ID   GPR6_RAT                Reviewed;         363 AA.
AC   P51651;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   27-MAR-2024, entry version 134.
DE   RecName: Full=G-protein coupled receptor 6;
DE   AltName: Full=Sphingosine 1-phosphate receptor GPR6;
GN   Name=Gpr6; Synonyms=Cnl3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Brain cortex;
RX   PubMed=8082799; DOI=10.1016/0014-5793(94)00888-4;
RA   Song Z.-H., Young W.S. III, Brownstein M.J., Bonner T.I.;
RT   "Molecular cloning of a novel candidate G protein-coupled receptor from rat
RT   brain.";
RL   FEBS Lett. 351:375-379(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=11169503;
RX   DOI=10.1002/1097-4695(20010215)46:3<167::aid-neu1000>3.0.co;2-j;
RA   Chenn A., Levin M.E., McConnell S.K.;
RT   "Temporally and spatially regulated expression of a candidate G-protein-
RT   coupled receptor during cerebral cortical development.";
RL   J. Neurobiol. 46:167-177(2001).
RN   [3]
RP   FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=17284443; DOI=10.1074/jbc.m700911200;
RA   Tanaka S., Ishii K., Kasai K., Yoon S.O., Saeki Y.;
RT   "Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-
RT   regulates cyclic AMP levels and promotes neurite outgrowth.";
RL   J. Biol. Chem. 282:10506-10515(2007).
CC   -!- FUNCTION: Orphan receptor with constitutive G(s) signaling activity
CC       that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin
CC       inhibition in neurons. {ECO:0000269|PubMed:17284443}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Note=Detected in the intracellular compartments.
CC       It is currently unclear whether this is a cell surface or intracellular
CC       receptor (By similarity). {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in the brain, with a prominent
CC       distribution in striatum. {ECO:0000269|PubMed:8082799}.
CC   -!- DEVELOPMENTAL STAGE: Abundantly expressed in granule neurons at all
CC       developmental stages. {ECO:0000269|PubMed:17284443}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; U12006; AAA21870.1; -; mRNA.
DR   EMBL; AF064706; AAC16886.1; -; mRNA.
DR   PIR; S48697; S48697.
DR   RefSeq; NP_113994.1; NM_031806.1.
DR   AlphaFoldDB; P51651; -.
DR   SMR; P51651; -.
DR   STRING; 10116.ENSRNOP00000067254; -.
DR   GlyCosmos; P51651; 3 sites, No reported glycans.
DR   GlyGen; P51651; 3 sites.
DR   iPTMnet; P51651; -.
DR   PhosphoSitePlus; P51651; -.
DR   PaxDb; 10116-ENSRNOP00000067254; -.
DR   Ensembl; ENSRNOT00000073276.2; ENSRNOP00000067254.1; ENSRNOG00000049580.2.
DR   Ensembl; ENSRNOT00055001158; ENSRNOP00055000913; ENSRNOG00055000679.
DR   Ensembl; ENSRNOT00060011533; ENSRNOP00060008654; ENSRNOG00060007021.
DR   Ensembl; ENSRNOT00065013790; ENSRNOP00065010239; ENSRNOG00065008683.
DR   GeneID; 83683; -.
DR   KEGG; rno:83683; -.
DR   AGR; RGD:70939; -.
DR   CTD; 2830; -.
DR   RGD; 70939; Gpr6.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT01060000248564; -.
DR   HOGENOM; CLU_065071_0_0_1; -.
DR   InParanoid; P51651; -.
DR   OMA; YCVVGDP; -.
DR   OrthoDB; 5397365at2759; -.
DR   PhylomeDB; P51651; -.
DR   PRO; PR:P51651; -.
DR   Proteomes; UP000002494; Chromosome 20.
DR   Bgee; ENSRNOG00000049580; Expressed in duodenum and 4 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0038036; F:sphingosine-1-phosphate receptor activity; ISO:RGD.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:RGD.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:RGD.
DR   GO; GO:0019222; P:regulation of metabolic process; IBA:GO_Central.
DR   GO; GO:0003376; P:sphingosine-1-phosphate receptor signaling pathway; ISO:RGD.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR001151; GPR6.
DR   InterPro; IPR000723; GPR_3/6/12_orphan.
DR   PANTHER; PTHR22750; G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR22750:SF19; G-PROTEIN COUPLED RECEPTOR 6; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00649; GPR6ORPHANR.
DR   PRINTS; PR00644; GPRORPHANR.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; P51651; RN.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Lipoprotein;
KW   Membrane; Palmitate; Phosphoprotein; Receptor; Reference proteome;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..363
FT                   /note="G-protein coupled receptor 6"
FT                   /id="PRO_0000069516"
FT   TOPO_DOM        1..75
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..95
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        96..107
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..131
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        132..143
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..165
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        166..186
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..206
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        207..231
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..250
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        251..278
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..305
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        306..310
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        311..332
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        333..363
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          28..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         357
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         359
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         361
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000255"
FT   LIPID           346
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        2
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        9
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        52
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   363 AA;  38115 MW;  4B2E665C0BAB2B78 CRC64;
     MNASAAALNE SQVVAVAAEG AAAAATAAGT PDTSEWGPPA ASAALGGGGG PNGSLELSSQ
     LPAGPSGLLL SAVNPWDVLL CVSGTVIAGE NALVVALIAS TPALRTPMFV LVGSLATADL
     LAGCGLILHF VFQYVVPSET VSLLMVGFLV ASFAASVSSL LAITVDRYLS LYNALTYYSR
     RTLLGVHLLL AATWTVSLGL GLLPVLGWNC LADRASCSVV RPLTRSHVAL LSTSFFVVFG
     IMLHLYVRIC QVVWRHAHQI ALQQHCLAPP HLAATRKGVG TLAVVLGTFG ASWLPFAIYC
     VVGSQEDPAI YTYATLLPAT YNSMINPIIY AFRNQEIQRA LWLLFCGCFQ SKVPFRSRSP
     SEV
//