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P51656

- DHB1_MOUSE

UniProt

P51656 - DHB1_MOUSE

Protein

Estradiol 17-beta-dehydrogenase 1

Gene

Hsd17b1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Favors the reduction of estrogens and androgens. Uses preferentially NADH.

    Catalytic activityi

    17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei143 – 1431SubstrateBy similarity
    Active sitei156 – 1561Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi3 – 3230NADBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. estradiol 17-beta-dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. bone development Source: Ensembl
    2. cellular response to metal ion Source: Ensembl
    3. estrogen biosynthetic process Source: UniProtKB-UniPathway
    4. testosterone biosynthetic process Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    ReactomeiREACT_210526. Estrogen biosynthesis.
    UniPathwayiUPA00769.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Estradiol 17-beta-dehydrogenase 1 (EC:1.1.1.62)
    Alternative name(s):
    17-beta-hydroxysteroid dehydrogenase type 1
    Short name:
    17-beta-HSD 1
    Gene namesi
    Name:Hsd17b1
    Synonyms:Edh17b1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:105077. Hsd17b1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 344343Estradiol 17-beta-dehydrogenase 1PRO_0000054568Add
    BLAST

    Proteomic databases

    PRIDEiP51656.

    Expressioni

    Gene expression databases

    ArrayExpressiP51656.
    BgeeiP51656.
    CleanExiMM_HSD17B1.
    GenevestigatoriP51656.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP51656.
    SMRiP51656. Positions 4-284.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1028.
    HOVERGENiHBG014077.
    InParanoidiP51656.
    KOiK00044.
    OMAiAMHRAVF.
    OrthoDBiEOG76T9RW.
    PhylomeDBiP51656.
    TreeFamiTF105451.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR011348. 17beta_DH.
    IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000095. 17beta-HSD. 1 hit.
    PRINTSiPR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P51656-1 [UniParc]FASTAAdd to Basket

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    MDPTVVLITG CSSGIGMHLA VRLASDRSQS FKVYATLRDL KAQGPLLEAA    50
    RTQGCPPGSL EILELDVRDS KSVAAAQACV TEGRVDVLVC NAGRGLFGPL 100
    EAHELNAVGA VLDVNVLGTI RMLQAFLPDM KRRHSGRVLV TASVGGLMGL 150
    PFHEVYCASK FALEGLCESL AILLPLFGVH VSLIECGAVH TAFYEKLVGG 200
    PGGALERADA QTRHLFAHYL RGYEQALSEA QDPEEVTELF LTAMRAPQPA 250
    LRYFSTNRFL PLARMRTEDP SGSSYVAAMH QEAFSNLQTQ ENAKAGAQVP 300
    GVSDTASSAL ICLPECAIPR VASELGWSAS DKPGQDNSCY QQKI 344
    Length:344
    Mass (Da):36,785
    Last modified:October 1, 1996 - v1
    Checksum:i0335C473F453C14A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X89627 mRNA. Translation: CAA61770.1.
    CCDSiCCDS25445.1.
    PIRiS62652.
    RefSeqiNP_034605.1. NM_010475.1.
    UniGeneiMm.188939.

    Genome annotation databases

    EnsembliENSMUST00000019445; ENSMUSP00000019445; ENSMUSG00000019301.
    GeneIDi15485.
    KEGGimmu:15485.
    UCSCiuc007lnb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X89627 mRNA. Translation: CAA61770.1 .
    CCDSi CCDS25445.1.
    PIRi S62652.
    RefSeqi NP_034605.1. NM_010475.1.
    UniGenei Mm.188939.

    3D structure databases

    ProteinModelPortali P51656.
    SMRi P51656. Positions 4-284.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL1914269.

    Proteomic databases

    PRIDEi P51656.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019445 ; ENSMUSP00000019445 ; ENSMUSG00000019301 .
    GeneIDi 15485.
    KEGGi mmu:15485.
    UCSCi uc007lnb.1. mouse.

    Organism-specific databases

    CTDi 3292.
    MGIi MGI:105077. Hsd17b1.

    Phylogenomic databases

    eggNOGi COG1028.
    HOVERGENi HBG014077.
    InParanoidi P51656.
    KOi K00044.
    OMAi AMHRAVF.
    OrthoDBi EOG76T9RW.
    PhylomeDBi P51656.
    TreeFami TF105451.

    Enzyme and pathway databases

    UniPathwayi UPA00769 .
    Reactomei REACT_210526. Estrogen biosynthesis.

    Miscellaneous databases

    NextBioi 288346.
    PROi P51656.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51656.
    Bgeei P51656.
    CleanExi MM_HSD17B1.
    Genevestigatori P51656.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR011348. 17beta_DH.
    IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000095. 17beta-HSD. 1 hit.
    PRINTSi PR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of mouse 17 beta-hydroxysteroid dehydrogenase type 1 and characterization of enzyme activity."
      Nokelainen P., Puranen T., Peltoketo H., Orava M., Vihko P., Vihko R.
      Eur. J. Biochem. 236:482-490(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiDHB1_MOUSE
    AccessioniPrimary (citable) accession number: P51656
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3