Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Estradiol 17-beta-dehydrogenase 2

Gene

Hsd17b2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH (By similarity).By similarity

Catalytic activityi

17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.
Testosterone + NAD+ = androstenedione + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei220SubstrateBy similarity1
Active sitei233Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi83 – 112NADBy similarityAdd BLAST30

GO - Molecular functioni

GO - Biological processi

  • in utero embryonic development Source: MGI
  • placenta development Source: MGI
  • response to retinoic acid Source: MGI
  • steroid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiR-MMU-193144. Estrogen biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Estradiol 17-beta-dehydrogenase 2 (EC:1.1.1.62)
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase type 2
Short name:
17-beta-HSD 2
Testosterone 17-beta-dehydrogenase (EC:1.1.1.239)
Gene namesi
Name:Hsd17b2
Synonyms:Edh17b2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1096386. Hsd17b2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1914270.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000545711 – 381Estradiol 17-beta-dehydrogenase 2Add BLAST381

Proteomic databases

MaxQBiP51658.
PaxDbiP51658.
PeptideAtlasiP51658.
PRIDEiP51658.

PTM databases

iPTMnetiP51658.
PhosphoSitePlusiP51658.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031844.
CleanExiMM_HSD17B2.
GenevisibleiP51658. MM.

Interactioni

Protein-protein interaction databases

MINTiMINT-1864098.
STRINGi10090.ENSMUSP00000034304.

Chemistry databases

BindingDBiP51658.

Structurei

3D structure databases

ProteinModelPortaliP51658.
SMRiP51658.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1610. Eukaryota.
ENOG410Y7FK. LUCA.
GeneTreeiENSGT00860000133667.
HOVERGENiHBG005482.
InParanoidiP51658.
KOiK13368.
OMAiIAGTSDK.
OrthoDBiEOG091G0LMI.
PhylomeDBiP51658.
TreeFamiTF325617.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51658-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPFASESAW LCLAAAAVLG GTLLCGCRSG RQLRSQAVCL AGLWGGACLL
60 70 80 90 100
SLSLLCTLFL LSVACFLLLY MSSSDQDLLP VDQKAVLVTG ADSGFGHGLA
110 120 130 140 150
KHLDKLGFTV FAGVLDKEGP GAEELRKHCS ERLSVLQMDV TKPEQIKDAH
160 170 180 190 200
SKVTEKIQDK GLWAVVNNAG VFHLPIDGEL IPMSIYRKCM AVNFFGTVEV
210 220 230 240 250
TKAFLPLLRK SKGRLVNVSS MGGTVPLQMT SAYAATKAAL TMFSTIIRQE
260 270 280 290 300
LDKWGVKVVT IKPGGFKTNI TGSQDIWDKM EKEILDHFSK DIQENYGQDY
310 320 330 340 350
VHTQKLIIPT LKERSNPDIT PVLRDIQHAI SARNPSSFYY PGRMAYLWVC
360 370 380
LAAYCPTSLL DYVIKKGFYP QPTPRALRTV H
Length:381
Mass (Da):41,836
Last modified:November 1, 1997 - v2
Checksum:i74A62797947E6086
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36 – 37QA → RP in CAA64982 (Ref. 2) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09517 mRNA. Translation: CAA70706.1.
X95685 mRNA. Translation: CAA64982.1.
CCDSiCCDS40491.1.
RefSeqiNP_032316.2. NM_008290.2.
UniGeneiMm.276466.

Genome annotation databases

EnsembliENSMUST00000034304; ENSMUSP00000034304; ENSMUSG00000031844.
GeneIDi15486.
KEGGimmu:15486.
UCSCiuc009npf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09517 mRNA. Translation: CAA70706.1.
X95685 mRNA. Translation: CAA64982.1.
CCDSiCCDS40491.1.
RefSeqiNP_032316.2. NM_008290.2.
UniGeneiMm.276466.

3D structure databases

ProteinModelPortaliP51658.
SMRiP51658.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1864098.
STRINGi10090.ENSMUSP00000034304.

Chemistry databases

BindingDBiP51658.
ChEMBLiCHEMBL1914270.

PTM databases

iPTMnetiP51658.
PhosphoSitePlusiP51658.

Proteomic databases

MaxQBiP51658.
PaxDbiP51658.
PeptideAtlasiP51658.
PRIDEiP51658.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034304; ENSMUSP00000034304; ENSMUSG00000031844.
GeneIDi15486.
KEGGimmu:15486.
UCSCiuc009npf.1. mouse.

Organism-specific databases

CTDi3294.
MGIiMGI:1096386. Hsd17b2.

Phylogenomic databases

eggNOGiKOG1610. Eukaryota.
ENOG410Y7FK. LUCA.
GeneTreeiENSGT00860000133667.
HOVERGENiHBG005482.
InParanoidiP51658.
KOiK13368.
OMAiIAGTSDK.
OrthoDBiEOG091G0LMI.
PhylomeDBiP51658.
TreeFamiTF325617.

Enzyme and pathway databases

ReactomeiR-MMU-193144. Estrogen biosynthesis.

Miscellaneous databases

PROiP51658.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031844.
CleanExiMM_HSD17B2.
GenevisibleiP51658. MM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDHB2_MOUSE
AccessioniPrimary (citable) accession number: P51658
Secondary accession number(s): O08898
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.