ID CNTF_MOUSE Reviewed; 198 AA. AC P51642; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 1. DT 24-JAN-2024, entry version 162. DE RecName: Full=Ciliary neurotrophic factor; DE Short=CNTF; GN Name=Cntf; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Testis; RX PubMed=7835706; DOI=10.1016/0378-1119(94)00717-7; RA Saotome Y., Winter C.G., Hirsh D.; RT "A widely expressed novel C2H2 zinc-finger protein with multiple consensus RT phosphorylation sites is conserved in mouse and man."; RL Gene 152:233-238(1995). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Thymus; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: CNTF is a survival factor for various neuronal cell types. CC Seems to prevent the degeneration of motor axons after axotomy. CC -!- SUBCELLULAR LOCATION: Cytoplasm. CC -!- TISSUE SPECIFICITY: Nervous system. CC -!- SIMILARITY: Belongs to the CNTF family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U05342; AAA81912.1; -; mRNA. DR EMBL; BC027539; AAH27539.1; -; mRNA. DR CCDS; CCDS29637.1; -. DR PIR; I48723; I48723. DR RefSeq; NP_740756.1; NM_170786.2. DR AlphaFoldDB; P51642; -. DR SMR; P51642; -. DR BioGRID; 198795; 3. DR STRING; 10090.ENSMUSP00000108555; -. DR iPTMnet; P51642; -. DR PhosphoSitePlus; P51642; -. DR PaxDb; 10090-ENSMUSP00000108555; -. DR ProteomicsDB; 283584; -. DR Antibodypedia; 34925; 697 antibodies from 41 providers. DR DNASU; 12803; -. DR Ensembl; ENSMUST00000112933.2; ENSMUSP00000108555.2; ENSMUSG00000079415.3. DR GeneID; 12803; -. DR KEGG; mmu:12803; -. DR UCSC; uc008gun.1; mouse. DR AGR; MGI:88439; -. DR CTD; 1270; -. DR MGI; MGI:88439; Cntf. DR VEuPathDB; HostDB:ENSMUSG00000079415; -. DR eggNOG; ENOG502S4XX; Eukaryota. DR GeneTree; ENSGT00420000029890; -. DR HOGENOM; CLU_118647_0_0_1; -. DR InParanoid; P51642; -. DR OMA; RWSEMTE; -. DR OrthoDB; 4215903at2759; -. DR PhylomeDB; P51642; -. DR TreeFam; TF336237; -. DR Reactome; R-MMU-6788467; IL-6-type cytokine receptor ligand interactions. DR BioGRID-ORCS; 12803; 2 hits in 77 CRISPR screens. DR ChiTaRS; Gm44505; mouse. DR PRO; PR:P51642; -. DR Proteomes; UP000000589; Chromosome 19. DR RNAct; P51642; Protein. DR Bgee; ENSMUSG00000079415; Expressed in lens of camera-type eye and 77 other cell types or tissues. DR ExpressionAtlas; P51642; baseline and differential. DR GO; GO:0030424; C:axon; ISO:MGI. DR GO; GO:0005615; C:extracellular space; IDA:MGI. DR GO; GO:0097386; C:glial cell projection; ISO:MGI. DR GO; GO:0043025; C:neuronal cell body; ISO:MGI. DR GO; GO:0032838; C:plasma membrane bounded cell projection cytoplasm; ISO:MGI. DR GO; GO:0005127; F:ciliary neurotrophic factor receptor binding; ISO:MGI. DR GO; GO:0005125; F:cytokine activity; ISO:MGI. DR GO; GO:0008083; F:growth factor activity; ISO:MGI. DR GO; GO:0005138; F:interleukin-6 receptor binding; ISO:MGI. DR GO; GO:0044877; F:protein-containing complex binding; ISO:MGI. DR GO; GO:0048143; P:astrocyte activation; ISO:MGI. DR GO; GO:0031103; P:axon regeneration; ISO:MGI. DR GO; GO:0070120; P:ciliary neurotrophic factor-mediated signaling pathway; ISO:MGI. DR GO; GO:0060081; P:membrane hyperpolarization; ISO:MGI. DR GO; GO:0048644; P:muscle organ morphogenesis; IGI:MGI. DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISO:MGI. DR GO; GO:0046533; P:negative regulation of photoreceptor cell differentiation; IDA:MGI. DR GO; GO:0007399; P:nervous system development; ISO:MGI. DR GO; GO:0048666; P:neuron development; IGI:MGI. DR GO; GO:0048680; P:positive regulation of axon regeneration; ISO:MGI. DR GO; GO:0030307; P:positive regulation of cell growth; ISO:MGI. DR GO; GO:0008284; P:positive regulation of cell population proliferation; IGI:MGI. DR GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI. DR GO; GO:0046887; P:positive regulation of hormone secretion; ISO:MGI. DR GO; GO:0043410; P:positive regulation of MAPK cascade; ISO:MGI. DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; ISO:MGI. DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; ISO:MGI. DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IDA:MGI. DR GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; ISO:MGI. DR GO; GO:0060075; P:regulation of resting membrane potential; ISO:MGI. DR GO; GO:0046668; P:regulation of retinal cell programmed cell death; IDA:MGI. DR GO; GO:0060221; P:retinal rod cell differentiation; IDA:MGI. DR Gene3D; 1.20.1250.10; -; 1. DR InterPro; IPR009079; 4_helix_cytokine-like_core. DR InterPro; IPR000151; Ciliary_neurotrophic_fac_CNTF. DR PANTHER; PTHR15196; CILIARY NEUROTROPHIC FACTOR; 1. DR PANTHER; PTHR15196:SF0; CILIARY NEUROTROPHIC FACTOR; 1. DR Pfam; PF01110; CNTF; 1. DR SUPFAM; SSF47266; 4-helical cytokines; 1. DR Genevisible; P51642; MM. PE 2: Evidence at transcript level; KW Cytoplasm; Developmental protein; Differentiation; Growth factor; KW Neurogenesis; Reference proteome. FT CHAIN 1..198 FT /note="Ciliary neurotrophic factor" FT /id="PRO_0000149520" SQ SEQUENCE 198 AA; 22587 MW; 4EB03E7455653667 CRC64; MAFAEQSPLT LHRRDLCSRS IWLARKIRSD LTALMESYVK HQGLNKNISL DSVDGVPVAS TDRWSEMTEA ERLQENLQAY RTFQGMLTKL LEDQRVHFTP TEGDFHQAIH TLTLQVSAFA YQLEELMALL EQKVPEKEAD GMPVTIGDGG LFEKKLWGLK VLQELSQWTV RSIHDLRVIS SHHMGISAHE SHYGAKQM //