Reviewed,
UniProtKB/Swiss-Prot P51656 (DHB1_MOUSE)
Last modified
November 3, 2009.
Version 71.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Estradiol 17-beta-dehydrogenase 1 EC=1.1.1.62 Alternative name(s): 17-beta-hydroxysteroid dehydrogenase type 1 Short name=17-beta-HSD 1 | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 344 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Favors the reduction of estrogens and androgens. Uses preferentially NADH. |
| Catalytic activity | Estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H. |
| Pathway | |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lipid synthesis Steroid biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | estrogen biosynthetic process Inferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | binding Inferred from electronic annotation. Source: InterPro estradiol 17-beta-dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Molecular cloning of mouse 17 beta-hydroxysteroid dehydrogenase type 1 and characterization of enzyme activity." Nokelainen P., Puranen T., Peltoketo H., Orava M., Vihko P., Vihko R. Eur. J. Biochem. 236:482-490(1996) [PubMed: 8612620] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X89627 mRNA. Translation: CAA61770.1. | |
| IPI | IPI00125074. |
| PIR | S62652. |
| RefSeq | NP_034605.1. |
| UniGene | Mm.188939 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FDW based on UniProtKB P14061. |
| SMR | P51656. Positions 4-284. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P51656. |
Proteomic databases | |
| PRIDE | P51656. |
Genome annotation databases | |
| Ensembl | ENSMUST00000019445; ENSMUSP00000019445; ENSMUSG00000019301; Mus musculus. [Genome view] |
| GeneID | 15485. |
| KEGG | mmu:15485. |
| UCSC | uc007lnb.1. mouse. |
Organism-specific databases | |
| CTD | 15485. |
| MGI | MGI:105077. Hsd17b1. |
Phylogenomic databases | |
| HOGENOM | P51656. |
| HOVERGEN | P51656. |
| OMA | LCESLAI. |
Enzyme and pathway databases | |
| BRENDA | 1.1.1.62. 244. |
Gene expression databases | |
| ArrayExpress | P51656. |
| Bgee | P51656. |
| CleanEx | MM_HSD17B1. |
| Genevestigator | P51656. |
| GermOnline | ENSMUSG00000019301. Mus musculus. |
Family and domain databases | |
| InterPro | IPR011348. 17beta_DH. IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| PANTHER | PTHR19410:SF47. 17beta_DH. 1 hit. PTHR19410. ADH_short_C2. 1 hit. |
| Pfam | PF00106. adh_short. 1 hit. [Graphical view] |
| PIRSF | PIRSF000095. 17beta-HSD. 1 hit. |
| PRINTS | PR00081. GDHRDH. PR00080. SDRFAMILY. |
| PROSITE | PS00061. ADH_SHORT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 288346. |
| SOURCE | Search... |
Entry information
| Entry name | DHB1_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P51656 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


