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Protein

Glypican-4

Gene

Gpc4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-MMU-2022928. HS-GAG biosynthesis.
R-MMU-2024096. HS-GAG degradation.
R-MMU-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Glypican-4
Alternative name(s):
K-glypican
Cleaved into the following chain:
Gene namesi
Name:Gpc4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:104902. Gpc4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001231719 – 529Glypican-4Add BLAST511
ChainiPRO_000033384819 – ?Secreted glypican-4
PropeptideiPRO_0000012318530 – 557Removed in mature formSequence analysisAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei357PhosphoserineBy similarity1
Glycosylationi494O-linked (Xyl...) (glycosaminoglycan)Sequence analysis1
Glycosylationi498O-linked (Xyl...) (glycosaminoglycan)Sequence analysis1
Glycosylationi500O-linked (Xyl...) (glycosaminoglycan)Sequence analysis1
Glycosylationi514N-linked (GlcNAc...)Sequence analysis1
Lipidationi529GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Heparan sulfate, Lipoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

MaxQBiP51655.
PaxDbiP51655.
PeptideAtlasiP51655.
PRIDEiP51655.

PTM databases

iPTMnetiP51655.
PhosphoSitePlusiP51655.
SwissPalmiP51655.

Expressioni

Tissue specificityi

Highly expressed in developing brain and kidney.

Gene expression databases

BgeeiENSMUSG00000031119.
CleanExiMM_GPC4.
GenevisibleiP51655. MM.

Interactioni

Protein-protein interaction databases

IntActiP51655. 1 interactor.
MINTiMINT-4096517.
STRINGi10090.ENSMUSP00000033450.

Structurei

3D structure databases

ProteinModelPortaliP51655.
SMRiP51655.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glypican family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3821. Eukaryota.
ENOG410XST2. LUCA.
GeneTreeiENSGT00550000074430.
HOGENOMiHOG000253003.
HOVERGENiHBG003464.
InParanoidiP51655.
KOiK08110.
OMAiDENYMRC.
OrthoDBiEOG091G06T6.
PhylomeDBiP51655.
TreeFamiTF105317.

Family and domain databases

InterProiIPR001863. Glypican.
IPR031180. Glypican-4.
IPR019803. Glypican_CS.
[Graphical view]
PANTHERiPTHR10822. PTHR10822. 1 hit.
PTHR10822:SF25. PTHR10822:SF25. 1 hit.
PfamiPF01153. Glypican. 1 hit.
[Graphical view]
PROSITEiPS01207. GLYPICAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51655-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARLGLLALL CTLAALSASL LAAELKSKSC SEVRRLYVSK GFNKNDAPLY
60 70 80 90 100
EINGDHLKIC PQDYTCCSQE MEEKYSLQSK DDFKTVVSEQ CNHLQAIFAS
110 120 130 140 150
RYKKFDEFFK ELLENAEKSL NDMFVKTYGH LYMQNSELFK DLFVELKRYY
160 170 180 190 200
VAGNVNLEEM LNDFWARLLE RMFRLVNSQY HFTDEYLECV SKYTEQLKPF
210 220 230 240 250
GDVPRKLKLQ VTRAFVAART FAQGLAVARD VVSKVSVVNP TAQCTHALLK
260 270 280 290 300
MIYCSHCRGL VTVKPCYNYC SNIMRGCLAN QGDLDFEWNN FIDAMLMVAE
310 320 330 340 350
RLEGPFNIES VMDPIDVKIS DAIMNMQDNS VQVSQKVFQG CGPPKPLPAG
360 370 380 390 400
RISRSISESA FSARFRPYHP EQRPTTAAGT SLDRLVTDVK EKLKQAKKFW
410 420 430 440 450
SSLPSTVCND ERMAAGNENE DDCWNGKGKS RYLFAVTGNG LANQGNNPEV
460 470 480 490 500
QVDTSKPDIL ILRQIMALRV MTSKMKNAYN GNDVDFFDIS DESSGEGSGS
510 520 530 540 550
GCEYQQCPSE FEYNATDHSG KSANEKADSA GGAHAEAKPY LLAALCILFL

AVQGEWR
Length:557
Mass (Da):62,586
Last modified:May 16, 2003 - v2
Checksum:iF216AA0FEF5ED840
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti537A → T in CAA58560 (PubMed:7657705).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83577 mRNA. Translation: CAA58560.1.
BC006622 mRNA. Translation: AAH06622.1.
CCDSiCCDS30124.1.
PIRiA57050.
RefSeqiNP_032176.2. NM_008150.2.
UniGeneiMm.1528.
Mm.478164.
Mm.491492.

Genome annotation databases

EnsembliENSMUST00000033450; ENSMUSP00000033450; ENSMUSG00000031119.
GeneIDi14735.
KEGGimmu:14735.
UCSCiuc012hhb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83577 mRNA. Translation: CAA58560.1.
BC006622 mRNA. Translation: AAH06622.1.
CCDSiCCDS30124.1.
PIRiA57050.
RefSeqiNP_032176.2. NM_008150.2.
UniGeneiMm.1528.
Mm.478164.
Mm.491492.

3D structure databases

ProteinModelPortaliP51655.
SMRiP51655.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP51655. 1 interactor.
MINTiMINT-4096517.
STRINGi10090.ENSMUSP00000033450.

PTM databases

iPTMnetiP51655.
PhosphoSitePlusiP51655.
SwissPalmiP51655.

Proteomic databases

MaxQBiP51655.
PaxDbiP51655.
PeptideAtlasiP51655.
PRIDEiP51655.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033450; ENSMUSP00000033450; ENSMUSG00000031119.
GeneIDi14735.
KEGGimmu:14735.
UCSCiuc012hhb.1. mouse.

Organism-specific databases

CTDi2239.
MGIiMGI:104902. Gpc4.

Phylogenomic databases

eggNOGiKOG3821. Eukaryota.
ENOG410XST2. LUCA.
GeneTreeiENSGT00550000074430.
HOGENOMiHOG000253003.
HOVERGENiHBG003464.
InParanoidiP51655.
KOiK08110.
OMAiDENYMRC.
OrthoDBiEOG091G06T6.
PhylomeDBiP51655.
TreeFamiTF105317.

Enzyme and pathway databases

ReactomeiR-MMU-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-MMU-2022928. HS-GAG biosynthesis.
R-MMU-2024096. HS-GAG degradation.
R-MMU-975634. Retinoid metabolism and transport.

Miscellaneous databases

PROiP51655.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031119.
CleanExiMM_GPC4.
GenevisibleiP51655. MM.

Family and domain databases

InterProiIPR001863. Glypican.
IPR031180. Glypican-4.
IPR019803. Glypican_CS.
[Graphical view]
PANTHERiPTHR10822. PTHR10822. 1 hit.
PTHR10822:SF25. PTHR10822:SF25. 1 hit.
PfamiPF01153. Glypican. 1 hit.
[Graphical view]
PROSITEiPS01207. GLYPICAN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPC4_MOUSE
AccessioniPrimary (citable) accession number: P51655
Secondary accession number(s): Q923C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 16, 2003
Last modified: November 2, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.