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P51655

- GPC4_MOUSE

UniProt

P51655 - GPC4_MOUSE

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Protein

Glypican-4

Gene

Gpc4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system.

Enzyme and pathway databases

ReactomeiREACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_198569. Retinoid metabolism and transport.
REACT_198654. HS-GAG biosynthesis.
REACT_198967. HS-GAG degradation.
REACT_268952. Defective B3GAT3 causes JDSSDHD.
REACT_269282. Defective B4GALT7 causes EDS, progeroid type.
REACT_270174. Defective EXT2 causes exostoses 2.
REACT_271374. Defective EXT1 causes exostoses 1, TRPS2 and CHDS.

Names & Taxonomyi

Protein namesi
Recommended name:
Glypican-4
Alternative name(s):
K-glypican
Cleaved into the following chain:
Gene namesi
Name:Gpc4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:104902. Gpc4.

Subcellular locationi

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. external side of plasma membrane Source: MGI
  3. extracellular vesicular exosome Source: Ensembl
  4. Golgi lumen Source: Reactome
  5. nucleus Source: Ensembl
  6. proteinaceous extracellular matrix Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 529511Glypican-4PRO_0000012317Add
BLAST
Chaini19 – ?Secreted glypican-4PRO_0000333848
Propeptidei530 – 55728Removed in mature formSequence AnalysisPRO_0000012318Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei357 – 3571PhosphoserineBy similarity
Glycosylationi494 – 4941O-linked (Xyl...) (glycosaminoglycan)Sequence Analysis
Glycosylationi498 – 4981O-linked (Xyl...) (glycosaminoglycan)Sequence Analysis
Glycosylationi500 – 5001O-linked (Xyl...) (glycosaminoglycan)Sequence Analysis
Glycosylationi514 – 5141N-linked (GlcNAc...)Sequence Analysis
Lipidationi529 – 5291GPI-anchor amidated serineSequence Analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Heparan sulfate, Lipoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

MaxQBiP51655.
PaxDbiP51655.
PRIDEiP51655.

PTM databases

PhosphoSiteiP51655.

Expressioni

Tissue specificityi

Highly expressed in developing brain and kidney.

Gene expression databases

BgeeiP51655.
CleanExiMM_GPC4.
GenevestigatoriP51655.

Interactioni

Protein-protein interaction databases

IntActiP51655. 1 interaction.
MINTiMINT-4096517.

Structurei

3D structure databases

ProteinModelPortaliP51655.
SMRiP51655. Positions 26-484.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glypican family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG235988.
GeneTreeiENSGT00550000074430.
HOGENOMiHOG000253003.
HOVERGENiHBG003464.
InParanoidiP51655.
KOiK08110.
OMAiQCPSEFE.
OrthoDBiEOG761BTG.
PhylomeDBiP51655.
TreeFamiTF105317.

Family and domain databases

InterProiIPR001863. Glypican.
IPR019803. Glypican_CS.
[Graphical view]
PANTHERiPTHR10822. PTHR10822. 1 hit.
PfamiPF01153. Glypican. 1 hit.
[Graphical view]
PROSITEiPS01207. GLYPICAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51655-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARLGLLALL CTLAALSASL LAAELKSKSC SEVRRLYVSK GFNKNDAPLY
60 70 80 90 100
EINGDHLKIC PQDYTCCSQE MEEKYSLQSK DDFKTVVSEQ CNHLQAIFAS
110 120 130 140 150
RYKKFDEFFK ELLENAEKSL NDMFVKTYGH LYMQNSELFK DLFVELKRYY
160 170 180 190 200
VAGNVNLEEM LNDFWARLLE RMFRLVNSQY HFTDEYLECV SKYTEQLKPF
210 220 230 240 250
GDVPRKLKLQ VTRAFVAART FAQGLAVARD VVSKVSVVNP TAQCTHALLK
260 270 280 290 300
MIYCSHCRGL VTVKPCYNYC SNIMRGCLAN QGDLDFEWNN FIDAMLMVAE
310 320 330 340 350
RLEGPFNIES VMDPIDVKIS DAIMNMQDNS VQVSQKVFQG CGPPKPLPAG
360 370 380 390 400
RISRSISESA FSARFRPYHP EQRPTTAAGT SLDRLVTDVK EKLKQAKKFW
410 420 430 440 450
SSLPSTVCND ERMAAGNENE DDCWNGKGKS RYLFAVTGNG LANQGNNPEV
460 470 480 490 500
QVDTSKPDIL ILRQIMALRV MTSKMKNAYN GNDVDFFDIS DESSGEGSGS
510 520 530 540 550
GCEYQQCPSE FEYNATDHSG KSANEKADSA GGAHAEAKPY LLAALCILFL

AVQGEWR
Length:557
Mass (Da):62,586
Last modified:May 16, 2003 - v2
Checksum:iF216AA0FEF5ED840
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti537 – 5371A → T in CAA58560. (PubMed:7657705)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83577 mRNA. Translation: CAA58560.1.
BC006622 mRNA. Translation: AAH06622.1.
CCDSiCCDS30124.1.
PIRiA57050.
RefSeqiNP_032176.2. NM_008150.2.
UniGeneiMm.1528.
Mm.478164.
Mm.491492.

Genome annotation databases

EnsembliENSMUST00000033450; ENSMUSP00000033450; ENSMUSG00000031119.
GeneIDi14735.
KEGGimmu:14735.
UCSCiuc012hhb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83577 mRNA. Translation: CAA58560.1 .
BC006622 mRNA. Translation: AAH06622.1 .
CCDSi CCDS30124.1.
PIRi A57050.
RefSeqi NP_032176.2. NM_008150.2.
UniGenei Mm.1528.
Mm.478164.
Mm.491492.

3D structure databases

ProteinModelPortali P51655.
SMRi P51655. Positions 26-484.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P51655. 1 interaction.
MINTi MINT-4096517.

PTM databases

PhosphoSitei P51655.

Proteomic databases

MaxQBi P51655.
PaxDbi P51655.
PRIDEi P51655.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033450 ; ENSMUSP00000033450 ; ENSMUSG00000031119 .
GeneIDi 14735.
KEGGi mmu:14735.
UCSCi uc012hhb.1. mouse.

Organism-specific databases

CTDi 2239.
MGIi MGI:104902. Gpc4.

Phylogenomic databases

eggNOGi NOG235988.
GeneTreei ENSGT00550000074430.
HOGENOMi HOG000253003.
HOVERGENi HBG003464.
InParanoidi P51655.
KOi K08110.
OMAi QCPSEFE.
OrthoDBi EOG761BTG.
PhylomeDBi P51655.
TreeFami TF105317.

Enzyme and pathway databases

Reactomei REACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_198569. Retinoid metabolism and transport.
REACT_198654. HS-GAG biosynthesis.
REACT_198967. HS-GAG degradation.
REACT_268952. Defective B3GAT3 causes JDSSDHD.
REACT_269282. Defective B4GALT7 causes EDS, progeroid type.
REACT_270174. Defective EXT2 causes exostoses 2.
REACT_271374. Defective EXT1 causes exostoses 1, TRPS2 and CHDS.

Miscellaneous databases

NextBioi 286785.
PROi P51655.
SOURCEi Search...

Gene expression databases

Bgeei P51655.
CleanExi MM_GPC4.
Genevestigatori P51655.

Family and domain databases

InterProi IPR001863. Glypican.
IPR019803. Glypican_CS.
[Graphical view ]
PANTHERi PTHR10822. PTHR10822. 1 hit.
Pfami PF01153. Glypican. 1 hit.
[Graphical view ]
PROSITEi PS01207. GLYPICAN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney."
    Watanabe K., Yamada H., Yamaguchi Y.
    J. Cell Biol. 130:1207-1218(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.

Entry informationi

Entry nameiGPC4_MOUSE
AccessioniPrimary (citable) accession number: P51655
Secondary accession number(s): Q923C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 16, 2003
Last modified: November 26, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3