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P51594

- GCH1_CAMJE

UniProt

P51594 - GCH1_CAMJE

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Protein
GTP cyclohydrolase 1
Gene
folE, Cj0194
Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi75 – 751Zinc By similarity
Metal bindingi78 – 781Zinc By similarity
Metal bindingi146 – 1461Zinc By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. one-carbon metabolic process Source: UniProtKB-HAMAP
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-189-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1 (EC:3.5.4.16)
Alternative name(s):
GTP cyclohydrolase I
Short name:
GTP-CH-I
Gene namesi
Name:folE
Ordered Locus Names:Cj0194
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000000799: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190GTP cyclohydrolase 1UniRule annotation
PRO_0000119393Add
BLAST

Interactioni

Subunit structurei

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Protein-protein interaction databases

IntActiP51594. 1 interaction.
STRINGi192222.Cj0194.

Structurei

3D structure databases

ProteinModelPortaliP51594.
SMRiP51594. Positions 2-183.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0302.
HOGENOMiHOG000221222.
KOiK01495.
OMAiYEQIEYA.
OrthoDBiEOG6XHC8G.

Family and domain databases

HAMAPiMF_00223. FolE.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51594-1 [UniParc]FASTAAdd to Basket

« Hide

MQKKFEDCVK TMLEIIGENP NREGLIKTPN RVFKAYEFLT SGYTQNVKEI    50
LNDALFESSN NEMVLVRDIE FYSLCEHHLL PFFGRAHVAY IPNKKVVGLS 100
KIPRLVEVFA RRLQIQEQLT EQIAQALMEN VDAKGVGVVI EARHMCVEMR 150
GVQKANSTTT TSALRGIFLK NEKTREEFFS LINSAKQVRF 190
Length:190
Mass (Da):21,800
Last modified:December 1, 2000 - v2
Checksum:i24B4CC39BEA49564
GO

Sequence cautioni

The sequence CAA59929.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X85954 Genomic DNA. Translation: CAA59929.1. Different initiation.
AL111168 Genomic DNA. Translation: CAL34363.1.
PIRiA81438.
I40754.
RefSeqiYP_002343652.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL34363; CAL34363; Cj0194.
GeneIDi904536.
KEGGicje:Cj0194.
PATRICi20057315. VBICamJej33762_0191.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X85954 Genomic DNA. Translation: CAA59929.1 . Different initiation.
AL111168 Genomic DNA. Translation: CAL34363.1 .
PIRi A81438.
I40754.
RefSeqi YP_002343652.1. NC_002163.1.

3D structure databases

ProteinModelPortali P51594.
SMRi P51594. Positions 2-183.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P51594. 1 interaction.
STRINGi 192222.Cj0194.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL34363 ; CAL34363 ; Cj0194 .
GeneIDi 904536.
KEGGi cje:Cj0194.
PATRICi 20057315. VBICamJej33762_0191.

Phylogenomic databases

eggNOGi COG0302.
HOGENOMi HOG000221222.
KOi K01495.
OMAi YEQIEYA.
OrthoDBi EOG6XHC8G.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci CJEJ192222:GJTS-189-MONOMER.

Family and domain databases

HAMAPi MF_00223. FolE.
InterProi IPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view ]
PANTHERi PTHR11109. PTHR11109. 1 hit.
Pfami PF01227. GTP_cyclohydroI. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00063. folE. 1 hit.
PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The gene for Campylobacter trigger factor: evidence for multiple transcription start sites and protein products."
    Griffiths P.L., Park R.W.A., Connerton I.F.
    Microbiology 141:1359-1367(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NCTC 11168.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 11168.

Entry informationi

Entry nameiGCH1_CAMJE
AccessioniPrimary (citable) accession number: P51594
Secondary accession number(s): Q0PBU5, Q9PIT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 1, 2000
Last modified: May 14, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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