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Protein

G-protein coupled receptor 6

Gene

Gpr6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 6
Alternative name(s):
Sphingosine 1-phosphate receptor GPR6
Gene namesi
Name:Gpr6
Synonyms:Cnl3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi70939 Gpr6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 75ExtracellularSequence analysisAdd BLAST75
Transmembranei76 – 95Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini96 – 107CytoplasmicSequence analysisAdd BLAST12
Transmembranei108 – 131Helical; Name=2Sequence analysisAdd BLAST24
Topological domaini132 – 143ExtracellularSequence analysisAdd BLAST12
Transmembranei144 – 165Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini166 – 186CytoplasmicSequence analysisAdd BLAST21
Transmembranei187 – 206Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini207 – 231ExtracellularSequence analysisAdd BLAST25
Transmembranei232 – 250Helical; Name=5Sequence analysisAdd BLAST19
Topological domaini251 – 278CytoplasmicSequence analysisAdd BLAST28
Transmembranei279 – 305Helical; Name=6Sequence analysisAdd BLAST27
Topological domaini306 – 310ExtracellularSequence analysis5
Transmembranei311 – 332Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini333 – 363CytoplasmicSequence analysisAdd BLAST31

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695161 – 363G-protein coupled receptor 6Add BLAST363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi346S-palmitoyl cysteineBy similarity1
Modified residuei357PhosphoserineSequence analysis1
Modified residuei359PhosphoserineSequence analysis1
Modified residuei361PhosphoserineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP51651
PRIDEiP51651

PTM databases

iPTMnetiP51651
PhosphoSitePlusiP51651

Expressioni

Tissue specificityi

Expressed in the brain, with a prominent distribution in striatum.1 Publication

Developmental stagei

Abundantly expressed in granule neurons at all developmental stages.1 Publication

Gene expression databases

BgeeiENSRNOG00000049580
GenevisibleiP51651 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067254

Structurei

3D structure databases

ProteinModelPortaliP51651
SMRiP51651
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi21 – 28Poly-Ala8
Compositional biasi46 – 50Poly-Gly5

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118804
HOVERGENiHBG079561
InParanoidiP51651
KOiK04313
OMAiLFCGCFQ
OrthoDBiEOG091G0CNB
PhylomeDBiP51651

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001151 GPR6
IPR000723 GPR_3/6/12_orphan
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00649 GPR6ORPHANR
PR00644 GPRORPHANR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P51651-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNASAAALNE SQVVAVAAEG AAAAATAAGT PDTSEWGPPA ASAALGGGGG
60 70 80 90 100
PNGSLELSSQ LPAGPSGLLL SAVNPWDVLL CVSGTVIAGE NALVVALIAS
110 120 130 140 150
TPALRTPMFV LVGSLATADL LAGCGLILHF VFQYVVPSET VSLLMVGFLV
160 170 180 190 200
ASFAASVSSL LAITVDRYLS LYNALTYYSR RTLLGVHLLL AATWTVSLGL
210 220 230 240 250
GLLPVLGWNC LADRASCSVV RPLTRSHVAL LSTSFFVVFG IMLHLYVRIC
260 270 280 290 300
QVVWRHAHQI ALQQHCLAPP HLAATRKGVG TLAVVLGTFG ASWLPFAIYC
310 320 330 340 350
VVGSQEDPAI YTYATLLPAT YNSMINPIIY AFRNQEIQRA LWLLFCGCFQ
360
SKVPFRSRSP SEV
Length:363
Mass (Da):38,115
Last modified:October 1, 1996 - v1
Checksum:i4B2E665C0BAB2B78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12006 mRNA Translation: AAA21870.1
AF064706 mRNA Translation: AAC16886.1
PIRiS48697
RefSeqiNP_113994.1, NM_031806.1
UniGeneiRn.32092

Genome annotation databases

EnsembliENSRNOT00000073276; ENSRNOP00000067254; ENSRNOG00000049580
GeneIDi83683
KEGGirno:83683

Similar proteinsi

Entry informationi

Entry nameiGPR6_RAT
AccessioniPrimary (citable) accession number: P51651
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health