Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P51655

- GPC4_MOUSE

UniProt

P51655 - GPC4_MOUSE

Protein

Glypican-4

Gene

Gpc4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (16 May 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system.

    Enzyme and pathway databases

    ReactomeiREACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
    REACT_198569. Retinoid metabolism and transport.
    REACT_198654. HS-GAG biosynthesis.
    REACT_198967. HS-GAG degradation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glypican-4
    Alternative name(s):
    K-glypican
    Cleaved into the following chain:
    Gene namesi
    Name:Gpc4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:104902. Gpc4.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. external side of plasma membrane Source: MGI
    3. extracellular space Source: UniProtKB-SubCell
    4. Golgi lumen Source: Reactome
    5. proteinaceous extracellular matrix Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 529511Glypican-4PRO_0000012317Add
    BLAST
    Chaini19 – ?Secreted glypican-4PRO_0000333848
    Propeptidei530 – 55728Removed in mature formSequence AnalysisPRO_0000012318Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei357 – 3571PhosphoserineBy similarity
    Glycosylationi494 – 4941O-linked (Xyl...) (glycosaminoglycan)Sequence Analysis
    Glycosylationi498 – 4981O-linked (Xyl...) (glycosaminoglycan)Sequence Analysis
    Glycosylationi500 – 5001O-linked (Xyl...) (glycosaminoglycan)Sequence Analysis
    Glycosylationi514 – 5141N-linked (GlcNAc...)Sequence Analysis
    Lipidationi529 – 5291GPI-anchor amidated serineSequence Analysis

    Keywords - PTMi

    Glycoprotein, GPI-anchor, Heparan sulfate, Lipoprotein, Phosphoprotein, Proteoglycan

    Proteomic databases

    MaxQBiP51655.
    PaxDbiP51655.
    PRIDEiP51655.

    PTM databases

    PhosphoSiteiP51655.

    Expressioni

    Tissue specificityi

    Highly expressed in developing brain and kidney.

    Gene expression databases

    BgeeiP51655.
    CleanExiMM_GPC4.
    GenevestigatoriP51655.

    Interactioni

    Protein-protein interaction databases

    IntActiP51655. 1 interaction.
    MINTiMINT-4096517.

    Structurei

    3D structure databases

    ProteinModelPortaliP51655.
    SMRiP51655. Positions 26-484.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glypican family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG235988.
    GeneTreeiENSGT00550000074430.
    HOGENOMiHOG000253003.
    HOVERGENiHBG003464.
    InParanoidiP51655.
    KOiK08110.
    OMAiQCPSEFE.
    OrthoDBiEOG761BTG.
    PhylomeDBiP51655.
    TreeFamiTF105317.

    Family and domain databases

    InterProiIPR001863. Glypican.
    IPR019803. Glypican_CS.
    [Graphical view]
    PANTHERiPTHR10822. PTHR10822. 1 hit.
    PfamiPF01153. Glypican. 1 hit.
    [Graphical view]
    PROSITEiPS01207. GLYPICAN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P51655-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARLGLLALL CTLAALSASL LAAELKSKSC SEVRRLYVSK GFNKNDAPLY    50
    EINGDHLKIC PQDYTCCSQE MEEKYSLQSK DDFKTVVSEQ CNHLQAIFAS 100
    RYKKFDEFFK ELLENAEKSL NDMFVKTYGH LYMQNSELFK DLFVELKRYY 150
    VAGNVNLEEM LNDFWARLLE RMFRLVNSQY HFTDEYLECV SKYTEQLKPF 200
    GDVPRKLKLQ VTRAFVAART FAQGLAVARD VVSKVSVVNP TAQCTHALLK 250
    MIYCSHCRGL VTVKPCYNYC SNIMRGCLAN QGDLDFEWNN FIDAMLMVAE 300
    RLEGPFNIES VMDPIDVKIS DAIMNMQDNS VQVSQKVFQG CGPPKPLPAG 350
    RISRSISESA FSARFRPYHP EQRPTTAAGT SLDRLVTDVK EKLKQAKKFW 400
    SSLPSTVCND ERMAAGNENE DDCWNGKGKS RYLFAVTGNG LANQGNNPEV 450
    QVDTSKPDIL ILRQIMALRV MTSKMKNAYN GNDVDFFDIS DESSGEGSGS 500
    GCEYQQCPSE FEYNATDHSG KSANEKADSA GGAHAEAKPY LLAALCILFL 550
    AVQGEWR 557
    Length:557
    Mass (Da):62,586
    Last modified:May 16, 2003 - v2
    Checksum:iF216AA0FEF5ED840
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti537 – 5371A → T in CAA58560. (PubMed:7657705)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X83577 mRNA. Translation: CAA58560.1.
    BC006622 mRNA. Translation: AAH06622.1.
    CCDSiCCDS30124.1.
    PIRiA57050.
    RefSeqiNP_032176.2. NM_008150.2.
    UniGeneiMm.1528.
    Mm.478164.
    Mm.491492.

    Genome annotation databases

    EnsembliENSMUST00000033450; ENSMUSP00000033450; ENSMUSG00000031119.
    GeneIDi14735.
    KEGGimmu:14735.
    UCSCiuc012hhb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X83577 mRNA. Translation: CAA58560.1 .
    BC006622 mRNA. Translation: AAH06622.1 .
    CCDSi CCDS30124.1.
    PIRi A57050.
    RefSeqi NP_032176.2. NM_008150.2.
    UniGenei Mm.1528.
    Mm.478164.
    Mm.491492.

    3D structure databases

    ProteinModelPortali P51655.
    SMRi P51655. Positions 26-484.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P51655. 1 interaction.
    MINTi MINT-4096517.

    PTM databases

    PhosphoSitei P51655.

    Proteomic databases

    MaxQBi P51655.
    PaxDbi P51655.
    PRIDEi P51655.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033450 ; ENSMUSP00000033450 ; ENSMUSG00000031119 .
    GeneIDi 14735.
    KEGGi mmu:14735.
    UCSCi uc012hhb.1. mouse.

    Organism-specific databases

    CTDi 2239.
    MGIi MGI:104902. Gpc4.

    Phylogenomic databases

    eggNOGi NOG235988.
    GeneTreei ENSGT00550000074430.
    HOGENOMi HOG000253003.
    HOVERGENi HBG003464.
    InParanoidi P51655.
    KOi K08110.
    OMAi QCPSEFE.
    OrthoDBi EOG761BTG.
    PhylomeDBi P51655.
    TreeFami TF105317.

    Enzyme and pathway databases

    Reactomei REACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
    REACT_198569. Retinoid metabolism and transport.
    REACT_198654. HS-GAG biosynthesis.
    REACT_198967. HS-GAG degradation.

    Miscellaneous databases

    NextBioi 286785.
    PROi P51655.
    SOURCEi Search...

    Gene expression databases

    Bgeei P51655.
    CleanExi MM_GPC4.
    Genevestigatori P51655.

    Family and domain databases

    InterProi IPR001863. Glypican.
    IPR019803. Glypican_CS.
    [Graphical view ]
    PANTHERi PTHR10822. PTHR10822. 1 hit.
    Pfami PF01153. Glypican. 1 hit.
    [Graphical view ]
    PROSITEi PS01207. GLYPICAN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney."
      Watanabe K., Yamada H., Yamaguchi Y.
      J. Cell Biol. 130:1207-1218(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiGPC4_MOUSE
    AccessioniPrimary (citable) accession number: P51655
    Secondary accession number(s): Q923C8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: May 16, 2003
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3