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P51609 (NOV_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein NOV homolog

Short name=Xnov
Alternative name(s):
CCN family member 3
Gene names
Name:nov
Synonyms:ccn3
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Immediate-early protein likely to play a role in cell growth regulation By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the CCN family.

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Contains 1 IGFBP N-terminal domain.

Contains 1 TSP type-1 domain.

Contains 1 VWFC domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionGrowth factor
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Biological_processregulation of cell growth

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 343325Protein NOV homolog
PRO_0000014418

Regions

Domain19 – 9072IGFBP N-terminal
Domain93 – 15967VWFC
Domain190 – 23546TSP type-1
Domain249 – 32375CTCK

Amino acid modifications

Glycosylation2651N-linked (GlcNAc...) Potential
Disulfide bond249 ↔ 286 By similarity
Disulfide bond266 ↔ 300 By similarity
Disulfide bond277 ↔ 316 By similarity
Disulfide bond280 ↔ 318 By similarity
Disulfide bond285 ↔ 322 By similarity

Sequences

Sequence LengthMass (Da)Tools
P51609 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 677D7078EB21365F

FASTA34338,070
        10         20         30         40         50         60 
MTPHLALCFI LLIQQVASQK CPSQCDQCPE EPPSCAPSVL LILDGCGCCP VCARQEGESC 

        70         80         90        100        110        120 
SHLNPCQEDK GLYCEFNADP RMETGTCMAL EGNSCVFDGV VYRNRESFQP SCKYHCTCLN 

       130        140        150        160        170        180 
GHIGCVPRCN LDLLLPGPDC PFPRRVKVPG ECCEKWVCDS KEEMAIGGFA MAAYRPEATL 

       190        200        210        220        230        240 
GIDASDTSFA CIAQTTEWSA CSKTCGMGVS SRVTNRNARC EMQKQIRLCM VRSCEEEPGW 

       250        260        270        280        290        300 
HVEKKGKKCV RVRKTTKPIH FHYKNCTSVQ PYKPKFCGQC SDGRCCTPHS TKTMHVEFVC 

       310        320        330        340 
PQKRIVKKPV MVISTCVCHY NCPQDSSLLQ VENARFPGLK TNL 

« Hide

References

[1]"Isolation and characterization of xnov, a Xenopus laevis ortholog of the chicken nov gene."
Ying Z., King M.L.
Gene 171:243-248(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U37063 mRNA. Translation: AAB17096.1.
RefSeqNP_001079127.1. NM_001085658.1.
UniGeneXl.1070.

3D structure databases

ProteinModelPortalP51609.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID373662.
KEGGxla:373662.

Organism-specific databases

CTD4856.
XenbaseXB-GENE-1013047. nov.

Phylogenomic databases

HOVERGENHBG000635.

Family and domain databases

InterProIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEPS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNOV_XENLA
AccessionPrimary (citable) accession number: P51609
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families