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Protein

ADP-ribosylation factor-like protein 5A

Gene

Arl5a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Lacks ADP-ribosylation enhancing activity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei159GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi23 – 30GTPBy similarity8
Nucleotide bindingi66 – 70GTPBy similarity5
Nucleotide bindingi125 – 128GTPBy similarity4

GO - Molecular functioni

  • GTP binding Source: RGD

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 5A
Gene namesi
Name:Arl5a
Synonyms:Arl5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi621327. Arl5a.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002074692 – 179ADP-ribosylation factor-like protein 5AAdd BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP51646.
PRIDEiP51646.

PTM databases

PhosphoSitePlusiP51646.

Expressioni

Tissue specificityi

Low amounts were found in most tissues examined with highest levels in brain, intestine and thymus.

Gene expression databases

BgeeiENSRNOG00000006839.
GenevisibleiP51646. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009181.

Structurei

3D structure databases

ProteinModelPortaliP51646.
SMRiP51646.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00880000137944.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiP51646.
KOiK07949.
OMAiDVKGCMS.
OrthoDBiEOG091G0W92.
PhylomeDBiP51646.
TreeFamiTF105465.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
PfamiView protein in Pfam
PF00025. Arf. 1 hit.
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51417. ARF. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51646-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGILFTRIWR LFNHQEHKVI IVGLDNAGKT TILYQFSMNE VVHTSPTIGS
60 70 80 90 100
NVEEIVVNNT RFLMWDIGGQ ESLRSSWNTY YTNTEFVIVV VDSTDRERIS
110 120 130 140 150
VTREELYKML AHEDLRKAGL LIFANKQDVK ECMTVAEISQ FLKLTSIKDH
160 170
QWHIQACCAL TGEGLCQGLE WMMSRLKIR
Length:179
Mass (Da):20,714
Last modified:October 1, 1996 - v1
Checksum:i518CCBCF928CB9D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78604 mRNA. Translation: CAA55338.1.
BC097294 mRNA. Translation: AAH97294.1.
PIRiS72161.
RefSeqiNP_446431.1. NM_053979.2.
UniGeneiRn.2803.

Genome annotation databases

EnsembliENSRNOT00000009181; ENSRNOP00000009181; ENSRNOG00000006839.
GeneIDi117050.
KEGGirno:117050.
UCSCiRGD:621327. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiARL5A_RAT
AccessioniPrimary (citable) accession number: P51646
Secondary accession number(s): Q4V8N2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 7, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families