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Protein

Estradiol 17-beta-dehydrogenase 1

Gene

Hsd17b1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Favors the reduction of estrogens and androgens. Uses preferentially NADH.

Catalytic activityi

17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.1 Publication

Pathwayi: estrogen biosynthesis

This protein is involved in the pathway estrogen biosynthesis, which is part of Steroid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway estrogen biosynthesis and in Steroid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei143SubstrateBy similarity1
Active sitei156Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi3 – 32NADBy similarityAdd BLAST30

GO - Molecular functioni

  • estradiol 17-beta-dehydrogenase activity Source: RGD
  • testosterone dehydrogenase (NAD+) activity Source: RGD

GO - Biological processi

  • bone development Source: RGD
  • cellular response to metal ion Source: RGD
  • estrogen biosynthetic process Source: RGD
  • testosterone biosynthetic process Source: RGD

Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis
LigandNAD

Enzyme and pathway databases

ReactomeiR-RNO-193144. Estrogen biosynthesis.
UniPathwayiUPA00769.

Names & Taxonomyi

Protein namesi
Recommended name:
Estradiol 17-beta-dehydrogenase 1 (EC:1.1.1.62)
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase type 1
Short name:
17-beta-HSD 1
Gene namesi
Name:Hsd17b1
Synonyms:Edh17b1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi2836. Hsd17b1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • cytosol Source: RGD

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1914267.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000545692 – 344Estradiol 17-beta-dehydrogenase 1Add BLAST343

Proteomic databases

PaxDbiP51657.
PRIDEiP51657.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019830.
GenevisibleiP51657. RN.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026878.

Chemistry databases

BindingDBiP51657.

Structurei

3D structure databases

ProteinModelPortaliP51657.
SMRiP51657.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1205. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00870000136396.
HOVERGENiHBG014077.
InParanoidiP51657.
KOiK00044.
OMAiECGPVRT.
OrthoDBiEOG091G0E9O.
PhylomeDBiP51657.

Family and domain databases

InterProiView protein in InterPro
IPR011348. 17beta_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PIRSFiPIRSF000095. 17beta-HSD. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51657-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSTVVLITG CSSGIGLHLA VRLASDRSQS FKVYATLRDL KSQGPLLEAA
60 70 80 90 100
RAQGCPPGSL EILELDVRDS ESVAAARACV TEGRVDVLVC NAGRGLFGPL
110 120 130 140 150
EAHELNAVGA VLDVNVLGTI RMLQAFLPDM KRRHSGRVLV TASVGGLMGL
160 170 180 190 200
PFHEVYCASK FALEGLCESL AILLPLFGVH VSLIECGAVH TAFHEKLEGG
210 220 230 240 250
PGGALERADA QTRHLFAHYQ RGYEQALSEA QDPEEVTELF LTAMRAPQPA
260 270 280 290 300
LRYFSTNRFL PLARMRTEDP SGSSYVEAMH REAFSDLQVQ EGAKAGAQVS
310 320 330 340
GDPDTPPRAL ICLPECAIPR VTAELGWSAS DKPGQNKSCY QQKI
Length:344
Mass (Da):36,967
Last modified:October 1, 1996 - v1
Checksum:iCB5FC139FBB3995E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78811 mRNA. Translation: CAA55389.1.
X97754 mRNA. Translation: CAA66349.1.
X98038 Genomic DNA. Translation: CAA66657.1.
BC086365 mRNA. Translation: AAH86365.1.
PIRiS57901.
RefSeqiNP_036983.1. NM_012851.2.
UniGeneiRn.10594.

Genome annotation databases

EnsembliENSRNOT00000026878; ENSRNOP00000026878; ENSRNOG00000019830.
GeneIDi25322.
KEGGirno:25322.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78811 mRNA. Translation: CAA55389.1.
X97754 mRNA. Translation: CAA66349.1.
X98038 Genomic DNA. Translation: CAA66657.1.
BC086365 mRNA. Translation: AAH86365.1.
PIRiS57901.
RefSeqiNP_036983.1. NM_012851.2.
UniGeneiRn.10594.

3D structure databases

ProteinModelPortaliP51657.
SMRiP51657.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026878.

Chemistry databases

BindingDBiP51657.
ChEMBLiCHEMBL1914267.

Proteomic databases

PaxDbiP51657.
PRIDEiP51657.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026878; ENSRNOP00000026878; ENSRNOG00000019830.
GeneIDi25322.
KEGGirno:25322.

Organism-specific databases

CTDi3292.
RGDi2836. Hsd17b1.

Phylogenomic databases

eggNOGiKOG1205. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00870000136396.
HOVERGENiHBG014077.
InParanoidiP51657.
KOiK00044.
OMAiECGPVRT.
OrthoDBiEOG091G0E9O.
PhylomeDBiP51657.

Enzyme and pathway databases

UniPathwayiUPA00769.
ReactomeiR-RNO-193144. Estrogen biosynthesis.

Miscellaneous databases

PROiPR:P51657.

Gene expression databases

BgeeiENSRNOG00000019830.
GenevisibleiP51657. RN.

Family and domain databases

InterProiView protein in InterPro
IPR011348. 17beta_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PIRSFiPIRSF000095. 17beta-HSD. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDHB1_RAT
AccessioniPrimary (citable) accession number: P51657
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 10, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.