P51657 (DHB1_RAT) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 98.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Estradiol 17-beta-dehydrogenase 1 EC=1.1.1.62 Alternative name(s): 17-beta-hydroxysteroid dehydrogenase type 1 Short name=17-beta-HSD 1 | ||||
| Gene names |
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| Organism | Rattus norvegicus (Rat) [Reference proteome] | ||||
| Taxonomic identifier | 10116 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus![]() |
Protein attributes
| Sequence length | 344 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Favors the reduction of estrogens and androgens. Uses preferentially NADH. |
| Catalytic activity | 17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H. Ref.1 |
| Pathway | |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lipid biosynthesis Lipid metabolism Steroid biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | bone development Inferred from expression pattern PubMed 15012600. Source: RGD cellular response to metal ionInferred from expression pattern PubMed 18602937. Source: RGD estrogen biosynthetic processInferred from direct assay Ref.2. Source: RGD testosterone biosynthetic processInferred from direct assay Ref.2. Source: RGD |
| Cellular_component | cytosol Inferred from direct assay PubMed 16940216. Source: RGD |
| Molecular_function | estradiol 17-beta-dehydrogenase activity Inferred from direct assay Ref.2. Source: RGD nucleotide bindingInferred from electronic annotation. Source: InterPro testosterone 17-beta-dehydrogenase (NAD+) activityInferred from direct assay Ref.2. Source: RGD |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 344 | 343 | Estradiol 17-beta-dehydrogenase 1 | PRO_0000054569 | |||||
Regions | |||||||||
| Nucleotide binding | 3 – 32 | 30 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 156 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 143 | 1 | Substrate By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Rat 17 beta-hydroxysteroid dehydrogenase type 1: primary structure and regulation of enzyme expression in rat ovary by diethylstilbestrol and gonadotropins in vivo." Ghersevich S., Nokelainen P., Poutanen M., Orava M., Autio-Harmainen H., Rajaniemi H., Vihko R. Endocrinology 135:1477-1487(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CATALYTIC ACTIVITY. Strain: Sprague-Dawley. Tissue: Ovary. |
| [2] | "Cloning of rat 17 beta-hydroxysteroid dehydrogenase type 2 and characterization of tissue distribution and catalytic activity of rat type 1 and type 2 enzymes." Akinola L.A., Poutanen M., Vihko R. Endocrinology 137:1572-1579(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Kidney. |
| [3] | "Characterization of rat 17 beta-hydroxysteroid dehydrogenase type 1 gene and mRNA transcripts." Akinola L.A., Poutanen M., Peltoketo H., Vihko R., Vihko P. Gene 208:229-238(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Sprague-Dawley. Tissue: Testis. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X78811 mRNA. Translation: CAA55389.1. X97754 mRNA. Translation: CAA66349.1. X98038 Genomic DNA. Translation: CAA66657.1. BC086365 mRNA. Translation: AAH86365.1. |
| IPI | IPI00204305. |
| PIR | S57901. |
| RefSeq | NP_036983.1. NM_012851.2. |
| UniGene | Rn.10594. |
3D structure databases | |
| ProteinModelPortal | P51657. |
| SMR | P51657. Positions 4-284. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 10116.ENSRNOP00000026878. |
Proteomic databases | |
| PRIDE | P51657. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSRNOT00000026878; ENSRNOP00000026878; ENSRNOG00000019830. |
| GeneID | 25322. |
| KEGG | rno:25322. |
Organism-specific databases | |
| CTD | 3292. |
| RGD | 2836. Hsd17b1. |
Phylogenomic databases | |
| eggNOG | COG1028. |
| GeneTree | ENSGT00650000092907. |
| HOVERGEN | HBG014077. |
| InParanoid | P51657. |
| KO | K00044. |
| OrthoDB | EOG45MN61. |
Enzyme and pathway databases | |
| UniPathway | UPA00769. |
Gene expression databases | |
| ArrayExpress | P51657. |
| Genevestigator | P51657. |
| GermOnline | ENSRNOG00000019830. Rattus norvegicus. |
Family and domain databases | |
| Gene3D | 3.40.50.720. 1 hit. |
| InterPro | IPR011348. 17beta_DH. IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view] |
| Pfam | PF00106. adh_short. 1 hit. [Graphical view] |
| PIRSF | PIRSF000095. 17beta-HSD. 1 hit. |
| PRINTS | PR00081. GDHRDH. PR00080. SDRFAMILY. |
| PROSITE | PS00061. ADH_SHORT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| ChEMBL | CHEMBL1914267. |
| NextBio | 606169. |
Entry information
| Entry name | DHB1_RAT | ||||||||
| Accession | Primary (citable) accession number: P51657 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with
