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P51655

- GPC4_MOUSE

UniProt

P51655 - GPC4_MOUSE

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Protein
Glypican-4
Gene
Gpc4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system.

Enzyme and pathway databases

ReactomeiREACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_198569. Retinoid metabolism and transport.
REACT_198654. HS-GAG biosynthesis.
REACT_198967. HS-GAG degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glypican-4
Alternative name(s):
K-glypican
Cleaved into the following chain:
Gene namesi
Name:Gpc4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:104902. Gpc4.

Subcellular locationi

GO - Cellular componenti

  1. Golgi lumen Source: Reactome
  2. anchored component of membrane Source: UniProtKB-KW
  3. external side of plasma membrane Source: MGI
  4. extracellular space Source: UniProtKB-SubCell
  5. proteinaceous extracellular matrix Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 529511Glypican-4
PRO_0000012317Add
BLAST
Chaini19 – ?Secreted glypican-4PRO_0000333848
Propeptidei530 – 55728Removed in mature form Reviewed prediction
PRO_0000012318Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei357 – 3571Phosphoserine By similarity
Glycosylationi494 – 4941O-linked (Xyl...) (glycosaminoglycan) Reviewed prediction
Glycosylationi498 – 4981O-linked (Xyl...) (glycosaminoglycan) Reviewed prediction
Glycosylationi500 – 5001O-linked (Xyl...) (glycosaminoglycan) Reviewed prediction
Glycosylationi514 – 5141N-linked (GlcNAc...) Reviewed prediction
Lipidationi529 – 5291GPI-anchor amidated serine Reviewed prediction

Keywords - PTMi

Glycoprotein, GPI-anchor, Heparan sulfate, Lipoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

MaxQBiP51655.
PaxDbiP51655.
PRIDEiP51655.

PTM databases

PhosphoSiteiP51655.

Expressioni

Tissue specificityi

Highly expressed in developing brain and kidney.

Gene expression databases

BgeeiP51655.
CleanExiMM_GPC4.
GenevestigatoriP51655.

Interactioni

Protein-protein interaction databases

IntActiP51655. 1 interaction.
MINTiMINT-4096517.

Structurei

3D structure databases

ProteinModelPortaliP51655.
SMRiP51655. Positions 26-484.

Family & Domainsi

Sequence similaritiesi

Belongs to the glypican family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG235988.
GeneTreeiENSGT00550000074430.
HOGENOMiHOG000253003.
HOVERGENiHBG003464.
InParanoidiP51655.
KOiK08110.
OMAiQCPSEFE.
OrthoDBiEOG761BTG.
PhylomeDBiP51655.
TreeFamiTF105317.

Family and domain databases

InterProiIPR001863. Glypican.
IPR019803. Glypican_CS.
[Graphical view]
PANTHERiPTHR10822. PTHR10822. 1 hit.
PfamiPF01153. Glypican. 1 hit.
[Graphical view]
PROSITEiPS01207. GLYPICAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51655-1 [UniParc]FASTAAdd to Basket

« Hide

MARLGLLALL CTLAALSASL LAAELKSKSC SEVRRLYVSK GFNKNDAPLY    50
EINGDHLKIC PQDYTCCSQE MEEKYSLQSK DDFKTVVSEQ CNHLQAIFAS 100
RYKKFDEFFK ELLENAEKSL NDMFVKTYGH LYMQNSELFK DLFVELKRYY 150
VAGNVNLEEM LNDFWARLLE RMFRLVNSQY HFTDEYLECV SKYTEQLKPF 200
GDVPRKLKLQ VTRAFVAART FAQGLAVARD VVSKVSVVNP TAQCTHALLK 250
MIYCSHCRGL VTVKPCYNYC SNIMRGCLAN QGDLDFEWNN FIDAMLMVAE 300
RLEGPFNIES VMDPIDVKIS DAIMNMQDNS VQVSQKVFQG CGPPKPLPAG 350
RISRSISESA FSARFRPYHP EQRPTTAAGT SLDRLVTDVK EKLKQAKKFW 400
SSLPSTVCND ERMAAGNENE DDCWNGKGKS RYLFAVTGNG LANQGNNPEV 450
QVDTSKPDIL ILRQIMALRV MTSKMKNAYN GNDVDFFDIS DESSGEGSGS 500
GCEYQQCPSE FEYNATDHSG KSANEKADSA GGAHAEAKPY LLAALCILFL 550
AVQGEWR 557
Length:557
Mass (Da):62,586
Last modified:May 16, 2003 - v2
Checksum:iF216AA0FEF5ED840
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti537 – 5371A → T in CAA58560. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X83577 mRNA. Translation: CAA58560.1.
BC006622 mRNA. Translation: AAH06622.1.
CCDSiCCDS30124.1.
PIRiA57050.
RefSeqiNP_032176.2. NM_008150.2.
UniGeneiMm.1528.
Mm.478164.
Mm.491492.

Genome annotation databases

EnsembliENSMUST00000033450; ENSMUSP00000033450; ENSMUSG00000031119.
GeneIDi14735.
KEGGimmu:14735.
UCSCiuc012hhb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X83577 mRNA. Translation: CAA58560.1 .
BC006622 mRNA. Translation: AAH06622.1 .
CCDSi CCDS30124.1.
PIRi A57050.
RefSeqi NP_032176.2. NM_008150.2.
UniGenei Mm.1528.
Mm.478164.
Mm.491492.

3D structure databases

ProteinModelPortali P51655.
SMRi P51655. Positions 26-484.
ModBasei Search...

Protein-protein interaction databases

IntActi P51655. 1 interaction.
MINTi MINT-4096517.

PTM databases

PhosphoSitei P51655.

Proteomic databases

MaxQBi P51655.
PaxDbi P51655.
PRIDEi P51655.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033450 ; ENSMUSP00000033450 ; ENSMUSG00000031119 .
GeneIDi 14735.
KEGGi mmu:14735.
UCSCi uc012hhb.1. mouse.

Organism-specific databases

CTDi 2239.
MGIi MGI:104902. Gpc4.

Phylogenomic databases

eggNOGi NOG235988.
GeneTreei ENSGT00550000074430.
HOGENOMi HOG000253003.
HOVERGENi HBG003464.
InParanoidi P51655.
KOi K08110.
OMAi QCPSEFE.
OrthoDBi EOG761BTG.
PhylomeDBi P51655.
TreeFami TF105317.

Enzyme and pathway databases

Reactomei REACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_198569. Retinoid metabolism and transport.
REACT_198654. HS-GAG biosynthesis.
REACT_198967. HS-GAG degradation.

Miscellaneous databases

NextBioi 286785.
PROi P51655.
SOURCEi Search...

Gene expression databases

Bgeei P51655.
CleanExi MM_GPC4.
Genevestigatori P51655.

Family and domain databases

InterProi IPR001863. Glypican.
IPR019803. Glypican_CS.
[Graphical view ]
PANTHERi PTHR10822. PTHR10822. 1 hit.
Pfami PF01153. Glypican. 1 hit.
[Graphical view ]
PROSITEi PS01207. GLYPICAN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney."
    Watanabe K., Yamada H., Yamaguchi Y.
    J. Cell Biol. 130:1207-1218(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.

Entry informationi

Entry nameiGPC4_MOUSE
AccessioniPrimary (citable) accession number: P51655
Secondary accession number(s): Q923C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 16, 2003
Last modified: September 3, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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