SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P51651

- GPR6_RAT

UniProt

P51651 - GPR6_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

G-protein coupled receptor 6

Gene
Gpr6, Cnl3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons.1 Publication

GO - Molecular functioni

  1. sphingosine-1-phosphate receptor activity Source: Ensembl

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: RGD
  2. positive regulation of cytosolic calcium ion concentration Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 6
Alternative name(s):
Sphingosine 1-phosphate receptor GPR6
Gene namesi
Name:Gpr6
Synonyms:Cnl3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 20

Organism-specific databases

RGDi70939. Gpr6.

Subcellular locationi

Cell membrane; Multi-pass membrane protein Inferred
Note: Detected in the intracellular compartments. It is currently unclear whether this is a cell surface or intracellular receptor By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7575Extracellular Reviewed predictionAdd
BLAST
Transmembranei76 – 9520Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini96 – 10712Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei108 – 13124Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini132 – 14312Extracellular Reviewed predictionAdd
BLAST
Transmembranei144 – 16522Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini166 – 18621Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei187 – 20620Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini207 – 23125Extracellular Reviewed predictionAdd
BLAST
Transmembranei232 – 25019Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini251 – 27828Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei279 – 30527Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini306 – 3105Extracellular Reviewed prediction
Transmembranei311 – 33222Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini333 – 36331Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363G-protein coupled receptor 6PRO_0000069516Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...) Reviewed prediction
Glycosylationi9 – 91N-linked (GlcNAc...) Reviewed prediction
Glycosylationi52 – 521N-linked (GlcNAc...) Reviewed prediction
Lipidationi346 – 3461S-palmitoyl cysteine By similarity
Modified residuei357 – 3571Phosphoserine Reviewed prediction
Modified residuei359 – 3591Phosphoserine Reviewed prediction
Modified residuei361 – 3611Phosphoserine Reviewed prediction

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Expressioni

Tissue specificityi

Expressed in the brain, with a prominent distribution in striatum.1 Publication

Developmental stagei

Abundantly expressed in granule neurons at all developmental stages.1 Publication

Gene expression databases

GenevestigatoriP51651.

Structurei

3D structure databases

ProteinModelPortaliP51651.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi21 – 288Poly-Ala
Compositional biasi46 – 505Poly-Gly

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00750000117639.
HOVERGENiHBG079561.
KOiK04313.
OMAiCGCFQSK.
OrthoDBiEOG7966H0.
PhylomeDBiP51651.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001151. GPR6.
IPR000723. GPR_3/6/12_orphan.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00649. GPR6ORPHANR.
PR00644. GPRORPHANR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51651-1 [UniParc]FASTAAdd to Basket

« Hide

MNASAAALNE SQVVAVAAEG AAAAATAAGT PDTSEWGPPA ASAALGGGGG    50
PNGSLELSSQ LPAGPSGLLL SAVNPWDVLL CVSGTVIAGE NALVVALIAS 100
TPALRTPMFV LVGSLATADL LAGCGLILHF VFQYVVPSET VSLLMVGFLV 150
ASFAASVSSL LAITVDRYLS LYNALTYYSR RTLLGVHLLL AATWTVSLGL 200
GLLPVLGWNC LADRASCSVV RPLTRSHVAL LSTSFFVVFG IMLHLYVRIC 250
QVVWRHAHQI ALQQHCLAPP HLAATRKGVG TLAVVLGTFG ASWLPFAIYC 300
VVGSQEDPAI YTYATLLPAT YNSMINPIIY AFRNQEIQRA LWLLFCGCFQ 350
SKVPFRSRSP SEV 363
Length:363
Mass (Da):38,115
Last modified:October 1, 1996 - v1
Checksum:i4B2E665C0BAB2B78
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12006 mRNA. Translation: AAA21870.1.
AF064706 mRNA. Translation: AAC16886.1.
PIRiS48697.
RefSeqiNP_113994.1. NM_031806.1.
UniGeneiRn.32092.

Genome annotation databases

EnsembliENSRNOT00000073276; ENSRNOP00000067254; ENSRNOG00000049580.
GeneIDi83683.
KEGGirno:83683.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12006 mRNA. Translation: AAA21870.1 .
AF064706 mRNA. Translation: AAC16886.1 .
PIRi S48697.
RefSeqi NP_113994.1. NM_031806.1.
UniGenei Rn.32092.

3D structure databases

ProteinModelPortali P51651.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 85.

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000073276 ; ENSRNOP00000067254 ; ENSRNOG00000049580 .
GeneIDi 83683.
KEGGi rno:83683.

Organism-specific databases

CTDi 2830.
RGDi 70939. Gpr6.

Phylogenomic databases

GeneTreei ENSGT00750000117639.
HOVERGENi HBG079561.
KOi K04313.
OMAi CGCFQSK.
OrthoDBi EOG7966H0.
PhylomeDBi P51651.

Miscellaneous databases

NextBioi 616241.
PROi P51651.

Gene expression databases

Genevestigatori P51651.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001151. GPR6.
IPR000723. GPR_3/6/12_orphan.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00649. GPR6ORPHANR.
PR00644. GPRORPHANR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of a novel candidate G protein-coupled receptor from rat brain."
    Song Z.-H., Young W.S. III, Brownstein M.J., Bonner T.I.
    FEBS Lett. 351:375-379(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Brain cortex.
  2. "Temporally and spatially regulated expression of a candidate G-protein-coupled receptor during cerebral cortical development."
    Chenn A., Levin M.E., McConnell S.K.
    J. Neurobiol. 46:167-177(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth."
    Tanaka S., Ishii K., Kasai K., Yoon S.O., Saeki Y.
    J. Biol. Chem. 282:10506-10515(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiGPR6_RAT
AccessioniPrimary (citable) accession number: P51651
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi