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Protein

N-acylglucosamine 2-epimerase

Gene

RENBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.1 Publication

Catalytic activityi

N-acyl-D-glucosamine = N-acyl-D-mannosamine.

Pathwayi: N-acetylneuraminate degradation

This protein is involved in the pathway N-acetylneuraminate degradation, which is part of Amino-sugar metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway N-acetylneuraminate degradation and in Amino-sugar metabolism.

GO - Molecular functioni

  • ATP binding Source: Ensembl
  • endopeptidase inhibitor activity Source: ProtInc
  • N-acylglucosamine 2-epimerase activity Source: UniProtKB

GO - Biological processi

  • N-acetylglucosamine metabolic process Source: GO_Central
  • N-acetylmannosamine metabolic process Source: Ensembl
  • N-acetylneuraminate catabolic process Source: UniProtKB
  • regulation of blood pressure Source: ProtInc
  • UDP-N-acetylglucosamine biosynthetic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciZFISH:HS02337-MONOMER.
ReactomeiR-HSA-446210. Synthesis of UDP-N-acetyl-glucosamine.
SABIO-RKP51606.
UniPathwayiUPA00629.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acylglucosamine 2-epimerase (EC:5.1.3.8)
Short name:
AGE
Alternative name(s):
GlcNAc 2-epimerase
N-acetyl-D-glucosamine 2-epimerase
Renin-binding protein
Short name:
RnBP
Gene namesi
Name:RENBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:9959. RENBP.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi5973.
OpenTargetsiENSG00000102032.
PharmGKBiPA34325.

Chemistry databases

DrugBankiDB00141. N-Acetyl-D-glucosamine.

Polymorphism and mutation databases

BioMutaiRENBP.
DMDMi294862458.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002089491 – 427N-acylglucosamine 2-epimeraseAdd BLAST427

Proteomic databases

EPDiP51606.
MaxQBiP51606.
PaxDbiP51606.
PeptideAtlasiP51606.
PRIDEiP51606.

PTM databases

iPTMnetiP51606.
PhosphoSitePlusiP51606.

Expressioni

Gene expression databases

BgeeiENSG00000102032.
CleanExiHS_RENBP.
ExpressionAtlasiP51606. baseline and differential.
GenevisibleiP51606. HS.

Organism-specific databases

HPAiHPA000428.
HPA000522.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi111905. 2 interactors.
IntActiP51606. 3 interactors.
MINTiMINT-1464879.
STRINGi9606.ENSP00000377303.

Structurei

3D structure databases

ProteinModelPortaliP51606.
SMRiP51606.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni195 – 216Leucine-zipperAdd BLAST22

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IE08. Eukaryota.
COG2942. LUCA.
GeneTreeiENSGT00390000013740.
HOGENOMiHOG000252296.
HOVERGENiHBG102994.
InParanoidiP51606.
KOiK01787.
OMAiPMMLLNL.
OrthoDBiEOG091G0EO8.
PhylomeDBiP51606.
TreeFamiTF329027.

Family and domain databases

Gene3Di1.50.10.10. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
[Graphical view]
SUPFAMiSSF48208. SSF48208. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P51606-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKGLPARQD MEKERETLQA WKERVGQELD RVVAFWMEHS HDQEHGGFFT
60 70 80 90 100
CLGREGRVYD DLKYVWLQGR QVWMYCRLYR TFERFRHAQL LDAAKAGGEF
110 120 130 140 150
LLRYARVAPP GKKCAFVLTR DGRPVKVQRT IFSECFYTMA MNELWRATGE
160 170 180 190 200
VRYQTEAVEM MDQIVHWVQE DASGLGRPQL QGAPAAEPMA VPMMLLNLVE
210 220 230 240 250
QLGEADEELA GKYAELGDWC ARRILQHVQR DGQAVLENVS EGGKELPGCL
260 270 280 290 300
GRQQNPGHTL EAGWFLLRHC IRKGDPELRA HVIDKFLLLP FHSGWDPDHG
310 320 330 340 350
GLFYFQDADN FCPTQLEWAM KLWWPHSEAM IAFLMGYSDS GDPVLLRLFY
360 370 380 390 400
QVAEYTFRQF RDPEYGEWFG YLSREGKVAL SIKGGPFKGC FHVPRCLAMC
410 420
EEMLGALLSR PAPAPSPAPT PACRGAE
Length:427
Mass (Da):48,831
Last modified:April 20, 2010 - v2
Checksum:i40D5C485C30BE009
GO
Isoform 2 (identifier: P51606-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     230-254: RDGQAVLENVSEGGKELPGCLGRQQ → ATRWKPAGFCSVIAFGKATPNFEPT
     255-427: Missing.

Show »
Length:254
Mass (Da):29,270
Checksum:i9CB7FE6EED3368F7
GO

Sequence cautioni

The sequence AAH15558 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA01082 differs from that shown. Contaminating sequence.Curated
The sequence BAA01082 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti236L → P in AAH15558 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029339169Q → R.Corresponds to variant rs2229241dbSNPEnsembl.1
Natural variantiVAR_049182284D → G.Corresponds to variant rs2269371dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039022230 – 254RDGQA…LGRQQ → ATRWKPAGFCSVIAFGKATP NFEPT in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_039023255 – 427Missing in isoform 2. 1 PublicationAdd BLAST173

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298125 mRNA. Translation: BAG60405.1.
U52112 Genomic DNA. No translation available.
BC015558 mRNA. Translation: AAH15558.1. Different initiation.
D10232 mRNA. Translation: BAA01082.1. Sequence problems.
CCDSiCCDS14738.2. [P51606-1]
PIRiJX0188.
RefSeqiNP_002901.2. NM_002910.5. [P51606-1]
XP_016885187.1. XM_017029698.1.
UniGeneiHs.158331.

Genome annotation databases

EnsembliENST00000393700; ENSP00000377303; ENSG00000102032. [P51606-1]
GeneIDi5973.
KEGGihsa:5973.
UCSCiuc004fjo.3. human. [P51606-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298125 mRNA. Translation: BAG60405.1.
U52112 Genomic DNA. No translation available.
BC015558 mRNA. Translation: AAH15558.1. Different initiation.
D10232 mRNA. Translation: BAA01082.1. Sequence problems.
CCDSiCCDS14738.2. [P51606-1]
PIRiJX0188.
RefSeqiNP_002901.2. NM_002910.5. [P51606-1]
XP_016885187.1. XM_017029698.1.
UniGeneiHs.158331.

3D structure databases

ProteinModelPortaliP51606.
SMRiP51606.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111905. 2 interactors.
IntActiP51606. 3 interactors.
MINTiMINT-1464879.
STRINGi9606.ENSP00000377303.

Chemistry databases

DrugBankiDB00141. N-Acetyl-D-glucosamine.

PTM databases

iPTMnetiP51606.
PhosphoSitePlusiP51606.

Polymorphism and mutation databases

BioMutaiRENBP.
DMDMi294862458.

Proteomic databases

EPDiP51606.
MaxQBiP51606.
PaxDbiP51606.
PeptideAtlasiP51606.
PRIDEiP51606.

Protocols and materials databases

DNASUi5973.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393700; ENSP00000377303; ENSG00000102032. [P51606-1]
GeneIDi5973.
KEGGihsa:5973.
UCSCiuc004fjo.3. human. [P51606-1]

Organism-specific databases

CTDi5973.
DisGeNETi5973.
GeneCardsiRENBP.
H-InvDBHIX0203300.
HGNCiHGNC:9959. RENBP.
HPAiHPA000428.
HPA000522.
MIMi312420. gene.
neXtProtiNX_P51606.
OpenTargetsiENSG00000102032.
PharmGKBiPA34325.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE08. Eukaryota.
COG2942. LUCA.
GeneTreeiENSGT00390000013740.
HOGENOMiHOG000252296.
HOVERGENiHBG102994.
InParanoidiP51606.
KOiK01787.
OMAiPMMLLNL.
OrthoDBiEOG091G0EO8.
PhylomeDBiP51606.
TreeFamiTF329027.

Enzyme and pathway databases

UniPathwayiUPA00629.
BioCyciZFISH:HS02337-MONOMER.
ReactomeiR-HSA-446210. Synthesis of UDP-N-acetyl-glucosamine.
SABIO-RKP51606.

Miscellaneous databases

ChiTaRSiRENBP. human.
GeneWikiiRENBP.
GenomeRNAii5973.
PROiP51606.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102032.
CleanExiHS_RENBP.
ExpressionAtlasiP51606. baseline and differential.
GenevisibleiP51606. HS.

Family and domain databases

Gene3Di1.50.10.10. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
[Graphical view]
SUPFAMiSSF48208. SSF48208. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRENBP_HUMAN
AccessioniPrimary (citable) accession number: P51606
Secondary accession number(s): B4DNZ3, Q96BI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 20, 2010
Last modified: November 30, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-11 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.