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P51594

- GCH1_CAMJE

UniProt

P51594 - GCH1_CAMJE

Protein

GTP cyclohydrolase 1

Gene

folE

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi75 – 751ZincBy similarity
    Metal bindingi78 – 781ZincBy similarity
    Metal bindingi146 – 1461ZincBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
    2. one-carbon metabolic process Source: UniProtKB-HAMAP
    3. tetrahydrofolate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    GTP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciCJEJ192222:GJTS-189-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase 1 (EC:3.5.4.16)
    Alternative name(s):
    GTP cyclohydrolase I
    Short name:
    GTP-CH-I
    Gene namesi
    Name:folE
    Ordered Locus Names:Cj0194
    OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
    Taxonomic identifieri192222 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
    ProteomesiUP000000799: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 190190GTP cyclohydrolase 1PRO_0000119393Add
    BLAST

    Interactioni

    Subunit structurei

    Toroid-shaped homodecamer, composed of two pentamers of five dimers.By similarity

    Protein-protein interaction databases

    IntActiP51594. 1 interaction.
    STRINGi192222.Cj0194.

    Structurei

    3D structure databases

    ProteinModelPortaliP51594.
    SMRiP51594. Positions 2-183.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase I family.Curated

    Phylogenomic databases

    eggNOGiCOG0302.
    HOGENOMiHOG000221222.
    KOiK01495.
    OMAiYEQIEYA.
    OrthoDBiEOG6XHC8G.

    Family and domain databases

    HAMAPiMF_00223. FolE.
    InterProiIPR001474. GTP_CycHdrlase_I.
    IPR018234. GTP_CycHdrlase_I_CS.
    IPR020602. GTP_CycHdrlase_I_dom.
    [Graphical view]
    PANTHERiPTHR11109. PTHR11109. 1 hit.
    PfamiPF01227. GTP_cyclohydroI. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00063. folE. 1 hit.
    PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51594-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKKFEDCVK TMLEIIGENP NREGLIKTPN RVFKAYEFLT SGYTQNVKEI    50
    LNDALFESSN NEMVLVRDIE FYSLCEHHLL PFFGRAHVAY IPNKKVVGLS 100
    KIPRLVEVFA RRLQIQEQLT EQIAQALMEN VDAKGVGVVI EARHMCVEMR 150
    GVQKANSTTT TSALRGIFLK NEKTREEFFS LINSAKQVRF 190
    Length:190
    Mass (Da):21,800
    Last modified:December 1, 2000 - v2
    Checksum:i24B4CC39BEA49564
    GO

    Sequence cautioni

    The sequence CAA59929.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X85954 Genomic DNA. Translation: CAA59929.1. Different initiation.
    AL111168 Genomic DNA. Translation: CAL34363.1.
    PIRiA81438.
    I40754.
    RefSeqiYP_002343652.1. NC_002163.1.

    Genome annotation databases

    EnsemblBacteriaiCAL34363; CAL34363; Cj0194.
    GeneIDi904536.
    KEGGicje:Cj0194.
    PATRICi20057315. VBICamJej33762_0191.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X85954 Genomic DNA. Translation: CAA59929.1 . Different initiation.
    AL111168 Genomic DNA. Translation: CAL34363.1 .
    PIRi A81438.
    I40754.
    RefSeqi YP_002343652.1. NC_002163.1.

    3D structure databases

    ProteinModelPortali P51594.
    SMRi P51594. Positions 2-183.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P51594. 1 interaction.
    STRINGi 192222.Cj0194.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL34363 ; CAL34363 ; Cj0194 .
    GeneIDi 904536.
    KEGGi cje:Cj0194.
    PATRICi 20057315. VBICamJej33762_0191.

    Phylogenomic databases

    eggNOGi COG0302.
    HOGENOMi HOG000221222.
    KOi K01495.
    OMAi YEQIEYA.
    OrthoDBi EOG6XHC8G.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci CJEJ192222:GJTS-189-MONOMER.

    Family and domain databases

    HAMAPi MF_00223. FolE.
    InterProi IPR001474. GTP_CycHdrlase_I.
    IPR018234. GTP_CycHdrlase_I_CS.
    IPR020602. GTP_CycHdrlase_I_dom.
    [Graphical view ]
    PANTHERi PTHR11109. PTHR11109. 1 hit.
    Pfami PF01227. GTP_cyclohydroI. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00063. folE. 1 hit.
    PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The gene for Campylobacter trigger factor: evidence for multiple transcription start sites and protein products."
      Griffiths P.L., Park R.W.A., Connerton I.F.
      Microbiology 141:1359-1367(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: NCTC 11168.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCTC 11168.

    Entry informationi

    Entry nameiGCH1_CAMJE
    AccessioniPrimary (citable) accession number: P51594
    Secondary accession number(s): Q0PBU5, Q9PIT5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3