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Protein

Estradiol 17-beta-dehydrogenase 1

Gene

Hsd17b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Favors the reduction of estrogens and androgens. Uses preferentially NADH.

Catalytic activityi

17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei143 – 1431SubstrateBy similarity
Active sitei156 – 1561Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi3 – 3230NADBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_271563. Estrogen biosynthesis.
UniPathwayiUPA00769.

Names & Taxonomyi

Protein namesi
Recommended name:
Estradiol 17-beta-dehydrogenase 1 (EC:1.1.1.62)
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase type 1
Short name:
17-beta-HSD 1
Gene namesi
Name:Hsd17b1
Synonyms:Edh17b1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:105077. Hsd17b1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 344343Estradiol 17-beta-dehydrogenase 1PRO_0000054568Add
BLAST

Proteomic databases

PRIDEiP51656.

Expressioni

Gene expression databases

BgeeiP51656.
CleanExiMM_HSD17B1.
ExpressionAtlasiP51656. baseline and differential.
GenevestigatoriP51656.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP51656.
SMRiP51656. Positions 4-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
HOVERGENiHBG014077.
InParanoidiP51656.
KOiK00044.
OMAiAMHRAVF.
OrthoDBiEOG76T9RW.
PhylomeDBiP51656.
TreeFamiTF105451.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011348. 17beta_DH.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFiPIRSF000095. 17beta-HSD. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51656-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPTVVLITG CSSGIGMHLA VRLASDRSQS FKVYATLRDL KAQGPLLEAA
60 70 80 90 100
RTQGCPPGSL EILELDVRDS KSVAAAQACV TEGRVDVLVC NAGRGLFGPL
110 120 130 140 150
EAHELNAVGA VLDVNVLGTI RMLQAFLPDM KRRHSGRVLV TASVGGLMGL
160 170 180 190 200
PFHEVYCASK FALEGLCESL AILLPLFGVH VSLIECGAVH TAFYEKLVGG
210 220 230 240 250
PGGALERADA QTRHLFAHYL RGYEQALSEA QDPEEVTELF LTAMRAPQPA
260 270 280 290 300
LRYFSTNRFL PLARMRTEDP SGSSYVAAMH QEAFSNLQTQ ENAKAGAQVP
310 320 330 340
GVSDTASSAL ICLPECAIPR VASELGWSAS DKPGQDNSCY QQKI
Length:344
Mass (Da):36,785
Last modified:October 1, 1996 - v1
Checksum:i0335C473F453C14A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89627 mRNA. Translation: CAA61770.1.
CCDSiCCDS25445.1.
PIRiS62652.
RefSeqiNP_034605.1. NM_010475.1.
UniGeneiMm.188939.

Genome annotation databases

EnsembliENSMUST00000019445; ENSMUSP00000019445; ENSMUSG00000019301.
GeneIDi15485.
KEGGimmu:15485.
UCSCiuc007lnb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89627 mRNA. Translation: CAA61770.1.
CCDSiCCDS25445.1.
PIRiS62652.
RefSeqiNP_034605.1. NM_010475.1.
UniGeneiMm.188939.

3D structure databases

ProteinModelPortaliP51656.
SMRiP51656. Positions 4-284.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

ChEMBLiCHEMBL1914269.

Proteomic databases

PRIDEiP51656.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019445; ENSMUSP00000019445; ENSMUSG00000019301.
GeneIDi15485.
KEGGimmu:15485.
UCSCiuc007lnb.1. mouse.

Organism-specific databases

CTDi3292.
MGIiMGI:105077. Hsd17b1.

Phylogenomic databases

eggNOGiCOG1028.
HOVERGENiHBG014077.
InParanoidiP51656.
KOiK00044.
OMAiAMHRAVF.
OrthoDBiEOG76T9RW.
PhylomeDBiP51656.
TreeFamiTF105451.

Enzyme and pathway databases

UniPathwayiUPA00769.
ReactomeiREACT_271563. Estrogen biosynthesis.

Miscellaneous databases

NextBioi288346.
PROiP51656.
SOURCEiSearch...

Gene expression databases

BgeeiP51656.
CleanExiMM_HSD17B1.
ExpressionAtlasiP51656. baseline and differential.
GenevestigatoriP51656.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011348. 17beta_DH.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFiPIRSF000095. 17beta-HSD. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of mouse 17 beta-hydroxysteroid dehydrogenase type 1 and characterization of enzyme activity."
    Nokelainen P., Puranen T., Peltoketo H., Orava M., Vihko P., Vihko R.
    Eur. J. Biochem. 236:482-490(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiDHB1_MOUSE
AccessioniPrimary (citable) accession number: P51656
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 1, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.