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P51637 (CAV3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Caveolin-3
Alternative name(s):
M-caveolin
Gene names
Name:Cav3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length151 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Ref.4

Subunit structure

Homooligomer By similarity. Interacts with DYSF. Interacts with DLG1 and KCNA5; forms a ternary complex. Interacts with DAG1 (via its C-terminal); the interaction prevents binding of DAG1 with DMD By similarity. Interacts with TRIM72. Interacts with MUSK; may regulate MUSK signaling. Ref.4 Ref.5

Subcellular location

Golgi apparatus membrane; Peripheral membrane protein By similarity. Cell membrane; Peripheral membrane protein By similarity. Membranecaveola; Peripheral membrane protein By similarity. Note: Potential hairpin-like structure in the membrane. Membrane protein of caveolae By similarity.

Tissue specificity

Expressed predominantly in muscle. Ref.1

Post-translational modification

Sumoylation with SUMO3 by PIAS4 may reduce agonist-induced internalization and desensitization of adrenergic receptor ABRD2 By similarity.

Sequence similarities

Belongs to the caveolin family.

Ontologies

Keywords
   Cellular componentCell membrane
Golgi apparatus
Membrane
   PTMIsopeptide bond
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactin filament organization

Inferred from mutant phenotype PubMed 14517320. Source: MGI

cardiac muscle cell development

Inferred from mutant phenotype PubMed 19535499. Source: MGI

caveola assembly

Inferred from mutant phenotype PubMed 18054955. Source: MGI

cell growth

Inferred from electronic annotation. Source: Ensembl

cholesterol homeostasis

Inferred from mutant phenotype PubMed 15314230. Source: MGI

cytoplasmic microtubule organization

Inferred from mutant phenotype PubMed 14517320. Source: MGI

endocytosis

Inferred from mutant phenotype PubMed 14600260. Source: MGI

establishment of protein localization to plasma membrane

Inferred from mutant phenotype Ref.4. Source: MGI

glucose homeostasis

Inferred from mutant phenotype PubMed 15314230. Source: MGI

heart trabecula formation

Inferred from mutant phenotype PubMed 19535499. Source: MGI

membrane raft organization

Inferred from mutant phenotype PubMed 11259414PubMed 14600260. Source: MGI

muscle cell cellular homeostasis

Inferred from mutant phenotype PubMed 11115849PubMed 12138167PubMed 14600260. Source: MGI

myoblast fusion

Inferred from mutant phenotype PubMed 14517320. Source: MGI

myotube differentiation

Inferred from mutant phenotype PubMed 21182936. Source: MGI

negative regulation of MAP kinase activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of MAPK cascade

Inferred from mutant phenotype PubMed 12138167. Source: MGI

negative regulation of calcium ion transport

Inferred from mutant phenotype PubMed 21084288. Source: MGI

negative regulation of cardiac muscle hypertrophy

Inferred from mutant phenotype PubMed 18552160. Source: MGI

negative regulation of cell growth involved in cardiac muscle cell development

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell size

Inferred from electronic annotation. Source: Ensembl

negative regulation of nitric-oxide synthase activity

Inferred from mutant phenotype PubMed 11159934. Source: MGI

negative regulation of potassium ion transmembrane transport

Inferred from electronic annotation. Source: Ensembl

negative regulation of potassium ion transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of protein kinase activity

Inferred from mutant phenotype PubMed 14600260. Source: MGI

negative regulation of sarcomere organization

Inferred from electronic annotation. Source: Ensembl

nucleus localization

Inferred from mutant phenotype PubMed 19535499. Source: MGI

plasma membrane organization

Inferred from mutant phenotype PubMed 11115849PubMed 12138167PubMed 14600260. Source: MGI

plasma membrane repair

Inferred from mutant phenotype Ref.4. Source: MGI

positive regulation of caveolin-mediated endocytosis

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration

Inferred from electronic annotation. Source: Ensembl

positive regulation of microtubule polymerization

Inferred from electronic annotation. Source: Ensembl

positive regulation of myotube differentiation

Inferred from mutant phenotype PubMed 14517320. Source: MGI

protein localization

Inferred from mutant phenotype PubMed 11259414PubMed 12138167PubMed 14600260PubMed 16319126. Source: MGI

protein localization to plasma membrane

Inferred from mutant phenotype PubMed 16455755. Source: MGI

regulation of branching involved in mammary gland duct morphogenesis

Inferred from mutant phenotype PubMed 19164602. Source: MGI

regulation of calcium ion import

Inferred from electronic annotation. Source: Ensembl

regulation of calcium ion transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

regulation of calcium ion transport

Inferred from mutant phenotype PubMed 16648270. Source: MGI

regulation of heart rate

Inferred from electronic annotation. Source: Ensembl

regulation of membrane depolarization during cardiac muscle cell action potential

Inferred from electronic annotation. Source: Ensembl

regulation of membrane potential

Inferred from genetic interaction PubMed 15277200. Source: MGI

regulation of nerve growth factor receptor activity

Inferred from electronic annotation. Source: Ensembl

regulation of p38MAPK cascade

Inferred from mutant phenotype PubMed 21182936. Source: MGI

regulation of protein kinase B signaling

Inferred from mutant phenotype PubMed 21182936. Source: MGI

regulation of signal transduction by receptor internalization

Inferred from electronic annotation. Source: Ensembl

regulation of skeletal muscle contraction

Inferred from electronic annotation. Source: Ensembl

regulation of sodium ion transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

regulation of transforming growth factor beta receptor signaling pathway

Inferred from mutant phenotype PubMed 21182936. Source: MGI

regulation of ventricular cardiac muscle cell membrane depolarization

Inferred from electronic annotation. Source: Ensembl

regulation of ventricular cardiac muscle cell membrane repolarization

Inferred from electronic annotation. Source: Ensembl

triglyceride metabolic process

Inferred from mutant phenotype PubMed 15314230. Source: MGI

ventricular cardiac muscle cell action potential

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentGolgi membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

T-tubule

Inferred from direct assay PubMed 16319126PubMed 9008709. Source: MGI

caveola

Inferred from direct assay PubMed 21084288. Source: BHF-UCL

cell surface

Inferred from electronic annotation. Source: Ensembl

dystrophin-associated glycoprotein complex

Inferred from electronic annotation. Source: Ensembl

endoplasmic reticulum

Inferred from sequence orthology PubMed 22792322. Source: MGI

membrane

Inferred from direct assay PubMed 10835421PubMed 15541368PubMed 21296051. Source: MGI

membrane raft

Inferred from direct assay PubMed 11259414. Source: MGI

neuromuscular junction

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from direct assay PubMed 14600260PubMed 15277200PubMed 17200204. Source: MGI

sarcolemma

Inferred from direct assay PubMed 21084288. Source: BHF-UCL

vesicle

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionalpha-tubulin binding

Inferred from direct assay PubMed 14517320. Source: MGI

calcium channel regulator activity

Inferred from electronic annotation. Source: Ensembl

connexin binding

Inferred from physical interaction PubMed 19544087. Source: BHF-UCL

ion channel binding

Inferred from physical interaction PubMed 18956885PubMed 21084288. Source: MGI

potassium channel inhibitor activity

Inferred from electronic annotation. Source: Ensembl

sodium channel regulator activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Cacna1gQ5SUG43EBI-298576,EBI-6918583
Cacna1hQ6PE925EBI-298576,EBI-6918775

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 151151Caveolin-3
PRO_0000144141

Regions

Topological domain1 – 8383Cytoplasmic Potential
Intramembrane84 – 10421Helical; Potential
Topological domain105 – 15147Cytoplasmic Potential
Region64 – 11451Required for interaction with DAG1 By similarity

Amino acid modifications

Cross-link38Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO3) By similarity

Experimental info

Mutagenesis271R → Q: Results in aberrent localization of TRIM72 and defects in membrane repair. Ref.4
Mutagenesis1051P → L: Dominant-negative mutant that induces defects in membrane repair. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P51637 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 7C1A181010CC60F1

FASTA15117,358
        10         20         30         40         50         60 
MMTEEHTDLE ARIIKDIHCK EIDLVNRDPK NINEDIVKVD FEDVIAEPEG TYSFDGVWKV 

        70         80         90        100        110        120 
SFTTFTVSKY WCYRLLSTLL GVPLALLWGF LFACISFCHI WAVVPCIKSY LIEIQCISHI 

       130        140        150 
YSLCIRTFCN PLFAALGQVC SNIKVVLRRE G 

« Hide

References

« Hide 'large scale' references
[1]"M-caveolin, a muscle-specific caveolin-related protein."
Way M., Parton R.G.
FEBS Lett. 376:108-112(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: BALB/c.
Tissue: Skeletal muscle.
[2]Erratum
Way M., Parton R.G.
FEBS Lett. 378:108-112(1996) [PubMed] [Europe PMC] [Abstract]
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon.
[4]"Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolin-3, and dysferlin."
Cai C., Weisleder N., Ko J.-K., Komazaki S., Sunada Y., Nishi M., Takeshima H., Ma J.
J. Biol. Chem. 284:15894-15902(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH TRIM72, MUTAGENESIS OF ARG-27 AND PRO-105.
[5]"Caveolin-3 promotes nicotinic acetylcholine receptor clustering and regulates neuromuscular junction activity."
Hezel M., de Groat W.C., Galbiati F.
Mol. Biol. Cell 21:302-310(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MUSK.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U36579 mRNA. Translation: AAC52352.1.
BC024383 mRNA. Translation: AAH24383.1.
PIRS68222.
RefSeqNP_031643.1. NM_007617.3.
UniGeneMm.3924.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198516. 8 interactions.
IntActP51637. 5 interactions.
MINTMINT-2982959.
STRING10090.ENSMUSP00000074922.

PTM databases

PhosphoSiteP51637.

Proteomic databases

PaxDbP51637.
PRIDEP51637.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000075477; ENSMUSP00000074922; ENSMUSG00000062694.
GeneID12391.
KEGGmmu:12391.
UCSCuc009dea.1. mouse.

Organism-specific databases

CTD859.
MGIMGI:107570. Cav3.

Phylogenomic databases

eggNOGNOG86001.
GeneTreeENSGT00390000014924.
HOGENOMHOG000036550.
HOVERGENHBG003422.
InParanoidP51637.
KOK12959.
OMAHFKEIDL.
OrthoDBEOG7V1FSD.
PhylomeDBP51637.
TreeFamTF315736.

Gene expression databases

ArrayExpressP51637.
BgeeP51637.
CleanExMM_CAV3.
GenevestigatorP51637.

Family and domain databases

InterProIPR001612. Caveolin.
IPR018361. Caveolin_CS.
[Graphical view]
PANTHERPTHR10844. PTHR10844. 1 hit.
PfamPF01146. Caveolin. 1 hit.
[Graphical view]
PROSITEPS01210. CAVEOLIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio281130.
PROP51637.
SOURCESearch...

Entry information

Entry nameCAV3_MOUSE
AccessionPrimary (citable) accession number: P51637
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot