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Protein

Estradiol 17-beta-dehydrogenase 1

Gene

Hsd17b1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Favors the reduction of estrogens and androgens. Uses preferentially NADH.

Catalytic activityi

17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.1 Publication

Pathwayi: estrogen biosynthesis

This protein is involved in the pathway estrogen biosynthesis, which is part of Steroid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway estrogen biosynthesis and in Steroid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei143SubstrateBy similarity1
Active sitei156Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi3 – 32NADBy similarityAdd BLAST30

GO - Molecular functioni

  • estradiol 17-beta-dehydrogenase activity Source: RGD
  • testosterone dehydrogenase (NAD+) activity Source: RGD

GO - Biological processi

  • bone development Source: RGD
  • cellular response to metal ion Source: RGD
  • estrogen biosynthetic process Source: RGD
  • testosterone biosynthetic process Source: RGD

Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis
LigandNAD

Enzyme and pathway databases

ReactomeiR-RNO-193144 Estrogen biosynthesis
UniPathwayiUPA00769

Names & Taxonomyi

Protein namesi
Recommended name:
Estradiol 17-beta-dehydrogenase 1 (EC:1.1.1.62)
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase type 1
Short name:
17-beta-HSD 1
Gene namesi
Name:Hsd17b1
Synonyms:Edh17b1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi2836 Hsd17b1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1914267

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000545691 – 344Estradiol 17-beta-dehydrogenase 1Add BLAST344

Proteomic databases

PaxDbiP51657
PRIDEiP51657

Expressioni

Gene expression databases

BgeeiENSRNOG00000019830
GenevisibleiP51657 RN

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026878

Chemistry databases

BindingDBiP51657

Structurei

3D structure databases

ProteinModelPortaliP51657
SMRiP51657
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1205 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00920000148940
HOVERGENiHBG014077
InParanoidiP51657
KOiK00044
OMAiECGPVRT
OrthoDBiEOG091G0E9O
PhylomeDBiP51657

Family and domain databases

InterProiView protein in InterPro
IPR011348 17beta_DH
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PIRSFiPIRSF000095 17beta-HSD, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

P51657-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSTVVLITG CSSGIGLHLA VRLASDRSQS FKVYATLRDL KSQGPLLEAA
60 70 80 90 100
RAQGCPPGSL EILELDVRDS ESVAAARACV TEGRVDVLVC NAGRGLFGPL
110 120 130 140 150
EAHELNAVGA VLDVNVLGTI RMLQAFLPDM KRRHSGRVLV TASVGGLMGL
160 170 180 190 200
PFHEVYCASK FALEGLCESL AILLPLFGVH VSLIECGAVH TAFHEKLEGG
210 220 230 240 250
PGGALERADA QTRHLFAHYQ RGYEQALSEA QDPEEVTELF LTAMRAPQPA
260 270 280 290 300
LRYFSTNRFL PLARMRTEDP SGSSYVEAMH REAFSDLQVQ EGAKAGAQVS
310 320 330 340
GDPDTPPRAL ICLPECAIPR VTAELGWSAS DKPGQNKSCY QQKI
Length:344
Mass (Da):36,967
Last modified:October 1, 1996 - v1
Checksum:iCB5FC139FBB3995E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78811 mRNA Translation: CAA55389.1
X97754 mRNA Translation: CAA66349.1
X98038 Genomic DNA Translation: CAA66657.1
BC086365 mRNA Translation: AAH86365.1
PIRiS57901
RefSeqiNP_036983.1, NM_012851.2
UniGeneiRn.10594

Genome annotation databases

EnsembliENSRNOT00000026878; ENSRNOP00000026878; ENSRNOG00000019830
GeneIDi25322
KEGGirno:25322

Similar proteinsi

Entry informationi

Entry nameiDHB1_RAT
AccessioniPrimary (citable) accession number: P51657
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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