Reviewed, UniProtKB/Swiss-Prot P51656 (DHB1_MOUSE)

Names and origin

Protein names

Recommended name:
    Estradiol 17-beta-dehydrogenase 1
    EC=1.1.1.62
Alternative name(s):
    17-beta-hydroxysteroid dehydrogenase type 1
      Short name=17-beta-HSD 1

Gene names

Name:	Hsd17b1
Synonyms:	Edh17b1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Favors the reduction of estrogens and androgens. Uses preferentially NADH.
Catalytic activity	Estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H.
Pathway	Steroid biosynthesis; estrogen biosynthesis.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Biological process	Lipid synthesis Steroid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	estrogen biosynthetic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro estradiol 17-beta-dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	Estradiol 17-beta-dehydrogenase 1		PRO_0000054568
Regions
	Nucleotide binding	3 – 32	30	NAD By similarity
Sites
	Active site	156	1	Proton acceptor By similarity
	Binding site	143	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P51656-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 0335C473F453C14A	FASTA	344	36,785
	10 20 30 40 50 60 MDPTVVLITG CSSGIGMHLA VRLASDRSQS FKVYATLRDL KAQGPLLEAA RTQGCPPGSL 70 80 90 100 110 120 EILELDVRDS KSVAAAQACV TEGRVDVLVC NAGRGLFGPL EAHELNAVGA VLDVNVLGTI 130 140 150 160 170 180 RMLQAFLPDM KRRHSGRVLV TASVGGLMGL PFHEVYCASK FALEGLCESL AILLPLFGVH 190 200 210 220 230 240 VSLIECGAVH TAFYEKLVGG PGGALERADA QTRHLFAHYL RGYEQALSEA QDPEEVTELF 250 260 270 280 290 300 LTAMRAPQPA LRYFSTNRFL PLARMRTEDP SGSSYVAAMH QEAFSNLQTQ ENAKAGAQVP 310 320 330 340 GVSDTASSAL ICLPECAIPR VASELGWSAS DKPGQDNSCY QQKI

References

[1]	"Molecular cloning of mouse 17 beta-hydroxysteroid dehydrogenase type 1 and characterization of enzyme activity." Nokelainen P., Puranen T., Peltoketo H., Orava M., Vihko P., Vihko R. Eur. J. Biochem. 236:482-490(1996) [PubMed: 8612620] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X89627 mRNA. Translation: CAA61770.1.
IPI	IPI00125074.
PIR	S62652.
RefSeq	NP_034605.1.
UniGene	Mm.188939
3D structure databases
HSSP	HSSP built from PDB template 1FDW based on UniProtKB P14061.
SMR	P51656. Positions 4-284.
ModBase	Search...
Protein-protein interaction databases
STRING	P51656.
Proteomic databases
PRIDE	P51656.
Genome annotation databases
Ensembl	ENSMUST00000019445; ENSMUSP00000019445; ENSMUSG00000019301; Mus musculus. [Genome view]
GeneID	15485.
KEGG	mmu:15485.
UCSC	uc007lnb.1. mouse.
Organism-specific databases
CTD	15485.
MGI	MGI:105077. Hsd17b1.
Phylogenomic databases
HOGENOM	P51656.
HOVERGEN	P51656.
OMA	LCESLAI.
Enzyme and pathway databases
BRENDA	1.1.1.62. 244.
Gene expression databases
ArrayExpress	P51656.
Bgee	P51656.
CleanEx	MM_HSD17B1.
Genevestigator	P51656.
GermOnline	ENSMUSG00000019301. Mus musculus.
Family and domain databases
InterPro	IPR011348. 17beta_DH. IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410:SF47. 17beta_DH. 1 hit. PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PIRSF	PIRSF000095. 17beta-HSD. 1 hit.
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	288346.
SOURCE	Search...

Entry information

Entry name

DHB1_MOUSE

Accession

Primary (citable) accession number: P51656

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 3, 2009
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)