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Protein

G-protein coupled receptor 6

Gene

Gpr6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 6
Alternative name(s):
Sphingosine 1-phosphate receptor GPR6
Gene namesi
Name:Gpr6
Synonyms:Cnl3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi70939. Gpr6.

Subcellular locationi

  • Cell membrane Curated; Multi-pass membrane protein Curated

  • Note: Detected in the intracellular compartments. It is currently unclear whether this is a cell surface or intracellular receptor (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7575ExtracellularSequence AnalysisAdd
BLAST
Transmembranei76 – 9520Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini96 – 10712CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei108 – 13124Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini132 – 14312ExtracellularSequence AnalysisAdd
BLAST
Transmembranei144 – 16522Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini166 – 18621CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei187 – 20620Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini207 – 23125ExtracellularSequence AnalysisAdd
BLAST
Transmembranei232 – 25019Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini251 – 27828CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei279 – 30527Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini306 – 3105ExtracellularSequence Analysis
Transmembranei311 – 33222Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini333 – 36331CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363G-protein coupled receptor 6PRO_0000069516Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
Lipidationi346 – 3461S-palmitoyl cysteineBy similarity
Modified residuei357 – 3571PhosphoserineSequence Analysis
Modified residuei359 – 3591PhosphoserineSequence Analysis
Modified residuei361 – 3611PhosphoserineSequence Analysis

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Expressioni

Tissue specificityi

Expressed in the brain, with a prominent distribution in striatum.1 Publication

Developmental stagei

Abundantly expressed in granule neurons at all developmental stages.1 Publication

Gene expression databases

GenevestigatoriP51651.

Structurei

3D structure databases

ProteinModelPortaliP51651.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi21 – 288Poly-Ala
Compositional biasi46 – 505Poly-Gly

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118804.
HOVERGENiHBG079561.
InParanoidiP51651.
KOiK04313.
OMAiCGCFQSK.
OrthoDBiEOG7966H0.
PhylomeDBiP51651.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001151. GPR6.
IPR000723. GPR_3/6/12_orphan.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00649. GPR6ORPHANR.
PR00644. GPRORPHANR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51651-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNASAAALNE SQVVAVAAEG AAAAATAAGT PDTSEWGPPA ASAALGGGGG
60 70 80 90 100
PNGSLELSSQ LPAGPSGLLL SAVNPWDVLL CVSGTVIAGE NALVVALIAS
110 120 130 140 150
TPALRTPMFV LVGSLATADL LAGCGLILHF VFQYVVPSET VSLLMVGFLV
160 170 180 190 200
ASFAASVSSL LAITVDRYLS LYNALTYYSR RTLLGVHLLL AATWTVSLGL
210 220 230 240 250
GLLPVLGWNC LADRASCSVV RPLTRSHVAL LSTSFFVVFG IMLHLYVRIC
260 270 280 290 300
QVVWRHAHQI ALQQHCLAPP HLAATRKGVG TLAVVLGTFG ASWLPFAIYC
310 320 330 340 350
VVGSQEDPAI YTYATLLPAT YNSMINPIIY AFRNQEIQRA LWLLFCGCFQ
360
SKVPFRSRSP SEV
Length:363
Mass (Da):38,115
Last modified:October 1, 1996 - v1
Checksum:i4B2E665C0BAB2B78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12006 mRNA. Translation: AAA21870.1.
AF064706 mRNA. Translation: AAC16886.1.
PIRiS48697.
RefSeqiNP_113994.1. NM_031806.1.
UniGeneiRn.32092.

Genome annotation databases

EnsembliENSRNOT00000073276; ENSRNOP00000067254; ENSRNOG00000049580.
GeneIDi83683.
KEGGirno:83683.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12006 mRNA. Translation: AAA21870.1.
AF064706 mRNA. Translation: AAC16886.1.
PIRiS48697.
RefSeqiNP_113994.1. NM_031806.1.
UniGeneiRn.32092.

3D structure databases

ProteinModelPortaliP51651.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

GuidetoPHARMACOLOGYi85.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000073276; ENSRNOP00000067254; ENSRNOG00000049580.
GeneIDi83683.
KEGGirno:83683.

Organism-specific databases

CTDi2830.
RGDi70939. Gpr6.

Phylogenomic databases

GeneTreeiENSGT00760000118804.
HOVERGENiHBG079561.
InParanoidiP51651.
KOiK04313.
OMAiCGCFQSK.
OrthoDBiEOG7966H0.
PhylomeDBiP51651.

Miscellaneous databases

NextBioi616241.
PROiP51651.

Gene expression databases

GenevestigatoriP51651.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001151. GPR6.
IPR000723. GPR_3/6/12_orphan.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00649. GPR6ORPHANR.
PR00644. GPRORPHANR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of a novel candidate G protein-coupled receptor from rat brain."
    Song Z.-H., Young W.S. III, Brownstein M.J., Bonner T.I.
    FEBS Lett. 351:375-379(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Brain cortex.
  2. "Temporally and spatially regulated expression of a candidate G-protein-coupled receptor during cerebral cortical development."
    Chenn A., Levin M.E., McConnell S.K.
    J. Neurobiol. 46:167-177(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth."
    Tanaka S., Ishii K., Kasai K., Yoon S.O., Saeki Y.
    J. Biol. Chem. 282:10506-10515(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiGPR6_RAT
AccessioniPrimary (citable) accession number: P51651
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 7, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.