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P51658

- DHB2_MOUSE

UniProt

P51658 - DHB2_MOUSE

Protein

Estradiol 17-beta-dehydrogenase 2

Gene

Hsd17b2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH By similarity.By similarity

    Catalytic activityi

    17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.
    Testosterone + NAD+ = androstenedione + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei220 – 2201SubstrateBy similarity
    Active sitei233 – 2331Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi83 – 11230NADBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. estradiol 17-beta-dehydrogenase activity Source: UniProtKB-EC
    2. testosterone dehydrogenase (NAD+) activity Source: UniProtKB-EC

    GO - Biological processi

    1. in utero embryonic development Source: MGI
    2. placenta development Source: MGI
    3. response to retinoic acid Source: Ensembl
    4. steroid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Estradiol 17-beta-dehydrogenase 2 (EC:1.1.1.62)
    Alternative name(s):
    17-beta-hydroxysteroid dehydrogenase type 2
    Short name:
    17-beta-HSD 2
    Testosterone 17-beta-dehydrogenase (EC:1.1.1.239)
    Gene namesi
    Name:Hsd17b2
    Synonyms:Edh17b2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1096386. Hsd17b2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 381381Estradiol 17-beta-dehydrogenase 2PRO_0000054571Add
    BLAST

    Proteomic databases

    MaxQBiP51658.
    PaxDbiP51658.
    PRIDEiP51658.

    PTM databases

    PhosphoSiteiP51658.

    Expressioni

    Gene expression databases

    ArrayExpressiP51658.
    BgeeiP51658.
    CleanExiMM_HSD17B2.
    GenevestigatoriP51658.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-1864098.
    STRINGi10090.ENSMUSP00000034304.

    Structurei

    3D structure databases

    ProteinModelPortaliP51658.
    SMRiP51658. Positions 83-324.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1028.
    GeneTreeiENSGT00650000093222.
    HOVERGENiHBG005482.
    InParanoidiP51658.
    KOiK13368.
    OMAiQEDYGQD.
    OrthoDBiEOG7FXZZX.
    PhylomeDBiP51658.
    TreeFamiTF325617.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51658-1 [UniParc]FASTAAdd to Basket

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    MSPFASESAW LCLAAAAVLG GTLLCGCRSG RQLRSQAVCL AGLWGGACLL    50
    SLSLLCTLFL LSVACFLLLY MSSSDQDLLP VDQKAVLVTG ADSGFGHGLA 100
    KHLDKLGFTV FAGVLDKEGP GAEELRKHCS ERLSVLQMDV TKPEQIKDAH 150
    SKVTEKIQDK GLWAVVNNAG VFHLPIDGEL IPMSIYRKCM AVNFFGTVEV 200
    TKAFLPLLRK SKGRLVNVSS MGGTVPLQMT SAYAATKAAL TMFSTIIRQE 250
    LDKWGVKVVT IKPGGFKTNI TGSQDIWDKM EKEILDHFSK DIQENYGQDY 300
    VHTQKLIIPT LKERSNPDIT PVLRDIQHAI SARNPSSFYY PGRMAYLWVC 350
    LAAYCPTSLL DYVIKKGFYP QPTPRALRTV H 381
    Length:381
    Mass (Da):41,836
    Last modified:November 1, 1997 - v2
    Checksum:i74A62797947E6086
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti36 – 372QA → RP in CAA64982. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09517 mRNA. Translation: CAA70706.1.
    X95685 mRNA. Translation: CAA64982.1.
    CCDSiCCDS40491.1.
    RefSeqiNP_032316.2. NM_008290.2.
    UniGeneiMm.276466.

    Genome annotation databases

    EnsembliENSMUST00000034304; ENSMUSP00000034304; ENSMUSG00000031844.
    GeneIDi15486.
    KEGGimmu:15486.
    UCSCiuc009npf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09517 mRNA. Translation: CAA70706.1 .
    X95685 mRNA. Translation: CAA64982.1 .
    CCDSi CCDS40491.1.
    RefSeqi NP_032316.2. NM_008290.2.
    UniGenei Mm.276466.

    3D structure databases

    ProteinModelPortali P51658.
    SMRi P51658. Positions 83-324.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1864098.
    STRINGi 10090.ENSMUSP00000034304.

    Chemistry

    ChEMBLi CHEMBL1914270.

    PTM databases

    PhosphoSitei P51658.

    Proteomic databases

    MaxQBi P51658.
    PaxDbi P51658.
    PRIDEi P51658.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034304 ; ENSMUSP00000034304 ; ENSMUSG00000031844 .
    GeneIDi 15486.
    KEGGi mmu:15486.
    UCSCi uc009npf.1. mouse.

    Organism-specific databases

    CTDi 3294.
    MGIi MGI:1096386. Hsd17b2.

    Phylogenomic databases

    eggNOGi COG1028.
    GeneTreei ENSGT00650000093222.
    HOVERGENi HBG005482.
    InParanoidi P51658.
    KOi K13368.
    OMAi QEDYGQD.
    OrthoDBi EOG7FXZZX.
    PhylomeDBi P51658.
    TreeFami TF325617.

    Miscellaneous databases

    NextBioi 288350.
    PROi P51658.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51658.
    Bgeei P51658.
    CleanExi MM_HSD17B2.
    Genevestigatori P51658.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of mouse 17beta-hydroxysteroid dehydrogenase type 2, and analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in mouse embryos and adult tissues."
      Mustonen M.
      Biochem. J. 325:199-205(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Liver.
    2. Stoffel W., Weiss B.
      Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-358.
      Strain: BALB/c.

    Entry informationi

    Entry nameiDHB2_MOUSE
    AccessioniPrimary (citable) accession number: P51658
    Secondary accession number(s): O08898
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3