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P51656 (DHB1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Estradiol 17-beta-dehydrogenase 1
EC=1.1.1.62
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase type 1
Short name=17-beta-HSD 1
Gene names
Name:Hsd17b1
Synonyms:Edh17b1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Favors the reduction of estrogens and androgens. Uses preferentially NADH.

Catalytic activity

Estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H.

Pathway

Steroid biosynthesis; estrogen biosynthesis.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
   Biological processLipid synthesis
Steroid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular functionestradiol 17-beta-dehydrogenase activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Estradiol 17-beta-dehydrogenase 1
PRO_0000054568

Regions

Nucleotide binding3 – 3230NAD By similarity

Sites

Active site1561Proton acceptor By similarity
Binding site1431Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P51656 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 0335C473F453C14A

FASTA34436,785
        10         20         30         40         50         60 
MDPTVVLITG CSSGIGMHLA VRLASDRSQS FKVYATLRDL KAQGPLLEAA RTQGCPPGSL 

        70         80         90        100        110        120 
EILELDVRDS KSVAAAQACV TEGRVDVLVC NAGRGLFGPL EAHELNAVGA VLDVNVLGTI 

       130        140        150        160        170        180 
RMLQAFLPDM KRRHSGRVLV TASVGGLMGL PFHEVYCASK FALEGLCESL AILLPLFGVH 

       190        200        210        220        230        240 
VSLIECGAVH TAFYEKLVGG PGGALERADA QTRHLFAHYL RGYEQALSEA QDPEEVTELF 

       250        260        270        280        290        300 
LTAMRAPQPA LRYFSTNRFL PLARMRTEDP SGSSYVAAMH QEAFSNLQTQ ENAKAGAQVP 

       310        320        330        340 
GVSDTASSAL ICLPECAIPR VASELGWSAS DKPGQDNSCY QQKI

« Hide

References

[1]"Molecular cloning of mouse 17 beta-hydroxysteroid dehydrogenase type 1 and characterization of enzyme activity."
Nokelainen P., Puranen T., Peltoketo H., Orava M., Vihko P., Vihko R.
Eur. J. Biochem. 236:482-490(1996) [PubMed: 8612620] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X89627 mRNA. Translation: CAA61770.1.
IPIIPI00125074.
PIRS62652.
RefSeqNP_034605.1. NM_010475.1.
UniGeneMm.188939.

3D structure databases

ProteinModelPortalP51656.
SMRP51656. Positions 4-284.
ModBaseSearch...

Protein-protein interaction databases

STRINGP51656.

Proteomic databases

PRIDEP51656.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000019445; ENSMUSP00000019445; ENSMUSG00000019301.
GeneID15485.
KEGGmmu:15485.

Organism-specific databases

CTD3292.
MGIMGI:105077. Hsd17b1.

Phylogenomic databases

eggNOGroNOG05160.
HOGENOMHBG750976.
HOVERGENHBG014077.
InParanoidP51656.
OMAHTAFYEK.
OrthoDBEOG45MN61.
PhylomeDBP51656.

Gene expression databases

ArrayExpressP51656.
BgeeP51656.
CleanExMM_HSD17B1.
GenevestigatorP51656.
GermOnlineENSMUSG00000019301. Mus musculus.

Family and domain databases

InterProIPR011348. 17beta_DH.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00044.
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFPIRSF000095. 17beta-HSD. 1 hit.
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288346.
SOURCESearch...

Entry information

Entry nameDHB1_MOUSE
AccessionPrimary (citable) accession number: P51656
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: December 14, 2011
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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