P51642 (CNTF_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ciliary neurotrophic factor
Short name=CNTF

Gene names

Name:

Cntf

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
Subcellular location	Cytoplasm.
Tissue specificity	Nervous system.
Sequence similarities	Belongs to the CNTF family.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Cytoplasm
Molecular function	Developmental protein Growth factor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ciliary neurotrophic factor-mediated signaling pathway Inferred from electronic annotation. Source: Compara growth Inferred from electronic annotation. Source: InterPro muscle organ morphogenesis Inferred from genetic interaction PubMed 15716414. Source: MGI negative regulation of neuron apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of photoreceptor cell differentiation Inferred from direct assay PubMed 15207851. Source: MGI neuron development Inferred from genetic interaction PubMed 15716414. Source: MGI positive regulation of cell proliferation Inferred from genetic interaction PubMed 15051883. Source: MGI positive regulation of tyrosine phosphorylation of Stat3 protein Inferred from direct assay PubMed 15207851. Source: MGI regulation of retinal cell programmed cell death Inferred from direct assay PubMed 11747369. Source: MGI
Cellular_component	CRLF-CLCF1 complex Inferred from electronic annotation. Source: Compara cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular space Inferred from direct assay PubMed 15207851. Source: MGI intracellular membrane-bounded organelle Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 198	198	Ciliary neurotrophic factor		PRO_0000149520

Sequences

	Sequence		Length	Mass (Da)
	P51642 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 4EB03E7455653667	FASTA	198	22,587
	10 20 30 40 50 60 MAFAEQSPLT LHRRDLCSRS IWLARKIRSD LTALMESYVK HQGLNKNISL DSVDGVPVAS 70 80 90 100 110 120 TDRWSEMTEA ERLQENLQAY RTFQGMLTKL LEDQRVHFTP TEGDFHQAIH TLTLQVSAFA 130 140 150 160 170 180 YQLEELMALL EQKVPEKEAD GMPVTIGDGG LFEKKLWGLK VLQELSQWTV RSIHDLRVIS 190 SHHMGISAHE SHYGAKQM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A widely expressed novel C2H2 zinc-finger protein with multiple consensus phosphorylation sites is conserved in mouse and man." Saotome Y., Winter C.G., Hirsh D. Gene 152:233-238(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Thymus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U05342 mRNA. Translation: AAA81912.1. BC027539 mRNA. Translation: AAH27539.1.
IPI	IPI00125017.
PIR	I48723.
RefSeq	NP_740756.1. NM_170786.2.
UniGene	Mm.290924.
3D structure databases
ProteinModelPortal	P51642.
SMR	P51642. Positions 12-182.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000108555.
PTM databases
PhosphoSite	P51642.
Proteomic databases
PRIDE	P51642.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000112933; ENSMUSP00000108555; ENSMUSG00000079415.
GeneID	12803.
KEGG	mmu:12803.
Organism-specific databases
CTD	1270.
MGI	MGI:88439. Cntf.
Phylogenomic databases
eggNOG	NOG114783.
HOGENOM	HOG000059605.
HOVERGEN	HBG005362.
InParanoid	P51642.
KO	K05420.
OMA	KLWGLKV.
OrthoDB	EOG4M65JM.
Gene expression databases
ArrayExpress	P51642.
Bgee	P51642.
Genevestigator	P51642.
GermOnline	ENSMUSG00000024695. Mus musculus.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR000151. Ciliary_neurotrophic_fac_CNTF. [Graphical view]
Pfam	PF01110. CNTF. 1 hit. [Graphical view]
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
ProtoNet	Search...
Other
NextBio	282234.
SOURCE	Search...

Entry information

Entry name

CNTF_MOUSE

Accession

Primary (citable) accession number: P51642

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program