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Protein

Caveolin-3

Gene

Cav3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity).By similarity

GO - Molecular functioni

  • calcium channel regulator activity Source: Ensembl
  • enzyme binding Source: RGD
  • ion channel binding Source: BHF-UCL
  • nitric-oxide synthase binding Source: RGD
  • potassium channel inhibitor activity Source: BHF-UCL
  • protein complex scaffold Source: RGD
  • sodium channel regulator activity Source: Ensembl

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-445355. Smooth Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolin-3
Gene namesi
Name:Cav3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi2281. Cav3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8383CytoplasmicSequence analysisAdd
BLAST
Intramembranei84 – 10421HelicalSequence analysisAdd
BLAST
Topological domaini105 – 15147CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • caveola Source: BHF-UCL
  • cell surface Source: RGD
  • cytoplasm Source: RGD
  • dystrophin-associated glycoprotein complex Source: Ensembl
  • endoplasmic reticulum Source: Ensembl
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: RGD
  • neuromuscular junction Source: RGD
  • plasma membrane Source: MGI
  • protein complex Source: RGD
  • sarcolemma Source: RGD
  • T-tubule Source: RGD
  • vesicle Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 151151Caveolin-3PRO_0000144142Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki38 – 38Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO3)By similarity

Post-translational modificationi

Sumoylation with SUMO3 by PIAS4 may reduce agonist-induced internalization and desensitization of adrenergic receptor ABRD2.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiP51638.
PRIDEiP51638.

PTM databases

iPTMnetiP51638.
PhosphoSiteiP51638.

Expressioni

Tissue specificityi

Expressed predominantly in muscle.

Gene expression databases

GenevisibleiP51638. RN.

Interactioni

Subunit structurei

Homooligomer (By similarity). Interacts with DYSF. Interacts with DLG1 and KCNA5; forms a ternary complex. Interacts with DAG1 (via its C-terminal); the interaction prevents binding of DAG1 with DMD (By similarity). Interacts with TRIM72. Interacts with MUSK; may regulate MUSK signaling (By similarity). Interacts with BVES (By similarity).By similarity1 Publication

GO - Molecular functioni

  • enzyme binding Source: RGD
  • ion channel binding Source: BHF-UCL
  • nitric-oxide synthase binding Source: RGD
  • protein complex scaffold Source: RGD

Protein-protein interaction databases

BioGridi247843. 4 interactions.
IntActiP51638. 1 interaction.
MINTiMINT-145738.
STRINGi10116.ENSRNOP00000007601.

Family & Domainsi

Sequence similaritiesi

Belongs to the caveolin family.Curated

Phylogenomic databases

eggNOGiENOG410IXSQ. Eukaryota.
ENOG41121CB. LUCA.
GeneTreeiENSGT00390000014924.
HOGENOMiHOG000036550.
HOVERGENiHBG003422.
InParanoidiP51638.
KOiK12959.
OMAiVKDIHFK.
OrthoDBiEOG7V1FSD.
PhylomeDBiP51638.
TreeFamiTF315736.

Family and domain databases

InterProiIPR031091. CAV-3.
IPR001612. Caveolin.
IPR018361. Caveolin_CS.
[Graphical view]
PANTHERiPTHR10844. PTHR10844. 1 hit.
PTHR10844:SF16. PTHR10844:SF16. 1 hit.
PfamiPF01146. Caveolin. 1 hit.
[Graphical view]
PROSITEiPS01210. CAVEOLIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51638-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTEEHTDLE ARIIKDIHCK EIDLVNRDPK NINEDIVKVD FEDVIAEPEG
60 70 80 90 100
TYSFDGVWRV SYTTFTVSKY WCYRLLSTLL GVPLALLWGF LFACISFCHI
110 120 130 140 150
WAVVPCIKSY LIEIQCISHI YSLCIRTFCN PLFAALGQVC SNIKVVLRRE

G
Length:151
Mass (Da):17,402
Last modified:October 1, 1996 - v1
Checksum:iA822A33EF9AA668F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31968 mRNA. Translation: AAC52377.1.
BC084692 mRNA. Translation: AAH84692.1.
RefSeqiNP_062028.1. NM_019155.2.
UniGeneiRn.98191.

Genome annotation databases

EnsembliENSRNOT00000007601; ENSRNOP00000007601; ENSRNOG00000005798.
GeneIDi29161.
KEGGirno:29161.
UCSCiRGD:2281. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31968 mRNA. Translation: AAC52377.1.
BC084692 mRNA. Translation: AAH84692.1.
RefSeqiNP_062028.1. NM_019155.2.
UniGeneiRn.98191.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247843. 4 interactions.
IntActiP51638. 1 interaction.
MINTiMINT-145738.
STRINGi10116.ENSRNOP00000007601.

PTM databases

iPTMnetiP51638.
PhosphoSiteiP51638.

Proteomic databases

PaxDbiP51638.
PRIDEiP51638.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007601; ENSRNOP00000007601; ENSRNOG00000005798.
GeneIDi29161.
KEGGirno:29161.
UCSCiRGD:2281. rat.

Organism-specific databases

CTDi859.
RGDi2281. Cav3.

Phylogenomic databases

eggNOGiENOG410IXSQ. Eukaryota.
ENOG41121CB. LUCA.
GeneTreeiENSGT00390000014924.
HOGENOMiHOG000036550.
HOVERGENiHBG003422.
InParanoidiP51638.
KOiK12959.
OMAiVKDIHFK.
OrthoDBiEOG7V1FSD.
PhylomeDBiP51638.
TreeFamiTF315736.

Enzyme and pathway databases

ReactomeiR-RNO-445355. Smooth Muscle Contraction.

Miscellaneous databases

PROiP51638.

Gene expression databases

GenevisibleiP51638. RN.

Family and domain databases

InterProiIPR031091. CAV-3.
IPR001612. Caveolin.
IPR018361. Caveolin_CS.
[Graphical view]
PANTHERiPTHR10844. PTHR10844. 1 hit.
PTHR10844:SF16. PTHR10844:SF16. 1 hit.
PfamiPF01146. Caveolin. 1 hit.
[Graphical view]
PROSITEiPS01210. CAVEOLIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle."
    Tang Z., Scherer P.E., Okamoto T., Song K., Chu K., Kohtz D.S., Nishimoto I., Lodish H.F., Lisanti M.P.
    J. Biol. Chem. 271:2255-2261(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart muscle.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. "Caveolin-3 and SAP97 form a scaffolding protein complex that regulates the voltage-gated potassium channel Kv1.5."
    Folco E.J., Liu G.-X., Koren G.
    Am. J. Physiol. 287:H681-H690(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DLG1 AND KCNA5.

Entry informationi

Entry nameiCAV3_RAT
AccessioniPrimary (citable) accession number: P51638
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 6, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.