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Protein

Glypican-2

Gene

Gpc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons.

GO - Molecular functioni

GO - Biological processi

  • neuron differentiation Source: RGD
  • regulation of signal transduction Source: InterPro
  • smoothened signaling pathway Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-RNO-2022928 HS-GAG biosynthesis
R-RNO-2024096 HS-GAG degradation
R-RNO-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Glypican-2
Alternative name(s):
Cerebroglycan
HSPG M13
Cleaved into the following chain:
Gene namesi
Name:Gpc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi621363 Gpc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001230722 – 556Glypican-2Add BLAST535
ChainiPRO_000033384322 – ?Secreted glypican-2
PropeptideiPRO_0000012308557 – 579Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi55O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi92O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi155O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi498O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi500O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Lipidationi556GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Heparan sulfate, Lipoprotein, Proteoglycan

Proteomic databases

PaxDbiP51653
PRIDEiP51653

Expressioni

Tissue specificityi

Nervous system.

Developmental stagei

Widely and transiently expressed by immature neurons, appearing around the time of final mitosis and disappearing after cell migration and axon outgrowth have been completed.

Gene expression databases

BgeeiENSRNOG00000001367
GenevisibleiP51653 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001849

Structurei

3D structure databases

SMRiP51653
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glypican family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3821 Eukaryota
ENOG410XST2 LUCA
GeneTreeiENSGT00550000074430
HOGENOMiHOG000253003
HOVERGENiHBG003464
InParanoidiP51653
KOiK08108
OMAiAAPCWTG
OrthoDBiEOG091G06T6
PhylomeDBiP51653
TreeFamiTF105317

Family and domain databases

InterProiView protein in InterPro
IPR001863 Glypican
IPR031181 Glypican-2
IPR019803 Glypican_CS
PANTHERiPTHR10822 PTHR10822, 1 hit
PTHR10822:SF24 PTHR10822:SF24, 1 hit
PfamiView protein in Pfam
PF01153 Glypican, 1 hit
PROSITEiView protein in PROSITE
PS01207 GLYPICAN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51653-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAVRPLLLL LLPLCPGPGP GHGSEAKVVR SCAETRQVLG ARGYSLNLIP
60 70 80 90 100
PSLISGEHLQ ICPQEYTCCS SETEQKLIRD AEVTFRGLVE DSGSFLIHTL
110 120 130 140 150
AARHRKFNEF FREMLSISQH SLAQLFSHSY GRLYSQHAVI FNSLFSGLRD
160 170 180 190 200
YYEKSGEGLD DTLADFWAQL LERAFPLLHP QYSFPPDFLL CLTRLTSTAD
210 220 230 240 250
GSLQPFGDSP RRLRLQITRA LVAARALVQG LETGRNVVSE ALKVPMLEGC
260 270 280 290 300
RQALMRLIGC PLCRGVPSLM PCRGFCLNVA HGCLSSRGLE PEWGGYLDGL
310 320 330 340 350
LLLAEKLQGP FSFELAAESI GVKISEGLMH LQENSVKVSA KVFQECGTPH
360 370 380 390 400
PVQSRNRRAP APREETSRSW RSSAEEERPT TAAGTNLHRL VWELRERLSR
410 420 430 440 450
VRGFWAGLPV TVCGDSRMAA DLSQEAAPCW TGVGRGRYMS PVVVGSLNEQ
460 470 480 490 500
LHNPELDTSS PDVPTRRRRL HLRAATARMK AAALGQDLDM HDADEDASGS
510 520 530 540 550
GGGQQYADDW KAGAAPVVPP ARPPRPPRPP RRDGLGVRGG SGSARYNQGR
560 570
SRNLGSSVGL HAPRVFILLP SALTLLGLR
Length:579
Mass (Da):63,354
Last modified:October 1, 1996 - v1
Checksum:i7C324001311D36A5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti377Missing AA sequence (PubMed:8294498).Curated1
Sequence conflicti379P → PP AA sequence (PubMed:8294498).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20468 mRNA Translation: AAA40961.1
PIRiA49649
RefSeqiNP_612520.1, NM_138511.1
UniGeneiRn.88131

Genome annotation databases

EnsembliENSRNOT00000001849; ENSRNOP00000001849; ENSRNOG00000001367
GeneIDi171517
KEGGirno:171517
UCSCiRGD:621363 rat

Similar proteinsi

Entry informationi

Entry nameiGPC2_RAT
AccessioniPrimary (citable) accession number: P51653
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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