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P51651

- GPR6_RAT

UniProt

P51651 - GPR6_RAT

Protein

G-protein coupled receptor 6

Gene

Gpr6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons.1 Publication

    GO - Molecular functioni

    1. sphingosine-1-phosphate receptor activity Source: Ensembl

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: RGD
    2. positive regulation of cytosolic calcium ion concentration Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G-protein coupled receptor 6
    Alternative name(s):
    Sphingosine 1-phosphate receptor GPR6
    Gene namesi
    Name:Gpr6
    Synonyms:Cnl3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 20

    Organism-specific databases

    RGDi70939. Gpr6.

    Subcellular locationi

    Cell membrane Curated; Multi-pass membrane protein Curated
    Note: Detected in the intracellular compartments. It is currently unclear whether this is a cell surface or intracellular receptor By similarity.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 363363G-protein coupled receptor 6PRO_0000069516Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
    Lipidationi346 – 3461S-palmitoyl cysteineBy similarity
    Modified residuei357 – 3571PhosphoserineSequence Analysis
    Modified residuei359 – 3591PhosphoserineSequence Analysis
    Modified residuei361 – 3611PhosphoserineSequence Analysis

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Expressioni

    Tissue specificityi

    Expressed in the brain, with a prominent distribution in striatum.1 Publication

    Developmental stagei

    Abundantly expressed in granule neurons at all developmental stages.1 Publication

    Gene expression databases

    GenevestigatoriP51651.

    Structurei

    3D structure databases

    ProteinModelPortaliP51651.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7575ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini96 – 10712CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini132 – 14312ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini166 – 18621CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini207 – 23125ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini251 – 27828CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini306 – 3105ExtracellularSequence Analysis
    Topological domaini333 – 36331CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei76 – 9520Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei108 – 13124Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei144 – 16522Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei187 – 20620Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei232 – 25019Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei279 – 30527Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei311 – 33222Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi21 – 288Poly-Ala
    Compositional biasi46 – 505Poly-Gly

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00750000117639.
    HOVERGENiHBG079561.
    KOiK04313.
    OMAiCGCFQSK.
    OrthoDBiEOG7966H0.
    PhylomeDBiP51651.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001151. GPR6.
    IPR000723. GPR_3/6/12_orphan.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00649. GPR6ORPHANR.
    PR00644. GPRORPHANR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51651-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNASAAALNE SQVVAVAAEG AAAAATAAGT PDTSEWGPPA ASAALGGGGG    50
    PNGSLELSSQ LPAGPSGLLL SAVNPWDVLL CVSGTVIAGE NALVVALIAS 100
    TPALRTPMFV LVGSLATADL LAGCGLILHF VFQYVVPSET VSLLMVGFLV 150
    ASFAASVSSL LAITVDRYLS LYNALTYYSR RTLLGVHLLL AATWTVSLGL 200
    GLLPVLGWNC LADRASCSVV RPLTRSHVAL LSTSFFVVFG IMLHLYVRIC 250
    QVVWRHAHQI ALQQHCLAPP HLAATRKGVG TLAVVLGTFG ASWLPFAIYC 300
    VVGSQEDPAI YTYATLLPAT YNSMINPIIY AFRNQEIQRA LWLLFCGCFQ 350
    SKVPFRSRSP SEV 363
    Length:363
    Mass (Da):38,115
    Last modified:October 1, 1996 - v1
    Checksum:i4B2E665C0BAB2B78
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12006 mRNA. Translation: AAA21870.1.
    AF064706 mRNA. Translation: AAC16886.1.
    PIRiS48697.
    RefSeqiNP_113994.1. NM_031806.1.
    UniGeneiRn.32092.

    Genome annotation databases

    EnsembliENSRNOT00000073276; ENSRNOP00000067254; ENSRNOG00000049580.
    GeneIDi83683.
    KEGGirno:83683.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12006 mRNA. Translation: AAA21870.1 .
    AF064706 mRNA. Translation: AAC16886.1 .
    PIRi S48697.
    RefSeqi NP_113994.1. NM_031806.1.
    UniGenei Rn.32092.

    3D structure databases

    ProteinModelPortali P51651.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 85.

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000073276 ; ENSRNOP00000067254 ; ENSRNOG00000049580 .
    GeneIDi 83683.
    KEGGi rno:83683.

    Organism-specific databases

    CTDi 2830.
    RGDi 70939. Gpr6.

    Phylogenomic databases

    GeneTreei ENSGT00750000117639.
    HOVERGENi HBG079561.
    KOi K04313.
    OMAi CGCFQSK.
    OrthoDBi EOG7966H0.
    PhylomeDBi P51651.

    Miscellaneous databases

    NextBioi 616241.
    PROi P51651.

    Gene expression databases

    Genevestigatori P51651.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001151. GPR6.
    IPR000723. GPR_3/6/12_orphan.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00649. GPR6ORPHANR.
    PR00644. GPRORPHANR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a novel candidate G protein-coupled receptor from rat brain."
      Song Z.-H., Young W.S. III, Brownstein M.J., Bonner T.I.
      FEBS Lett. 351:375-379(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Brain cortex.
    2. "Temporally and spatially regulated expression of a candidate G-protein-coupled receptor during cerebral cortical development."
      Chenn A., Levin M.E., McConnell S.K.
      J. Neurobiol. 46:167-177(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. "Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth."
      Tanaka S., Ishii K., Kasai K., Yoon S.O., Saeki Y.
      J. Biol. Chem. 282:10506-10515(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiGPR6_RAT
    AccessioniPrimary (citable) accession number: P51651
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3