P51656 (DHB1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Estradiol 17-beta-dehydrogenase 1
EC=1.1.1.62

Alternative name(s):
17-beta-hydroxysteroid dehydrogenase type 1
Short name=17-beta-HSD 1

Gene names

Name:	Hsd17b1
Synonyms:	Edh17b1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Favors the reduction of estrogens and androgens. Uses preferentially NADH.
Catalytic activity	17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.
Pathway	Steroid biosynthesis; estrogen biosynthesis.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Biological process	Lipid biosynthesis Lipid metabolism Steroid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	bone development Inferred from electronic annotation. Source: Compara cellular response to metal ion Inferred from electronic annotation. Source: Compara estrogen biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway testosterone biosynthetic process Inferred from electronic annotation. Source: Compara
Cellular_component	cytosol Inferred from electronic annotation. Source: Compara
Molecular_function	estradiol 17-beta-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro testosterone 17-beta-dehydrogenase (NAD+) activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 344	343	Estradiol 17-beta-dehydrogenase 1		PRO_0000054568
Regions
	Nucleotide binding	3 – 32	30	NAD By similarity
Sites
	Active site	156	1	Proton acceptor By similarity
	Binding site	143	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P51656 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 0335C473F453C14A	FASTA	344	36,785
	10 20 30 40 50 60 MDPTVVLITG CSSGIGMHLA VRLASDRSQS FKVYATLRDL KAQGPLLEAA RTQGCPPGSL 70 80 90 100 110 120 EILELDVRDS KSVAAAQACV TEGRVDVLVC NAGRGLFGPL EAHELNAVGA VLDVNVLGTI 130 140 150 160 170 180 RMLQAFLPDM KRRHSGRVLV TASVGGLMGL PFHEVYCASK FALEGLCESL AILLPLFGVH 190 200 210 220 230 240 VSLIECGAVH TAFYEKLVGG PGGALERADA QTRHLFAHYL RGYEQALSEA QDPEEVTELF 250 260 270 280 290 300 LTAMRAPQPA LRYFSTNRFL PLARMRTEDP SGSSYVAAMH QEAFSNLQTQ ENAKAGAQVP 310 320 330 340 GVSDTASSAL ICLPECAIPR VASELGWSAS DKPGQDNSCY QQKI

References

[1]	"Molecular cloning of mouse 17 beta-hydroxysteroid dehydrogenase type 1 and characterization of enzyme activity." Nokelainen P., Puranen T., Peltoketo H., Orava M., Vihko P., Vihko R. Eur. J. Biochem. 236:482-490(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X89627 mRNA. Translation: CAA61770.1.
IPI	IPI00125074.
PIR	S62652.
RefSeq	NP_034605.1. NM_010475.1.
UniGene	Mm.188939.
3D structure databases
ProteinModelPortal	P51656.
SMR	P51656. Positions 4-284.
ModBase	Search...
Proteomic databases
PRIDE	P51656.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000019445; ENSMUSP00000019445; ENSMUSG00000019301.
GeneID	15485.
KEGG	mmu:15485.
Organism-specific databases
CTD	3292.
MGI	MGI:105077. Hsd17b1.
Phylogenomic databases
eggNOG	COG1028.
HOVERGEN	HBG014077.
InParanoid	P51656.
KO	K00044.
OMA	LRYFTTE.
OrthoDB	EOG45MN61.
Enzyme and pathway databases
UniPathway	UPA00769.
Gene expression databases
ArrayExpress	P51656.
Bgee	P51656.
CleanEx	MM_HSD17B1.
Genevestigator	P51656.
GermOnline	ENSMUSG00000019301. Mus musculus.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR011348. 17beta_DH. IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PIRSF	PIRSF000095. 17beta-HSD. 1 hit.
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL1914269.
NextBio	288346.
SOURCE	Search...

Entry information

Entry name

DHB1_MOUSE

Accession

Primary (citable) accession number: P51656

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program