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Protein

Succinate-semialdehyde dehydrogenase, mitochondrial

Gene

Aldh5a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).By similarity

Catalytic activityi

Succinate semialdehyde + NAD+ + H2O = succinate + NADH.

Enzyme regulationi

Redox-regulated. Inhibited under oxydizing conditions (By similarity).By similarity

Pathwayi: 4-aminobutanoate degradation

This protein is involved in the pathway 4-aminobutanoate degradation, which is part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the pathway 4-aminobutanoate degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei193Transition state stabilizerBy similarity1
Binding sitei201NADBy similarity1
Binding sitei201SubstrateBy similarity1
Active sitei294Proton acceptorPROSITE-ProRule annotation1
Binding sitei322SubstrateBy similarity1
Active sitei328NucleophilePROSITE-ProRule annotation1
Binding sitei486SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi216 – 219NADBy similarity4
Nucleotide bindingi272 – 277NADBy similarity6

GO - Molecular functioni

  • carboxylic acid binding Source: RGD
  • NAD binding Source: RGD
  • succinate-semialdehyde dehydrogenase (NAD+) activity Source: UniProtKB
  • succinate-semialdehyde dehydrogenase [NAD(P)+] activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BRENDAi1.2.1.3 5301
SABIO-RKiP51650
UniPathwayiUPA00733

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate-semialdehyde dehydrogenase, mitochondrial (EC:1.2.1.24)
Alternative name(s):
Aldehyde dehydrogenase family 5 member A1
NAD(+)-dependent succinic semialdehyde dehydrogenase
Gene namesi
Name:Aldh5a1
Synonyms:Ssadh
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi621422 Aldh5a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 35Mitochondrion2 PublicationsAdd BLAST35
ChainiPRO_000005656736 – 523Succinate-semialdehyde dehydrogenase, mitochondrialAdd BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei114N6-acetyllysine; alternateBy similarity1
Modified residuei114N6-succinyllysine; alternateBy similarity1
Modified residuei123N6-succinyllysineBy similarity1
Modified residuei172N6-succinyllysineBy similarity1
Modified residuei253N6-acetyllysine; alternateBy similarity1
Modified residuei253N6-succinyllysine; alternateBy similarity1
Disulfide bondi328 ↔ 330In inhibited formBy similarity
Modified residuei353N6-acetyllysineBy similarity1
Modified residuei390N6-succinyllysineBy similarity1
Modified residuei399N6-acetyllysineBy similarity1
Modified residuei487PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP51650
PeptideAtlasiP51650
PRIDEiP51650

2D gel databases

World-2DPAGEi0004:P51650

PTM databases

iPTMnetiP51650
PhosphoSitePlusiP51650

Expressioni

Tissue specificityi

Brain, pancreas, heart, liver, skeletal muscle, kidney. Lower in spleen, lung, kidney and testis.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000035601

Structurei

3D structure databases

ProteinModelPortaliP51650
SMRiP51650
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2451 Eukaryota
COG1012 LUCA
HOGENOMiHOG000271509
HOVERGENiHBG108515
InParanoidiP51650
PhylomeDBiP51650

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR010102 Succ_semiAld_DH
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR01780 SSADH, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P51650-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATCFLLRNF CAARPALRPP GRLLREPAGA QRRSYVGGPA DLHADLLRGD
60 70 80 90 100
SFVGGRWLPT PATFPVYDPA SGAKLGTVAD CGVPEARAAV RAAYDAFSSW
110 120 130 140 150
KEISVKERSS LLRKWYDLMI QNKDELAKII TAESGKPLKE AQGEILYSAF
160 170 180 190 200
FLEWFSEEAR RVYGDIIYTS AKDKRGLVLK QPVGVASIIT PWNFPSAMIT
210 220 230 240 250
RKVGAALAAG CTVVVKPAED TPYSALALAQ LANQAGIPPG VYNVIPCSRT
260 270 280 290 300
KAKEVGEVLC TDPLVSKISF TGSTATGKIL LHHAANSVKR VSMELGGLAP
310 320 330 340 350
FIVFDSANVD QAVAGAMASK FRNAGQTCVC SNRFLVQRGI HDSFVTKFAE
360 370 380 390 400
AMKKSLRVGN GFEEGTTQGP LINEKAVEKV EKHVNDAVAK GATVVTGGKR
410 420 430 440 450
HQSGGNFFEP TLLSNVTRDM LCITEETFGP VAPVIKFDKE EEAVAIANAA
460 470 480 490 500
DVGLAGYFYS QDPAQIWRVA EQLEVGMVGV NEGLISSVEC PFGGVKQSGL
510 520
GREGSKYGID EYLEVKYVCY GGL
Length:523
Mass (Da):56,131
Last modified:April 8, 2008 - v2
Checksum:i4CA521139C9FA98F
GO
Isoform Short (identifier: P51650-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-134: Missing.

Note: No experimental confirmation available.
Show »
Length:495
Mass (Da):52,798
Checksum:iFC69A1D9215CEF5F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001284107 – 134Missing in isoform Short. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03105019 Genomic DNA No translation available.
L34821 mRNA Translation: AAA67058.1
PIRiI61704
UniGeneiRn.10070

Genome annotation databases

UCSCiRGD:621422 rat [P51650-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSSDH_RAT
AccessioniPrimary (citable) accession number: P51650
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 8, 2008
Last modified: May 23, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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