Estradiol 17-beta-dehydrogenase 1 - Rattus norvegicus (Rat)

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P51657 (DHB1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 98. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Estradiol 17-beta-dehydrogenase 1
EC=1.1.1.62

Alternative name(s):
17-beta-hydroxysteroid dehydrogenase type 1
Short name=17-beta-HSD 1

Gene names

Name:	Hsd17b1
Synonyms:	Edh17b1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Favors the reduction of estrogens and androgens. Uses preferentially NADH.
Catalytic activity	17-beta-estradiol + NAD(P)⁺ = estrone + NAD(P)H. Ref.1
Pathway	Steroid biosynthesis; estrogen biosynthesis.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Biological process	Lipid biosynthesis Lipid metabolism Steroid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	bone development Inferred from expression pattern PubMed 15012600. Source: RGD cellular response to metal ion Inferred from expression pattern PubMed 18602937. Source: RGD estrogen biosynthetic process Inferred from direct assay Ref.2. Source: RGD testosterone biosynthetic process Inferred from direct assay Ref.2. Source: RGD
Cellular_component	cytosol Inferred from direct assay PubMed 16940216. Source: RGD
Molecular_function	estradiol 17-beta-dehydrogenase activity Inferred from direct assay Ref.2. Source: RGD nucleotide binding Inferred from electronic annotation. Source: InterPro testosterone 17-beta-dehydrogenase (NAD+) activity Inferred from direct assay Ref.2. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed By similarity

Chain

2 – 344

343

Estradiol 17-beta-dehydrogenase 1

PRO_0000054569

Regions

Nucleotide binding

3 – 32

NAD By similarity

Sites

Active site

156

Proton acceptor By similarity

Binding site

143

Substrate By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P51657 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: CB5FC139FBB3995E
Show »

FASTA

344

36,967

        10         20         30         40         50         60 
MDSTVVLITG CSSGIGLHLA VRLASDRSQS FKVYATLRDL KSQGPLLEAA RAQGCPPGSL 

        70         80         90        100        110        120 
EILELDVRDS ESVAAARACV TEGRVDVLVC NAGRGLFGPL EAHELNAVGA VLDVNVLGTI 

       130        140        150        160        170        180 
RMLQAFLPDM KRRHSGRVLV TASVGGLMGL PFHEVYCASK FALEGLCESL AILLPLFGVH 

       190        200        210        220        230        240 
VSLIECGAVH TAFHEKLEGG PGGALERADA QTRHLFAHYQ RGYEQALSEA QDPEEVTELF 

       250        260        270        280        290        300 
LTAMRAPQPA LRYFSTNRFL PLARMRTEDP SGSSYVEAMH REAFSDLQVQ EGAKAGAQVS 

       310        320        330        340 
GDPDTPPRAL ICLPECAIPR VTAELGWSAS DKPGQNKSCY QQKI

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Rat 17 beta-hydroxysteroid dehydrogenase type 1: primary structure and regulation of enzyme expression in rat ovary by diethylstilbestrol and gonadotropins in vivo." Ghersevich S., Nokelainen P., Poutanen M., Orava M., Autio-Harmainen H., Rajaniemi H., Vihko R. Endocrinology 135:1477-1487(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CATALYTIC ACTIVITY. Strain: Sprague-Dawley. Tissue: Ovary.
[2]	"Cloning of rat 17 beta-hydroxysteroid dehydrogenase type 2 and characterization of tissue distribution and catalytic activity of rat type 1 and type 2 enzymes." Akinola L.A., Poutanen M., Vihko R. Endocrinology 137:1572-1579(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Kidney.
[3]	"Characterization of rat 17 beta-hydroxysteroid dehydrogenase type 1 gene and mRNA transcripts." Akinola L.A., Poutanen M., Peltoketo H., Vihko R., Vihko P. Gene 208:229-238(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Sprague-Dawley. Tissue: Testis.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X78811 mRNA. Translation: CAA55389.1. X97754 mRNA. Translation: CAA66349.1. X98038 Genomic DNA. Translation: CAA66657.1. BC086365 mRNA. Translation: AAH86365.1.
IPI	IPI00204305.
PIR	S57901.
RefSeq	NP_036983.1. NM_012851.2.
UniGene	Rn.10594.
3D structure databases
ProteinModelPortal	P51657.
SMR	P51657. Positions 4-284.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000026878.
Proteomic databases
PRIDE	P51657.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000026878; ENSRNOP00000026878; ENSRNOG00000019830.
GeneID	25322.
KEGG	rno:25322.
Organism-specific databases
CTD	3292.
RGD	2836. Hsd17b1.
Phylogenomic databases
eggNOG	COG1028.
GeneTree	ENSGT00650000092907.
HOVERGEN	HBG014077.
InParanoid	P51657.
KO	K00044.
OrthoDB	EOG45MN61.
Enzyme and pathway databases
UniPathway	UPA00769.
Gene expression databases
ArrayExpress	P51657.
Genevestigator	P51657.
GermOnline	ENSRNOG00000019830. Rattus norvegicus.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR011348. 17beta_DH. IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PIRSF	PIRSF000095. 17beta-HSD. 1 hit.
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL1914267.
NextBio	606169.

Entry information

Entry name

DHB1_RAT

Accession

Primary (citable) accession number: P51657

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents