P51609 (NOV_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein NOV homolog
Short name=Xnov

Alternative name(s):
CCN family member 3

Gene names

Name:	nov
Synonyms:	ccn3

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Immediate-early protein likely to play a role in cell growth regulation By similarity.
Subcellular location	Secreted.
Sequence similarities	Belongs to the CCN family. Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 1 IGFBP N-terminal domain. Contains 1 TSP type-1 domain. Contains 1 VWFC domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Growth factor
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological_process	regulation of cell growth Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 343	325	Protein NOV homolog		PRO_0000014418
Regions
	Domain	19 – 90	72	IGFBP N-terminal
	Domain	93 – 159	67	VWFC
	Domain	190 – 235	46	TSP type-1
	Domain	249 – 323	75	CTCK
Amino acid modifications
	Glycosylation	265	1	N-linked (GlcNAc...) Potential
	Disulfide bond	249 ↔ 286		By similarity
	Disulfide bond	266 ↔ 300		By similarity
	Disulfide bond	277 ↔ 316		By similarity
	Disulfide bond	280 ↔ 318		By similarity
	Disulfide bond	285 ↔ 322		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P51609 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 677D7078EB21365F	FASTA	343	38,070
	10 20 30 40 50 60 MTPHLALCFI LLIQQVASQK CPSQCDQCPE EPPSCAPSVL LILDGCGCCP VCARQEGESC 70 80 90 100 110 120 SHLNPCQEDK GLYCEFNADP RMETGTCMAL EGNSCVFDGV VYRNRESFQP SCKYHCTCLN 130 140 150 160 170 180 GHIGCVPRCN LDLLLPGPDC PFPRRVKVPG ECCEKWVCDS KEEMAIGGFA MAAYRPEATL 190 200 210 220 230 240 GIDASDTSFA CIAQTTEWSA CSKTCGMGVS SRVTNRNARC EMQKQIRLCM VRSCEEEPGW 250 260 270 280 290 300 HVEKKGKKCV RVRKTTKPIH FHYKNCTSVQ PYKPKFCGQC SDGRCCTPHS TKTMHVEFVC 310 320 330 340 PQKRIVKKPV MVISTCVCHY NCPQDSSLLQ VENARFPGLK TNL

References

[1]	"Isolation and characterization of xnov, a Xenopus laevis ortholog of the chicken nov gene." Ying Z., King M.L. Gene 171:243-248(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U37063 mRNA. Translation: AAB17096.1.
RefSeq	NP_001079127.1. NM_001085658.1.
UniGene	Xl.1070.
3D structure databases
ProteinModelPortal	P51609.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	373662.
KEGG	xla:373662.
Organism-specific databases
CTD	4856.
Xenbase	XB-GENE-1013047. nov.
Phylogenomic databases
HOVERGEN	HBG000635.
Family and domain databases
InterPro	IPR006208. Cys_knot. IPR006207. Cys_knot_C. IPR000867. IGFBP-like. IPR012395. IGFBP_CNN. IPR017891. Insulin_GF-bd_Cys-rich_CS. IPR000884. Thrombospondin_1_rpt. IPR001007. VWF_C. [Graphical view]
Pfam	PF00007. Cys_knot. 1 hit. PF00219. IGFBP. 1 hit. PF00090. TSP_1. 1 hit. PF00093. VWC. 1 hit. [Graphical view]
PIRSF	PIRSF036495. IGFBP_rP_CNN. 1 hit.
SMART	SM00041. CT. 1 hit. SM00121. IB. 1 hit. SM00209. TSP1. 1 hit. SM00214. VWC. 1 hit. [Graphical view]
SUPFAM	SSF82895. TSP1. 1 hit.
PROSITE	PS01185. CTCK_1. False negative. PS01225. CTCK_2. 1 hit. PS00222. IGFBP_N_1. 1 hit. PS51323. IGFBP_N_2. 1 hit. PS50092. TSP1. 1 hit. PS01208. VWFC_1. 1 hit. PS50184. VWFC_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NOV_XENLA

Accession

Primary (citable) accession number: P51609

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program