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P51637

- CAV3_MOUSE

UniProt

P51637 - CAV3_MOUSE

Protein

Caveolin-3

Gene

Cav3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress.1 Publication

    GO - Molecular functioni

    1. alpha-tubulin binding Source: MGI
    2. calcium channel regulator activity Source: Ensembl
    3. connexin binding Source: BHF-UCL
    4. ion channel binding Source: MGI
    5. potassium channel inhibitor activity Source: Ensembl
    6. protein binding Source: IntAct
    7. sodium channel regulator activity Source: Ensembl

    GO - Biological processi

    1. actin filament organization Source: MGI
    2. cardiac muscle cell development Source: MGI
    3. caveola assembly Source: MGI
    4. cell growth Source: Ensembl
    5. cholesterol homeostasis Source: MGI
    6. cytoplasmic microtubule organization Source: MGI
    7. endocytosis Source: MGI
    8. establishment of protein localization to plasma membrane Source: MGI
    9. glucose homeostasis Source: MGI
    10. heart trabecula formation Source: MGI
    11. membrane raft organization Source: MGI
    12. muscle cell cellular homeostasis Source: MGI
    13. myoblast fusion Source: MGI
    14. myotube differentiation Source: MGI
    15. negative regulation of calcium ion transport Source: MGI
    16. negative regulation of cardiac muscle hypertrophy Source: MGI
    17. negative regulation of cell growth involved in cardiac muscle cell development Source: Ensembl
    18. negative regulation of cell size Source: Ensembl
    19. negative regulation of MAPK cascade Source: MGI
    20. negative regulation of MAP kinase activity Source: Ensembl
    21. negative regulation of nitric-oxide synthase activity Source: MGI
    22. negative regulation of potassium ion transmembrane transport Source: Ensembl
    23. negative regulation of potassium ion transmembrane transporter activity Source: Ensembl
    24. negative regulation of protein kinase activity Source: MGI
    25. negative regulation of sarcomere organization Source: Ensembl
    26. nucleus localization Source: MGI
    27. plasma membrane organization Source: MGI
    28. plasma membrane repair Source: MGI
    29. positive regulation of caveolin-mediated endocytosis Source: Ensembl
    30. positive regulation of cell proliferation Source: Ensembl
    31. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    32. positive regulation of microtubule polymerization Source: Ensembl
    33. positive regulation of myotube differentiation Source: MGI
    34. protein localization Source: MGI
    35. protein localization to plasma membrane Source: MGI
    36. regulation of branching involved in mammary gland duct morphogenesis Source: MGI
    37. regulation of calcium ion import Source: Ensembl
    38. regulation of calcium ion transmembrane transporter activity Source: Ensembl
    39. regulation of calcium ion transport Source: MGI
    40. regulation of heart rate Source: Ensembl
    41. regulation of membrane depolarization during cardiac muscle cell action potential Source: Ensembl
    42. regulation of membrane potential Source: MGI
    43. regulation of nerve growth factor receptor activity Source: Ensembl
    44. regulation of p38MAPK cascade Source: MGI
    45. regulation of protein kinase B signaling Source: MGI
    46. regulation of signal transduction by receptor internalization Source: Ensembl
    47. regulation of skeletal muscle contraction Source: Ensembl
    48. regulation of sodium ion transmembrane transporter activity Source: Ensembl
    49. regulation of transforming growth factor beta receptor signaling pathway Source: MGI
    50. regulation of ventricular cardiac muscle cell membrane depolarization Source: Ensembl
    51. regulation of ventricular cardiac muscle cell membrane repolarization Source: Ensembl
    52. triglyceride metabolic process Source: MGI
    53. ventricular cardiac muscle cell action potential Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Caveolin-3
    Alternative name(s):
    M-caveolin
    Gene namesi
    Name:Cav3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:107570. Cav3.

    Subcellular locationi

    Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity. Membranecaveola By similarity; Peripheral membrane protein By similarity
    Note: Potential hairpin-like structure in the membrane. Membrane protein of caveolae By similarity.By similarity

    GO - Cellular componenti

    1. caveola Source: BHF-UCL
    2. cell surface Source: Ensembl
    3. dystrophin-associated glycoprotein complex Source: Ensembl
    4. endoplasmic reticulum Source: MGI
    5. Golgi membrane Source: UniProtKB-SubCell
    6. membrane Source: MGI
    7. membrane raft Source: MGI
    8. neuromuscular junction Source: Ensembl
    9. plasma membrane Source: MGI
    10. sarcolemma Source: BHF-UCL
    11. T-tubule Source: MGI
    12. vesicle Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Golgi apparatus, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi27 – 271R → Q: Results in aberrent localization of TRIM72 and defects in membrane repair. 1 Publication
    Mutagenesisi105 – 1051P → L: Dominant-negative mutant that induces defects in membrane repair. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 151151Caveolin-3PRO_0000144141Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki38 – 38Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO3)By similarity

    Post-translational modificationi

    Sumoylation with SUMO3 by PIAS4 may reduce agonist-induced internalization and desensitization of adrenergic receptor ABRD2.By similarity

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    PaxDbiP51637.
    PRIDEiP51637.

    PTM databases

    PhosphoSiteiP51637.

    Expressioni

    Tissue specificityi

    Expressed predominantly in muscle.1 Publication

    Gene expression databases

    ArrayExpressiP51637.
    BgeeiP51637.
    CleanExiMM_CAV3.
    GenevestigatoriP51637.

    Interactioni

    Subunit structurei

    Homooligomer By similarity. Interacts with DYSF. Interacts with DLG1 and KCNA5; forms a ternary complex. Interacts with DAG1 (via its C-terminal); the interaction prevents binding of DAG1 with DMD By similarity. Interacts with TRIM72. Interacts with MUSK; may regulate MUSK signaling.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Cacna1gQ5SUG43EBI-298576,EBI-6918583
    Cacna1hQ6PE925EBI-298576,EBI-6918775

    Protein-protein interaction databases

    BioGridi198516. 8 interactions.
    IntActiP51637. 5 interactions.
    MINTiMINT-2982959.
    STRINGi10090.ENSMUSP00000074922.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8383CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini105 – 15147CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei84 – 10421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni64 – 11451Required for interaction with DAG1By similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the caveolin family.Curated

    Phylogenomic databases

    eggNOGiNOG86001.
    GeneTreeiENSGT00390000014924.
    HOGENOMiHOG000036550.
    HOVERGENiHBG003422.
    InParanoidiP51637.
    KOiK12959.
    OMAiNEFETRT.
    OrthoDBiEOG7V1FSD.
    PhylomeDBiP51637.
    TreeFamiTF315736.

    Family and domain databases

    InterProiIPR001612. Caveolin.
    IPR018361. Caveolin_CS.
    [Graphical view]
    PANTHERiPTHR10844. PTHR10844. 1 hit.
    PfamiPF01146. Caveolin. 1 hit.
    [Graphical view]
    PROSITEiPS01210. CAVEOLIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51637-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMTEEHTDLE ARIIKDIHCK EIDLVNRDPK NINEDIVKVD FEDVIAEPEG    50
    TYSFDGVWKV SFTTFTVSKY WCYRLLSTLL GVPLALLWGF LFACISFCHI 100
    WAVVPCIKSY LIEIQCISHI YSLCIRTFCN PLFAALGQVC SNIKVVLRRE 150
    G 151
    Length:151
    Mass (Da):17,358
    Last modified:October 1, 1996 - v1
    Checksum:i7C1A181010CC60F1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U36579 mRNA. Translation: AAC52352.1.
    BC024383 mRNA. Translation: AAH24383.1.
    CCDSiCCDS20406.1.
    PIRiS68222.
    RefSeqiNP_031643.1. NM_007617.3.
    UniGeneiMm.3924.

    Genome annotation databases

    EnsembliENSMUST00000075477; ENSMUSP00000074922; ENSMUSG00000062694.
    GeneIDi12391.
    KEGGimmu:12391.
    UCSCiuc009dea.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U36579 mRNA. Translation: AAC52352.1 .
    BC024383 mRNA. Translation: AAH24383.1 .
    CCDSi CCDS20406.1.
    PIRi S68222.
    RefSeqi NP_031643.1. NM_007617.3.
    UniGenei Mm.3924.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198516. 8 interactions.
    IntActi P51637. 5 interactions.
    MINTi MINT-2982959.
    STRINGi 10090.ENSMUSP00000074922.

    PTM databases

    PhosphoSitei P51637.

    Proteomic databases

    PaxDbi P51637.
    PRIDEi P51637.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000075477 ; ENSMUSP00000074922 ; ENSMUSG00000062694 .
    GeneIDi 12391.
    KEGGi mmu:12391.
    UCSCi uc009dea.1. mouse.

    Organism-specific databases

    CTDi 859.
    MGIi MGI:107570. Cav3.

    Phylogenomic databases

    eggNOGi NOG86001.
    GeneTreei ENSGT00390000014924.
    HOGENOMi HOG000036550.
    HOVERGENi HBG003422.
    InParanoidi P51637.
    KOi K12959.
    OMAi NEFETRT.
    OrthoDBi EOG7V1FSD.
    PhylomeDBi P51637.
    TreeFami TF315736.

    Miscellaneous databases

    NextBioi 281130.
    PROi P51637.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51637.
    Bgeei P51637.
    CleanExi MM_CAV3.
    Genevestigatori P51637.

    Family and domain databases

    InterProi IPR001612. Caveolin.
    IPR018361. Caveolin_CS.
    [Graphical view ]
    PANTHERi PTHR10844. PTHR10844. 1 hit.
    Pfami PF01146. Caveolin. 1 hit.
    [Graphical view ]
    PROSITEi PS01210. CAVEOLIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "M-caveolin, a muscle-specific caveolin-related protein."
      Way M., Parton R.G.
      FEBS Lett. 376:108-112(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: BALB/c.
      Tissue: Skeletal muscle.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.
    3. "Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolin-3, and dysferlin."
      Cai C., Weisleder N., Ko J.-K., Komazaki S., Sunada Y., Nishi M., Takeshima H., Ma J.
      J. Biol. Chem. 284:15894-15902(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TRIM72, MUTAGENESIS OF ARG-27 AND PRO-105.
    4. "Caveolin-3 promotes nicotinic acetylcholine receptor clustering and regulates neuromuscular junction activity."
      Hezel M., de Groat W.C., Galbiati F.
      Mol. Biol. Cell 21:302-310(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MUSK.

    Entry informationi

    Entry nameiCAV3_MOUSE
    AccessioniPrimary (citable) accession number: P51637
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3