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P51656

- DHB1_MOUSE

UniProt

P51656 - DHB1_MOUSE

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Protein

Estradiol 17-beta-dehydrogenase 1

Gene

Hsd17b1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Favors the reduction of estrogens and androgens. Uses preferentially NADH.

Catalytic activityi

17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei143 – 1431SubstrateBy similarity
Active sitei156 – 1561Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi3 – 3230NADBy similarityAdd
BLAST

GO - Molecular functioni

  1. estradiol 17-beta-dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. bone development Source: Ensembl
  2. cellular response to metal ion Source: Ensembl
  3. estrogen biosynthetic process Source: UniProtKB-UniPathway
  4. testosterone biosynthetic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_210526. Estrogen biosynthesis.
UniPathwayiUPA00769.

Names & Taxonomyi

Protein namesi
Recommended name:
Estradiol 17-beta-dehydrogenase 1 (EC:1.1.1.62)
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase type 1
Short name:
17-beta-HSD 1
Gene namesi
Name:Hsd17b1
Synonyms:Edh17b1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:105077. Hsd17b1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. nuclear membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 344343Estradiol 17-beta-dehydrogenase 1PRO_0000054568Add
BLAST

Proteomic databases

PRIDEiP51656.

Expressioni

Gene expression databases

BgeeiP51656.
CleanExiMM_HSD17B1.
ExpressionAtlasiP51656. baseline and differential.
GenevestigatoriP51656.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP51656.
SMRiP51656. Positions 4-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
HOVERGENiHBG014077.
InParanoidiP51656.
KOiK00044.
OMAiAMHRAVF.
OrthoDBiEOG76T9RW.
PhylomeDBiP51656.
TreeFamiTF105451.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011348. 17beta_DH.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFiPIRSF000095. 17beta-HSD. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51656-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPTVVLITG CSSGIGMHLA VRLASDRSQS FKVYATLRDL KAQGPLLEAA
60 70 80 90 100
RTQGCPPGSL EILELDVRDS KSVAAAQACV TEGRVDVLVC NAGRGLFGPL
110 120 130 140 150
EAHELNAVGA VLDVNVLGTI RMLQAFLPDM KRRHSGRVLV TASVGGLMGL
160 170 180 190 200
PFHEVYCASK FALEGLCESL AILLPLFGVH VSLIECGAVH TAFYEKLVGG
210 220 230 240 250
PGGALERADA QTRHLFAHYL RGYEQALSEA QDPEEVTELF LTAMRAPQPA
260 270 280 290 300
LRYFSTNRFL PLARMRTEDP SGSSYVAAMH QEAFSNLQTQ ENAKAGAQVP
310 320 330 340
GVSDTASSAL ICLPECAIPR VASELGWSAS DKPGQDNSCY QQKI
Length:344
Mass (Da):36,785
Last modified:October 1, 1996 - v1
Checksum:i0335C473F453C14A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X89627 mRNA. Translation: CAA61770.1.
CCDSiCCDS25445.1.
PIRiS62652.
RefSeqiNP_034605.1. NM_010475.1.
UniGeneiMm.188939.

Genome annotation databases

EnsembliENSMUST00000019445; ENSMUSP00000019445; ENSMUSG00000019301.
GeneIDi15485.
KEGGimmu:15485.
UCSCiuc007lnb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X89627 mRNA. Translation: CAA61770.1 .
CCDSi CCDS25445.1.
PIRi S62652.
RefSeqi NP_034605.1. NM_010475.1.
UniGenei Mm.188939.

3D structure databases

ProteinModelPortali P51656.
SMRi P51656. Positions 4-284.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL1914269.

Proteomic databases

PRIDEi P51656.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019445 ; ENSMUSP00000019445 ; ENSMUSG00000019301 .
GeneIDi 15485.
KEGGi mmu:15485.
UCSCi uc007lnb.1. mouse.

Organism-specific databases

CTDi 3292.
MGIi MGI:105077. Hsd17b1.

Phylogenomic databases

eggNOGi COG1028.
HOVERGENi HBG014077.
InParanoidi P51656.
KOi K00044.
OMAi AMHRAVF.
OrthoDBi EOG76T9RW.
PhylomeDBi P51656.
TreeFami TF105451.

Enzyme and pathway databases

UniPathwayi UPA00769 .
Reactomei REACT_210526. Estrogen biosynthesis.

Miscellaneous databases

NextBioi 288346.
PROi P51656.
SOURCEi Search...

Gene expression databases

Bgeei P51656.
CleanExi MM_HSD17B1.
ExpressionAtlasi P51656. baseline and differential.
Genevestigatori P51656.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR011348. 17beta_DH.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PIRSFi PIRSF000095. 17beta-HSD. 1 hit.
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of mouse 17 beta-hydroxysteroid dehydrogenase type 1 and characterization of enzyme activity."
    Nokelainen P., Puranen T., Peltoketo H., Orava M., Vihko P., Vihko R.
    Eur. J. Biochem. 236:482-490(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiDHB1_MOUSE
AccessioniPrimary (citable) accession number: P51656
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3