence conflicti500 – 5001R → G in AAB64249. (PubMed:10728821)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34337 mRNA. Translation: AAA62308.1.
    L47569 Genomic DNA. Translation: AAA81576.1.
    U78478 Genomic DNA. Translation: AAB64249.1.
    U78477 mRNA. Translation: AAB64248.1.
    L28716 Genomic DNA. Translation: AAA83384.1.
    PIRiS52085.
    RefSeqiNP_001068568.1. NM_001075100.2.
    UniGeneiOar.397.

    Genome annotation databases

    GeneIDi767576.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34337 mRNA. Translation: AAA62308.1 .
    L47569 Genomic DNA. Translation: AAA81576.1 .
    U78478 Genomic DNA. Translation: AAB64249.1 .
    U78477 mRNA. Translation: AAB64248.1 .
    L28716 Genomic DNA. Translation: AAA83384.1 .
    PIRi S52085.
    RefSeqi NP_001068568.1. NM_001075100.2.
    UniGenei Oar.397.

    3D structure databases

    ProteinModelPortali P51663.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 767576.

    Organism-specific databases

    CTDi 1584.

    Phylogenomic databases

    HOVERGENi HBG051098.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression analysis of a cytochrome P-450(11 beta) cDNA in sheep."
      Boon W.C., Roche P.J., Hammond V.E., Jeyaseelan K., Crawford R.J., Coghlan J.P.
      Biochim. Biophys. Acta 1260:109-112(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Merino.
      Tissue: Adrenal cortex.
    2. "Structure of an ovine CYP11B1 gene."
      Anwar A., Coghlan J.P., Jeyaseelan K.
      DNA Seq. 8:357-374(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Tissue: Adrenal gland and Liver.
    3. "Molecular cloning and characterization of the ovine CYP11B1 promoter."
      Anwar A., Jeyaseelan K., Coghlan J.P.
      Biochem. Mol. Biol. Int. 33:1169-1178(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-77.

    Entry informationi

    Entry nameiC11B1_SHEEP
    AccessioniPrimary (citable) accession number: P51663
    Secondary accession number(s): O19181
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 79 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3