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P51642 (CNTF_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ciliary neurotrophic factor

Short name=CNTF
Gene names
Name:Cntf
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.

Subcellular location

Cytoplasm.

Tissue specificity

Nervous system.

Sequence similarities

Belongs to the CNTF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 198198Ciliary neurotrophic factor
PRO_0000149520

Sequences

Sequence LengthMass (Da)Tools
P51642 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 4EB03E7455653667

FASTA19822,587
        10         20         30         40         50         60 
MAFAEQSPLT LHRRDLCSRS IWLARKIRSD LTALMESYVK HQGLNKNISL DSVDGVPVAS 

        70         80         90        100        110        120 
TDRWSEMTEA ERLQENLQAY RTFQGMLTKL LEDQRVHFTP TEGDFHQAIH TLTLQVSAFA 

       130        140        150        160        170        180 
YQLEELMALL EQKVPEKEAD GMPVTIGDGG LFEKKLWGLK VLQELSQWTV RSIHDLRVIS 

       190 
SHHMGISAHE SHYGAKQM 

« Hide

References

« Hide 'large scale' references
[1]"A widely expressed novel C2H2 zinc-finger protein with multiple consensus phosphorylation sites is conserved in mouse and man."
Saotome Y., Winter C.G., Hirsh D.
Gene 152:233-238(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Thymus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U05342 mRNA. Translation: AAA81912.1.
BC027539 mRNA. Translation: AAH27539.1.
PIRI48723.
RefSeqNP_740756.1. NM_170786.2.
UniGeneMm.290924.

3D structure databases

ProteinModelPortalP51642.
SMRP51642. Positions 12-182.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198795. 3 interactions.
STRING10090.ENSMUSP00000108555.

PTM databases

PhosphoSiteP51642.

Proteomic databases

PRIDEP51642.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000112933; ENSMUSP00000108555; ENSMUSG00000079415.
GeneID12803.
KEGGmmu:12803.
UCSCuc008gun.1. mouse.

Organism-specific databases

CTD1270.
MGIMGI:88439. Cntf.

Phylogenomic databases

eggNOGNOG114783.
HOGENOMHOG000059605.
HOVERGENHBG005362.
InParanoidP51642.
KOK05420.
OMAKLWGLKV.
OrthoDBEOG700893.
PhylomeDBP51642.
TreeFamTF336237.

Gene expression databases

BgeeP51642.
GenevestigatorP51642.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000151. Ciliary_neurotrophic_fac_CNTF.
[Graphical view]
PfamPF01110. CNTF. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
ProtoNetSearch...

Other

NextBio282234.
PROP51642.
SOURCESearch...

Entry information

Entry nameCNTF_MOUSE
AccessionPrimary (citable) accession number: P51642
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot