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Protein

Cytochrome P450 11B1, mitochondrial

Gene

CYP11B1

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.

Catalytic activityi

A steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11-beta- hydroxysteroid + 2 oxidized adrenodoxin + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi450 – 4501Iron (heme axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Steroidogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 11B1, mitochondrial
Alternative name(s):
CYPXIB1
Cytochrome P450C11
Steroid 11-beta-hydroxylase (EC:1.14.15.4)
Gene namesi
Name:CYP11B1
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
ProteomesiUP000002356 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424MitochondrionAdd
BLAST
Chaini25 – 503479Cytochrome P450 11B1, mitochondrialPRO_0000003606Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP51663.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG051098.
KOiK00497.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51663-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALWAKARVW MAGPWLSLHR ARPLGTRASA APKAVLPFEA MPRCPGNKWM
60 70 80 90 100
RVLQIWKEQG SENMHLDMHQ TFQELGPIFR YDVGGRHMVF VMLPEDVERL
110 120 130 140 150
QQAESLHPQR MLLEPWLAYR QARGHKCGVF LLNGPQWRLD RLRLNPDVLS
160 170 180 190 200
LPALQKYTPL VDGVARDFSQ TLKARVLQNA RGSLTLDIAP SVFRYTIEAS
210 220 230 240 250
TLVLYGERLG LLTQQPNPDS LNFIHALEAM FKSTVQLMFV PRRLSRWTSS
260 270 280 290 300
SMWREHFEAW DYIFQYANRA IQRIYQELAL GHPWHYSGIV AELLMRADMT
310 320 330 340 350
LDTIKANTID LTAGSVDTTA FPLLMTLFEL ARNPEVQQAL RQESLVAEAR
360 370 380 390 400
ISENPQRATT ELPLLRAALK ETLRLYPVGI TLERQVSSDL VLQNYHIPAG
410 420 430 440 450
TLVKVLLYSL GRNPAVFARP ESYHPQRWLD RQGSGSRFPH LAFGFGMRQC
460 470 480 490 500
LGRRVAEVEM LLLLHHVLKN FLVETLAQED IKMVYRFILM PSTLPLFTFR

AIQ
Length:503
Mass (Da):57,784
Last modified:July 15, 1998 - v2
Checksum:i968F2DF6EE7D595B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti99 – 991R → S in AAB64248 (PubMed:10728821).Curated
Sequence conflicti99 – 991R → S in AAB64249 (PubMed:10728821).Curated
Sequence conflicti189 – 1891A → G in AAA62308 (PubMed:7999785).Curated
Sequence conflicti439 – 4391P → R in AAA62308 (PubMed:7999785).Curated
Sequence conflicti500 – 5001R → G in AAB64248 (PubMed:10728821).Curated
Sequence conflicti500 – 5001R → G in AAB64249 (PubMed:10728821).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34337 mRNA. Translation: AAA62308.1.
L47569 Genomic DNA. Translation: AAA81576.1.
U78478 Genomic DNA. Translation: AAB64249.1.
U78477 mRNA. Translation: AAB64248.1.
L28716 Genomic DNA. Translation: AAA83384.1.
PIRiS52085.
RefSeqiNP_001068568.1. NM_001075100.2.
UniGeneiOar.397.

Genome annotation databases

GeneIDi767576.
KEGGioas:767576.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34337 mRNA. Translation: AAA62308.1.
L47569 Genomic DNA. Translation: AAA81576.1.
U78478 Genomic DNA. Translation: AAB64249.1.
U78477 mRNA. Translation: AAB64248.1.
L28716 Genomic DNA. Translation: AAA83384.1.
PIRiS52085.
RefSeqiNP_001068568.1. NM_001075100.2.
UniGeneiOar.397.

3D structure databases

ProteinModelPortaliP51663.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi767576.
KEGGioas:767576.

Organism-specific databases

CTDi1584.

Phylogenomic databases

HOVERGENiHBG051098.
KOiK00497.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and expression analysis of a cytochrome P-450(11 beta) cDNA in sheep."
    Boon W.C., Roche P.J., Hammond V.E., Jeyaseelan K., Crawford R.J., Coghlan J.P.
    Biochim. Biophys. Acta 1260:109-112(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Merino.
    Tissue: Adrenal cortex.
  2. "Structure of an ovine CYP11B1 gene."
    Anwar A., Coghlan J.P., Jeyaseelan K.
    DNA Seq. 8:357-374(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Adrenal gland and Liver.
  3. "Molecular cloning and characterization of the ovine CYP11B1 promoter."
    Anwar A., Jeyaseelan K., Coghlan J.P.
    Biochem. Mol. Biol. Int. 33:1169-1178(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-77.

Entry informationi

Entry nameiC11B1_SHEEP
AccessioniPrimary (citable) accession number: P51663
Secondary accession number(s): O19181
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1998
Last modified: January 7, 2015
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.