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P51642

- CNTF_MOUSE

UniProt

P51642 - CNTF_MOUSE

Protein

Ciliary neurotrophic factor

Gene

Cntf

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.

    GO - Biological processi

    1. ciliary neurotrophic factor-mediated signaling pathway Source: Ensembl
    2. growth Source: InterPro
    3. muscle organ morphogenesis Source: MGI
    4. negative regulation of neuron apoptotic process Source: Ensembl
    5. negative regulation of photoreceptor cell differentiation Source: MGI
    6. neuron development Source: MGI
    7. positive regulation of cell proliferation Source: MGI
    8. positive regulation of tyrosine phosphorylation of Stat3 protein Source: MGI
    9. regulation of retinal cell programmed cell death Source: MGI

    Keywords - Molecular functioni

    Developmental protein, Growth factor

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ciliary neurotrophic factor
    Short name:
    CNTF
    Gene namesi
    Name:Cntf
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:88439. Cntf.

    Subcellular locationi

    GO - Cellular componenti

    1. CRLF-CLCF1 complex Source: Ensembl
    2. cytoplasm Source: UniProtKB-SubCell
    3. extracellular space Source: MGI
    4. intracellular membrane-bounded organelle Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 198198Ciliary neurotrophic factorPRO_0000149520Add
    BLAST

    Proteomic databases

    PRIDEiP51642.

    PTM databases

    PhosphoSiteiP51642.

    Expressioni

    Tissue specificityi

    Nervous system.

    Gene expression databases

    BgeeiP51642.
    GenevestigatoriP51642.

    Interactioni

    Protein-protein interaction databases

    BioGridi198795. 3 interactions.
    STRINGi10090.ENSMUSP00000108555.

    Structurei

    3D structure databases

    ProteinModelPortaliP51642.
    SMRiP51642. Positions 12-182.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CNTF family.Curated

    Phylogenomic databases

    eggNOGiNOG114783.
    HOGENOMiHOG000059605.
    HOVERGENiHBG005362.
    InParanoidiP51642.
    KOiK05420.
    OMAiSAHESHY.
    OrthoDBiEOG700893.
    PhylomeDBiP51642.
    TreeFamiTF336237.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000151. Ciliary_neurotrophic_fac_CNTF.
    [Graphical view]
    PfamiPF01110. CNTF. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P51642-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFAEQSPLT LHRRDLCSRS IWLARKIRSD LTALMESYVK HQGLNKNISL    50
    DSVDGVPVAS TDRWSEMTEA ERLQENLQAY RTFQGMLTKL LEDQRVHFTP 100
    TEGDFHQAIH TLTLQVSAFA YQLEELMALL EQKVPEKEAD GMPVTIGDGG 150
    LFEKKLWGLK VLQELSQWTV RSIHDLRVIS SHHMGISAHE SHYGAKQM 198
    Length:198
    Mass (Da):22,587
    Last modified:October 1, 1996 - v1
    Checksum:i4EB03E7455653667
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U05342 mRNA. Translation: AAA81912.1.
    BC027539 mRNA. Translation: AAH27539.1.
    CCDSiCCDS29637.1.
    PIRiI48723.
    RefSeqiNP_740756.1. NM_170786.2.
    UniGeneiMm.290924.

    Genome annotation databases

    EnsembliENSMUST00000112933; ENSMUSP00000108555; ENSMUSG00000079415.
    GeneIDi12803.
    KEGGimmu:12803.
    UCSCiuc008gun.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U05342 mRNA. Translation: AAA81912.1 .
    BC027539 mRNA. Translation: AAH27539.1 .
    CCDSi CCDS29637.1.
    PIRi I48723.
    RefSeqi NP_740756.1. NM_170786.2.
    UniGenei Mm.290924.

    3D structure databases

    ProteinModelPortali P51642.
    SMRi P51642. Positions 12-182.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198795. 3 interactions.
    STRINGi 10090.ENSMUSP00000108555.

    PTM databases

    PhosphoSitei P51642.

    Proteomic databases

    PRIDEi P51642.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000112933 ; ENSMUSP00000108555 ; ENSMUSG00000079415 .
    GeneIDi 12803.
    KEGGi mmu:12803.
    UCSCi uc008gun.1. mouse.

    Organism-specific databases

    CTDi 1270.
    MGIi MGI:88439. Cntf.

    Phylogenomic databases

    eggNOGi NOG114783.
    HOGENOMi HOG000059605.
    HOVERGENi HBG005362.
    InParanoidi P51642.
    KOi K05420.
    OMAi SAHESHY.
    OrthoDBi EOG700893.
    PhylomeDBi P51642.
    TreeFami TF336237.

    Miscellaneous databases

    NextBioi 282234.
    PROi P51642.
    SOURCEi Search...

    Gene expression databases

    Bgeei P51642.
    Genevestigatori P51642.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000151. Ciliary_neurotrophic_fac_CNTF.
    [Graphical view ]
    Pfami PF01110. CNTF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A widely expressed novel C2H2 zinc-finger protein with multiple consensus phosphorylation sites is conserved in mouse and man."
      Saotome Y., Winter C.G., Hirsh D.
      Gene 152:233-238(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Thymus.

    Entry informationi

    Entry nameiCNTF_MOUSE
    AccessioniPrimary (citable) accession number: P51642
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3