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P51609

- NOV_XENLA

UniProt

P51609 - NOV_XENLA

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Protein

Protein NOV homolog

Gene

nov

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Immediate-early protein likely to play a role in cell growth regulation.By similarity

GO - Biological processi

  1. regulation of cell growth Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NOV homolog
Short name:
Xnov
Alternative name(s):
CCN family member 3
Gene namesi
Name:nov
Synonyms:ccn3
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1013047. nov.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 343325Protein NOV homologPRO_0000014418Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi249 ↔ 286By similarity
Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi266 ↔ 300By similarity
Disulfide bondi277 ↔ 316By similarity
Disulfide bondi280 ↔ 318By similarity
Disulfide bondi285 ↔ 322By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP51609.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 9072IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini93 – 15967VWFCPROSITE-ProRule annotationAdd
BLAST
Domaini190 – 23546TSP type-1PROSITE-ProRule annotationAdd
BLAST
Domaini249 – 32375CTCKPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CCN family.Curated
Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG000635.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51609-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTPHLALCFI LLIQQVASQK CPSQCDQCPE EPPSCAPSVL LILDGCGCCP
60 70 80 90 100
VCARQEGESC SHLNPCQEDK GLYCEFNADP RMETGTCMAL EGNSCVFDGV
110 120 130 140 150
VYRNRESFQP SCKYHCTCLN GHIGCVPRCN LDLLLPGPDC PFPRRVKVPG
160 170 180 190 200
ECCEKWVCDS KEEMAIGGFA MAAYRPEATL GIDASDTSFA CIAQTTEWSA
210 220 230 240 250
CSKTCGMGVS SRVTNRNARC EMQKQIRLCM VRSCEEEPGW HVEKKGKKCV
260 270 280 290 300
RVRKTTKPIH FHYKNCTSVQ PYKPKFCGQC SDGRCCTPHS TKTMHVEFVC
310 320 330 340
PQKRIVKKPV MVISTCVCHY NCPQDSSLLQ VENARFPGLK TNL
Length:343
Mass (Da):38,070
Last modified:October 1, 1996 - v1
Checksum:i677D7078EB21365F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U37063 mRNA. Translation: AAB17096.1.
RefSeqiNP_001079127.1. NM_001085658.1.
UniGeneiXl.1070.

Genome annotation databases

GeneIDi373662.
KEGGixla:373662.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U37063 mRNA. Translation: AAB17096.1 .
RefSeqi NP_001079127.1. NM_001085658.1.
UniGenei Xl.1070.

3D structure databases

ProteinModelPortali P51609.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 373662.
KEGGi xla:373662.

Organism-specific databases

CTDi 4856.
Xenbasei XB-GENE-1013047. nov.

Phylogenomic databases

HOVERGENi HBG000635.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view ]
PIRSFi PIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTi SM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEi PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of xnov, a Xenopus laevis ortholog of the chicken nov gene."
    Ying Z., King M.L.
    Gene 171:243-248(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiNOV_XENLA
AccessioniPrimary (citable) accession number: P51609
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3