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P51655 (GPC4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glypican-4
Alternative name(s):
K-glypican

Cleaved into the following chain:

  1. Secreted glypican-4
Gene names
Name:Gpc4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor; Extracellular side.

Secreted glypican-4: Secretedextracellular space By similarity.

Tissue specificity

Highly expressed in developing brain and kidney.

Sequence similarities

Belongs to the glypican family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 529511Glypican-4
PRO_0000012317
Chain19 – ?Secreted glypican-4PRO_0000333848
Propeptide530 – 55728Removed in mature form Potential
PRO_0000012318

Amino acid modifications

Modified residue3571Phosphoserine By similarity
Lipidation5291GPI-anchor amidated serine Potential
Glycosylation4941O-linked (Xyl...) (glycosaminoglycan) Potential
Glycosylation4981O-linked (Xyl...) (glycosaminoglycan) Potential
Glycosylation5001O-linked (Xyl...) (glycosaminoglycan) Potential
Glycosylation5141N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict5371A → T in CAA58560. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P51655 [UniParc].

Last modified May 16, 2003. Version 2.
Checksum: F216AA0FEF5ED840

FASTA55762,586
        10         20         30         40         50         60 
MARLGLLALL CTLAALSASL LAAELKSKSC SEVRRLYVSK GFNKNDAPLY EINGDHLKIC 

        70         80         90        100        110        120 
PQDYTCCSQE MEEKYSLQSK DDFKTVVSEQ CNHLQAIFAS RYKKFDEFFK ELLENAEKSL 

       130        140        150        160        170        180 
NDMFVKTYGH LYMQNSELFK DLFVELKRYY VAGNVNLEEM LNDFWARLLE RMFRLVNSQY 

       190        200        210        220        230        240 
HFTDEYLECV SKYTEQLKPF GDVPRKLKLQ VTRAFVAART FAQGLAVARD VVSKVSVVNP 

       250        260        270        280        290        300 
TAQCTHALLK MIYCSHCRGL VTVKPCYNYC SNIMRGCLAN QGDLDFEWNN FIDAMLMVAE 

       310        320        330        340        350        360 
RLEGPFNIES VMDPIDVKIS DAIMNMQDNS VQVSQKVFQG CGPPKPLPAG RISRSISESA 

       370        380        390        400        410        420 
FSARFRPYHP EQRPTTAAGT SLDRLVTDVK EKLKQAKKFW SSLPSTVCND ERMAAGNENE 

       430        440        450        460        470        480 
DDCWNGKGKS RYLFAVTGNG LANQGNNPEV QVDTSKPDIL ILRQIMALRV MTSKMKNAYN 

       490        500        510        520        530        540 
GNDVDFFDIS DESSGEGSGS GCEYQQCPSE FEYNATDHSG KSANEKADSA GGAHAEAKPY 

       550 
LLAALCILFL AVQGEWR 

« Hide

References

« Hide 'large scale' references
[1]"K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney."
Watanabe K., Yamada H., Yamaguchi Y.
J. Cell Biol. 130:1207-1218(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X83577 mRNA. Translation: CAA58560.1.
BC006622 mRNA. Translation: AAH06622.1.
CCDSCCDS30124.1.
PIRA57050.
RefSeqNP_032176.2. NM_008150.2.
UniGeneMm.1528.
Mm.478164.
Mm.491492.

3D structure databases

ProteinModelPortalP51655.
SMRP51655. Positions 26-484.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP51655. 1 interaction.
MINTMINT-4096517.

PTM databases

PhosphoSiteP51655.

Proteomic databases

MaxQBP51655.
PaxDbP51655.
PRIDEP51655.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033450; ENSMUSP00000033450; ENSMUSG00000031119.
GeneID14735.
KEGGmmu:14735.
UCSCuc012hhb.1. mouse.

Organism-specific databases

CTD2239.
MGIMGI:104902. Gpc4.

Phylogenomic databases

eggNOGNOG235988.
GeneTreeENSGT00550000074430.
HOGENOMHOG000253003.
HOVERGENHBG003464.
InParanoidP51655.
KOK08110.
OMAQCPSEFE.
OrthoDBEOG761BTG.
PhylomeDBP51655.
TreeFamTF105317.

Enzyme and pathway databases

ReactomeREACT_188937. Metabolism.
REACT_189085. Disease.

Gene expression databases

BgeeP51655.
CleanExMM_GPC4.
GenevestigatorP51655.

Family and domain databases

InterProIPR001863. Glypican.
IPR019803. Glypican_CS.
[Graphical view]
PANTHERPTHR10822. PTHR10822. 1 hit.
PfamPF01153. Glypican. 1 hit.
[Graphical view]
PROSITEPS01207. GLYPICAN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286785.
PROP51655.
SOURCESearch...

Entry information

Entry nameGPC4_MOUSE
AccessionPrimary (citable) accession number: P51655
Secondary accession number(s): Q923C8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 16, 2003
Last modified: July 9, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot