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P51654

- GPC3_HUMAN

UniProt

P51654 - GPC3_HUMAN

Protein

Glypican-3

Gene

GPC3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition.1 Publication

    GO - Molecular functioni

    1. peptidyl-dipeptidase inhibitor activity Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. anatomical structure morphogenesis Source: ProtInc
    2. anterior/posterior axis specification Source: Ensembl
    3. body morphogenesis Source: Ensembl
    4. bone mineralization Source: Ensembl
    5. branching involved in ureteric bud morphogenesis Source: Ensembl
    6. carbohydrate metabolic process Source: Reactome
    7. cell proliferation involved in metanephros development Source: Ensembl
    8. chondroitin sulfate metabolic process Source: Reactome
    9. coronary vasculature development Source: Ensembl
    10. embryonic hindlimb morphogenesis Source: Ensembl
    11. glycosaminoglycan biosynthetic process Source: Reactome
    12. glycosaminoglycan catabolic process Source: Reactome
    13. glycosaminoglycan metabolic process Source: Reactome
    14. lung development Source: Ensembl
    15. mesenchymal cell proliferation involved in ureteric bud development Source: UniProtKB
    16. mesonephric duct morphogenesis Source: Ensembl
    17. negative regulation of canonical Wnt signaling pathway Source: Ensembl
    18. negative regulation of epithelial cell proliferation Source: Ensembl
    19. negative regulation of growth Source: Ensembl
    20. negative regulation of smoothened signaling pathway Source: Ensembl
    21. osteoclast differentiation Source: Ensembl
    22. phototransduction, visible light Source: Reactome
    23. positive regulation of BMP signaling pathway Source: Ensembl
    24. positive regulation of endocytosis Source: Ensembl
    25. positive regulation of glucose import Source: Ensembl
    26. positive regulation of protein catabolic process Source: Ensembl
    27. positive regulation of smoothened signaling pathway Source: Ensembl
    28. positive regulation of Wnt signaling pathway, planar cell polarity pathway Source: Ensembl
    29. retinoid metabolic process Source: Reactome
    30. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Protease inhibitor

    Enzyme and pathway databases

    ReactomeiREACT_120752. HS-GAG degradation.
    REACT_121248. HS-GAG biosynthesis.
    REACT_121408. A tetrasaccharide linker sequence is required for GAG synthesis.
    REACT_24968. Retinoid metabolism and transport.
    SignaLinkiP51654.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glypican-3
    Alternative name(s):
    GTR2-2
    Intestinal protein OCI-5
    MXR7
    Cleaved into the following chain:
    Gene namesi
    Name:GPC3
    Synonyms:OCI5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:4451. GPC3.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity; Extracellular side By similarity

    GO - Cellular componenti

    1. anchored component of plasma membrane Source: Ensembl
    2. extracellular space Source: UniProtKB-SubCell
    3. extracellular vesicular exosome Source: UniProt
    4. Golgi lumen Source: Reactome
    5. integral component of plasma membrane Source: ProtInc
    6. lysosomal lumen Source: Reactome
    7. plasma membrane Source: Reactome
    8. proteinaceous extracellular matrix Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Simpson-Golabi-Behmel syndrome 1 (SGBS1) [MIM:312870]: A condition characterized by pre- and postnatal overgrowth (gigantism), facial dysmorphism and a variety of inconstant visceral and skeletal malformations. Characteristic dysmorphic features include macrocephaly with coarse, distinctive facies with a large protruding jaw, broad nasal bridge and cleft palate. Cardiac defects are frequent.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti296 – 2961W → R in SGBS1. 1 Publication
    VAR_021385

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi312870. phenotype.
    Orphaneti373. Simpson-Golabi-Behmel syndrome.
    PharmGKBiPA28832.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei? – 580Removed in mature formSequence AnalysisPRO_0000012310
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – ?Glypican-3PRO_0000012309
    Chaini25 – ?Secreted glypican-3PRO_0000333844

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi418 – 4181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi495 – 4951O-linked (Xyl...) (heparan sulfate)Sequence Analysis
    Glycosylationi509 – 5091O-linked (Xyl...) (heparan sulfate)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, GPI-anchor, Heparan sulfate, Lipoprotein, Proteoglycan

    Proteomic databases

    MaxQBiP51654.
    PaxDbiP51654.
    PRIDEiP51654.

    PTM databases

    PhosphoSiteiP51654.

    Expressioni

    Tissue specificityi

    Highly expressed in lung, liver and kidney.

    Gene expression databases

    ArrayExpressiP51654.
    BgeeiP51654.
    CleanExiHS_GPC3.
    GenevestigatoriP51654.

    Organism-specific databases

    HPAiCAB017784.
    HPA006316.

    Interactioni

    Subunit structurei

    Interacts with DPP4.1 Publication

    Protein-protein interaction databases

    BioGridi108983. 2 interactions.
    IntActiP51654. 1 interaction.
    STRINGi9606.ENSP00000359854.

    Structurei

    3D structure databases

    ProteinModelPortaliP51654.
    SMRiP51654. Positions 34-475.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glypican family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG281821.
    HOVERGENiHBG005896.
    KOiK08109.
    OMAiCWNGQEL.
    OrthoDBiEOG761BTG.
    PhylomeDBiP51654.
    TreeFamiTF105317.

    Family and domain databases

    InterProiIPR001863. Glypican.
    IPR015501. Glypican-3.
    IPR019803. Glypican_CS.
    [Graphical view]
    PANTHERiPTHR10822. PTHR10822. 1 hit.
    PTHR10822:SF4. PTHR10822:SF4. 1 hit.
    PfamiPF01153. Glypican. 1 hit.
    [Graphical view]
    PROSITEiPS01207. GLYPICAN. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P51654-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGTVRTACL VVAMLLSLDF PGQAQPPPPP PDATCHQVRS FFQRLQPGLK    50
    WVPETPVPGS DLQVCLPKGP TCCSRKMEEK YQLTARLNME QLLQSASMEL 100
    KFLIIQNAAV FQEAFEIVVR HAKNYTNAMF KNNYPSLTPQ AFEFVGEFFT 150
    DVSLYILGSD INVDDMVNEL FDSLFPVIYT QLMNPGLPDS ALDINECLRG 200
    ARRDLKVFGN FPKLIMTQVS KSLQVTRIFL QALNLGIEVI NTTDHLKFSK 250
    DCGRMLTRMW YCSYCQGLMM VKPCGGYCNV VMQGCMAGVV EIDKYWREYI 300
    LSLEELVNGM YRIYDMENVL LGLFSTIHDS IQYVQKNAGK LTTTIGKLCA 350
    HSQQRQYRSA YYPEDLFIDK KVLKVAHVEH EETLSSRRRE LIQKLKSFIS 400
    FYSALPGYIC SHSPVAENDT LCWNGQELVE RYSQKAARNG MKNQFNLHEL 450
    KMKGPEPVVS QIIDKLKHIN QLLRTMSMPK GRVLDKNLDE EGFESGDCGD 500
    DEDECIGGSG DGMIKVKNQL RFLAELAYDL DVDDAPGNSQ QATPKDNEIS 550
    TFHNLGNVHS PLKLLTSMAI SVVCFFFLVH 580
    Length:580
    Mass (Da):65,563
    Last modified:October 1, 1996 - v1
    Checksum:i19485B76D3CE15FC
    GO
    Isoform 2 (identifier: P51654-2) [UniParc]FASTAAdd to Basket

    Also known as: Variant B

    The sequence of this isoform differs from the canonical sequence as follows:
         59-112: Missing.

    Show »
    Length:526
    Mass (Da):59,475
    Checksum:iA0858770AF739C17
    GO
    Isoform 3 (identifier: P51654-3) [UniParc]FASTAAdd to Basket

    Also known as: Variant C

    The sequence of this isoform differs from the canonical sequence as follows:
         344-344: T → TETEKKIWHFKYPIFFLCIGLDLQ

    Show »
    Length:603
    Mass (Da):68,414
    Checksum:i1930C0382E91AF60
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti296 – 2961W → R in SGBS1. 1 Publication
    VAR_021385
    Natural varianti429 – 4291V → M.1 Publication
    Corresponds to variant rs413112608 [ dbSNP | Ensembl ].
    VAR_069139

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei59 – 11254Missing in isoform 2. 1 PublicationVSP_046117Add
    BLAST
    Alternative sequencei344 – 3441T → TETEKKIWHFKYPIFFLCIG LDLQ in isoform 3. 1 PublicationVSP_046703

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U50410 mRNA. Translation: AAA93471.1.
    L47124 Genomic DNA. Translation: AAA98131.1.
    L47125 mRNA. Translation: AAA98132.1.
    L47176 mRNA. Translation: AAB58806.1.
    Z37987 mRNA. Translation: CAA86069.1.
    DQ349136 mRNA. Translation: ABC72125.1.
    DQ349138 mRNA. Translation: ABC72127.1.
    AL008712
    , AC002420, AF003529, AL009174, Z99570 Genomic DNA. Translation: CAI43110.1.
    AL009174
    , AC002420, AF003529, AL008712, Z99570 Genomic DNA. Translation: CAI42761.1.
    Z99570
    , AC002420, AF003529, AL008712, AL009174 Genomic DNA. Translation: CAI42277.1.
    AL034401 Genomic DNA. No translation available.
    AL662851 Genomic DNA. No translation available.
    Z97196 Genomic DNA. No translation available.
    CH471107 Genomic DNA. Translation: EAX11771.1.
    AF003529 Genomic DNA. Translation: AAB87062.1.
    CCDSiCCDS14638.1. [P51654-1]
    CCDS55495.1. [P51654-2]
    CCDS55496.1. [P51654-3]
    RefSeqiNP_001158089.1. NM_001164617.1. [P51654-3]
    NP_001158091.1. NM_001164619.1. [P51654-2]
    NP_004475.1. NM_004484.3. [P51654-1]
    UniGeneiHs.644108.

    Genome annotation databases

    EnsembliENST00000370818; ENSP00000359854; ENSG00000147257. [P51654-1]
    ENST00000394299; ENSP00000377836; ENSG00000147257. [P51654-3]
    GeneIDi2719.
    KEGGihsa:2719.
    UCSCiuc004exe.2. human. [P51654-1]
    uc010nro.2. human.

    Polymorphism databases

    DMDMi1708022.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U50410 mRNA. Translation: AAA93471.1 .
    L47124 Genomic DNA. Translation: AAA98131.1 .
    L47125 mRNA. Translation: AAA98132.1 .
    L47176 mRNA. Translation: AAB58806.1 .
    Z37987 mRNA. Translation: CAA86069.1 .
    DQ349136 mRNA. Translation: ABC72125.1 .
    DQ349138 mRNA. Translation: ABC72127.1 .
    AL008712
    , AC002420 , AF003529 , AL009174 , Z99570 Genomic DNA. Translation: CAI43110.1 .
    AL009174
    , AC002420 , AF003529 , AL008712 , Z99570 Genomic DNA. Translation: CAI42761.1 .
    Z99570
    , AC002420 , AF003529 , AL008712 , AL009174 Genomic DNA. Translation: CAI42277.1 .
    AL034401 Genomic DNA. No translation available.
    AL662851 Genomic DNA. No translation available.
    Z97196 Genomic DNA. No translation available.
    CH471107 Genomic DNA. Translation: EAX11771.1 .
    AF003529 Genomic DNA. Translation: AAB87062.1 .
    CCDSi CCDS14638.1. [P51654-1 ]
    CCDS55495.1. [P51654-2 ]
    CCDS55496.1. [P51654-3 ]
    RefSeqi NP_001158089.1. NM_001164617.1. [P51654-3 ]
    NP_001158091.1. NM_001164619.1. [P51654-2 ]
    NP_004475.1. NM_004484.3. [P51654-1 ]
    UniGenei Hs.644108.

    3D structure databases

    ProteinModelPortali P51654.
    SMRi P51654. Positions 34-475.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108983. 2 interactions.
    IntActi P51654. 1 interaction.
    STRINGi 9606.ENSP00000359854.

    PTM databases

    PhosphoSitei P51654.

    Polymorphism databases

    DMDMi 1708022.

    Proteomic databases

    MaxQBi P51654.
    PaxDbi P51654.
    PRIDEi P51654.

    Protocols and materials databases

    DNASUi 2719.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370818 ; ENSP00000359854 ; ENSG00000147257 . [P51654-1 ]
    ENST00000394299 ; ENSP00000377836 ; ENSG00000147257 . [P51654-3 ]
    GeneIDi 2719.
    KEGGi hsa:2719.
    UCSCi uc004exe.2. human. [P51654-1 ]
    uc010nro.2. human.

    Organism-specific databases

    CTDi 2719.
    GeneCardsi GC0XM132669.
    GeneReviewsi GPC3.
    HGNCi HGNC:4451. GPC3.
    HPAi CAB017784.
    HPA006316.
    MIMi 300037. gene.
    312870. phenotype.
    neXtProti NX_P51654.
    Orphaneti 373. Simpson-Golabi-Behmel syndrome.
    PharmGKBi PA28832.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG281821.
    HOVERGENi HBG005896.
    KOi K08109.
    OMAi CWNGQEL.
    OrthoDBi EOG761BTG.
    PhylomeDBi P51654.
    TreeFami TF105317.

    Enzyme and pathway databases

    Reactomei REACT_120752. HS-GAG degradation.
    REACT_121248. HS-GAG biosynthesis.
    REACT_121408. A tetrasaccharide linker sequence is required for GAG synthesis.
    REACT_24968. Retinoid metabolism and transport.
    SignaLinki P51654.

    Miscellaneous databases

    ChiTaRSi GPC3. human.
    GeneWikii Glypican_3.
    GenomeRNAii 2719.
    NextBioi 10734.
    PROi P51654.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51654.
    Bgeei P51654.
    CleanExi HS_GPC3.
    Genevestigatori P51654.

    Family and domain databases

    InterProi IPR001863. Glypican.
    IPR015501. Glypican-3.
    IPR019803. Glypican_CS.
    [Graphical view ]
    PANTHERi PTHR10822. PTHR10822. 1 hit.
    PTHR10822:SF4. PTHR10822:SF4. 1 hit.
    Pfami PF01153. Glypican. 1 hit.
    [Graphical view ]
    PROSITEi PS01207. GLYPICAN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mapping of the Simpson-Golabi-Behmel overgrowth syndrome gene (GPC3) to chromosome X in human and rat by fluorescence in situ hybridization."
      Shen T., Sonoda G., Hamid J., Li M., Filmus J., Buick R.N., Testa J.R.
      Mamm. Genome 8:72-72(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome."
      Pilia G., Hughes-Benzie R.M., Mackenzie A., Baybayan P., Chen E.Y., Huber R., Neri G., Cao A., Forabosco A., Schlessinger D.
      Nat. Genet. 12:241-247(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), DISEASE.
      Tissue: Embryo.
    3. "Cloning and characterization of human cDNAs encoding a protein with high homology to rat intestinal development protein OCI-5."
      Lage H., Dietel M.
      Gene 188:151-156(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Expression of the Glypican-3 protein in hepatoma cells."
      Grozdanov P.N., Yovchev M.I., Dabeva M.D.
      Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), VARIANT MET-429.
    5. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "Analysis of exon/intron structure and 400 kb of genomic sequence surrounding the 5'-promoter and 3'-terminal ends of the human glypican 3 (GPC3) gene."
      Huber R., Crisponi L., Mazzarella R., Chen C.N., Su Y., Shizuya H., Chen E.Y., Cao A., Pilia G.
      Genomics 45:48-58(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-58.
    8. "The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26."
      Davoodi J., Kelly J., Gendron N.H., MacKenzie A.E.
      Proteomics 7:2300-2310(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH DPP4.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene."
      Veugelers M., Cat B.D., Muyldermans S.Y., Reekmans G., Delande N., Frints S., Legius E., Fryns J.-P., Schrander-Stumpel C., Weidle B., Magdalena N., David G.
      Hum. Mol. Genet. 9:1321-1328(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT SGBS1 ARG-296.

    Entry informationi

    Entry nameiGPC3_HUMAN
    AccessioniPrimary (citable) accession number: P51654
    Secondary accession number(s): C9JLE3
    , G3V1R0, Q2L880, Q2L882
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 135 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3