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P51658 (DHB2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Estradiol 17-beta-dehydrogenase 2

EC=1.1.1.62
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase type 2
Short name=17-beta-HSD 2
Testosterone 17-beta-dehydrogenase
EC=1.1.1.239
Gene names
Name:Hsd17b2
Synonyms:Edh17b2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH By similarity.

Catalytic activity

17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.

Testosterone + NAD+ = androstenedione + NADH.

Subcellular location

Membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 381381Estradiol 17-beta-dehydrogenase 2
PRO_0000054571

Regions

Transmembrane4 – 2421Helical; Signal-anchor for type II membrane protein; Potential
Nucleotide binding83 – 11230NAD By similarity

Sites

Active site2331Proton acceptor By similarity
Binding site2201Substrate By similarity

Experimental info

Sequence conflict36 – 372QA → RP in CAA64982. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P51658 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 74A62797947E6086

FASTA38141,836
        10         20         30         40         50         60 
MSPFASESAW LCLAAAAVLG GTLLCGCRSG RQLRSQAVCL AGLWGGACLL SLSLLCTLFL 

        70         80         90        100        110        120 
LSVACFLLLY MSSSDQDLLP VDQKAVLVTG ADSGFGHGLA KHLDKLGFTV FAGVLDKEGP 

       130        140        150        160        170        180 
GAEELRKHCS ERLSVLQMDV TKPEQIKDAH SKVTEKIQDK GLWAVVNNAG VFHLPIDGEL 

       190        200        210        220        230        240 
IPMSIYRKCM AVNFFGTVEV TKAFLPLLRK SKGRLVNVSS MGGTVPLQMT SAYAATKAAL 

       250        260        270        280        290        300 
TMFSTIIRQE LDKWGVKVVT IKPGGFKTNI TGSQDIWDKM EKEILDHFSK DIQENYGQDY 

       310        320        330        340        350        360 
VHTQKLIIPT LKERSNPDIT PVLRDIQHAI SARNPSSFYY PGRMAYLWVC LAAYCPTSLL 

       370        380 
DYVIKKGFYP QPTPRALRTV H 

« Hide

References

[1]"Cloning of mouse 17beta-hydroxysteroid dehydrogenase type 2, and analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in mouse embryos and adult tissues."
Mustonen M.
Biochem. J. 325:199-205(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Liver.
[2]Stoffel W., Weiss B.
Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-358.
Strain: BALB/c.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y09517 mRNA. Translation: CAA70706.1.
X95685 mRNA. Translation: CAA64982.1.
CCDSCCDS40491.1.
RefSeqNP_032316.2. NM_008290.2.
UniGeneMm.276466.

3D structure databases

ProteinModelPortalP51658.
SMRP51658. Positions 83-324.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1864098.
STRING10090.ENSMUSP00000034304.

Chemistry

ChEMBLCHEMBL1914270.

PTM databases

PhosphoSiteP51658.

Proteomic databases

MaxQBP51658.
PaxDbP51658.
PRIDEP51658.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000034304; ENSMUSP00000034304; ENSMUSG00000031844.
GeneID15486.
KEGGmmu:15486.
UCSCuc009npf.1. mouse.

Organism-specific databases

CTD3294.
MGIMGI:1096386. Hsd17b2.

Phylogenomic databases

eggNOGCOG1028.
GeneTreeENSGT00650000093222.
HOVERGENHBG005482.
InParanoidP51658.
KOK13368.
OMAQEDYGQD.
OrthoDBEOG7FXZZX.
PhylomeDBP51658.
TreeFamTF325617.

Gene expression databases

ArrayExpressP51658.
BgeeP51658.
CleanExMM_HSD17B2.
GenevestigatorP51658.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288350.
PROP51658.
SOURCESearch...

Entry information

Entry nameDHB2_MOUSE
AccessionPrimary (citable) accession number: P51658
Secondary accession number(s): O08898
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot