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Protein

Ciliary neurotrophic factor receptor subunit alpha

Gene

CNTFR

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to CNTF (GPA). The alpha subunit provides the receptor specificity.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-GGA-6788467. IL-6-type cytokine receptor ligand interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Ciliary neurotrophic factor receptor subunit alpha
Short name:
CNTF receptor subunit alpha
Short name:
CNTFR-alpha
Alternative name(s):
Growth-promoting activity receptor subunit alpha
Short name:
GPA receptor subunit alpha
Short name:
GPAR-alpha
Gene namesi
Name:CNTFR
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001099720 – 334Ciliary neurotrophic factor receptor subunit alphaAdd BLAST315
PropeptideiPRO_0000010998335 – 362Removed in mature formSequence analysisAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 87PROSITE-ProRule annotation
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi140N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi334GPI-anchor amidated aspartateSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Expressioni

Tissue specificityi

Highly expressed in nervous system. Also found in skeletal muscle.

Gene expression databases

BgeeiENSGALG00000028140.

Interactioni

Subunit structurei

Heterotrimer of the alpha subunit, LIFR and IL6ST.

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP51641.
SMRiP51641.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 103Ig-like C2-typeAdd BLAST81
Domaini106 – 203Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST98
Domaini204 – 304Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST101

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi288 – 292WSXWS motif5

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

HOVERGENiHBG051048.
InParanoidiP51641.
KOiK05059.
OMAiQETPHVQ.
OrthoDBiEOG091G0B8P.
PhylomeDBiP51641.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 3 hits.
InterProiView protein in InterPro
IPR003961. FN3_dom.
IPR036116. FN3_sf.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
PfamiView protein in Pfam
PF00041. fn3. 1 hit.
SMARTiView protein in SMART
SM00060. FN3. 1 hit.
SM00408. IGc2. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
PROSITEiView protein in PROSITE
PS50853. FN3. 2 hits.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51641-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANPVPSACC VVLAAVVVVY AQRHSQQDSH IQYERVGADV TMKCGSMDWD
60 70 80 90 100
AAVTWTANGT DIDDSHLNGS YLILKNVDLT QSGQYSCYEG SSWHLKYQTY
110 120 130 140 150
LRVGVPPKEP VLMCRSNNYP KGFYCSWHLP SPTYIPNSFN ISVIHGTREM
160 170 180 190 200
VCEKDIFPKN RCHIRYLQLF STVKYKVTLT VTNALGKNST TLTFDEFAIV
210 220 230 240 250
KPDPPESVVA KPVPNNPRRL EVSWQNPSSW PDPESFPLKF FLRYRPLILD
260 270 280 290 300
QWQHVELSDG TSHTITDAYA GKEYIIQVAA KDNDIGTWSD WSVAVHATPW
310 320 330 340 350
TEEPKHLTTE VQITETTSTS TSSFMPPPTT KICDKGAGVG SGAVAVCWTA
360
GLVLAAYGVL FI
Length:362
Mass (Da):40,308
Last modified:October 1, 1996 - v1
Checksum:i5A90217EB48419F7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti337A → V in CAA88184 (PubMed:7671828).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29245 mRNA. Translation: AAA87838.1.
Z48168 mRNA. Translation: CAA88184.1.
PIRiS60614.
RefSeqiNP_990359.1. NM_205028.1.
UniGeneiGga.522.

Genome annotation databases

GeneIDi395885.
KEGGigga:395885.

Similar proteinsi

Entry informationi

Entry nameiCNTFR_CHICK
AccessioniPrimary (citable) accession number: P51641
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 25, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families