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P51636

- CAV2_HUMAN

UniProt

P51636 - CAV2_HUMAN

Protein

Caveolin-2

Gene

CAV2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression By similarity.By similarity

    GO - Molecular functioni

    1. D1 dopamine receptor binding Source: BHF-UCL
    2. protein binding Source: UniProtKB
    3. protein homodimerization activity Source: MGI

    GO - Biological processi

    1. caveola assembly Source: BHF-UCL
    2. endoplasmic reticulum organization Source: UniProtKB
    3. mitochondrion organization Source: UniProtKB
    4. negative regulation of endothelial cell proliferation Source: UniProtKB
    5. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    6. positive regulation of dopamine receptor signaling pathway Source: BHF-UCL
    7. positive regulation of endothelial cell proliferation Source: Ensembl
    8. protein oligomerization Source: Ensembl
    9. regulation of mitosis Source: BHF-UCL
    10. skeletal muscle fiber development Source: UniProtKB
    11. synaptic transmission Source: Ensembl
    12. vesicle docking Source: BHF-UCL
    13. vesicle fusion Source: BHF-UCL
    14. vesicle organization Source: BHF-UCL

    Enzyme and pathway databases

    SignaLinkiP51636.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Caveolin-2
    Gene namesi
    Name:CAV2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:1528. CAV2.

    Subcellular locationi

    Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membranecaveola; Peripheral membrane protein
    Note: Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin By similarity. Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments.By similarity

    GO - Cellular componenti

    1. acrosomal membrane Source: Ensembl
    2. caveola Source: BHF-UCL
    3. cell surface Source: Ensembl
    4. cytoplasmic vesicle Source: MGI
    5. cytosol Source: Ensembl
    6. extrinsic component of cytoplasmic side of plasma membrane Source: BHF-UCL
    7. Golgi apparatus Source: BHF-UCL
    8. Golgi membrane Source: UniProtKB-SubCell
    9. integral component of plasma membrane Source: MGI
    10. intracellular Source: BHF-UCL
    11. lipid particle Source: Ensembl
    12. membrane Source: BHF-UCL
    13. membrane raft Source: HGNC
    14. nucleus Source: UniProtKB-SubCell
    15. perinuclear region of cytoplasm Source: BHF-UCL
    16. plasma membrane Source: BHF-UCL
    17. protein complex Source: MGI
    18. transport vesicle Source: LIFEdb

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Golgi apparatus, Membrane, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi19 – 191Y → A: Greatly reduced Src-mediated phosphorylation and binding of RASA1, SRC and NCK1. Completely eliminates Src-mediated tyrosine phosphorylation and binding to RASA1, SRC and NCK1; when associated with A-27. 1 Publication
    Mutagenesisi23 – 231S → A: Abolishes phosphorylation. 1 Publication
    Mutagenesisi27 – 271Y → A: Greatly reduced Src-mediated phosphorylation and binding of RASA1, SRC and NCK1. Completely eliminates Src-mediated phosphorylation and binding of RASA1, SRC and NCK1; when associated with A-19. 1 Publication
    Mutagenesisi36 – 361S → A: Abolishes phosphorylation. 1 Publication

    Organism-specific databases

    PharmGKBiPA26108.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 162162Caveolin-2PRO_0000004772Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei19 – 191Phosphotyrosine; by SRC2 Publications
    Modified residuei23 – 231Phosphoserine1 Publication
    Modified residuei27 – 271Phosphotyrosine; by SRC1 Publication
    Modified residuei36 – 361Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells By similarity. Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP51636.
    PaxDbiP51636.
    PRIDEiP51636.

    PTM databases

    PhosphoSiteiP51636.

    Expressioni

    Tissue specificityi

    Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts.1 Publication

    Gene expression databases

    ArrayExpressiP51636.
    BgeeiP51636.
    CleanExiHS_CAV2.
    GenevestigatoriP51636.

    Organism-specific databases

    HPAiCAB013488.
    HPA044810.

    Interactioni

    Subunit structurei

    Monomer or homodimer. Interacts with CAV1; the interaction forms a stable heterooligomeric complex that is required for targeting to lipid rafts and for caveolae formation. Tyrosine phosphorylated forms do not form heterooligomers with the Tyr-19-phosphorylated form existing as a monomer or dimer, and the Tyr-27-form as a monomer only. Interacts (tyrosine phosphorylated form) with the SH2 domain-containing proteins, RASA1, NCK1 and SRC. Interacts (tyrosine phosphorylated form) with INSR, the interaction (Tyr-27-phosphorylated form) is increased on insulin stimulation. Interacts (Tyr-19 phosphorylated form) with MAPK1 (phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with STAT3; the interaction is increased on insulin-induced tyrosine phosphorylation leading to STAT activation By similarity.By similarity

    Protein-protein interaction databases

    BioGridi107306. 12 interactions.
    DIPiDIP-34929N.
    IntActiP51636. 6 interactions.
    MINTiMINT-1403441.
    STRINGi9606.ENSP00000222693.

    Structurei

    3D structure databases

    ProteinModelPortaliP51636.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8686CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini108 – 16255CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei87 – 10721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the caveolin family.Curated

    Phylogenomic databases

    eggNOGiNOG74268.
    HOGENOMiHOG000036550.
    HOVERGENiHBG003422.
    InParanoidiP51636.
    KOiK12958.
    OMAiSTHSFDK.
    OrthoDBiEOG7V1FSD.
    PhylomeDBiP51636.
    TreeFamiTF315736.

    Family and domain databases

    InterProiIPR001612. Caveolin.
    IPR018361. Caveolin_CS.
    [Graphical view]
    PANTHERiPTHR10844. PTHR10844. 1 hit.
    PfamiPF01146. Caveolin. 1 hit.
    [Graphical view]
    PROSITEiPS01210. CAVEOLIN. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative initiation. Align

    Isoform Alpha (identifier: P51636-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGLETEKADV QLFMDDDSYS HHSGLEYADP EKFADSDQDR DPHRLNSHLK    50
    LGFEDVIAEP VTTHSFDKVW ICSHALFEIS KYVMYKFLTV FLAIPLAFIA 100
    GILFATLSCL HIWILMPFVK TCLMVLPSVQ TIWKSVTDVI IAPLCTSVGR 150
    CFSSVSLQLS QD 162
    Length:162
    Mass (Da):18,291
    Last modified:July 15, 1999 - v2
    Checksum:i89FDEDA861330B87
    GO
    Isoform Beta (identifier: P51636-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-13: Missing.

    Note: Produced by alternative initiation.

    Show »
    Length:149
    Mass (Da):16,829
    Checksum:i0706B574F5E1AAD8
    GO
    Isoform C (identifier: P51636-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         51-112: LGFEDVIAEP...LFATLSCLHI → DFNAFCKDLP...WTPGLEIGIL
         113-162: Missing.

    Note: Produced by alternative splicing.

    Show »
    Length:112
    Mass (Da):12,780
    Checksum:i7C60DC5ABD6B0105
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti130 – 1301Q → E.
    Corresponds to variant rs8940 [ dbSNP | Ensembl ].
    VAR_012071

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1313Missing in isoform Beta. CuratedVSP_018696Add
    BLAST
    Alternative sequencei51 – 11262LGFED…SCLHI → DFNAFCKDLPNGSAFSADNM EECDRCYHCSIVYERRTMLL FCQPATEPGLNTWTPGLEIG IL in isoform C. 1 PublicationVSP_038114Add
    BLAST
    Alternative sequencei113 – 16250Missing in isoform C. 1 PublicationVSP_038115Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF035752 mRNA. Translation: AAB88492.1.
    AJ133269 Genomic DNA. Translation: CAB63653.1.
    BT007051 mRNA. Translation: AAP35700.1.
    BC005256 mRNA. Translation: AAH05256.1.
    AJ242718 Genomic DNA. Translation: CAB65090.1.
    AK310786 mRNA. No translation available.
    CH236947 Genomic DNA. Translation: EAL24361.1.
    CCDSiCCDS5765.1. [P51636-3]
    CCDS5766.1. [P51636-1]
    RefSeqiNP_001193676.1. NM_001206747.1. [P51636-2]
    NP_001193677.1. NM_001206748.1.
    NP_001224.1. NM_001233.4. [P51636-1]
    NP_937855.1. NM_198212.2. [P51636-3]
    UniGeneiHs.212332.
    Hs.603096.

    Genome annotation databases

    EnsembliENST00000222693; ENSP00000222693; ENSG00000105971. [P51636-1]
    ENST00000343213; ENSP00000345679; ENSG00000105971. [P51636-3]
    GeneIDi858.
    KEGGihsa:858.
    UCSCiuc003vid.3. human. [P51636-1]
    uc003vie.3. human. [P51636-3]
    uc022akj.1. human. [P51636-2]

    Keywords - Coding sequence diversityi

    Alternative initiation, Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Caveolin entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF035752 mRNA. Translation: AAB88492.1 .
    AJ133269 Genomic DNA. Translation: CAB63653.1 .
    BT007051 mRNA. Translation: AAP35700.1 .
    BC005256 mRNA. Translation: AAH05256.1 .
    AJ242718 Genomic DNA. Translation: CAB65090.1 .
    AK310786 mRNA. No translation available.
    CH236947 Genomic DNA. Translation: EAL24361.1 .
    CCDSi CCDS5765.1. [P51636-3 ]
    CCDS5766.1. [P51636-1 ]
    RefSeqi NP_001193676.1. NM_001206747.1. [P51636-2 ]
    NP_001193677.1. NM_001206748.1.
    NP_001224.1. NM_001233.4. [P51636-1 ]
    NP_937855.1. NM_198212.2. [P51636-3 ]
    UniGenei Hs.212332.
    Hs.603096.

    3D structure databases

    ProteinModelPortali P51636.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107306. 12 interactions.
    DIPi DIP-34929N.
    IntActi P51636. 6 interactions.
    MINTi MINT-1403441.
    STRINGi 9606.ENSP00000222693.

    PTM databases

    PhosphoSitei P51636.

    Proteomic databases

    MaxQBi P51636.
    PaxDbi P51636.
    PRIDEi P51636.

    Protocols and materials databases

    DNASUi 858.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000222693 ; ENSP00000222693 ; ENSG00000105971 . [P51636-1 ]
    ENST00000343213 ; ENSP00000345679 ; ENSG00000105971 . [P51636-3 ]
    GeneIDi 858.
    KEGGi hsa:858.
    UCSCi uc003vid.3. human. [P51636-1 ]
    uc003vie.3. human. [P51636-3 ]
    uc022akj.1. human. [P51636-2 ]

    Organism-specific databases

    CTDi 858.
    GeneCardsi GC07P115926.
    HGNCi HGNC:1528. CAV2.
    HPAi CAB013488.
    HPA044810.
    MIMi 601048. gene.
    neXtProti NX_P51636.
    PharmGKBi PA26108.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG74268.
    HOGENOMi HOG000036550.
    HOVERGENi HBG003422.
    InParanoidi P51636.
    KOi K12958.
    OMAi STHSFDK.
    OrthoDBi EOG7V1FSD.
    PhylomeDBi P51636.
    TreeFami TF315736.

    Enzyme and pathway databases

    SignaLinki P51636.

    Miscellaneous databases

    ChiTaRSi CAV2. human.
    GeneWikii Caveolin_2.
    GenomeRNAii 858.
    NextBioi 3560.
    PROi P51636.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51636.
    Bgeei P51636.
    CleanExi HS_CAV2.
    Genevestigatori P51636.

    Family and domain databases

    InterProi IPR001612. Caveolin.
    IPR018361. Caveolin_CS.
    [Graphical view ]
    PANTHERi PTHR10844. PTHR10844. 1 hit.
    Pfami PF01146. Caveolin. 1 hit.
    [Graphical view ]
    PROSITEi PS01210. CAVEOLIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification, sequence, and expression of caveolin-2 defines a caveolin gene family."
      Scherer P.E., Okamoto T., Chun M., Nishimoto I., Lodish H.F., Lisanti M.P.
      Proc. Natl. Acad. Sci. U.S.A. 93:131-135(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
    2. "Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo."
      Scherer P.E., Lewis R.Y., Volonte D., Engelman J.A., Galbiati F., Couet J., Kohtz D.S., van Donselaar E., Peters P., Lisanti M.P.
      J. Biol. Chem. 272:29337-29346(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA), INTERACTION WITH CAV1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    3. "Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1). Methylation of a CpG island in the 5' promoter region of the caveolin-1 gene in human breast cancer cell lines."
      Engelman J.A., Zhang X.L., Lisanti M.P.
      FEBS Lett. 448:221-230(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C).
      Tissue: Hepatoma.
    6. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
      Tissue: Kidney.
    8. "Mutational analysis of caveolin-induced vesicle formation. Expression of caveolin-1 recruits caveolin-2 to caveolae membranes."
      Li S., Galbiati F., Volonte D., Sargiacomo M., Engelman J.A., Das K., Scherer P.E., Lisanti M.P.
      FEBS Lett. 434:127-134(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CAV1, ALTERNATIVE PRODUCTS, SUBCELLULAR LOCATION.
    9. "Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1."
      Lee H., Park D.S., Wang X.B., Scherer P.E., Schwartz P.E., Lisanti M.P.
      J. Biol. Chem. 277:34556-34567(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT TYR-19, SUBCELLULAR LOCATION, INTERACTION WITH CAV1; SRC; RASA1 AND NCK1.
    10. "Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27)."
      Wang X.B., Lee H., Capozza F., Marmon S., Sotgia F., Brooks J.W., Campos-Gonzalez R., Lisanti M.P.
      Biochemistry 43:13694-13706(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT TYR-19 AND TYR-27, SUBCELLULAR LOCATION, INTERACTION WITH CAV1; NCK1; RASA1 AND SRC, FUNCTION, MUTAGENESIS OF TYR-19 AND TYR-27.
    11. "Serine 23 and 36 phosphorylation of caveolin-2 is differentially regulated by targeting to lipid raft/caveolae and in mitotic endothelial cells."
      Sowa G., Xie L., Xu L., Sessa W.C.
      Biochemistry 47:101-111(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-23 AND SER-36, FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF SER-23 AND SER-36.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCAV2_HUMAN
    AccessioniPrimary (citable) accession number: P51636
    Secondary accession number(s): A4D0U2, Q9UGM7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: July 15, 1999
    Last modified: October 1, 2014
    This is version 143 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3