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Protein

Aldo-keto reductase family 1 member C18

Gene

Akr1c18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of progesterone into 20-alpha-dihydroprogesterone (20 alpha-OHP).

Catalytic activityi

17-alpha,20-alpha-dihydroxypregn-4-en-3-one + NAD(P)+ = 17-alpha-hydroxyprogesterone + NAD(P)H.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei50NADPBy similarity1
Sitei54Important for substrate specificityBy similarity1
Active sitei55Proton donorBy similarity1
Sitei84Lowers pKa of active site TyrBy similarity1
Binding sitei117SubstrateBy similarity1
Binding sitei190NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 24NADPBy similarity5
Nucleotide bindingi166 – 167NADPBy similarity2
Nucleotide bindingi216 – 221NADPBy similarity6
Nucleotide bindingi270 – 280NADPBy similarityAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

ReactomeiR-RNO-193368. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
R-RNO-193775. Synthesis of bile acids and bile salts via 24-hydroxycholesterol.
R-RNO-193807. Synthesis of bile acids and bile salts via 27-hydroxycholesterol.
R-RNO-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
R-RNO-5365859. RA biosynthesis pathway.
R-RNO-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldo-keto reductase family 1 member C18 (EC:1.1.-.-)
Alternative name(s):
20-alpha-hydroxysteroid dehydrogenase (EC:1.1.1.149)
Short name:
20-alpha-HSD
HSD1
Gene namesi
Name:Akr1c18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi708428. Akr1c18.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001246501 – 323Aldo-keto reductase family 1 member C18Add BLAST323

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

PaxDbiP51652.
PRIDEiP51652.

Expressioni

Tissue specificityi

Corpus luteum (large luteal cells).

Developmental stagei

Remains repressed throughout pregnancy and becomes highly and rapidly expressed before parturition.

Inductioni

Repressed by prolactin.

Gene expression databases

BgeeiENSRNOG00000017531.
GenevisibleiP51652. RN.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023739.

Structurei

3D structure databases

ProteinModelPortaliP51652.
SMRiP51652.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

eggNOGiKOG1577. Eukaryota.
COG0656. LUCA.
GeneTreeiENSGT00760000119041.
HOVERGENiHBG000020.
InParanoidiP51652.
KOiK05295.
OMAiRFNDPGF.
OrthoDBiEOG091G0D69.
PhylomeDBiP51652.
TreeFamiTF106492.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiView protein in InterPro
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
IPR036812. NADP_OxRdtase_dom_sf.
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiView protein in Pfam
PF00248. Aldo_ket_red. 1 hit.
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiView protein in PROSITE
PS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

P51652-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSKIQKMEL NDGHSIPVLG FGTYATEENL RKKSMESTKI AIDVGFRHID
60 70 80 90 100
CSHLYQNEEE IGQAIVSKIE DGTVKREDIF YTSKLWSTSH RPELVRPSLE
110 120 130 140 150
NSLRKLNLDY VDLYLIHFPV SLKPGDELLP QDEHGNLILD TVDLCDTWEA
160 170 180 190 200
MEKCKDAGLA KSIGVSNFNR RQLEKILNKP GLKHRPVCNQ VECHLYLNQS
210 220 230 240 250
KLLAYCKMND IVLVAYGALG TQRYKYCINE DTPVLLDDPI LCTMAKKYKR
260 270 280 290 300
TPALIALRYQ LERGIVTLVK SFNEERIREN LQVFDFQLAS DDMEILDNLD
310 320
RNLRYFPANM FKAHPNFPFS DEY
Length:323
Mass (Da):37,300
Last modified:October 1, 1996 - v1
Checksum:iD14270961515195E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242C → L AA sequence (PubMed:8194472).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L32601 mRNA. Translation: AAA40601.1.
D14424 mRNA. Translation: BAA03317.1.
BC100248 mRNA. Translation: AAI00249.1.
PIRiJC2330.
RefSeqiNP_612519.1. NM_138510.1.
UniGeneiRn.10030.

Genome annotation databases

EnsembliENSRNOT00000023739; ENSRNOP00000023739; ENSRNOG00000017531.
GeneIDi171516.
KEGGirno:171516.
UCSCiRGD:708428. rat.

Similar proteinsi

Entry informationi

Entry nameiAKC1H_RAT
AccessioniPrimary (citable) accession number: P51652
Secondary accession number(s): Q498E4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome