Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Caveolin-3

Gene

Cav3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress.1 Publication

GO - Molecular functioni

GO - Biological processi

  • actin filament organization Source: MGI
  • cardiac muscle cell development Source: MGI
  • caveola assembly Source: MGI
  • cell growth Source: Ensembl
  • cholesterol homeostasis Source: MGI
  • cytoplasmic microtubule organization Source: MGI
  • detection of muscle stretch Source: BHF-UCL
  • endocytosis Source: MGI
  • establishment of protein localization to plasma membrane Source: MGI
  • glucose homeostasis Source: MGI
  • heart trabecula formation Source: MGI
  • membrane raft organization Source: MGI
  • muscle cell cellular homeostasis Source: MGI
  • myoblast fusion Source: MGI
  • myotube differentiation Source: MGI
  • negative regulation of calcium ion transport Source: MGI
  • negative regulation of cardiac muscle hypertrophy Source: MGI
  • negative regulation of cell growth involved in cardiac muscle cell development Source: Ensembl
  • negative regulation of cell size Source: MGI
  • negative regulation of MAPK cascade Source: MGI
  • negative regulation of MAP kinase activity Source: MGI
  • negative regulation of membrane depolarization during cardiac muscle cell action potential Source: BHF-UCL
  • negative regulation of nitric-oxide synthase activity Source: MGI
  • negative regulation of potassium ion transmembrane transporter activity Source: Ensembl
  • negative regulation of protein kinase activity Source: MGI
  • negative regulation of sarcomere organization Source: MGI
  • nucleus localization Source: MGI
  • plasma membrane organization Source: MGI
  • plasma membrane repair Source: MGI
  • positive regulation of caveolin-mediated endocytosis Source: Ensembl
  • positive regulation of cell proliferation Source: Ensembl
  • positive regulation of cytosolic calcium ion concentration Source: Ensembl
  • positive regulation of microtubule polymerization Source: Ensembl
  • positive regulation of myotube differentiation Source: MGI
  • protein localization Source: MGI
  • protein localization to plasma membrane Source: MGI
  • regulation of branching involved in mammary gland duct morphogenesis Source: MGI
  • regulation of calcium ion import Source: MGI
  • regulation of calcium ion transmembrane transporter activity Source: MGI
  • regulation of calcium ion transport Source: MGI
  • regulation of cardiac muscle contraction Source: MGI
  • regulation of heart rate Source: MGI
  • regulation of membrane depolarization during cardiac muscle cell action potential Source: MGI
  • regulation of membrane potential Source: MGI
  • regulation of nerve growth factor receptor activity Source: MGI
  • regulation of p38MAPK cascade Source: MGI
  • regulation of protein kinase B signaling Source: MGI
  • regulation of signal transduction by receptor internalization Source: MGI
  • regulation of skeletal muscle contraction Source: MGI
  • regulation of sodium ion transmembrane transporter activity Source: MGI
  • regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  • regulation of ventricular cardiac muscle cell membrane depolarization Source: MGI
  • regulation of ventricular cardiac muscle cell membrane repolarization Source: MGI
  • triglyceride metabolic process Source: MGI
  • ventricular cardiac muscle cell action potential Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_317508. Muscle contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolin-3
Alternative name(s):
M-caveolin
Gene namesi
Name:Cav3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:107570. Cav3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8383CytoplasmicSequence AnalysisAdd
BLAST
Intramembranei84 – 10421HelicalSequence AnalysisAdd
BLAST
Topological domaini105 – 15147CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • caveola Source: BHF-UCL
  • cell surface Source: Ensembl
  • cytosol Source: GOC
  • dystrophin-associated glycoprotein complex Source: MGI
  • endoplasmic reticulum Source: MGI
  • Golgi membrane Source: UniProtKB-SubCell
  • intercalated disc Source: Ensembl
  • membrane Source: MGI
  • membrane raft Source: MGI
  • neuromuscular junction Source: Ensembl
  • plasma membrane Source: MGI
  • sarcolemma Source: BHF-UCL
  • T-tubule Source: MGI
  • vesicle Source: Ensembl
  • Z disc Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi27 – 271R → Q: Results in aberrent localization of TRIM72 and defects in membrane repair. 1 Publication
Mutagenesisi105 – 1051P → L: Dominant-negative mutant that induces defects in membrane repair. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 151151Caveolin-3PRO_0000144141Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki38 – 38Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO3)By similarity

Post-translational modificationi

Sumoylation with SUMO3 by PIAS4 may reduce agonist-induced internalization and desensitization of adrenergic receptor ABRD2.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiP51637.
PRIDEiP51637.

PTM databases

PhosphoSiteiP51637.

Expressioni

Tissue specificityi

Expressed predominantly in muscle.1 Publication

Gene expression databases

BgeeiP51637.
CleanExiMM_CAV3.
ExpressionAtlasiP51637. baseline and differential.
GenevisibleiP51637. MM.

Interactioni

Subunit structurei

Homooligomer (By similarity). Interacts with DYSF. Interacts with DLG1 and KCNA5; forms a ternary complex. Interacts with DAG1 (via its C-terminal); the interaction prevents binding of DAG1 with DMD (By similarity). Interacts with TRIM72. Interacts with MUSK; may regulate MUSK signaling.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Cacna1gQ5SUG43EBI-298576,EBI-6918583
Cacna1hQ6PE925EBI-298576,EBI-6918775

Protein-protein interaction databases

BioGridi198516. 8 interactions.
DIPiDIP-31069N.
IntActiP51637. 8 interactions.
MINTiMINT-2982959.
STRINGi10090.ENSMUSP00000074922.

Structurei

3D structure databases

ProteinModelPortaliP51637.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni64 – 11451Required for interaction with DAG1By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the caveolin family.Curated

Phylogenomic databases

eggNOGiNOG86001.
GeneTreeiENSGT00390000014924.
HOGENOMiHOG000036550.
HOVERGENiHBG003422.
InParanoidiP51637.
KOiK12959.
OMAiVKDIHFK.
OrthoDBiEOG7V1FSD.
PhylomeDBiP51637.
TreeFamiTF315736.

Family and domain databases

InterProiIPR001612. Caveolin.
IPR031091. Caveolin-3.
IPR018361. Caveolin_CS.
[Graphical view]
PANTHERiPTHR10844. PTHR10844. 1 hit.
PTHR10844:SF16. PTHR10844:SF16. 1 hit.
PfamiPF01146. Caveolin. 1 hit.
[Graphical view]
PROSITEiPS01210. CAVEOLIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51637-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTEEHTDLE ARIIKDIHCK EIDLVNRDPK NINEDIVKVD FEDVIAEPEG
60 70 80 90 100
TYSFDGVWKV SFTTFTVSKY WCYRLLSTLL GVPLALLWGF LFACISFCHI
110 120 130 140 150
WAVVPCIKSY LIEIQCISHI YSLCIRTFCN PLFAALGQVC SNIKVVLRRE

G
Length:151
Mass (Da):17,358
Last modified:October 1, 1996 - v1
Checksum:i7C1A181010CC60F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36579 mRNA. Translation: AAC52352.1.
BC024383 mRNA. Translation: AAH24383.1.
CCDSiCCDS20406.1.
PIRiS68222.
RefSeqiNP_031643.1. NM_007617.3.
UniGeneiMm.3924.

Genome annotation databases

EnsembliENSMUST00000075477; ENSMUSP00000074922; ENSMUSG00000062694.
GeneIDi12391.
KEGGimmu:12391.
UCSCiuc009dea.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36579 mRNA. Translation: AAC52352.1.
BC024383 mRNA. Translation: AAH24383.1.
CCDSiCCDS20406.1.
PIRiS68222.
RefSeqiNP_031643.1. NM_007617.3.
UniGeneiMm.3924.

3D structure databases

ProteinModelPortaliP51637.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198516. 8 interactions.
DIPiDIP-31069N.
IntActiP51637. 8 interactions.
MINTiMINT-2982959.
STRINGi10090.ENSMUSP00000074922.

PTM databases

PhosphoSiteiP51637.

Proteomic databases

PaxDbiP51637.
PRIDEiP51637.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075477; ENSMUSP00000074922; ENSMUSG00000062694.
GeneIDi12391.
KEGGimmu:12391.
UCSCiuc009dea.1. mouse.

Organism-specific databases

CTDi859.
MGIiMGI:107570. Cav3.

Phylogenomic databases

eggNOGiNOG86001.
GeneTreeiENSGT00390000014924.
HOGENOMiHOG000036550.
HOVERGENiHBG003422.
InParanoidiP51637.
KOiK12959.
OMAiVKDIHFK.
OrthoDBiEOG7V1FSD.
PhylomeDBiP51637.
TreeFamiTF315736.

Enzyme and pathway databases

ReactomeiREACT_317508. Muscle contraction.

Miscellaneous databases

NextBioi281130.
PROiP51637.
SOURCEiSearch...

Gene expression databases

BgeeiP51637.
CleanExiMM_CAV3.
ExpressionAtlasiP51637. baseline and differential.
GenevisibleiP51637. MM.

Family and domain databases

InterProiIPR001612. Caveolin.
IPR031091. Caveolin-3.
IPR018361. Caveolin_CS.
[Graphical view]
PANTHERiPTHR10844. PTHR10844. 1 hit.
PTHR10844:SF16. PTHR10844:SF16. 1 hit.
PfamiPF01146. Caveolin. 1 hit.
[Graphical view]
PROSITEiPS01210. CAVEOLIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "M-caveolin, a muscle-specific caveolin-related protein."
    Way M., Parton R.G.
    FEBS Lett. 376:108-112(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Skeletal muscle.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  3. "Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolin-3, and dysferlin."
    Cai C., Weisleder N., Ko J.-K., Komazaki S., Sunada Y., Nishi M., Takeshima H., Ma J.
    J. Biol. Chem. 284:15894-15902(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TRIM72, MUTAGENESIS OF ARG-27 AND PRO-105.
  4. "Caveolin-3 promotes nicotinic acetylcholine receptor clustering and regulates neuromuscular junction activity."
    Hezel M., de Groat W.C., Galbiati F.
    Mol. Biol. Cell 21:302-310(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MUSK.

Entry informationi

Entry nameiCAV3_MOUSE
AccessioniPrimary (citable) accession number: P51637
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 22, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.