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P51637

- CAV3_MOUSE

UniProt

P51637 - CAV3_MOUSE

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Protein

Caveolin-3

Gene

Cav3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress.1 Publication

GO - Molecular functioni

  1. alpha-tubulin binding Source: MGI
  2. calcium channel regulator activity Source: Ensembl
  3. connexin binding Source: BHF-UCL
  4. ion channel binding Source: MGI
  5. potassium channel inhibitor activity Source: Ensembl
  6. sodium channel regulator activity Source: Ensembl

GO - Biological processi

  1. actin filament organization Source: MGI
  2. cardiac muscle cell development Source: MGI
  3. caveola assembly Source: MGI
  4. cell growth Source: Ensembl
  5. cholesterol homeostasis Source: MGI
  6. cytoplasmic microtubule organization Source: MGI
  7. endocytosis Source: MGI
  8. establishment of protein localization to plasma membrane Source: MGI
  9. glucose homeostasis Source: MGI
  10. heart trabecula formation Source: MGI
  11. membrane raft organization Source: MGI
  12. muscle cell cellular homeostasis Source: MGI
  13. myoblast fusion Source: MGI
  14. myotube differentiation Source: MGI
  15. negative regulation of calcium ion transport Source: MGI
  16. negative regulation of cardiac muscle hypertrophy Source: MGI
  17. negative regulation of cell growth involved in cardiac muscle cell development Source: Ensembl
  18. negative regulation of cell size Source: Ensembl
  19. negative regulation of MAPK cascade Source: MGI
  20. negative regulation of MAP kinase activity Source: Ensembl
  21. negative regulation of nitric-oxide synthase activity Source: MGI
  22. negative regulation of potassium ion transmembrane transport Source: Ensembl
  23. negative regulation of potassium ion transmembrane transporter activity Source: Ensembl
  24. negative regulation of protein kinase activity Source: MGI
  25. negative regulation of sarcomere organization Source: Ensembl
  26. nucleus localization Source: MGI
  27. plasma membrane organization Source: MGI
  28. plasma membrane repair Source: MGI
  29. positive regulation of caveolin-mediated endocytosis Source: Ensembl
  30. positive regulation of cell proliferation Source: Ensembl
  31. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  32. positive regulation of microtubule polymerization Source: Ensembl
  33. positive regulation of myotube differentiation Source: MGI
  34. protein localization Source: MGI
  35. protein localization to plasma membrane Source: MGI
  36. regulation of branching involved in mammary gland duct morphogenesis Source: MGI
  37. regulation of calcium ion import Source: Ensembl
  38. regulation of calcium ion transmembrane transporter activity Source: Ensembl
  39. regulation of calcium ion transport Source: MGI
  40. regulation of heart rate Source: Ensembl
  41. regulation of membrane depolarization during cardiac muscle cell action potential Source: Ensembl
  42. regulation of membrane potential Source: MGI
  43. regulation of nerve growth factor receptor activity Source: Ensembl
  44. regulation of p38MAPK cascade Source: MGI
  45. regulation of protein kinase B signaling Source: MGI
  46. regulation of signal transduction by receptor internalization Source: Ensembl
  47. regulation of skeletal muscle contraction Source: Ensembl
  48. regulation of sodium ion transmembrane transporter activity Source: Ensembl
  49. regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  50. regulation of ventricular cardiac muscle cell membrane depolarization Source: Ensembl
  51. regulation of ventricular cardiac muscle cell membrane repolarization Source: Ensembl
  52. triglyceride metabolic process Source: MGI
  53. ventricular cardiac muscle cell action potential Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolin-3
Alternative name(s):
M-caveolin
Gene namesi
Name:Cav3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:107570. Cav3.

Subcellular locationi

Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity. Membranecaveola By similarity; Peripheral membrane protein By similarity
Note: Potential hairpin-like structure in the membrane. Membrane protein of caveolae By similarity.By similarity

GO - Cellular componenti

  1. caveola Source: BHF-UCL
  2. cell surface Source: Ensembl
  3. dystrophin-associated glycoprotein complex Source: Ensembl
  4. endoplasmic reticulum Source: MGI
  5. Golgi apparatus Source: UniProtKB-KW
  6. membrane Source: MGI
  7. membrane raft Source: MGI
  8. neuromuscular junction Source: Ensembl
  9. plasma membrane Source: MGI
  10. sarcolemma Source: BHF-UCL
  11. T-tubule Source: MGI
  12. vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi27 – 271R → Q: Results in aberrent localization of TRIM72 and defects in membrane repair. 1 Publication
Mutagenesisi105 – 1051P → L: Dominant-negative mutant that induces defects in membrane repair. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 151151Caveolin-3PRO_0000144141Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki38 – 38Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO3)By similarity

Post-translational modificationi

Sumoylation with SUMO3 by PIAS4 may reduce agonist-induced internalization and desensitization of adrenergic receptor ABRD2.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiP51637.
PRIDEiP51637.

PTM databases

PhosphoSiteiP51637.

Expressioni

Tissue specificityi

Expressed predominantly in muscle.1 Publication

Gene expression databases

BgeeiP51637.
CleanExiMM_CAV3.
ExpressionAtlasiP51637. baseline and differential.
GenevestigatoriP51637.

Interactioni

Subunit structurei

Homooligomer By similarity. Interacts with DYSF. Interacts with DLG1 and KCNA5; forms a ternary complex. Interacts with DAG1 (via its C-terminal); the interaction prevents binding of DAG1 with DMD By similarity. Interacts with TRIM72. Interacts with MUSK; may regulate MUSK signaling.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Cacna1gQ5SUG43EBI-298576,EBI-6918583
Cacna1hQ6PE925EBI-298576,EBI-6918775

Protein-protein interaction databases

BioGridi198516. 8 interactions.
IntActiP51637. 5 interactions.
MINTiMINT-2982959.
STRINGi10090.ENSMUSP00000074922.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8383CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini105 – 15147CytoplasmicSequence AnalysisAdd
BLAST

Intramembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei84 – 10421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni64 – 11451Required for interaction with DAG1By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the caveolin family.Curated

Phylogenomic databases

eggNOGiNOG86001.
GeneTreeiENSGT00390000014924.
HOGENOMiHOG000036550.
HOVERGENiHBG003422.
InParanoidiP51637.
KOiK12959.
OMAiNEFETRT.
OrthoDBiEOG7V1FSD.
PhylomeDBiP51637.
TreeFamiTF315736.

Family and domain databases

InterProiIPR001612. Caveolin.
IPR018361. Caveolin_CS.
[Graphical view]
PANTHERiPTHR10844. PTHR10844. 1 hit.
PfamiPF01146. Caveolin. 1 hit.
[Graphical view]
PROSITEiPS01210. CAVEOLIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51637-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMTEEHTDLE ARIIKDIHCK EIDLVNRDPK NINEDIVKVD FEDVIAEPEG
60 70 80 90 100
TYSFDGVWKV SFTTFTVSKY WCYRLLSTLL GVPLALLWGF LFACISFCHI
110 120 130 140 150
WAVVPCIKSY LIEIQCISHI YSLCIRTFCN PLFAALGQVC SNIKVVLRRE

G
Length:151
Mass (Da):17,358
Last modified:October 1, 1996 - v1
Checksum:i7C1A181010CC60F1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U36579 mRNA. Translation: AAC52352.1.
BC024383 mRNA. Translation: AAH24383.1.
CCDSiCCDS20406.1.
PIRiS68222.
RefSeqiNP_031643.1. NM_007617.3.
UniGeneiMm.3924.

Genome annotation databases

EnsembliENSMUST00000075477; ENSMUSP00000074922; ENSMUSG00000062694.
GeneIDi12391.
KEGGimmu:12391.
UCSCiuc009dea.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U36579 mRNA. Translation: AAC52352.1 .
BC024383 mRNA. Translation: AAH24383.1 .
CCDSi CCDS20406.1.
PIRi S68222.
RefSeqi NP_031643.1. NM_007617.3.
UniGenei Mm.3924.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198516. 8 interactions.
IntActi P51637. 5 interactions.
MINTi MINT-2982959.
STRINGi 10090.ENSMUSP00000074922.

PTM databases

PhosphoSitei P51637.

Proteomic databases

PaxDbi P51637.
PRIDEi P51637.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000075477 ; ENSMUSP00000074922 ; ENSMUSG00000062694 .
GeneIDi 12391.
KEGGi mmu:12391.
UCSCi uc009dea.1. mouse.

Organism-specific databases

CTDi 859.
MGIi MGI:107570. Cav3.

Phylogenomic databases

eggNOGi NOG86001.
GeneTreei ENSGT00390000014924.
HOGENOMi HOG000036550.
HOVERGENi HBG003422.
InParanoidi P51637.
KOi K12959.
OMAi NEFETRT.
OrthoDBi EOG7V1FSD.
PhylomeDBi P51637.
TreeFami TF315736.

Miscellaneous databases

NextBioi 281130.
PROi P51637.
SOURCEi Search...

Gene expression databases

Bgeei P51637.
CleanExi MM_CAV3.
ExpressionAtlasi P51637. baseline and differential.
Genevestigatori P51637.

Family and domain databases

InterProi IPR001612. Caveolin.
IPR018361. Caveolin_CS.
[Graphical view ]
PANTHERi PTHR10844. PTHR10844. 1 hit.
Pfami PF01146. Caveolin. 1 hit.
[Graphical view ]
PROSITEi PS01210. CAVEOLIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "M-caveolin, a muscle-specific caveolin-related protein."
    Way M., Parton R.G.
    FEBS Lett. 376:108-112(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Skeletal muscle.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  3. "Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolin-3, and dysferlin."
    Cai C., Weisleder N., Ko J.-K., Komazaki S., Sunada Y., Nishi M., Takeshima H., Ma J.
    J. Biol. Chem. 284:15894-15902(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TRIM72, MUTAGENESIS OF ARG-27 AND PRO-105.
  4. "Caveolin-3 promotes nicotinic acetylcholine receptor clustering and regulates neuromuscular junction activity."
    Hezel M., de Groat W.C., Galbiati F.
    Mol. Biol. Cell 21:302-310(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MUSK.

Entry informationi

Entry nameiCAV3_MOUSE
AccessioniPrimary (citable) accession number: P51637
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3