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Protein

N-acylglucosamine 2-epimerase

Gene

Renbp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.

Catalytic activityi

N-acyl-D-glucosamine = N-acyl-D-mannosamine.

Pathwayi: N-acetylneuraminate degradation

This protein is involved in the pathway N-acetylneuraminate degradation, which is part of Amino-sugar metabolism.
View all proteins of this organism that are known to be involved in the pathway N-acetylneuraminate degradation and in Amino-sugar metabolism.

GO - Molecular functioni

  • ATP binding Source: RGD
  • enzyme inhibitor activity Source: RGD
  • N-acylglucosamine 2-epimerase activity Source: RGD
  • protein homodimerization activity Source: RGD
  • purine nucleotide binding Source: RGD

GO - Biological processi

  • N-acetylglucosamine metabolic process Source: RGD
  • N-acetylmannosamine metabolic process Source: RGD
  • N-acetylneuraminate catabolic process Source: UniProtKB-UniPathway
  • negative regulation of catalytic activity Source: RGD
  • negative regulation of endopeptidase activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

UniPathwayiUPA00629.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acylglucosamine 2-epimerase (EC:5.1.3.8)
Short name:
AGE
Alternative name(s):
GlcNAc 2-epimerase
N-acetyl-D-glucosamine 2-epimerase
Renin-binding protein
Short name:
RnBP
Gene namesi
Name:Renbp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi621688. Renbp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430N-acylglucosamine 2-epimerasePRO_0000208952Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei429 – 4291PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP51607.
PRIDEiP51607.

Expressioni

Tissue specificityi

Kidney, adrenal gland, brain, lung, spleen, ovary, testis and heart.1 Publication

Gene expression databases

GenevisibleiP51607. RN.

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053175.

Structurei

3D structure databases

ProteinModelPortaliP51607.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni196 – 21722Leucine-zipperAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IE08. Eukaryota.
COG2942. LUCA.
GeneTreeiENSGT00390000013740.
HOGENOMiHOG000252296.
HOVERGENiHBG054048.
InParanoidiP51607.
KOiK01787.
OMAiPMMLLNL.
OrthoDBiEOG7VDXP3.
PhylomeDBiP51607.

Family and domain databases

Gene3Di1.50.10.10. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
[Graphical view]
SUPFAMiSSF48208. SSF48208. 1 hit.

Sequencei

Sequence statusi: Complete.

P51607-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDPGLLVLQ DMEKERETLQ VWKQRVGQEL DSVIAFWMEH SHDQEHGGFF
60 70 80 90 100
TCLGRDGQVY DHLKYVWLQG RQVWMYCRLY RTFERFRRVE LLDAAKAGGE
110 120 130 140 150
FLLSYARVAP PGKKCAFVLT QDGRPVKVQR TIFSECFYTM AMNELWKVTG
160 170 180 190 200
EMHYQREAVE MMDQIIHWVR EDPAGLGRPQ LSGTLATEPM AVPMMLLNLV
210 220 230 240 250
EQLGEEDEEM TDKYAELGDW CAHRILQHVQ RDGQVVLENV SEDGKELPGC
260 270 280 290 300
LGRHQNPGHT LEAGWFLLQY ALRKGDPKLQ RHIIDKFLLL PFHSGWDPEH
310 320 330 340 350
GGLFYFQDAD DLCPTQLEWN MKLWWPHTEA MIAFLMGYRD SGDPALLNLF
360 370 380 390 400
YQVAEYTFHQ FRDPEYGEWF GYLNQEGKVA LTIKGGPFKG CFHVPRCLAM
410 420 430
CEQILGALLQ RLGPAPLGSL PAVPTREGSK
Length:430
Mass (Da):49,605
Last modified:April 20, 2010 - v2
Checksum:i6DECB8A7A727EE6F
GO

Sequence cautioni

The sequence BAA01083.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CB691242 mRNA. No translation available.
D10233 mRNA. Translation: BAA01083.1. Different initiation.
PIRiJX0187.
RefSeqiNP_112357.1. NM_031095.1.
XP_006229677.1. XM_006229615.2.
UniGeneiRn.11116.

Genome annotation databases

EnsembliENSRNOT00000083442; ENSRNOP00000069721; ENSRNOG00000054765.
GeneIDi81759.
KEGGirno:81759.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CB691242 mRNA. No translation available.
D10233 mRNA. Translation: BAA01083.1. Different initiation.
PIRiJX0187.
RefSeqiNP_112357.1. NM_031095.1.
XP_006229677.1. XM_006229615.2.
UniGeneiRn.11116.

3D structure databases

ProteinModelPortaliP51607.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053175.

Proteomic databases

PaxDbiP51607.
PRIDEiP51607.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000083442; ENSRNOP00000069721; ENSRNOG00000054765.
GeneIDi81759.
KEGGirno:81759.

Organism-specific databases

CTDi5973.
RGDi621688. Renbp.

Phylogenomic databases

eggNOGiENOG410IE08. Eukaryota.
COG2942. LUCA.
GeneTreeiENSGT00390000013740.
HOGENOMiHOG000252296.
HOVERGENiHBG054048.
InParanoidiP51607.
KOiK01787.
OMAiPMMLLNL.
OrthoDBiEOG7VDXP3.
PhylomeDBiP51607.

Enzyme and pathway databases

UniPathwayiUPA00629.

Miscellaneous databases

NextBioi615538.
PROiP51607.

Gene expression databases

GenevisibleiP51607. RN.

Family and domain databases

Gene3Di1.50.10.10. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
[Graphical view]
SUPFAMiSSF48208. SSF48208. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Amgen rat EST program."
    Amgen EST program
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-106.
  2. "Genetic and molecular properties of human and rat renin-binding proteins with reference to the function of the leucine zipper motif."
    Inoue H., Takahashi S., Fukui K., Miyake Y.
    J. Biochem. 110:493-500(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-430.
  3. "Tissue-specific regulation of renin-binding protein gene expression in rats."
    Tada M., Takahashi S., Miyano M., Miyake Y.
    J. Biochem. 112:175-182(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiRENBP_RAT
AccessioniPrimary (citable) accession number: P51607
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 20, 2010
Last modified: May 11, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1, Met-2 or Met-12 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.