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Protein

Ciliary neurotrophic factor

Gene

Cntf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.

GO - Molecular functioni

  1. growth factor activity Source: MGI
  2. interleukin-6 receptor binding Source: MGI

GO - Biological processi

  1. ciliary neurotrophic factor-mediated signaling pathway Source: MGI
  2. growth Source: InterPro
  3. muscle organ morphogenesis Source: MGI
  4. negative regulation of neuron apoptotic process Source: MGI
  5. negative regulation of photoreceptor cell differentiation Source: MGI
  6. neuron development Source: MGI
  7. positive regulation of cell proliferation Source: MGI
  8. positive regulation of tyrosine phosphorylation of Stat3 protein Source: MGI
  9. regulation of retinal cell programmed cell death Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Ciliary neurotrophic factor
Short name:
CNTF
Gene namesi
Name:Cntf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:88439. Cntf.

Subcellular locationi

GO - Cellular componenti

  1. CRLF-CLCF1 complex Source: Ensembl
  2. cytoplasm Source: UniProtKB-SubCell
  3. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198Ciliary neurotrophic factorPRO_0000149520Add
BLAST

Proteomic databases

MaxQBiP51642.
PRIDEiP51642.

PTM databases

PhosphoSiteiP51642.

Expressioni

Tissue specificityi

Nervous system.

Gene expression databases

BgeeiP51642.
ExpressionAtlasiP51642. baseline.
GenevestigatoriP51642.

Interactioni

Protein-protein interaction databases

BioGridi198795. 3 interactions.
STRINGi10090.ENSMUSP00000108555.

Structurei

3D structure databases

ProteinModelPortaliP51642.
SMRiP51642. Positions 12-182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CNTF family.Curated

Phylogenomic databases

eggNOGiNOG114783.
HOGENOMiHOG000059605.
HOVERGENiHBG005362.
InParanoidiP51642.
KOiK05420.
OMAiKLWGLKV.
OrthoDBiEOG700893.
PhylomeDBiP51642.
TreeFamiTF336237.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000151. Ciliary_neurotrophic_fac_CNTF.
[Graphical view]
PfamiPF01110. CNTF. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

P51642-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFAEQSPLT LHRRDLCSRS IWLARKIRSD LTALMESYVK HQGLNKNISL
60 70 80 90 100
DSVDGVPVAS TDRWSEMTEA ERLQENLQAY RTFQGMLTKL LEDQRVHFTP
110 120 130 140 150
TEGDFHQAIH TLTLQVSAFA YQLEELMALL EQKVPEKEAD GMPVTIGDGG
160 170 180 190
LFEKKLWGLK VLQELSQWTV RSIHDLRVIS SHHMGISAHE SHYGAKQM
Length:198
Mass (Da):22,587
Last modified:October 1, 1996 - v1
Checksum:i4EB03E7455653667
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05342 mRNA. Translation: AAA81912.1.
BC027539 mRNA. Translation: AAH27539.1.
CCDSiCCDS29637.1.
PIRiI48723.
RefSeqiNP_740756.1. NM_170786.2.
UniGeneiMm.290924.

Genome annotation databases

EnsembliENSMUST00000112933; ENSMUSP00000108555; ENSMUSG00000079415.
GeneIDi12803.
KEGGimmu:12803.
UCSCiuc008gun.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05342 mRNA. Translation: AAA81912.1.
BC027539 mRNA. Translation: AAH27539.1.
CCDSiCCDS29637.1.
PIRiI48723.
RefSeqiNP_740756.1. NM_170786.2.
UniGeneiMm.290924.

3D structure databases

ProteinModelPortaliP51642.
SMRiP51642. Positions 12-182.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198795. 3 interactions.
STRINGi10090.ENSMUSP00000108555.

PTM databases

PhosphoSiteiP51642.

Proteomic databases

MaxQBiP51642.
PRIDEiP51642.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112933; ENSMUSP00000108555; ENSMUSG00000079415.
GeneIDi12803.
KEGGimmu:12803.
UCSCiuc008gun.1. mouse.

Organism-specific databases

CTDi1270.
MGIiMGI:88439. Cntf.

Phylogenomic databases

eggNOGiNOG114783.
HOGENOMiHOG000059605.
HOVERGENiHBG005362.
InParanoidiP51642.
KOiK05420.
OMAiKLWGLKV.
OrthoDBiEOG700893.
PhylomeDBiP51642.
TreeFamiTF336237.

Miscellaneous databases

NextBioi282234.
PROiP51642.
SOURCEiSearch...

Gene expression databases

BgeeiP51642.
ExpressionAtlasiP51642. baseline.
GenevestigatoriP51642.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000151. Ciliary_neurotrophic_fac_CNTF.
[Graphical view]
PfamiPF01110. CNTF. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A widely expressed novel C2H2 zinc-finger protein with multiple consensus phosphorylation sites is conserved in mouse and man."
    Saotome Y., Winter C.G., Hirsh D.
    Gene 152:233-238(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.

Entry informationi

Entry nameiCNTF_MOUSE
AccessioniPrimary (citable) accession number: P51642
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 4, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.