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Protein

Glypican-2

Gene

Gpc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons.

GO - Molecular functioni

GO - Biological processi

  • neuron differentiation Source: RGD
  • smoothened signaling pathway Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-RNO-2022928. HS-GAG biosynthesis.
R-RNO-2024096. HS-GAG degradation.
R-RNO-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Glypican-2
Alternative name(s):
Cerebroglycan
HSPG M13
Cleaved into the following chain:
Gene namesi
Name:Gpc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi621363. Gpc2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001230722 – 556Glypican-2Add BLAST535
ChainiPRO_000033384322 – ?Secreted glypican-2
PropeptideiPRO_0000012308557 – 579Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi55O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi92O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi155O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi498O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi500O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Lipidationi556GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Heparan sulfate, Lipoprotein, Proteoglycan

Proteomic databases

PaxDbiP51653.
PRIDEiP51653.

Expressioni

Tissue specificityi

Nervous system.

Developmental stagei

Widely and transiently expressed by immature neurons, appearing around the time of final mitosis and disappearing after cell migration and axon outgrowth have been completed.

Gene expression databases

BgeeiENSRNOG00000001367.
GenevisibleiP51653. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001849.

Structurei

3D structure databases

SMRiP51653.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glypican family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3821. Eukaryota.
ENOG410XST2. LUCA.
GeneTreeiENSGT00550000074430.
HOGENOMiHOG000253003.
HOVERGENiHBG003464.
InParanoidiP51653.
KOiK08108.
OMAiAAPCWTG.
OrthoDBiEOG091G06T6.
PhylomeDBiP51653.
TreeFamiTF105317.

Family and domain databases

InterProiView protein in InterPro
IPR001863. Glypican.
IPR031181. Glypican-2.
IPR019803. Glypican_CS.
PANTHERiPTHR10822. PTHR10822. 1 hit.
PTHR10822:SF40. PTHR10822:SF40. 1 hit.
PfamiView protein in Pfam
PF01153. Glypican. 1 hit.
PROSITEiView protein in PROSITE
PS01207. GLYPICAN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51653-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAVRPLLLL LLPLCPGPGP GHGSEAKVVR SCAETRQVLG ARGYSLNLIP
60 70 80 90 100
PSLISGEHLQ ICPQEYTCCS SETEQKLIRD AEVTFRGLVE DSGSFLIHTL
110 120 130 140 150
AARHRKFNEF FREMLSISQH SLAQLFSHSY GRLYSQHAVI FNSLFSGLRD
160 170 180 190 200
YYEKSGEGLD DTLADFWAQL LERAFPLLHP QYSFPPDFLL CLTRLTSTAD
210 220 230 240 250
GSLQPFGDSP RRLRLQITRA LVAARALVQG LETGRNVVSE ALKVPMLEGC
260 270 280 290 300
RQALMRLIGC PLCRGVPSLM PCRGFCLNVA HGCLSSRGLE PEWGGYLDGL
310 320 330 340 350
LLLAEKLQGP FSFELAAESI GVKISEGLMH LQENSVKVSA KVFQECGTPH
360 370 380 390 400
PVQSRNRRAP APREETSRSW RSSAEEERPT TAAGTNLHRL VWELRERLSR
410 420 430 440 450
VRGFWAGLPV TVCGDSRMAA DLSQEAAPCW TGVGRGRYMS PVVVGSLNEQ
460 470 480 490 500
LHNPELDTSS PDVPTRRRRL HLRAATARMK AAALGQDLDM HDADEDASGS
510 520 530 540 550
GGGQQYADDW KAGAAPVVPP ARPPRPPRPP RRDGLGVRGG SGSARYNQGR
560 570
SRNLGSSVGL HAPRVFILLP SALTLLGLR
Length:579
Mass (Da):63,354
Last modified:October 1, 1996 - v1
Checksum:i7C324001311D36A5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti377Missing AA sequence (PubMed:8294498).Curated1
Sequence conflicti379P → PP AA sequence (PubMed:8294498).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20468 mRNA. Translation: AAA40961.1.
PIRiA49649.
RefSeqiNP_612520.1. NM_138511.1.
UniGeneiRn.88131.

Genome annotation databases

EnsembliENSRNOT00000001849; ENSRNOP00000001849; ENSRNOG00000001367.
GeneIDi171517.
KEGGirno:171517.
UCSCiRGD:621363. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20468 mRNA. Translation: AAA40961.1.
PIRiA49649.
RefSeqiNP_612520.1. NM_138511.1.
UniGeneiRn.88131.

3D structure databases

SMRiP51653.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001849.

Proteomic databases

PaxDbiP51653.
PRIDEiP51653.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001849; ENSRNOP00000001849; ENSRNOG00000001367.
GeneIDi171517.
KEGGirno:171517.
UCSCiRGD:621363. rat.

Organism-specific databases

CTDi221914.
RGDi621363. Gpc2.

Phylogenomic databases

eggNOGiKOG3821. Eukaryota.
ENOG410XST2. LUCA.
GeneTreeiENSGT00550000074430.
HOGENOMiHOG000253003.
HOVERGENiHBG003464.
InParanoidiP51653.
KOiK08108.
OMAiAAPCWTG.
OrthoDBiEOG091G06T6.
PhylomeDBiP51653.
TreeFamiTF105317.

Enzyme and pathway databases

ReactomeiR-RNO-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-RNO-2022928. HS-GAG biosynthesis.
R-RNO-2024096. HS-GAG degradation.
R-RNO-975634. Retinoid metabolism and transport.

Miscellaneous databases

PROiPR:P51653.

Gene expression databases

BgeeiENSRNOG00000001367.
GenevisibleiP51653. RN.

Family and domain databases

InterProiView protein in InterPro
IPR001863. Glypican.
IPR031181. Glypican-2.
IPR019803. Glypican_CS.
PANTHERiPTHR10822. PTHR10822. 1 hit.
PTHR10822:SF40. PTHR10822:SF40. 1 hit.
PfamiView protein in Pfam
PF01153. Glypican. 1 hit.
PROSITEiView protein in PROSITE
PS01207. GLYPICAN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGPC2_RAT
AccessioniPrimary (citable) accession number: P51653
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 10, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.