##gff-version 3 P51659 UniProtKB Chain 1 736 . . . ID=PRO_0000054583;Note=Peroxisomal multifunctional enzyme type 2 P51659 UniProtKB Chain 1 311 . . . ID=PRO_0000400082;Note=(3R)-hydroxyacyl-CoA dehydrogenase P51659 UniProtKB Chain 312 736 . . . ID=PRO_0000400083;Note=Enoyl-CoA hydratase 2 P51659 UniProtKB Domain 484 600 . . . Note=MaoC-like P51659 UniProtKB Domain 624 736 . . . Note=SCP2 P51659 UniProtKB Region 1 305 . . . Note=(3R)-hydroxyacyl-CoA dehydrogenase P51659 UniProtKB Region 322 622 . . . Note=Enoyl-CoA hydratase 2 P51659 UniProtKB Motif 734 736 . . . Note=Microbody targeting signal;Ontology_term=ECO:0000255;evidence=ECO:0000255 P51659 UniProtKB Active site 164 164 . . . Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10001 P51659 UniProtKB Binding site 13 37 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P51659 UniProtKB Binding site 21 21 . . . . P51659 UniProtKB Binding site 40 40 . . . . P51659 UniProtKB Binding site 75 76 . . . . P51659 UniProtKB Binding site 99 99 . . . . P51659 UniProtKB Binding site 151 151 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P51659 UniProtKB Binding site 164 168 . . . . P51659 UniProtKB Binding site 196 199 . . . . P51659 UniProtKB Binding site 406 407 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P51659 UniProtKB Binding site 435 435 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P51659 UniProtKB Binding site 510 515 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P51659 UniProtKB Binding site 533 533 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P51659 UniProtKB Binding site 563 563 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P51659 UniProtKB Binding site 706 706 . . . . P51659 UniProtKB Binding site 724 724 . . . . P51659 UniProtKB Modified residue 46 46 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P51660 P51659 UniProtKB Modified residue 46 46 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P51660 P51659 UniProtKB Modified residue 52 52 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 P51659 UniProtKB Modified residue 57 57 . . . Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P51660 P51659 UniProtKB Modified residue 68 68 . . . Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P51660 P51659 UniProtKB Modified residue 84 84 . . . Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P51660 P51659 UniProtKB Modified residue 265 265 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P51659 UniProtKB Modified residue 275 275 . . . Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P51660 P51659 UniProtKB Modified residue 304 304 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 P51659 UniProtKB Modified residue 309 309 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195 P51659 UniProtKB Modified residue 356 356 . . . Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P51660 P51659 UniProtKB Modified residue 424 424 . . . Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P51660 P51659 UniProtKB Modified residue 565 565 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P51659 UniProtKB Modified residue 579 579 . . . Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P51660 P51659 UniProtKB Modified residue 663 663 . . . Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P51660 P51659 UniProtKB Modified residue 669 669 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P51659 UniProtKB Modified residue 707 707 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P51659 UniProtKB Modified residue 725 725 . . . Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P51660 P51659 UniProtKB Alternative sequence 1 38 . . . ID=VSP_046152;Note=In isoform 2. MGSPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVV->MVILEAPHLLRRKEPETPGLSSRIGPSLCPGFCRKRSVSCCFQNLCNNPMEKIISQCRFFVSM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 P51659 UniProtKB Alternative sequence 20 37 . . . ID=VSP_046153;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 P51659 UniProtKB Natural variant 16 16 . . . ID=VAR_037576;Note=In DBPD%3B no dehydrogenase activity. G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10671535,ECO:0000269|PubMed:9482850;Dbxref=dbSNP:rs137853096,PMID:10671535,PMID:9482850 P51659 UniProtKB Natural variant 90 90 . . . ID=VAR_052309;Note=F->L;Dbxref=dbSNP:rs28943588 P51659 UniProtKB Natural variant 106 106 . . . ID=VAR_014872;Note=R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:25956234;Dbxref=dbSNP:rs25640,PMID:14702039,PMID:25956234 P51659 UniProtKB Natural variant 106 106 . . . ID=VAR_065906;Note=In DBPD. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11743515;Dbxref=dbSNP:rs25640,PMID:11743515 P51659 UniProtKB Natural variant 140 140 . . . ID=VAR_052310;Note=K->N;Dbxref=dbSNP:rs28943589 P51659 UniProtKB Natural variant 217 217 . . . ID=VAR_065907;Note=In PRLTS1. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20673864;Dbxref=dbSNP:rs387906825,PMID:20673864 P51659 UniProtKB Natural variant 292 292 . . . ID=VAR_024625;Note=T->S;Dbxref=dbSNP:rs1143650 P51659 UniProtKB Natural variant 427 427 . . . ID=VAR_052311;Note=A->V;Dbxref=dbSNP:rs28943590 P51659 UniProtKB Natural variant 457 457 . . . ID=VAR_065908;Note=In DBPD%3B the mutation leads to an unstable protein. N->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10400999;Dbxref=dbSNP:rs137853097,PMID:10400999 P51659 UniProtKB Natural variant 491 491 . . . ID=VAR_052312;Note=A->T;Dbxref=dbSNP:rs28943591 P51659 UniProtKB Natural variant 511 511 . . . ID=VAR_014873;Note=W->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10400999;Dbxref=dbSNP:rs11539471,PMID:10400999 P51659 UniProtKB Natural variant 559 559 . . . ID=VAR_014874;Note=I->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:25956234;Dbxref=dbSNP:rs11205,PMID:14702039,PMID:25956234 P51659 UniProtKB Natural variant 606 606 . . . ID=VAR_052313;Note=A->S;Dbxref=dbSNP:rs15228 P51659 UniProtKB Natural variant 687 687 . . . ID=VAR_052314;Note=T->I;Dbxref=dbSNP:rs28943592 P51659 UniProtKB Natural variant 728 728 . . . ID=VAR_052315;Note=M->V;Dbxref=dbSNP:rs28943594 P51659 UniProtKB Mutagenesis 347 347 . . . Note=No hydratase activity. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10671535;Dbxref=PMID:10671535 P51659 UniProtKB Mutagenesis 366 366 . . . Note=No hydratase activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10671535;Dbxref=PMID:10671535 P51659 UniProtKB Mutagenesis 370 370 . . . Note=No effect. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10671535;Dbxref=PMID:10671535 P51659 UniProtKB Mutagenesis 406 406 . . . Note=No effect. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10671535;Dbxref=PMID:10671535 P51659 UniProtKB Mutagenesis 408 408 . . . Note=No effect. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10671535;Dbxref=PMID:10671535 P51659 UniProtKB Mutagenesis 410 410 . . . Note=No effect. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10671535;Dbxref=PMID:10671535 P51659 UniProtKB Mutagenesis 490 490 . . . Note=No effect. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10671535;Dbxref=PMID:10671535 P51659 UniProtKB Mutagenesis 505 505 . . . Note=Completely inactive. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10671535;Dbxref=PMID:10671535 P51659 UniProtKB Mutagenesis 510 510 . . . Note=No hydratase activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10671535;Dbxref=PMID:10671535 P51659 UniProtKB Mutagenesis 515 515 . . . Note=Completely inactive. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10671535;Dbxref=PMID:10671535 P51659 UniProtKB Mutagenesis 517 517 . . . Note=No effect. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10671535;Dbxref=PMID:10671535 P51659 UniProtKB Mutagenesis 532 532 . . . Note=No effect. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10671535;Dbxref=PMID:10671535 P51659 UniProtKB Sequence conflict 587 587 . . . Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 P51659 UniProtKB Beta strand 11 14 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1ZBQ P51659 UniProtKB Turn 15 18 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1ZBQ P51659 UniProtKB Helix 20 31 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1ZBQ P51659 UniProtKB Beta strand 35 39 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1ZBQ P51659 UniProtKB Helix 53 64 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1ZBQ P51659 UniProtKB Beta strand 68 72 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1ZBQ P51659 UniProtKB Helix 76 78 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1ZBQ P51659 UniProtKB Helix 79 90 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1ZBQ P51659 UniProtKB Beta strand 95 98 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1ZBQ P51659 UniProtKB Helix 108 110 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1ZBQ P51659 UniProtKB Helix 113 141 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1ZBQ P51659 UniProtKB Beta strand 144 149 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1ZBQ P51659 UniProtKB Helix 152 156 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1ZBQ P51659 UniProtKB Helix 162 182 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1ZBQ P51659 UniProtKB Helix 183 185 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1ZBQ P51659 UniProtKB Beta strand 187 194 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1ZBQ P51659 UniProtKB Turn 199 204 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1ZBQ P51659 UniProtKB Helix 207 212 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1ZBQ P51659 UniProtKB Helix 215 217 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1ZBQ P51659 UniProtKB Helix 219 225 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1ZBQ P51659 UniProtKB Beta strand 236 240 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1ZBQ P51659 UniProtKB Beta strand 243 251 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1ZBQ P51659 UniProtKB Helix 266 271 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1ZBQ P51659 UniProtKB Helix 273 277 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1ZBQ P51659 UniProtKB Helix 288 303 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1ZBQ P51659 UniProtKB Beta strand 335 339 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1S9C P51659 UniProtKB Helix 341 350 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1S9C P51659 UniProtKB Helix 358 360 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1S9C P51659 UniProtKB Helix 361 364 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1S9C P51659 UniProtKB Helix 375 377 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1S9C P51659 UniProtKB Helix 378 381 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1S9C P51659 UniProtKB Helix 383 385 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1S9C P51659 UniProtKB Helix 401 403 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1S9C P51659 UniProtKB Beta strand 405 415 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1S9C P51659 UniProtKB Beta strand 419 432 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1S9C P51659 UniProtKB Beta strand 440 462 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1S9C P51659 UniProtKB Beta strand 490 496 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1S9C P51659 UniProtKB Helix 501 505 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1S9C P51659 UniProtKB Helix 506 508 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1S9C P51659 UniProtKB Helix 513 515 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1S9C P51659 UniProtKB Helix 518 522 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1S9C P51659 UniProtKB Turn 523 525 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1S9C P51659 UniProtKB Helix 533 548 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1S9C P51659 UniProtKB Helix 553 555 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1S9C P51659 UniProtKB Beta strand 556 563 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1S9C P51659 UniProtKB Beta strand 572 580 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1S9C P51659 UniProtKB Beta strand 583 590 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1S9C P51659 UniProtKB Turn 591 593 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1S9C P51659 UniProtKB Beta strand 596 605 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1S9C P51659 UniProtKB Helix 624 646 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8AF3 P51659 UniProtKB Beta strand 648 670 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8AF3 P51659 UniProtKB Beta strand 674 679 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8AF3 P51659 UniProtKB Beta strand 685 691 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8AF3 P51659 UniProtKB Helix 692 699 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8AF3 P51659 UniProtKB Helix 705 710 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8AF3 P51659 UniProtKB Beta strand 713 718 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8AF3 P51659 UniProtKB Helix 720 723 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8AF3 P51659 UniProtKB Helix 729 732 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8AF3 P51659 UniProtKB Helix 733 735 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8AF3