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P51651 (GPR6_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G-protein coupled receptor 6
Alternative name(s):
Sphingosine 1-phosphate receptor GPR6
Gene names
Name:Gpr6
Synonyms:Cnl3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons. Ref.3

Subcellular location

Cell membrane; Multi-pass membrane protein Probable. Note: Detected in the intracellular compartments. It is currently unclear whether this is a cell surface or intracellular receptor By similarity.

Tissue specificity

Expressed in the brain, with a prominent distribution in striatum. Ref.1

Developmental stage

Abundantly expressed in granule neurons at all developmental stages. Ref.3

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363G-protein coupled receptor 6
PRO_0000069516

Regions

Topological domain1 – 7575Extracellular Potential
Transmembrane76 – 9520Helical; Name=1; Potential
Topological domain96 – 10712Cytoplasmic Potential
Transmembrane108 – 13124Helical; Name=2; Potential
Topological domain132 – 14312Extracellular Potential
Transmembrane144 – 16522Helical; Name=3; Potential
Topological domain166 – 18621Cytoplasmic Potential
Transmembrane187 – 20620Helical; Name=4; Potential
Topological domain207 – 23125Extracellular Potential
Transmembrane232 – 25019Helical; Name=5; Potential
Topological domain251 – 27828Cytoplasmic Potential
Transmembrane279 – 30527Helical; Name=6; Potential
Topological domain306 – 3105Extracellular Potential
Transmembrane311 – 33222Helical; Name=7; Potential
Topological domain333 – 36331Cytoplasmic Potential
Compositional bias21 – 288Poly-Ala
Compositional bias46 – 505Poly-Gly

Amino acid modifications

Modified residue3571Phosphoserine Potential
Modified residue3591Phosphoserine Potential
Modified residue3611Phosphoserine Potential
Lipidation3461S-palmitoyl cysteine By similarity
Glycosylation21N-linked (GlcNAc...) Potential
Glycosylation91N-linked (GlcNAc...) Potential
Glycosylation521N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P51651 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 4B2E665C0BAB2B78

FASTA36338,115
        10         20         30         40         50         60 
MNASAAALNE SQVVAVAAEG AAAAATAAGT PDTSEWGPPA ASAALGGGGG PNGSLELSSQ 

        70         80         90        100        110        120 
LPAGPSGLLL SAVNPWDVLL CVSGTVIAGE NALVVALIAS TPALRTPMFV LVGSLATADL 

       130        140        150        160        170        180 
LAGCGLILHF VFQYVVPSET VSLLMVGFLV ASFAASVSSL LAITVDRYLS LYNALTYYSR 

       190        200        210        220        230        240 
RTLLGVHLLL AATWTVSLGL GLLPVLGWNC LADRASCSVV RPLTRSHVAL LSTSFFVVFG 

       250        260        270        280        290        300 
IMLHLYVRIC QVVWRHAHQI ALQQHCLAPP HLAATRKGVG TLAVVLGTFG ASWLPFAIYC 

       310        320        330        340        350        360 
VVGSQEDPAI YTYATLLPAT YNSMINPIIY AFRNQEIQRA LWLLFCGCFQ SKVPFRSRSP 


SEV 

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References

[1]"Molecular cloning of a novel candidate G protein-coupled receptor from rat brain."
Song Z.-H., Young W.S. III, Brownstein M.J., Bonner T.I.
FEBS Lett. 351:375-379(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Brain cortex.
[2]"Temporally and spatially regulated expression of a candidate G-protein-coupled receptor during cerebral cortical development."
Chenn A., Levin M.E., McConnell S.K.
J. Neurobiol. 46:167-177(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[3]"Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth."
Tanaka S., Ishii K., Kasai K., Yoon S.O., Saeki Y.
J. Biol. Chem. 282:10506-10515(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DEVELOPMENTAL STAGE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U12006 mRNA. Translation: AAA21870.1.
AF064706 mRNA. Translation: AAC16886.1.
PIRS48697.
RefSeqNP_113994.1. NM_031806.1.
UniGeneRn.32092.

3D structure databases

ProteinModelPortalP51651.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY85.

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000073276; ENSRNOP00000067254; ENSRNOG00000049580.
GeneID83683.
KEGGrno:83683.

Organism-specific databases

CTD2830.
RGD70939. Gpr6.

Phylogenomic databases

GeneTreeENSGT00750000117639.
HOVERGENHBG079561.
KOK04313.
OMACGCFQSK.
OrthoDBEOG7966H0.
PhylomeDBP51651.

Gene expression databases

GenevestigatorP51651.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001151. GPR6.
IPR000723. GPR_3/6/12_orphan.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00649. GPR6ORPHANR.
PR00644. GPRORPHANR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio616241.
PROP51651.

Entry information

Entry nameGPR6_RAT
AccessionPrimary (citable) accession number: P51651
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries